Imamura Minako

写真a

Title

Professor

Researcher Number(JSPS Kakenhi)

00596124
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Graduate School of Medicine   Professor  

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University 【 display / non-display 】

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    1995.03

    Kyushu University   Faculty of Medicine   Graduated

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Graduate School 【 display / non-display 】

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    2002.09

    Kyushu University    Doctor's Course  Completed

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External Career 【 display / non-display 】

  • 2002.10
    　
    　

     

  • 2003.09
    　
    　

     

  • 2010.09
    　
    　

     

  • 2014.08
    　
    　

     

  • 2015.11
    　
    　

    University of the Ryukyus  

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Affiliated academic organizations 【 display / non-display 】

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    The Journal of Clinical Endocrinology & Metabolism    Editorial Board

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    JAPANESE SOCIETY OF LABORATORY MEDICINE 

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    The Japan Endocrine Society 

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    THE JAPANESE SOCIETY OF INTERNAL MEDICINE 

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    THE JAPAN SOCIETY OF HUMAN GENETICS 

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Research Areas 【 display / non-display 】

  • Life Science / Medical biochemistry

  • Life Science / Metabolism and endocrinology

  • Laboratory medicine

  • Life Science / Metabolism and endocrinology

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Published Papers 【 display / non-display 】

  • Genetic studies on metabolic disorder-associated kidney diseases.

    Imamura M, Kadowaki T, Maeda S

    Kidney international ( Kidney International )  108 ( 1 ) 30 - 37   2025.07 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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  • A variant in <i>HMMR/HMMR-AS1</i> is associated with serum alanine aminotransferase levels in the Ryukyu population

    Ohyama, N; Matsunami, M; Imamura, M; Yoshida, A; Javed, A; Liu, XX; Kimura, R; Matsuda, K; BioBank Japan Project; Terao, C; Maeda, S

    SCIENTIFIC REPORTS ( Scientific Reports )  15 ( 1 ) 6494 - 6494   2025.02 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    The Ryukyu archipelago is located southwest of the Japanese islands, and people originally from this region, the Ryukyu population, have a unique genetic background distinct from that of other populations, including people from mainland Japan. However, few genetic studies have focused on the Ryukyu population. In this study, we performed genome-wide association studies (GWAS) on the serum levels of alanine aminotransferase (ALT, n = 15,224), aspartate aminotransferase (AST, n = 15,203), and gamma-glutamyl transferase (GGT, n = 14,496) in the Ryukyu population. We found 13 loci with a genome-wide significant association (P < 5 × 10-8), three for ALT, four for AST, and six for GGT, including one novel locus associated with ALT: rs117595134-A in HMMR/HMMR-AS1, ß =  - 0.131, standard error = 0.024, P = 4.90 × 10-8. Rs117595134-A is common in the Japanese population but is not observed in other ethnic populations in the 1000 genomes database. Additionally, 77 of 80 loci derived from Korean GWAS and 541 of 716 loci from European GWAS showed the same directions of effect (P = 1.41 × 10-19, P = 2.50 × 10-44, binomial test), indicating that most of susceptibility loci are shared between the Ryukyu population and other ethnic populations.

  • Genetic studies of type 2 diabetes, and microvascular complications of diabetes

    Imamura, M; Maeda, S

    DIABETOLOGY INTERNATIONAL ( Diabetology International )  15 ( 4 ) 699 - 706   2024.10 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Genome-wide association studies for pelvic organ prolapse in the Japanese population

    Matsunami, M; Imamura, M; Ashikari, A; Liu, XX; Tomizuka, K; Hikino, K; Miwa, K; Kadekawa, K; Suda, T; Matsuda, K; Miyazato, M; Terao, C; Maeda, S

    COMMUNICATIONS BIOLOGY ( Nature Research )  7 ( 1 ) 1188 - 9   2024.09 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by thedescent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wideassociation study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in theJapanese population. We identified a significant association of WT1 locus with POP in the Japanesepopulation; rs10742277; odds ratio (OR) = 1.48, 95% confidence interval (CI), 1.29–1.68,P = 6.72 × 10−9. Subsequent cross-ancestry GWAS meta-analysis combining the Japanese data andpreviously reported European data, including 28,857 cases and 622,916 controls, identified FGFR2locus as a novel susceptibility locus to POP (rs7072877; OR = 1.06, 95% CI, 1.04–1.08,P = 4.11 × 10−8). We also observed consistent directions of the effects for 21 out of 24 European GWASderived loci (binomial test P = 2.8 × 10−4), indicating that most of susceptibility loci for POP are sharedacross the Japanese and European populations.

  • Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study

    Uema, T; Tsukita, M; Okamoto, S; Uehara, M; Honma, KI; Nakayama, Y; Tamaki, A; Miyazato, M; Ashikari, A; Maeda, S; Imamura, M; Matsushita, M; Nakamura, K; Masuzaki, H

    DIABETES RESEARCH AND CLINICAL PRACTICE ( ELSEVIER )  213   111747 - 8   2024.07

    Type of publication: Research paper (scientific journal)

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    Aim: The present cohort study explored whether specific gut microbiota (GM) profile would predict the development of impaired glucose tolerance (IGT) in individuals with normal glucose tolerance (NGT). Methods: A total of 114 study subjects with NGT in Kumejima island, Japan participated in the present study and underwent 75 g oral glucose tolerance tests at baseline and one year later. We compared the profile of GM at baseline between individuals who consistently maintained NGT (NRN, n = 108) and those who transitioned from NGT to IGT (NTI, n = 6). Results: Within-individual bacterial richness and evenness as well as inter-individual bacterial composition showed no significant differences between NRN and NTI. Of note, however, partial least squares discriminant analyses revealed distinct compositions of GM between groups, with no overlap in their 95 % confidence interval ellipses. Multi-factor analyses at the genus level demonstrated that the proportions of CF231, Corynebacterium, Succinivibrio, and Geobacillus were significantly elevated in NTI compared to NRN (p < 0.005, FDR < 0.1, respectively) after adjusting for age, sex, HbA1c level, and BMI. Conclusions: Our data suggest that increased proportion of specific GM is linked to the future deterioration of glucose tolerance, thereby serving as a promising predictive marker for type 2 diabetes mellitus.

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Books 【 display / non-display 】

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Other Papers 【 display / non-display 】

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Deciphering the prehistoric peopling of the Ryukyu Archipelago based on ancient genome data

    Grant-in-Aid for Scientific Research(B)

    Project Year: 2023.04  -  2027.03 

    Direct: 14,400,000 (YEN)  Overheads: 18,720,000 (YEN)  Total: 4,320,000 (YEN)

  • Deciphering the prehistoric peopling of the Ryukyu Archipelago based on ancient genome data

    Grant-in-Aid for Scientific Research(B)

    Project Year: 2023.04  -  2027.03 

    Direct: 14,400,000 (YEN)  Overheads: 18,720,000 (YEN)  Total: 4,320,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2023.04  -  2026.03 

    Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2023.04  -  2026.03 

    Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2020.04  -  2023.03 

    Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

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Social Activity 【 display / non-display 】

  • 2023.09
    　
    　

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