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Current Affiliation Organization 【 display / non-display 】

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Affiliated academic organizations 【 display / non-display 】

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Research Interests 【 display / non-display 】

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Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study.

  Kono T, Maimaituxun G, Tanabe H, Higa M, Saito H, Tanaka K, Masuzaki H, Sata M, Kazama JJ, Shimabukuro M

  BMJ open diabetes research & care ( BMJ Open Diabetes Research and Care )  12 ( 2 )   2024.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  INTRODUCTION: It remains unclear whether increased perirenal fat (PRF) accumulation is equally related to renal involvement in patients with and without diabetes mellitus (DM). We evaluated the association between PRF volume (PRFV) and low glomerular filtration rate (GFR) and proteinuria in people with or without type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of 473 individuals without T2DM (non-DM, n=202) and with T2DM (DM, n=271). PRFV (cm3), obtained from non-contrast CT, was indexed as PRF index (PRFV/body surface area, cm3/m2). Multivariate-adjusted models were used to determine the ORs of PRFV and PRFV index for detecting estimated GFR (eGFR) decrease of <60 mL/min/1.73 m2 proteinuria onset, or both. RESULTS: Although body mass index (BMI), visceral fat area, and waist circumference were comparable between the non-DM and DM groups, kidney volume, PRFV, and PRFV index were higher in individuals with T2DM than in those without T2DM. In the multivariate analysis, after adjusting for age, sex, BMI, hypertension, smoking history, and visceral fat area ≥100 cm2, the cut-off values of PRFV index were associated with an eGFR<60 in individuals with DM (OR 6.01, 95% CI 2.20 to 16.4, p<0.001) but not in those without DM. CONCLUSIONS: PRFV is associated with low eGFR in patients with T2DM but not in those without T2DM. This suggests that PRF accumulation is more closely related to the onset and progression of diabetic kidney disease (DKD) than non-DKD. Clarifying the mechanisms through which PRF influences DKD development could pave the way for novel prevention and treatment strategies.

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• Impact of coronavirus disease 2019 on medical practice in endocrine and metabolic diseases in Japan: a nationwide surveillance study conducted by the Japan Endocrine Society.

  Manaka K, Kato S, Sakamoto R, Yamakage H, Uema T, Kawai S, Shibata M, Hiratsuka I, Nakachi S, Onoue T, Tsuchiya T, Fukui M, Hashimoto K, Suzuki A, Makita N, Ogawa Y, Arima H, Satoh-Asahara N, Masuzaki H

  Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 )   2024.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  <p>We investigated the impact of the Coronavirus disease 2019 (COVID-19) pandemic on the management of endocrine and metabolic disorders in Japan. We conducted a cross-sectional nationwide questionnaire survey targeting board-certified endocrinologists under the auspices of the Japan Endocrine Society. The questionnaire consisted of multiple-choice questions and open-ended responses. Out of approximately 2,700 specialists, 528 (19.5%) opted to participate, suggesting a high level of interest in COVID-19 management among endocrinologists. The study found that almost half of participants had encountered cases of endocrine and metabolic disorders following COVID-19 infection or vaccination. Conditions related to thyroid diseases, glucose metabolism disorders/diabetes, and hypothalamic-pituitary disorders were particularly prevalent. Diabetes and obesity were identified as having high rates of severe cases or fatalities due to COVID-19. The study also highlighted challenges in routine diagnosis and treatment, emphasizing the potential benefits of combining remote consultations with in-person visits to optimize the frequency of examinations and check-ups during infectious disease outbreak which disrupts access to healthcare providers. The insights obtained from this survey are expected to contribute to ensuring appropriate healthcare provision for patients with endocrine and metabolic disorders by using flexible consultation formats, particularly even in the conditions where medical access may be limited due to future outbreaks of emerging or re-emerging infectious diseases.</p>

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• Sex differences in the association between epicardial adipose tissue volume and left atrial volume index.

  Yamaguchi S, Maeda M, Oba K, Maimaituxun G, Arasaki O, Yagi S, Kusunose K, Soeki T, Yamada H, Fukuda D, Masuzaki H, Sata M, Shimabukuro M

  BMC cardiovascular disorders ( BMC Cardiovascular Disorders )  24 ( 1 ) 46 - 46   2024.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: Sex disparities in the association between epicardial adipose tissue volume (EATV) and cardiovascular disease have been reported. The sex-dependent effects of EATV on left atrial (LA) size have not been elucidated. METHODS: Consecutive 247 subjects (median 65 [interquartile range 57, 75] years; 67% of men) who underwent multi-detector computed tomography without significant coronary artery disease or moderate to severe valvular disease were divided into two groups: patients with sinus rhythm (SR) or atrial fibrillation (AF). Sex differences in the association between the EATV index (EATVI) (mL/m2) and LA volume index (LAVI) in 63 SR (28 men and 35 women) and 184 AF (137 men and 47 women) patients were evaluated using univariate and multivariate regression analyses. RESULTS: In overall that includes both men and women, the relationship between EATVI and LAVI was not significantly correlated for patients with SR and AF. The relationship between EATVI and LAVI differed between men and women in both SR and AF groups. In SR patients, there was a positive relationship between EATVI and LAVI in men, but not in women. In contrast, in patients with AF, a negative relationship was found between EATVI and LAVI in women, whereas no association was found in men. CONCLUSIONS: We evaluated sex differences in the association between EATVI and LAVI in patients with either SR or AF, and found a positive relationship in men with SR and a negative relationship in women with AF. This is the first report to evaluate sex differences in the relationship between EATVI and LAVI, suggesting that EAT may play a role, at least in part, in sex differences in the etiology of AF.

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• A Foreword to the Special Issue

  Masuzaki Hiroaki

  Journal of the Japan Diabetes Society ( THE JAPAN DIABETES SOCIETY )  66 ( 6 ) 459 - 459   2023.06

  Type of publication: Research paper (scientific journal)

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• Effect of dapagliflozin on 24-hour glycemic variables in Japanese patients with type 2 diabetes mellitus receiving basal insulin supported oral therapy (DBOT): a multicenter, randomized, open-label, parallel-group study.

  Kudo A, Machii N, Ono T, Saito H, Oshiro Y, Takahashi R, Oshiro K, Taneda Y, Higa M, Nakachi K, Yagi S, Masuzaki H, Sata M, Shimabukuro M

  BMJ open diabetes research & care ( BMJ Open Diabetes Research and Care )  11 ( 2 )   2023.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  INTRODUCTION: This study aimed to evaluate the impacts of dapagliflozin on 24-hour glucose variability and diabetes-related biochemical variables in Japanese patients with type 2 diabetes who had received basal insulin supported oral therapy (BOT). RESEARCH DESIGN AND METHODS: Changes in mean daily blood glucose level before and after 48-72 hours of add-on or no add-on of dapagliflozin (primary end point) and diabetes-related biochemical variables and major safety variables during the 12 weeks (secondary end point) were evaluated in the multicenter, randomized, two-arm, open-label, parallel-group comparison study. RESULTS: Among 36 participants, 18 were included in the no add-on group and 18 were included in the dapagliflozin add-on group. Age, gender, and body mass index were comparable between the groups. There were no changes in continuous glucose monitoring metrics in the no add-on group. In the dapagliflozin add-on group, mean glucose (183-156 mg/dL, p=0.001), maximum glucose (300-253, p<0.01), and SD glucose (57-45, p<0.05) decreased. Time in range increased (p<0.05), while time above the range decreased in the dapagliflozin add-on group but not in the no add-on group. After 12-week treatment with dapagliflozin add-on, 8-hydroxy-2'-deoxyguanosine (8OHdG), as well as hemoglobin A1c (HbA1c), decreased. CONCLUSIONS: This study showed that the mean daily blood glucose and other daily glucose profiles were amended after 48-72 hours of dapagliflozin add-on in Japanese patients with type 2 diabetes who received BOT. The diabetes-related biochemical variables such as HbA1c and urinary 8OHdG were also obtained during the 12 weeks of dapagliflozin add-on without major adverse events. A preferable 24-hour glucose profile in 'time in ranges' and an improvement in reactive oxygen species by dapagliflozin warrant us to evaluate these benefits in larger clinical studies. TRIAL REGISTRATION NUMBER: UMIN000019457.

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Books 【 display / non-display 】

Books 【 display / non-display 】

• 米糠由来機能成分 γオリザノールを活用する脳機能改善・糖尿病予防のアプローチ

  益崎 裕章、小塚 智沙代、與那嶺 正人、島袋 充生 ( Part: Multiple Authorship )

  Society for Glycative Stress Research  2017

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Other Papers 【 display / non-display 】

• Nivolumabを用いたHLA半合致移植後に免疫関連有害事象による筋炎を合併した難治性ホジキンリンパ腫の一例(A rare case of myositis induced by nivolumab coupled with haplo-SCT in refractory Hodgkin lymphoma)

  中島 知, 西 由希子, 宮城 理子, 北村 紗希子, 花城 多恵子, 玉城 啓太, 手登根 伊織, 森近 一穂, 仲地 佐和子, 森島 聡子, 益崎 裕章

  日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS2 - 3   2021.09  [Refereed]

   

• NGSに基づく高解像度タイピングはATLにおけるHLA遺伝子変異に関する新規視点を明らかにする

  玉城啓太, 森島聡子, 鈴木進悟, 重成敦子, 野村育美, 横田雄太郎, 森近一穂, 西由希子, 仲地佐和子, 岡本士毅, 福島卓也, 椎名隆, 益崎裕章

  日本血液学会学術集会抄録(Web) ( (一社)日本血液学会 )  83回   OS1 - 5   2021.09

   

  J-GLOBAL

• 高齢者糖尿病における糖尿病性網膜症の発症及び悪化要因に関する臨床疫学的後方視解析

  新里 幸子, 中山 良朗, 比嘉 盛丈, 新垣 孝一郎, 島袋 充生, 古泉 英貴, 益崎 裕章

  糖尿病 ( (一社)日本糖尿病学会 )  62 ( 9 ) 611 - 611   2019.09

   

• 高力価インヒビター保有血友病A患者の脳外科手術における止血管理(Management of a hemophilia A patient with high titer inhibitor in brain surgery)

  島袋 奈津紀, 内堀 幸恵, 北村 紗希子, 友利 昌平, 花城 多恵子, 手登根 伊織, 玉城 啓太, 森近 一穂, 西 由希子, 仲地 佐和子, 森島 聡子, 益崎 裕章

  臨床血液 ( (一社)日本血液学会-東京事務局 )  59 ( 9 ) 1807 - 1807   2018.09  [Refereed]

   

• DLBCLにおけるSTAT3関連因子群の臨床病理学的統合解析(Integrated analysis of STAT3 associated factors in diffuse large B-cell lymphoma)

  森近 一穂, 加留部 謙之輔, 渡辺 理紗, 川木 護, 北村 紗希子, 内堀 幸恵, 友利 昌平, 花城 多恵子, 島袋 奈津紀, 手登根 伊織, 玉城 啓太, 西 由希子, 仲地 佐和子, 森島 聡子, 内原 潤之介, 友寄 毅昭, 大城 一郁, 仲里 巌, 山入端 敦, 宮城 敬, 中里 哲郎, 林 正樹, 高原 大志, 佐藤 啓, 島田 聡子, 島田 和之, 都築 豊徳, 中村 栄男, 福島 卓也, 益崎 裕章

  臨床血液 ( (一社)日本血液学会-東京事務局 )  59 ( 9 ) 1494 - 1494   2018.09  [Refereed]

   

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• 若年健康成人における腸内細菌叢（腸内フローラ）と食習慣に関する 観察研究

  上間 次己, 難波 豊隆, ジャスミン・フランシス・ミルマン, 赤嶺 ゆかり, 岡本 士毅, 益崎 裕章

  日本肥満学会  2019.11  -  2019.11 

• 沖縄 発：未来を託す子供たちに私たちが今、出来ること ～分子栄養学と脳科学からのアプローチ～

  益崎 裕章

  日本臨床内科医会  2019.10  -  2019.10 

• 合同シンポジウム１：全身加齢と局所変化

  益崎 裕章

  日本糖尿病合併症学会  2019.09  -  2019.09 

• 健康長寿社会に求められる食と行動の科学 ～沖縄の取り組みから～

  益崎 裕章, 小塚 智沙代, Jasmine F. Millman, 與那嶺 正人, 尾形 絵美, 山崎 聡, 島袋 充生, 岡本 士毅

  日本体質医学会  2019.08  -  2019.08 

Industrial Property 【 display / non-display 】

Industrial Property 【 display / non-display 】

• Metabolic Oncology

  Industrial Property No 2017-044254  (2017.04.03)

  Patent No 6015034  (2018.01.26)

• no_title

  Industrial Property No no_data  (1900.01.01)

  Unexpectedly No no_data  (1900.01.01)

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• The Pfizer Scholars in Endocrinology Award in Recognition of Outstanding Achievement in the Advancement of Endocrinologic Science (USA)

  2013.03.15    

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Study on proper use of oral anticoagulants combined with 5-fluorouracil

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 2,900,000 (YEN)  Overheads: 3,770,000 (YEN)  Total: 870,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Study on proper use of oral anticoagulants combined with 5-fluorouracil

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 2,900,000 (YEN)  Overheads: 3,770,000 (YEN)  Total: 870,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

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Media Coverage 【 display / non-display 】

Media Coverage 【 display / non-display 】

• 30分以上の座位避けて：サルコペニア肥満の懸念  Newspaper, magazine

  沖縄タイムス  2023.2

  Author： Myself 

• 世界糖尿病デー：定期健診で早期発見重要  Newspaper, magazine

  沖縄タイムス  2022.11

  Author： Myself 

• 『長寿県沖縄』今は昔：沖縄復帰50周年  Internet

  時事通信デジタル  2022.5

  Author： Myself 

• 糖尿病薬で血液がん抑制  Newspaper, magazine

  琉球新報  2022.4

  Author： Myself 

• 今こそ栄養学のすすめ  Newspaper, magazine

  読売新聞  2021.1

  Author： Myself 

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Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• 2023.9

  　

  　

  種別： Academic society, research group, etc. 

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  河野通浩先生 秋田大学 大学院医学系研究科 皮膚科学・形成外科学講座 教授 希少疾患における地域センター病院の役割：遺伝性血管性浮腫での取り組みから学ぶ

• 2023.8

  　

  　

  種別： Academic society, research group, etc. 

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  杉本研先生 川崎医科大学 総合老年医学 主任教授 糖尿病併発症としてのフレイル・サルコペニア：～評価・予防・治療をどのように行うのか～

• （ 京都府立医科大学（京都府　京都市） ）

  2023.7

  　

  　

  種別： Academic society, research group, etc. 

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  前田法一先生 近畿大学医学部 内分泌・代謝・糖尿病内科 教授 肥満２型糖尿病に対する新たな治療選択：経口GLP-1受容体作動薬

• （ 京都府立医科大学（京都府　京都市） ）

  2023.7

  　

  　

  種別： Competition, symposium, etc. 

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  中里雅光先生 宮崎大学医学部 生体制御医学研究講座 教授 吉田俊秀先生 壬生大路病院 病院長 橋本健志先生 立命館大学スポーツ健康科学部 教授 太田正之先生 大分大学グローカル感染症研究センター 教授

• 2023.7

  　

  　

  種別： Academic society, research group, etc. 

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  レクチャー：FreeStyle Libreの現状とこれからを考える 錦戸慎平先生 長崎大学病院 第一内科 内分泌・代謝内科 パネル討論：行動変容とそれを促すための介入・２型糖尿病 難渋症例 岩田慎平先生 公立八女総合病院 内科 坂本竜一先生 九州大学 病態制御内科学：第三内科 椎屋智美先生 古賀総合病院 内科 知念玲先生 琉球大学 内分泌代謝・血液・膠原病内科学：第二内科 矢野百合子先生 産業医科大学病院　糖尿病看護認定看護師

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