Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

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Acquisition of a qualification 【 display / non-display 】

Acquisition of a qualification 【 display / non-display 】

Thesis 【 display / non-display 】

Thesis 【 display / non-display 】

• Studies on Bioactive Compounds from Unutilized Marine Natural Resources

  2006.06

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Chemical Compositions of the Marine Red Alga <i>Laurencia composita</i> Collected in Japan

  Miwa, T; Sato, K; Osada, D; Nimura, K; Kato, A; Tsuge, K; Fukada, R; Yokoshima, K; Ishii, T; Yamagishi, Y; Kamada, T

  CHEMISTRY & BIODIVERSITY     e202403326   2025.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Anti-biofouling marine diterpenoids from Okinawan soft corals

  Ishigami, S; Nakagawa, R; Yagi, F; Takada, H; Suzuki, A; Kamada, T; Nimura, K; Oshima, I; Phan, CS; Ishii, T

  BIOFOULING ( Biofouling )  41 ( 1 ) 103 - 112   2025.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Lemnalol acetate, ylangene-type sesquiterpenoid isolated as natural product from the soft coral genus Lemnalia collected in Okinawa

  Nakagawa, R., Miwa, T., Miyaji, T., Nakamura, R., Nimura, K., Fukada, R., Ishii, T., Hamada, T., Kamada, T.

  Galaxea     2025 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Morphological and Chemical Diversity within Japanese Laurencia Complex (Rhodomelaceae, Ceramiales, Rhodophyta).

  Yamagishi Y, Kamada T, Ishii T, Matsuura H, Kikuchi N, Abe T, Suzuki M

  Chemistry & biodiversity ( Wiley )    e202400833   2024.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Seaweeds of the red algal genus Laurencia are widely distributed worldwide in tropical, subtropical to temperate zones, and grow in Japan from Hokkaido to Okinawa. Laurencia is one of the most studied seaweeds by organic chemists because it produces a variety of compounds with unique structures. In Japan, various halogenated compounds have been found in Laurencia, while some species do not produce any halogenated compounds. Laurencia is one of the most difficult seaweeds to classify morphologically; however, the major halogenated secondary metabolites produced tend to be species‐specific, and these compounds can be used as chemical markers for chemical systematics (chemotaxonomy). Similarly, it has been confirmed that domestic Laurencia species produce species‐specific halogenated compounds of certain types. Laurencia is one of the "weedy seaweeds" that have not been effectively utilized at present, but it produces a wide variety of metabolites, so there is a good possibility that compounds with specific activity may be found. Thus, it can be seen that the secondary metabolites in Laurencia have many interesting aspects. In this review, we reported significant morphological features to distinguish species in this genus, and the morphological features, habitat, distribution, and chemical composition that help discriminate Japanese Laurencia species.

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• Halogenated Cyclic Monoterpenoids with Anti-biofouling Activity from the Okinawan Red Marine Algae Portieria hornemannii.

  Ishigami S, Fukada R, Nagasaka G, Tsuruta T, Nishikawa K, Sasaki Y, Nimura K, Oshima I, Yamagishi Y, Morimoto Y, Kamada T, Ishii T

  Chemistry & biodiversity     e202400436   2024.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Potential validation of antimalarial seeds derived from fungi

  岡野太一, 木村奏一朗, 渡邊善洋, 渡邊善洋, 橋本瑞希, 小島裕貴, 小島裕貴, 野中健一, 稲橋佑起, 稲橋佑起, 石井貴広, 照屋俊明, 石山亜紀, 石山亜紀, 穗苅玲, 穗苅玲, 清和成, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   144th   2024

   

  J-GLOBAL

• Search for new antimalarial compounds from microbial metabolites

  木村奏一朗, 渡邊善洋, 渡邊善洋, 稲橋佑起, 稲橋佑起, 野中健一, 石井貴広, 照屋俊明, 穗苅玲, 穗苅玲, 石山亜紀, 石山亜紀, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   144th   2024

   

  J-GLOBAL

• Search for antileishmanial compounds from microbial metabolites

  橋本瑞希, 村山諒, 渡邊善洋, 渡邊善洋, 肥後茉由佳, 肥後茉由佳, 野中健一, 野中健一, 稲橋佑起, 稲橋佑起, 石川春樹, 丑田公規, 石井貴広, 照屋俊明, 石山亜紀, 石山亜紀, 穗苅玲, 穗苅玲, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   143rd   2023

   

  J-GLOBAL

• Corrigendum: Two New Halogenated Compounds from the Marine Red Alga Laurencia nipponica Yamada from the Kunashiri and Etorofu Islands.

  Kosuke Sato, Kensuke Kaneko, Tsuyoshi Kamekawa, Kanako Taba, Shinnosuke Ishigami, Masahiro Wada, Takahiro Ishii, Tsuyoshi Abe, Takashi Kamada, Minoru Suzuki

  Chemistry & biodiversity   19 ( 3 ) e202200112   2022.03

   

  DOI PubMed

• Search for antimalarial compounds from microbial metabolites

  木村奏一朗, 渡邊善洋, 渡邊善洋, 小池李茉, 穗苅玲, 穗苅玲, 石山亜紀, 石山亜紀, 浅見行弘, 浅見行弘, 野中健一, 野中健一, 稲橋佑起, 稲橋佑起, 木村透, 照屋俊明, 石井貴広, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   142nd   2022

   

  J-GLOBAL

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• マレーシア産軟体サンゴ由来の生物活性物質

  Phan Chin-Soon・鎌田昂・石井貴広・濱田季之・Vairappan Charles S.

  日本サンゴ礁学会第22回大会  (札幌)  2019.11  -  2019.11 

• マレーシアサバ州に分布する軟質サンゴ由来の新規テルペンとその生物活性

  パンチンスン・鎌田昂・濱田季之・石井貴広・バイラパンチャールズ

  第63回香料・テルペンおよび精油化学に関する討論会  (秋田)  2019.09  -  2019.09 

• Bioactive Terpenes from Soft Corals in North Borneo

  2018.10  -  2018.10 

• Bioactive Terpenes from Soft Corals in North Borneo

  2018.10  -  2018.10 

• Sex steroid as the possible key in oocyte development of the scleractinian coral, Acropora tenuis

  Tan, E., Izumi, R., Ishii, T., Takeuchi, Y., Yang, S., Shikina, S., Chang, C. F., Takemura, A.

  日本動物学会第89回大会  (札幌)  2018.09  -  2018.09 

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Industrial Property 【 display / non-display 】

Industrial Property 【 display / non-display 】

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Silver award (Research and Innovation Competition (Pereka) UMS 2009)

  2009.07   Universiti Malaysia Sabah  

  　View Summary

  Novel marine metabolites with potent pharmaceutical potentials

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Search for advanced inhibitors of YUCCA, a key enzyme in auxin biosynthesis

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2014.04  -  2017.03 

  Investigator(s): ISHII Takahiro, SHIMADA Yukihisa, SOENO Kazuo 

  Direct: 4,000,000 (YEN)  Overheads: 5,200,000 (YEN)  Total: 1,200,000 (YEN)

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  From the results of screening of own chemical library (including about 200 samples) using both YUCCA enzyme inhibition test (in vitro) and plant growth test with Arabidopsis seeds (in vivo), it was found that several extracts from the red algal genus Laurencia and sea hares, together with 2-APB known as a TRP channel inhibitor, exhibited strong inhibitory effects. Bioassay-guided fractionation of these active extracts resulted in the isolation of three halogenated laurane-type sesquiterpenes with different chemical structures from known YUCCA inhibitors. Among these active compounds, laurinterol and 2-APB showed stronger inhibitory activity than known inhibitors in the plant growth inhibition assay.