Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

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Acquisition of a qualification 【 display / non-display 】

Acquisition of a qualification 【 display / non-display 】

Thesis 【 display / non-display 】

Thesis 【 display / non-display 】

• Studies on Bioactive Compounds from Unutilized Marine Natural Resources

  2006.06

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Elucidation of a New Snyderane-Type Sesquiterpene from Okinawan Sea Hare Aplysia argus and Identification of Their Feeding Targets.

  Fukada R, Nakagawa R, Yokoshima K, Inafuku M, Kumagai M, Kamada T, Ishii T

  Chemistry & biodiversity ( Chemistry and Biodiversity )  23 ( 2 ) e03372   2026.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Skeletal Diversity of Diterpenoids Isolated from the Soft Coral Sclerophytum heterospiculatum in Kikai Island

  Tani, K; Tsuruta, T; Yoshino, Y; Fukushige, A; Doe, M; Miyake, H; Morimoto, Y; Hashimoto, M; Ukiya, M; Marumoto, S; Ishii, T; Nishikawa, K

  JOURNAL OF NATURAL PRODUCTS ( Journal of Natural Products )  89 ( 2 ) 548 - 559   2026.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Ufisonitriles A and B, Antimalarial Isonitriles with Mitochondrial Function Inhibitory Activity Produced by <i>Amycolatopsis</i> sp. OK19-0009

  Arakawa, E; Watanabe, Y; Tsutsumi, H; Ikeda, A; Hirose, T; Sato, N; Chinen, T; Take, A; Kanto, H; Inahashi, Y; Ishii, T; Teruya, T; Sunazuka, T; Hanaki, H; Usui, T; Hokari, R; Ishiyama, A; Asami, Y; Iwatsuki, M

  JOURNAL OF NATURAL PRODUCTS ( Journal of Natural Products )  88 ( 10 ) 2472 - 2480   2025.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Two novel antimalarials, named ufisonitriles A (1) and B (2), were isolated by bioassay-guided fractionation on mitochondrial function inhibitory activity using multidrug-sensitive budding yeast from the cultured broth of the Okinawan rare actinomycete Amycolatopsis sp. OK19-0009 strain. Their structures were comprehensively elucidated using HR-ESI-MS and 1D/2D NMR analyses and the modified Mosher's method. Structurally, 1 and 2 possess a novel skeleton with an isocyano group. In vitro antimalarial evaluation against Plasmodium falciparum strains revealed that 1 and 2 exhibited moderate activity with IC50 values ranging from 28.6 to 1.12 μM. Furthermore, 1 and 2 reduced the malaria parasites by approximately 45% in vivo on intraperitoneal administration (30 mg/kg/day for 4 days) with no observed toxicity. We also provide a plausible biosynthesis pathway based on the genome sequence analysis.

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• Chemical structure and antifouling activity of yoshioaplysins A-C isolated from red alga genus Laurencia

  Fukada, R; Nishikawa, K; Nagasaka, M; Kirihara, M; Takizawa, S; Morimoto, Y; Nimura, K; Kikuchi, N; Yamagishi, Y; Ishii, T; Kamada, T

  FITOTERAPIA ( Fitoterapia )  185   106683 - 106683   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Our experiments aim to find marine natural products that inhibit byssus thread formation in mussels. Three new labdane-type brominated diterpenes, yoshioaplysins A-C (1-3), were isolated from the marine red alga Laurencia sp. collected from Yoshio (Katsuura, Chiba Prefecture, Japan). Their structures were established using IR, NMR, high-resolution MS, and chemical synthesis. An enantiodivergent phenomenon was observed between compounds 1-3 and aplysin-20 (7) / aplysin-20 aldehyde (8) previously isolated from L. venusta collected from the same location. Moreover, compounds 1-3 showed a remarkable antifouling activity against the mussel Mytilus galloprovincialis at concentrations as low as 0.16 μmol/cm2. We believe that these new brominated diterpenes can be used as natural antifouling drugs.

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• New acetogenin katsuurallene from <i>Laurencia saitoi</i> collected from Katsuura, Japan (vol 12, 10, 2022)

  Minamida, Y; Matsuura, H; Ishii, T; Miyagi, M; Shinjo, Y; Sato, K; Kamada, T; Mihara, Y; Togashi, I; Sugimoto, K; Abe, T; Kikuchi, N; Suzuki, M

  NATURAL PRODUCTS AND BIOPROSPECTING   15 ( 1 ) 59   2025.08 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Search and optimization of antimalarial seeds derived from fungi

  岡野太一, 木村奏一朗, 中原大生, 吉岡修志, 渡邊善洋, 渡邊善洋, 千成恒, 千成恒, 橋本瑞希, 小島裕貴, 小島裕貴, 野中健一, 菅原章公, 菅原章公, 稲橋佑起, 稲橋佑起, 石井貴広, 照屋俊明, 石山亜紀, 石山亜紀, 穗苅玲, 穗苅玲, 廣瀬友靖, 廣瀬友靖, 砂塚敏明, 砂塚敏明, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   145th   2025

   

  J-GLOBAL

• Potential validation of antimalarial seeds derived from fungi

  岡野太一, 木村奏一朗, 渡邊善洋, 渡邊善洋, 橋本瑞希, 小島裕貴, 小島裕貴, 野中健一, 稲橋佑起, 稲橋佑起, 石井貴広, 照屋俊明, 石山亜紀, 石山亜紀, 穗苅玲, 穗苅玲, 清和成, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   144th   2024

   

  J-GLOBAL

• Search for new antimalarial compounds from microbial metabolites

  木村奏一朗, 渡邊善洋, 渡邊善洋, 稲橋佑起, 稲橋佑起, 野中健一, 石井貴広, 照屋俊明, 穗苅玲, 穗苅玲, 石山亜紀, 石山亜紀, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   144th   2024

   

  J-GLOBAL

• Search for antileishmanial compounds from microbial metabolites

  橋本瑞希, 村山諒, 渡邊善洋, 渡邊善洋, 肥後茉由佳, 肥後茉由佳, 野中健一, 野中健一, 稲橋佑起, 稲橋佑起, 石川春樹, 丑田公規, 石井貴広, 照屋俊明, 石山亜紀, 石山亜紀, 穗苅玲, 穗苅玲, 岩月正人, 岩月正人

  日本薬学会年会要旨集(Web)   143rd   2023

   

  J-GLOBAL

• Corrigendum: Two New Halogenated Compounds from the Marine Red Alga Laurencia nipponica Yamada from the Kunashiri and Etorofu Islands.

  Kosuke Sato, Kensuke Kaneko, Tsuyoshi Kamekawa, Kanako Taba, Shinnosuke Ishigami, Masahiro Wada, Takahiro Ishii, Tsuyoshi Abe, Takashi Kamada, Minoru Suzuki

  Chemistry & biodiversity   19 ( 3 ) e202200112   2022.03

   

  DOI PubMed

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• マレーシア産軟体サンゴ由来の生物活性物質

  Phan Chin-Soon・鎌田昂・石井貴広・濱田季之・Vairappan Charles S.

  日本サンゴ礁学会第22回大会  (札幌)  2019.11  -  2019.11 

• マレーシアサバ州に分布する軟質サンゴ由来の新規テルペンとその生物活性

  パンチンスン・鎌田昂・濱田季之・石井貴広・バイラパンチャールズ

  第63回香料・テルペンおよび精油化学に関する討論会  (秋田)  2019.09  -  2019.09 

• Bioactive Terpenes from Soft Corals in North Borneo

  2018.10  -  2018.10 

• Bioactive Terpenes from Soft Corals in North Borneo

  2018.10  -  2018.10 

• Sex steroid as the possible key in oocyte development of the scleractinian coral, Acropora tenuis

  Tan, E., Izumi, R., Ishii, T., Takeuchi, Y., Yang, S., Shikina, S., Chang, C. F., Takemura, A.

  日本動物学会第89回大会  (札幌)  2018.09  -  2018.09 

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Industrial Property 【 display / non-display 】

Industrial Property 【 display / non-display 】

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Silver award (Research and Innovation Competition (Pereka) UMS 2009)

  2009.07   Universiti Malaysia Sabah  

  　View Summary

  Novel marine metabolites with potent pharmaceutical potentials

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Search for advanced inhibitors of YUCCA, a key enzyme in auxin biosynthesis

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2014.04  -  2017.03 

  Investigator(s): ISHII Takahiro, SHIMADA Yukihisa, SOENO Kazuo 

  Direct: 4,000,000 (YEN)  Overheads: 5,200,000 (YEN)  Total: 1,200,000 (YEN)

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  From the results of screening of own chemical library (including about 200 samples) using both YUCCA enzyme inhibition test (in vitro) and plant growth test with Arabidopsis seeds (in vivo), it was found that several extracts from the red algal genus Laurencia and sea hares, together with 2-APB known as a TRP channel inhibitor, exhibited strong inhibitory effects. Bioassay-guided fractionation of these active extracts resulted in the isolation of three halogenated laurane-type sesquiterpenes with different chemical structures from known YUCCA inhibitors. Among these active compounds, laurinterol and 2-APB showed stronger inhibitory activity than known inhibitors in the plant growth inhibition assay.