Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

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• Studies on Bioactive Compounds from Unutilized Marine Natural Resources

  2006.06

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Halogenated Cyclic Monoterpenoids with Anti-biofouling Activity from the Okinawan Red Marine Algae Portieria hornemannii.

  Ishigami S, Fukada R, Nagasaka G, Tsuruta T, Nishikawa K, Sasaki Y, Nimura K, Oshima I, Yamagishi Y, Morimoto Y, Kamada T, Ishii T

  Chemistry & biodiversity     e202400436   2024.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001.

  Janthanom R, Kikuchi Y, Kanto H, Hirose T, Tahara A, Ishii T, Thamchaipenet A, Inahashi Y

  Beilstein journal of organic chemistry ( Beilstein Journal of Organic Chemistry )  20   497 - 503   2024 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Actinomycetes are well-known as the main producers of bioactive compounds such as antibiotics, anticancers, and immunosuppressants. Screening of natural products from actinomycetes has been an essential part of several drug discovery programs. Finding such novel biologically active metabolites is immensely important because of their beneficial health effects. Recently, the discovery of new compounds has diverted attention to rare actinomycetes, since they are rich sources of natural products. In this study, a collection of rare actinomycetes at Kitasato University has been screened for potential novel compound producers. Among the rare actinomycetes, Saccharopolyspora sp. KR21-0001 isolated from soil on Ōha Island, Okinawa, Japan was selected as a potential producer. The strain was cultured in 20 L of production medium in a jar fermenter and the culture broth was extracted. Further purification revealed the presence of a new compound designated KR21-0001A (1). The structure was elucidated by NMR, and the absolute stereochemistry was determined by advanced Marfey's method. The results indicated that 1 is a new analog of dihydroxybenzoic acid. 1 has no antimicrobial activity against bacteria and fungi but showed potent antioxidant activity.

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• A novel aromatic compound from the fungus <i>Synnemellisia</i> sp. FKR-0921

  Tahara, A; Tani, K; Wakatsuki, M; Tokiwa, T; Higo, M; Nonaka, K; Hirose, T; Hokari, R; Ishiyama, A; Iwatsuki, M; Watanabe, Y; Honsho, M; Asami, Y; Matsui, H; Sunazuka, T; Hanaki, H; Teruya, T; Ishii, T

  JOURNAL OF ANTIBIOTICS ( Journal of Antibiotics )    2023.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Diversity of Halogenated Secondary Metabolites in Okinawan Aplysia argus Including 12-Hydroxypinnaterpene C and Their Feeding Targets.

  Nagasaka M, Isa H, Tahara A, Fukada R, Kamada T, Ishii T

  Chemistry & biodiversity ( Chemistry and Biodiversity )  20 ( 8 ) e202300791   2023.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  A new irieane-type diterpene, 12-hydroxypinnaterpene C (1), and 21 known compounds, angasiol acetate (2), angasiol (3), 11-deacetylpinnaterpene C (4), palisadin A (5), 12-acetoxypalisadin B (6), 12-hydroxypalisadin B (7), aplysistatin (8), luzodiol (9), 5-acetoxy-2-bromo-3-chloro-chamigra-7(14),9-dien-8-one (10), neoirietriol (11), neoirietetraol (12), (3Z)-laurenyne (13), cupalaurenol (14), cupalaurenol acetate (15), (3Z)-venustinene (16), 10-hydroxykahukuene B (17), aplysiol B (18), (3Z)-13-epipinnatifidenyne (19), 3Z,6R,7R,12S,13S-obtusenyne (20), (3Z,9Z)-7-chloro-6-hydroxy-12-oxo-pentadeca-3,9-dien-1-yne (21), and cholest-7-en-3,5,7-triol (22) were isolated from the digestive diverticula of Aplysia argus from the Ikei Island in Okinawa, Japan. The structures of these compounds were determined using spectroscopic methods such as NMR and HR-ESI-MS. These compounds were tested for their antibacterial activity against the phytopathogen Ralstonia solanacearum. Compounds 11 and 21 exhibited antibacterial activity at 30 μg/disc. In this study, we also discuss the types of red algae that A. argus feeds on in the shallow waters of Okinawa Prefecture.

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• Antifouling Brominated Diterpenoids from Japanese Marine Red Alga Laurencia venusta Yamada.

  Fukada R, Yamagishi Y, Nagasaka M, Osada D, Nimura K, Oshima I, Tsujimoto K, Kirihara M, Takizawa S, Kikuchi N, Ishii T, Kamada T

  Chemistry & biodiversity ( Chemistry and Biodiversity )  20 ( 8 ) e202300888   2023.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  The marine red algal genus Laurencia has abundant halogenated secondary metabolites, which exhibit novel structural types and possess various unique biological potentials, including antifouling activity. In this study, we report the isolation, structure elucidation, and antifouling activities of two novel brominated diterpenoids, aplysin-20 aldehyde (1), 13-dehydroxyisoaplysin-20 (2), and its congeners. We screened marine red alga Laurencia venusta Yamada for their antifouling activity against the mussel Mytilus galloprovincialis. Ethyl acetate extracts of L. venusta from Hiroshima and Chiba, Japan, were isolated and purified, and the compound structures were identified using 1D and 2D NMR, HR-APCI-MS, IR, and chemical synthesis. Seven secondary metabolites were identified, and their antifouling activities were evaluated. Compounds 1, 2, and aplysin-20 (3) exhibited strong activities against M. galloprovincialis. Therefore, these compounds can be explored as natural antifouling drugs.

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• Search for antileishmanial compounds from microbial metabolites

  橋本瑞希, 村山諒, 渡邊善洋, 渡邊善洋, 肥後茉由佳, 肥後茉由佳, 野中健一, 野中健一, 稲橋佑起, 稲橋佑起, 石川春樹, 丑田公規, 石井貴広, 照屋俊明, 石山亜紀, 石山亜紀, 穗苅玲, 穗苅玲, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   143rd   2023

   

  J-GLOBAL

• Corrigendum: Two New Halogenated Compounds from the Marine Red Alga Laurencia nipponica Yamada from the Kunashiri and Etorofu Islands.

  Kosuke Sato, Kensuke Kaneko, Tsuyoshi Kamekawa, Kanako Taba, Shinnosuke Ishigami, Masahiro Wada, Takahiro Ishii, Tsuyoshi Abe, Takashi Kamada, Minoru Suzuki

  Chemistry & biodiversity   19 ( 3 ) e202200112   2022.03

   

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• Search for antimalarial compounds from microbial metabolites

  木村奏一朗, 渡邊善洋, 渡邊善洋, 小池李茉, 穗苅玲, 穗苅玲, 石山亜紀, 石山亜紀, 浅見行弘, 浅見行弘, 野中健一, 野中健一, 稲橋佑起, 稲橋佑起, 木村透, 照屋俊明, 石井貴広, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   142nd   2022

   

  J-GLOBAL

• Search for therapeutic seeds for cutaneous leishmaniasis with mitochondrial function inhibitory activity using multidrug-sensitive Saccharomyces cerevisia

  山中綾乃, 穗苅玲, 穗苅玲, 村山諒, 荒川絵美, 渡邊善洋, 渡邊善洋, 石山亜紀, 石山亜紀, 本庄雅子, 浅見行弘, 浅見行弘, 野中健一, 野中健一, 肥後茉由佳, 肥後茉由佳, 村松怜子, 稲橋佑起, 稲橋佑起, 丑田公規, 照屋俊明, 石井貴広, 臼井健郎, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   142nd   2022

   

  J-GLOBAL

• Corrigendum to: Auxin signaling through SCFTIR1/AFBs mediates feedback regulation of IAA biosynthesis.

  Shin Takato, Yusuke Kakei, Marie Mitsui, Yosuke Ishida, Masashi Suzuki, Chiaki Yamazaki, Ken-Ichiro Hayashi, Takahiro Ishii, Ayako Nakamura, Kazuo Soeno, Yukihisa Shimada

  Bioscience, Biotechnology, and Biochemistry   85 ( 6 ) 1562 - 1562   2021.05  [Refereed]

   

  DOI PubMed

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• マレーシア産軟体サンゴ由来の生物活性物質

  Phan Chin-Soon・鎌田昂・石井貴広・濱田季之・Vairappan Charles S.

  日本サンゴ礁学会第22回大会  (札幌)  2019.11  -  2019.11 

• マレーシアサバ州に分布する軟質サンゴ由来の新規テルペンとその生物活性

  パンチンスン・鎌田昂・濱田季之・石井貴広・バイラパンチャールズ

  第63回香料・テルペンおよび精油化学に関する討論会  (秋田)  2019.09  -  2019.09 

• Bioactive Terpenes from Soft Corals in North Borneo

  2018.10  -  2018.10 

• Bioactive Terpenes from Soft Corals in North Borneo

  2018.10  -  2018.10 

• Sex steroid as the possible key in oocyte development of the scleractinian coral, Acropora tenuis

  Tan, E., Izumi, R., Ishii, T., Takeuchi, Y., Yang, S., Shikina, S., Chang, C. F., Takemura, A.

  日本動物学会第89回大会  (札幌)  2018.09  -  2018.09 

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Industrial Property 【 display / non-display 】

Industrial Property 【 display / non-display 】

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Silver award (Research and Innovation Competition (Pereka) UMS 2009)

  2009.07   Universiti Malaysia Sabah  

  　View Summary

  Novel marine metabolites with potent pharmaceutical potentials

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Search for advanced inhibitors of YUCCA, a key enzyme in auxin biosynthesis

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2014.04  -  2017.03 

  Investigator(s): ISHII Takahiro, SHIMADA Yukihisa, SOENO Kazuo 

  Direct: 4,000,000 (YEN)  Overheads: 5,200,000 (YEN)  Total: 1,200,000 (YEN)

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  From the results of screening of own chemical library (including about 200 samples) using both YUCCA enzyme inhibition test (in vitro) and plant growth test with Arabidopsis seeds (in vivo), it was found that several extracts from the red algal genus Laurencia and sea hares, together with 2-APB known as a TRP channel inhibitor, exhibited strong inhibitory effects. Bioassay-guided fractionation of these active extracts resulted in the isolation of three halogenated laurane-type sesquiterpenes with different chemical structures from known YUCCA inhibitors. Among these active compounds, laurinterol and 2-APB showed stronger inhibitory activity than known inhibitors in the plant growth inhibition assay.