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• Reconstruction of the elbow using pedicle joint freezing after wide excision for soft tissue sarcoma: A case report

  Hashimoto, Y; Tome, Y; Oshiro, H; Aoki, Y; Maehara, H; Nishida, K

  MOLECULAR AND CLINICAL ONCOLOGY ( Molecular and Clinical Oncology )  14 ( 6 ) 115   2021.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• The Efficacy of High-Dose Chemotherapy and Autologous Stem Cell Transplantation for High-Risk Osteosarcoma

  Sakiyama, H; Hamada, S; Yagi, T; Miyamoto, J; Oshiro, T; Uehara, T; Kiyuna, S; Tome, Y; Maehara, H; Matsuda, T; Higa, T; Hyakuna, N; Nakanishi, K

  PEDIATRIC BLOOD & CANCER   66   S60 - S60   2019.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Radiation-induced sarcoma in a 10-year survivor with stage IV EGFR-mutated lung adenocarcinoma

  Shibahara, D; Furugen, M; Kasashima, S; Kaneku, K; Yamashiro, T; Arakaki, W; Ariga, T; Atsumi, E; Aoyama, H; Matsumoto, H; Maehara, H; Fujita, J

  RESPIRATORY MEDICINE CASE REPORTS ( Respiratory Medicine Case Reports )  28   100889 - 100889   2019 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

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  A 70-year-old Japanese man with stage IV EGFR-mutated lung adenocarcinoma complained of right mild back pain. The patient had been heavily treated with several cytotoxic or molecular targeted agents for 10 years and received a palliative radiation therapy of 2nd sacral vertebra 5 years ago. Computed tomography showed the abnormal lesion in right iliopsoas muscle. A pathological examination confirmed undifferentiated pleomorphic sarcoma, consistent with the diagnosis of radiation-induced sarcoma (RIS). Since RIS is a rare late-onset complication of radiation therapy, to our knowledge, this is the first report of RIS that was associated with advanced lung cancer and detected after palliative radiation therapy. The careful long-term follow-up is thus necessary even after palliative radiation therapy and we have to be aware of the existence of RIS.

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• MRI findings and demographics of elastofibroma dorsi: assessment of diffusion-weighted imaging and contrast enhancement patterns

  Tsubakimoto, M; Yamashiro, T; Tsuchiya, N; Okada, M; Maehara, H; Kitsukawa, K; Murayama, S

  ACTA RADIOLOGICA ( Acta Radiologica )  59 ( 6 ) 709 - 715   2018.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Background Elastofibroma dorsi is a rare pseudotumoral lesion. Thus, there is no report of magnetic resonance imaging (MRI) findings that investigates multiple patients particularly with respect to diffusion-weighted imaging (DWI) findings and contrast enhancement patterns. Purpose To describe the imaging findings of elastofibroma on MRI, particularly DWI findings and contrast enhancement patterns, and to further investigate patient demographics. Material and Methods Forty-four patients with elastofibroma that underwent MRI were enrolled in this retrospective study. All images were evaluated by two radiologists to visually assess the signal intensity for each sequence. Enhanced elastofibromas were classified into four categories to assess the enhancement pattern. Differences in gender and laterality were also assessed statistically. Results An equal number of men and women were included (n = 22 each). There was no significant difference in laterality ( P = 0.783). All lesions (73 lesions) had low signal intensity on both T1-weighted (T1W) and T2-weighted (T2W) images: heterogeneous in 56, homogeneous in 17. None of the 41 lesions with DWI had true abnormal diffusion restriction. The average ADC value was 1.36 × 10-3 ± 0.29 mm2/s. All 31 lesions that had contrast-enhanced MRI were classified according to enhancement pattern: homogeneous (three lesions, 9.7%); heterogeneous (15 lesions, 48.4%); streak-like (three lesions, 9.7%); and rim-like (ten lesions, 32.2%). Conclusion There were no statistically significant differences in gender or laterality. Elastofibroma showed homogeneous to heterogeneous low signal intensity on T1W and T2W images. No lesion showed abnormal diffusion restriction, and all lesions demonstrated enhancement on MRI.

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• Fluorescence-Guided Surgery of Retroperitoneal-Implanted Human Fibrosarcoma in Nude Mice Delays or Eliminates Tumor Recurrence and Increases Survival Compared to Bright-Light Surgery

  Uehara, F; Hiroshima, Y; Miwa, S; Tome, Y; Yano, S; Yamamoto, M; Matsumoto, Y; Maehara, H; Tanaka, K; Bouvet, M; Kanaya, F; Hoffman, RM

  PLOS ONE ( PLoS ONE )  10 ( 2 ) e0116865   2015.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  The aim of this study is to determine if fluorescence-guided surgery (FGS) can eradicate human fibrosarcoma growing in the retroperitoneum of nude mice. One week after retroperitoneal implantation of human HT1080 fibrosarcoma cells, expressing green fluorescent protein (GFP) (HT-1080-GFP), in nude mice, bright-light surgery (BLS) was performed on all tumor-bearing mice (n = 22). After BLS, mice were randomized into 2 treatment groups; BLS-only (n = 11) or the combination of BLS + FGS (n = 11). The residual tumors remaining after BLS were resected with FGS using a hand-held portable imaging system under fluorescence navigation. The average residual tumor area after BLS + FGS was significantly smaller than after BLS-only (0.4 ± 0.4 mm(2) and 10.5 ± 2.4 mm(2), respectively; p = 0.006). Five weeks after surgery, the fluorescent-tumor areas of BLS- and BLS + FGS-treated mice were 379 ± 147 mm(2) and 11.7 ± 6.9 mm(2), respectively, indicating that FGS greatly inhibited tumor recurrence compared to BLS. The combination of BLS + FGS significantly decreased fibrosarcoma recurrence compared to BLS-only treated mice (p < 0.001). Mice treated with BLS+FGS had a significantly higher disease-free survival rate than mice treated with BLS-only at five weeks after surgery. These results suggest that combination of BLS + FGS significantly reduced the residual fibrosarcoma volume after BLS and improved disease-free survival.

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• The research of biochemical effects of early active mobilization protocol after flexor tendon repair.

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2012.04  -  2015.03 

  Investigator(s): FUTENMA Chojo, KANAYA Fuminori, MAEHARA Hiroki 

  Direct: 1,100,000 (YEN)  Overheads: 1,430,000 (YEN)  Total: 330,000 (YEN)

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  Rat's 2nd, 3rd and 4th toe flexor tendons were transected and repaired under general anesthesia. The repaired tendons were divided into 2 groups; group 1 (immobilized group): the ankle joint was maximum flexed and MTP joints were 90-degree flexion: group 2 (active mobilized group): the ankle was 0-degree flexed and the toes were permitted active flexion and extension. Tensile strength, macroscopic findings and pathological findings were evaluated on 0 or 7 or 14 or 21 or 28 days after surgery. The tensile strengths of active mobilized group were significantly greater than immobilized group on 21 and 28 days. On macroscopic, the repair sites of immobilized group were atrophic compared to active mobilized group on 21 and 28 days. On pathologic findings, the healing process of active mobilized group was earlier than immobilized group. Extractions of RNA were failed, because there were few cells on repaired tendons. We couldn't perform about RT - PCR or adherence gene research.

• The research of biochemical effects of early active mobilization protocol after flexor tendon repair.

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2012.04  -  2015.03 

  Investigator(s): FUTENMA Chojo, KANAYA Fuminori, MAEHARA Hiroki 

  Direct: 1,100,000 (YEN)  Overheads: 1,430,000 (YEN)  Total: 330,000 (YEN)

  　View Summary

  Rat's 2nd, 3rd and 4th toe flexor tendons were transected and repaired under general anesthesia. The repaired tendons were divided into 2 groups; group 1 (immobilized group): the ankle joint was maximum flexed and MTP joints were 90-degree flexion: group 2 (active mobilized group): the ankle was 0-degree flexed and the toes were permitted active flexion and extension. Tensile strength, macroscopic findings and pathological findings were evaluated on 0 or 7 or 14 or 21 or 28 days after surgery. The tensile strengths of active mobilized group were significantly greater than immobilized group on 21 and 28 days. On macroscopic, the repair sites of immobilized group were atrophic compared to active mobilized group on 21 and 28 days. On pathologic findings, the healing process of active mobilized group was earlier than immobilized group. Extractions of RNA were failed, because there were few cells on repaired tendons. We couldn't perform about RT - PCR or adherence gene research.