Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

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Research Areas 【 display / non-display 】

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Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Machine learning-based reproducible prediction of type 2 diabetes subtypes.

  Tanabe H, Sato M, Miyake A, Shimajiri Y, Ojima T, Narita A, Saito H, Tanaka K, Masuzaki H, Kazama JJ, Katagiri H, Tamiya G, Kawakami E, Shimabukuro M

  Diabetologia ( Diabetologia )    2024.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Young-onset type 2 diabetes mellitus enhances proteinuria, but not glomerular filtration rate decline: A Japanese cohort study.

  Saito H, Tanabe H, Hirai H, Higa M, Tanaka K, Yamaguchi S, Maimaituxun G, Masuzaki H, Kazama JJ, Shimabukuro M

  Journal of diabetes investigation ( Journal of Diabetes Investigation )  15 ( 10 ) 1444 - 1456   2024.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study.

  Uema T, Tsukita M, Okamoto S, Uehara M, Honma KI, Nakayama Y, Tamaki A, Miyazato M, Ashikari A, Maeda S, Imamura M, Matsushita M, Nakamura K, Masuzaki H

  Diabetes research and clinical practice ( Diabetes Research and Clinical Practice )  213   111747 - 111747   2024.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIM: The present cohort study explored whether specific gut microbiota (GM) profile would predict the development of impaired glucose tolerance (IGT) in individuals with normal glucose tolerance (NGT). METHODS: A total of 114 study subjects with NGT in Kumejima island, Japan participated in the present study and underwent 75 g oral glucose tolerance tests at baseline and one year later. We compared the profile of GM at baseline between individuals who consistently maintained NGT (NRN, n = 108) and those who transitioned from NGT to IGT (NTI, n = 6). RESULTS: Within-individual bacterial richness and evenness as well as inter-individual bacterial composition showed no significant differences between NRN and NTI. Of note, however, partial least squares discriminant analyses revealed distinct compositions of GM between groups, with no overlap in their 95 % confidence interval ellipses. Multi-factor analyses at the genus level demonstrated that the proportions of CF231, Corynebacterium, Succinivibrio, and Geobacillus were significantly elevated in NTI compared to NRN (p < 0.005, FDR < 0.1, respectively) after adjusting for age, sex, HbA1c level, and BMI. CONCLUSIONS: Our data suggest that increased proportion of specific GM is linked to the future deterioration of glucose tolerance, thereby serving as a promising predictive marker for type 2 diabetes mellitus.

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• Impact of the transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for the measurement of plasma aldosterone concentration (PAC) on the diagnosis of primary aldosteronism (PA) via retrospective analyses in Okinawa, Japan.

  Honma KI, Nakayama Y, Tamaki A, Uehara M, Teruya T, Yabiku T, Ishiki Y, Yonaha K, Chinen R, Uema T, Okamoto S, Masuzaki H

  Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 895 - 906   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  In Japan, the traditional method for measuring plasma aldosterone concentration (PAC) was radioimmunoassay (RIA), which had several challenges, including poor traceability of certified reference materials and reduced detection sensitivity at low concentrations. To overcome these issues, a chemiluminescent enzyme immunoassay (CLEIA) for PAC measurement was introduced in April 2021 and the Japan Endocrine Society published new guidelines for primary aldosteronism (PA). This study aimed to evaluate the impact of the transition from RIA to CLEIA for PAC measurement on PA diagnosis. Data from 190 patients admitted to the Second Department of Internal Medicine, University of the Ryukyus Hospital, between April 2012 and March 2021 were analyzed. Patients who were diagnosed with PA underwent adrenal venous sampling. The PAC measured by RIA (PAC(RIA)) was converted to the estimated PAC measured by CLEIA (ePAC(CLEIA)) using a conversion formula. The present study evaluated the discordance rates in diagnoses based on screening (SC), captopril challenge test (CCT), saline infusion test (SIT), and diagnosis of PA between results judged by PAC(RIA) according to the previous guidelines and those judged by ePAC(CLEIA) according to the new guidelines. The results revealed discordant diagnosis rates of 6.4% for SC and 10.1% for CCT, with no discordance for SIT. The discordant diagnosis rate for PA was 3.7%. Our study reveals the challenges in establishing appropriate diagnostic criteria for PA using PAC(CLEIA) and highlights the demand for further research on provisionally positive categories.

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• Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report with review of literature.

  Ishiki Y, Tamaki A, Honma KI, Yonaha K, Yabiku T, Teruya T, Uehara M, Nakayama Y, Chinen R, Uema T, Nakachi S, Okamoto S, Masuzaki H

  Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 817 - 824   2024.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Post-traumatic pituitary stalk transection syndrome (PSTS) is an extremely rare cause of combined pituitary hormone deficiency (CPHD), affecting approximately 9 per 100,000 cases of traumatic brain injury. In contrast, pituitary stalk interruption syndrome (PSIS) is also a rare cause of CPHD. Importantly, these conditions are often confused due to their similar names and resembling findings on magnetic resonance imaging (MRI). PSIS has been thought to be a prenatal developmental event resulting from a couple of genetic aberrations. In typical PSIS, anterior pituitary hormone deficiencies are restricted to growth hormone (GH) and gonadotropin during the pediatric age, gradually and generally progressing to panhypopituitarism in most cases. In contrast, global deficiencies of the anterior pituitary hormones in PSTS are temporally associated with trauma. To the best of our knowledge, no case reports of PSTS combined with acute traumatic spinal cord injury have been reported. A 34-year-old female was transferred to our hospital after jumping from the fourth building floor. She was diagnosed as an acute traumatic spinal cord injury and underwent the operation of elective posterior spinal fusion. On postoperative day 7, the blood tests revealed considerable hyperkalemia, hyponatremia and eosinophilia. Notably, menstruation stopped after falling from a height. Pituitary function tests revealed GH deficiency, hypogonadism, hypothyroidism and hypoadrenocorticism. MRI revealed loss of the pituitary stalk, whilst the hyperintense signal from distal axon of hypothalamus was still identified. Based on these findings, she was diagnosed as PSTS. Our case highlights endocrinological landscape of transection of the pituitary stalk by acute trauma.

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Books 【 display / non-display 】

Books 【 display / non-display 】

• 米糠由来機能成分 γオリザノールを活用する脳機能改善・糖尿病予防のアプローチ

  益崎 裕章、小塚 智沙代、與那嶺 正人、島袋 充生 ( Part: Multiple Authorship )

  Society for Glycative Stress Research  2017

Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity.

  Sasaki A, Yokote K, Naitoh T, Fujikura J, Hayashi K, Hirota Y, Inagaki N, Ishigaki Y, Kasama K, Kikkawa E, Koyama H, Masuzaki H, Miyatsuka T, Nozaki T, Ogawa W, Ohta M, Okazumi S, Shimabukuro M, Shimomura I, Nishizawa H, Saiki A, Seki Y, Shojima N, Tsujino M, Ugi S, Watada H, Yamauchi T, Yamaguchi T, Ueki K, Kadowaki T, Tatsuno I, Joint Committee in the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, the Japan Society for the Study of Obesity

  Diabetology international ( Diabetology International )  13 ( 1 ) 1 - 30   2022.01

   

  DOI PubMed

• Nivolumabを用いたHLA半合致移植後に免疫関連有害事象による筋炎を合併した難治性ホジキンリンパ腫の一例(A rare case of myositis induced by nivolumab coupled with haplo-SCT in refractory Hodgkin lymphoma)

  中島 知, 西 由希子, 宮城 理子, 北村 紗希子, 花城 多恵子, 玉城 啓太, 手登根 伊織, 森近 一穂, 仲地 佐和子, 森島 聡子, 益崎 裕章

  日本血液学会学術集会 ( (一社)日本血液学会 )  83回   OS2 - 3   2021.09  [Refereed]

   

• NGSに基づく高解像度タイピングはATLにおけるHLA遺伝子変異に関する新規視点を明らかにする

  玉城啓太, 森島聡子, 鈴木進悟, 重成敦子, 野村育美, 横田雄太郎, 森近一穂, 西由希子, 仲地佐和子, 岡本士毅, 福島卓也, 椎名隆, 益崎裕章

  日本血液学会学術集会抄録(Web) ( (一社)日本血液学会 )  83回   OS1 - 5   2021.09

   

  J-GLOBAL

• Should we avoid pretransplant mogamulizumab therapy in ATL-patients?

  北村紗希子, 西由希子, 友利昌平, 宮城理子, 内堀幸恵, 花城多恵子, 島袋奈津紀, 玉城啓太, 手登根伊織, 森近一穂, 仲地佐和子, 加留部謙之輔, 福島卓也, 森島聡子, 益崎裕章

  日本造血細胞移植学会総会プログラム・抄録集   42nd   2020

   

  J-GLOBAL

• A case of clinically amyopathic dermatomyositis with interstitial lung disease after allo-HSCT

  宮城理子, 仲地佐和子, 玉城泰太郎, 北村紗希子, 内堀幸恵, 友利昌平, 花城多恵子, 島袋奈津紀, 玉城啓太, 手登根伊織, 森近一穂, 西由希子, 加留部謙之輔, 福島卓也, 森島聡子, 益崎裕章

  日本造血細胞移植学会総会プログラム・抄録集   42nd   2020

   

  J-GLOBAL

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• 若年健康成人における腸内細菌叢（腸内フローラ）と食習慣に関する 観察研究

  上間 次己, 難波 豊隆, ジャスミン・フランシス・ミルマン, 赤嶺 ゆかり, 岡本 士毅, 益崎 裕章

  日本肥満学会  2019.11  -  2019.11 

• 沖縄 発：未来を託す子供たちに私たちが今、出来ること ～分子栄養学と脳科学からのアプローチ～

  益崎 裕章

  日本臨床内科医会  2019.10  -  2019.10 

• 合同シンポジウム１：全身加齢と局所変化

  益崎 裕章

  日本糖尿病合併症学会  2019.09  -  2019.09 

• 健康長寿社会に求められる食と行動の科学 ～沖縄の取り組みから～

  益崎 裕章, 小塚 智沙代, Jasmine F. Millman, 與那嶺 正人, 尾形 絵美, 山崎 聡, 島袋 充生, 岡本 士毅

  日本体質医学会  2019.08  -  2019.08 

Industrial Property 【 display / non-display 】

Industrial Property 【 display / non-display 】

• Metabolic Oncology

  Industrial Property No 2017-044254  (2017.04.03)

  Patent No 6015034  (2018.01.26)

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• The Pfizer Scholars in Endocrinology Award in Recognition of Outstanding Achievement in the Advancement of Endocrinologic Science (USA)

  2013.03.15    

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Study on proper use of oral anticoagulants combined with 5-fluorouracil

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 2,900,000 (YEN)  Overheads: 3,770,000 (YEN)  Total: 870,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Study on proper use of oral anticoagulants combined with 5-fluorouracil

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 2,900,000 (YEN)  Overheads: 3,770,000 (YEN)  Total: 870,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

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Media Coverage 【 display / non-display 】

Media Coverage 【 display / non-display 】

• 30分以上の座位避けて：サルコペニア肥満の懸念  Newspaper, magazine

  沖縄タイムス  2023.2

  Author： Myself 

• 世界糖尿病デー：定期健診で早期発見重要  Newspaper, magazine

  沖縄タイムス  2022.11

  Author： Myself 

• 『長寿県沖縄』今は昔：沖縄復帰50周年  Internet

  時事通信デジタル  2022.5

  Author： Myself 

• 糖尿病薬で血液がん抑制  Newspaper, magazine

  琉球新報  2022.4

  Author： Myself 

• 今こそ栄養学のすすめ  Newspaper, magazine

  読売新聞  2021.1

  Author： Myself 

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Academic Activities 【 display / non-display 】

Academic Activities 【 display / non-display 】

• （ ホテル ザ・ナハテラス（沖縄県　那覇市） ）

  2024.8

  　

  　

  種別： Academic society, research group, etc. 

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  金井好克先生 大阪大学 ヒューマン・メタバース疾患研究拠点 疾患代謝シグナル制御学　特任教授 特別講演：SGLT２阻害薬がもたらす２型糖尿病治療の新たな視点～創薬から振り返る～

• （ 沖縄ハーバービューホテル（沖縄県　那覇市） ）

  2024.8

  　

  　

  種別： Academic society, research group, etc. 

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  山田裕揮先生 株式会社Medii 代表取締役 医師 基調講演：医師の調べ物改革：Chat GPTの上手な活用法

• （ ホテル ザ・ナハテラス（沖縄県　那覇市） ）

  2024.7

  　

  　

  種別： Academic society, research group, etc. 

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  古川慎哉先生 愛媛大学 総合健康センター 教授 特別講演：睡眠障害と糖尿病：夜間頻尿を中心に

• 2024.6

  　

  　

  種別： Academic society, research group, etc. 

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  寺内康夫先生　横浜市立大学大学院医学研究科 分子内分泌・糖尿病内科学 教授 特別講演：インクレチン製剤導入のポイント：DPP-4阻害薬と経口GLP-1受容体作動薬の使い分けを含めて

• （ 沖縄県立博物館・美術館（沖縄県　那覇市） ）

  2024.6

  　

  　

  種別： Academic society, research group, etc. 

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  桑原宏一郎先生　信州大学医学部循環器内科学教室 教授 特別講演：糖尿病合併高血圧患者の治療戦略：EAGLE-DH試験を含めて

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