論文 - 益崎　裕章

Unequal distribution of plasma glucagon levels among clustering-based diabetes subtypes: a Japanese cohort.

Tanabe H, Shimajiri Y, Shiroma K, Higa M, Masuzaki H, Shimabukuro M

The Journal of clinical endocrinology and metabolism ( The Endocrine Society )    2025年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Abstract Context Hyperglucagonemia contributes to disturbances in glucose metabolism. Data-driven diabetes clustering reflects risk of diabetic complications better than classical classification, type 1 diabetes (T1D) vs. type 2 diabetes (T2D); however, the pathophysiological features have not been clarified. Objective To assess the distribution of plasma glucagon levels among clustering-based diabetes subtypes. Methods A total of 546 Japanese participants with T1D or T2D were categorized into five diabetes subtypes. Plasma glucagon levels were compared across subtypes and factors associated with hyperglucagonemia were evaluated using logistic regression analyses. Results Plasma glucagon levels differed significantly among diabetes subtypes. Among the five subtypes, plasma glucagon levels and the frequency of hyperglucagonemia were highest in the severe insulin-resistant diabetes (SIRD) subtype (45.6%). The SIRD subtype was an independent risk factor for hyperglucagonemia (adjusted odds ratio 2.17, 95%CI 1.03–4.54, P=0.041), even after adjusting for other risk factors, such as body mass index, HbA1c, and metabolic dysfunction-associated steatotic liver disease. Conclusion The distribution of plasma glucagon levels differed among the clustering-based diabetes subtypes. SIRD is a subtype of diabetes with a hyperglucagonemic phenotype. Elucidating the reason for hyperglucagonemia in SIRD may help to clarify the mechanisms underlying the unfavorable clinical phenotype.

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SGLT-2 Inhibitors Are Potent to Suppress Aggressive Transformation From Indolent Type of Adult T-Cell Leukemia/Lymphoma: Unique Insight Into Therapeutics for Diabetes-Related Hematological Malignancy.

Morichika K, Tamaki K, Fukushima T, Masuzaki H

EJHaem   6 ( 5 ) e70109   2025年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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INTRODUCTION: We previously reported that sodium-glucose co-transporter 2 (SGLT-2) was ectopically overexpressed in adult T-cell leukemia (ATL) cells notably in aggressive type but in indolent type, and widely-used anti-diabetic SGLT-2 inhibitors (SGLT-2i) considerably attenuated proliferation of leukemic cells. METHODS: We performed retrospective analyses for 10 years to see whether SGLT-2i would prevent aggressive transformation in patients with indolent type ATL accompanied by diabetes. Nucleosome occupancy in the promotor region of the SGLT-2 gene was also assessed to explore the possible involvement of epigenetic modification in such an ectopic overexpression. RESULTS: In patients of indolent ATL with diabetes, the cumulative progression rate in the non-SGLT-2i-treated group was 71%, while no patients developed aggressive transformation in the SGLT-2i treated group. ATL cells showed an apparent trend to decrease nucleosome occupancy in the promotor region of the SGLT-2 gene. CONCLUSION: Our data suggest that SGLT-2i is advantageous for preventing aggravative transformation in indolent ATL. TRIAL REGISTRATION: Authors confirmed that clinical trial registration was not requested for the present study and this manuscript.

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Extranodal natural killer/T-cell lymphoma with lung involvement in a young adult with suspected mosquito bite hypersensitivity: A case report.

Higa M, Atsumi E, Hoshino H, Yamashiro M, Nakajima T, Tomita M, Masuzaki H, Wada N, Owan I

Respiratory investigation ( Respiratory Investigation )  63 ( 5 ) 872 - 876   2025年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A young adult with suspected pulmonary lymphoma was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL). The patient had a history of possible mosquito bite hypersensitivity (MBH), suggesting a potential association between MBH and ENKTL. Although ENKTL typically affects middle-aged adults, it has rarely been reported in children with MBH or chronic active Epstein-Barr virus (EBV) disease. This case highlights the challenges of obtaining pathological confirmation from small biopsy samples of pulmonary ENKTL. Detailed history taking and EBV DNA testing may aid in diagnosis, particularly in younger patients.

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Adjunct Therapy with Ipragliflozin Exerts Limited Effects on Kidney Protection in Type 1 Diabetes: A Retrospective Study Conducted at 25 Centers in Japan (IPRA-CKD).

Nakamura Y, Horie I, Yano H, Nomoto H, Fukui T, Yuyama Y, Kawamura T, Ueda M, Yamamoto A, Hirota Y, Kusunoki Y, Nishida K, Sekiguchi D, Maeda Y, Minami M, Nagayama A, Iwata S, Minagawa H, Furukawa S, Miyake T, Ueno H, Chinen R, Nakayama Y, Masuzaki H, Miyachi Y, Okada Y, Okamoto M, Ono K, Tanaka KI, Kurozumi A, Sakai T, Yamasaki H, Yasui JI, Ito A, Kawakami A, Abiru N, IPRA-CKD Study Group

Biomedicines ( Biomedicines )  13 ( 6 )   2025年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background/Objectives: While sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated additional non-glycemic benefits for renal protection in individuals with type 2 diabetes, less evidence is available for those with type 1 diabetes (T1D). To determine whether the adjunctive use of the SGLT2 inhibitor ipragliflozin confers kidney protection in individuals with T1D, we retrospectively analyzed data from a real-world cohort examined at 25 centers in Japan. Methods: We enrolled 359 subjects aged 20-74 years with T1D (IPRA group: 159 ipragliflozin users; control [CTRL] group: 200 non-users). The primary outcome was changes in the estimated glomerular filtration rate (eGFR) from baseline to 24 months after the initiation of ipragliflozin. The secondary outcomes were all other changes, including the urinary albumin-creatinine ratio (UACR) and urinary protein-creatinine ratio (UPCR). Results: The IPRA group's eGFR decline slopes were 0.79 mL/min/1.73 m2/year milder than the CTRL group's after propensity score matching, but this difference was not significant. The subjects complicated by chronic kidney disease (CKD) defined as UACR ≥ 30 mg/g and/or UPCR ≥ 0.5 g/g and/or eGFR < 60 mL/min/1.73 m2 showed changes in UPCR (g/g) from baseline to 24 months that were significantly lower in the IPRA group (-0.27 ± 1.63) versus the CTRL group (0.18 ± 0.36) (p = 0.016). No significant increase in adverse events (including severe hypoglycemia and hospitalization due to ketosis/ketoacidosis or cardiovascular diseases) was observed in the IPRA group. Conclusions: Adjunctive treatment with ipragliflozin exerted potential renal benefits by decreasing proteinuria in T1D subjects with CKD. Further investigations are required to determine whether its additional benefits exceed the increased risk of ketoacidosis.

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Two Cases of Plasmablastic Myeloma Mimicking Plasmablastic Lymphoma With In-Depth Review of Literature.

Kitamura S, Morichika K, Nakachi S, Hanashiro T, Miyagi R, Nakajima T, Nishi Y, Tamaki K, Fukushima T, Masuzaki H

Cancer reports (Hoboken, N.J.) ( Cancer Reports )  8 ( 2 ) e70094   2025年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Association between low serum testosterone level and severe asthma among elderly women

Ryu K.

Allergology International ( Allergology International )  74 ( 3 ) 453 - 460   2025年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p><i>Background:</i> Elderly asthma has distinct pathophysiologic and phenotypic characteristics compared with asthma in younger patients. However, a potential relationship between sex hormones and the severity of asthma remains unknown in the elderly population. The aim of the present study was to elucidate the relationship between the level of circulating free testosterone and severity of asthma among Japanese with elderly asthma.</p><p><i>Methods:</i> The level of free testosterone was measured using sera from elderly patients with asthma aged ≥60 years (n = 192), and its association with the severity of asthma was examined after stratification by sex.</p><p><i>Results:</i> Based on previous literature and our preliminary analysis showing that current oral corticosteroid (OCS) use might be a risk factor for a lower free testosterone level regardless of severity of asthma, analyzed patients were limited to those who were not currently using OCS (n = 164). Regarding elderly men who were not currently using OCS (n = 62), there was no significant association between free testosterone level and severity of asthma. However, in female counterparts (n = 102), a low free testosterone level was significantly associated with severe asthma even after adjustment for age (p for trend, 0.03).</p><p><i>Conclusions:</i> The present study showed a significant association between the serum free testosterone level and severity of asthma among elderly women who were not currently using OCS. Although the causal relationship is unclear, this finding may provide a clue to understand the sex difference in the mechanisms of severe asthma in elderly populations.</p>

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[Intramuscular abscess and multiple lymphadenitis due to Nocardia asiatica infection requiring differential diagnosis from smoldering adult T-cell leukemia/lymphoma].

Yamashiro M, Nakajima T, Irei Y, Miyagi R, Kitamura S, Tamaki K, Nishi Y, Morichika K, Nakachi S, Maehara H, Fukushima T, Masuzaki H

[Rinsho ketsueki] The Japanese journal of clinical hematology ( 一般社団法人 日本血液学会 )  66 ( 2 ) 121 - 126   2025年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>左上腕三頭筋の腫瘤を主訴に来院した72歳男性。切開術を施行し排膿を認めた。病理検査で悪性所見はなく起因微生物の同定にも到らずcefazolinも無効であった。追加のCT検査で全身性リンパ節腫脹を，血液検査でHTLV-1抗体を検出。末梢血単核球でHTLV-1プロウイルスのモノクロナリティを確認した。左腋窩リンパ節の再生検でも異常細胞は確認されず成人T細胞白血病・リンパ腫くすぶり型と診断。膿培養の延長を行い<i>Nocardia</i> sp.を検出。16S rRNA解析で<i>Nocardia asiatica</i>を同定。薬剤感受性試験の結果を踏まえてST合剤とminocyclineを開始し，3ヶ月で全身性リンパ節腫脹は改善した。多発リンパ節腫脹を呈する<i>Nocardia asiatica</i>感染症の報告は極めて稀であるが免疫能低下を背景とした全身性リンパ節腫脹の鑑別診断で考慮することが重要である。</p>

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沖縄県における造血幹細胞移植医療の現状

仲地 佐和子, 北村 紗希子, 森近 一穂, 中島 知, 宮城 理子, 上間 道仁, 横田 雄太郎, 宮城 敬, 狩俣 かおり, 山入端 敦, 大濵 昌代, 友寄 未希, 友寄 毅昭, 福島 卓也, 益崎 裕章

日本造血・免疫細胞療法学会雑誌 ( 一般社団法人 日本造血・免疫細胞療法学会 )  14 ( 3 ) 130 - 134   2025年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p> 沖縄県では1990年代より血縁者間骨髄移植が行われるようになり2000年以降は年間約40例で推移している。沖縄県の移植医療の特徴として離島や僻地の医療を担う責務に加え，難治性で移植が必要な成人T細胞白血病リンパ腫（ATL）患者の頻度が高く血液悪性腫瘍に対する移植医療のニーズに対応する県内完結型の医療体制が不可欠であることが挙げられる。医療事故や血液内科医の不足から琉球大学病院における造血幹細胞移植はこれまでに2度の中断を余儀なくされ，バンクを介した移植が実施出来ない時期が長く続き，患者は経済的・精神的・身体的に大きな負担を強いられてきた。その後，非血縁者間移植施設の認定を再取得し，現在では沖縄県内の血液内科専門8施設中，唯一，琉球大学病院のみで実施している。沖縄県の移植医療の経緯と今後の課題について概説する。</p>

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Precision HealthとPrecision Nutritionが拓く100年健康長寿の未来

益崎 裕章

糖尿病と妊娠   25   2025年

掲載種別: 研究論文（学術雑誌）

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Editorial: Nutrient signaling and neuroendocrine pathways in brain-organ communication.

Aizawa H, Masuzaki H

Frontiers in molecular neuroscience ( Frontiers in Molecular Neuroscience )  18   1711443   2025年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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令和６年度 アカデミア賞 受賞記念講演 健康長寿を実現する脳科学・機能性食品科学の分子医学的アプローチと社会実装の展開

益崎 裕章

会誌ACADEMIA   199   53 - 77   2025年

掲載種別: 研究論文（研究会，シンポジウム資料等）

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A Rare Case of Autoimmune-Mediated Lecithin:Cholesterol Acyltransferase Insufficiency Manifesting as the Acute Onset of Extremely Hypo-High-Density Lipoprotein-Cholesterolemia and Spontaneous Improvement: A Case Report with a Review of the Literature.

Tamaki A, Kuroda M, Yonaha K, Ishiki Y, Uehara M, Nakayama Y, Honma KI, Chinen R, Uema T, Okamoto S, Miyoshi J, Kirinashizawa M, Sato K, Aohara T, Yamamoto M, Maezawa Y, Yokote K, Masuzaki H

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  advpub ( 0 ) 649 - 659   2024年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A 59-year-old Japanese woman was referred for an extremely low level of circulating high-density lipoprotein cholesterol (HDL-C). The serum HDL-C level had long been within the normal range but suddenly decreased asymptomatically to 7 mg/dL. She had no typical symptoms associated with familial lecithin, cholesterol acyltransferase deficiency (FLD), including proteinuria, anemia, and corneal opacity. The circulating level of ApoA-1 was also markedly decreased at 48 mg/dL, and the proportion of esterified cholesterol to free cholesterol was irregularly low at 26%. Whole-genome sequencing revealed no apparent pathological mutations in the LCAT gene. Notably, anti-LCAT antibodies were detected in the serum at 146±1.7 ng/mL, resulting in her being diagnosed with acquired LCAT insufficiency (ALCATI) caused by anti-LCAT antibodies. Five years after her HDL-C levels spontaneously decreased, they increased without any identifiable cause. To our knowledge, only six cases of ALCATI caused by anti-LCAT antibodies have been reported to date. In contrast to the present case, previously reported cases of ALCATI manifested proteinuria that improved with steroid therapy. The unique clinical course in the present case highlights the heterogeneity of ALCATI, warranting further research to clarify the molecular pathophysiology of FLD and ALCATI.

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Machine learning-based reproducible prediction of type 2 diabetes subtypes.

Tanabe H, Sato M, Miyake A, Shimajiri Y, Ojima T, Narita A, Saito H, Tanaka K, Masuzaki H, Kazama JJ, Katagiri H, Tamiya G, Kawakami E, Shimabukuro M

Diabetologia ( Diabetologia )  67 ( 11 ) 2446 - 2458   2024年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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AIMS/HYPOTHESIS: Clustering-based subclassification of type 2 diabetes, which reflects pathophysiology and genetic predisposition, is a promising approach for providing personalised and effective therapeutic strategies. Ahlqvist's classification is currently the most vigorously validated method because of its superior ability to predict diabetes complications but it does not have strong consistency over time and requires HOMA2 indices, which are not routinely available in clinical practice and standard cohort studies. We developed a machine learning (ML) model to classify individuals with type 2 diabetes into Ahlqvist's subtypes consistently over time. METHODS: Cohort 1 dataset comprised 619 Japanese individuals with type 2 diabetes who were divided into training and test sets for ML models in a 7:3 ratio. Cohort 2 dataset, comprising 597 individuals with type 2 diabetes, was used for external validation. Participants were pre-labelled (T2Dkmeans) by unsupervised k-means clustering based on Ahlqvist's variables (age at diagnosis, BMI, HbA1c, HOMA2-B and HOMA2-IR) to four subtypes: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD). We adopted 15 variables for a multiclass classification random forest (RF) algorithm to predict type 2 diabetes subtypes (T2DRF15). The proximity matrix computed by RF was visualised using a uniform manifold approximation and projection. Finally, we used a putative subset with missing insulin-related variables to test the predictive performance of the validation cohort, consistency of subtypes over time and prediction ability of diabetes complications. RESULTS: T2DRF15 demonstrated a 94% accuracy for predicting T2Dkmeans type 2 diabetes subtypes (AUCs ≥0.99 and F1 score [an indicator calculated by harmonic mean from precision and recall] ≥0.9) and retained the predictive performance in the external validation cohort (86.3%). T2DRF15 showed an accuracy of 82.9% for detecting T2Dkmeans, also in a putative subset with missing insulin-related variables, when used with an imputation algorithm. In Kaplan-Meier analysis, the diabetes clusters of T2DRF15 demonstrated distinct accumulation risks of diabetic retinopathy in SIDD and that of chronic kidney disease in SIRD during a median observation period of 11.6 (4.5-18.3) years, similarly to the subtypes using T2Dkmeans. The predictive accuracy was improved after excluding individuals with low predictive probability, who were categorised as an 'undecidable' cluster. T2DRF15, after excluding undecidable individuals, showed higher consistency (100% for SIDD, 68.6% for SIRD, 94.4% for MOD and 97.9% for MARD) than T2Dkmeans. CONCLUSIONS/INTERPRETATION: The new ML model for predicting Ahlqvist's subtypes of type 2 diabetes has great potential for application in clinical practice and cohort studies because it can classify individuals with missing HOMA2 indices and predict glycaemic control, diabetic complications and treatment outcomes with long-term consistency by using readily available variables. Future studies are needed to assess whether our approach is applicable to research and/or clinical practice in multiethnic populations.

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Young-onset type 2 diabetes mellitus enhances proteinuria, but not glomerular filtration rate decline: A Japanese cohort study.

Saito H, Tanabe H, Hirai H, Higa M, Tanaka K, Yamaguchi S, Maimaituxun G, Masuzaki H, Kazama JJ, Shimabukuro M

Journal of diabetes investigation ( Journal of Diabetes Investigation )  15 ( 10 ) 1444 - 1456   2024年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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AIMS/INTRODUCTION: The time course of chronic kidney disease in young-onset type 2 diabetes mellitus remains unclear. We compared the trajectories of proteinuria and estimated glomerular filtration rate (eGFR) decline between young-onset (aged ≤40 years) and late-onset (aged >40 years) type 2 diabetes mellitus in a Japanese multicenter cohort. MATERIALS AND METHODS: Participants without diabetic kidney disease were divided into two groups according to age at diagnosis: young- and late-onset. The primary endpoint was eGFR <60 mL/min/1.73 m2, proteinuria or both. Multivariable Cox proportional hazards were calculated to estimate incidence. RESULTS: Among 626 participants with type 2 diabetes mellitus, 78 (12.4%) had young-onset and 548 (87.6%) had late-onset diabetes. The incidence of eGFR <60 mL/min/1.73 m2 was lower (16.7% vs 33.5%, P = 0.003), but that of proteinuria was higher (46.2% vs 28.9%, P = 0.002) in the young-onset type 2 diabetes mellitus group. The Kaplan-Meyer curve showed that young-onset type 2 diabetes mellitus was associated with a decreased hazard ratio (HR) for eGFR <60 mL/min/1.73 m2 and an increased HR for proteinuria compared with late-onset type 2 diabetes mellitus. In the multivariate Cox analysis, young-onset type 2 diabetes mellitus increased the HR (95% confidence interval) of proteinuria (1.53, 95% confidence interval 1.03-2.26), but did not change the eGFR <60 mL/min/1.73 m2 HR. CONCLUSIONS: Young-onset type 2 diabetes mellitus has a lower HR of eGFR <60 mL/min/1.73 m2 and an increased HR of proteinuria compared with late-onset type 2 diabetes mellitus, indicating that young-onset type 2 diabetes mellitus has a different time course for the development of proteinuria and subsequent eGFR decline.

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Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study.

Uema T, Tsukita M, Okamoto S, Uehara M, Honma KI, Nakayama Y, Tamaki A, Miyazato M, Ashikari A, Maeda S, Imamura M, Matsushita M, Nakamura K, Masuzaki H

Diabetes research and clinical practice ( Diabetes Research and Clinical Practice )  213   111747 - 111747   2024年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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AIM: The present cohort study explored whether specific gut microbiota (GM) profile would predict the development of impaired glucose tolerance (IGT) in individuals with normal glucose tolerance (NGT). METHODS: A total of 114 study subjects with NGT in Kumejima island, Japan participated in the present study and underwent 75 g oral glucose tolerance tests at baseline and one year later. We compared the profile of GM at baseline between individuals who consistently maintained NGT (NRN, n = 108) and those who transitioned from NGT to IGT (NTI, n = 6). RESULTS: Within-individual bacterial richness and evenness as well as inter-individual bacterial composition showed no significant differences between NRN and NTI. Of note, however, partial least squares discriminant analyses revealed distinct compositions of GM between groups, with no overlap in their 95 % confidence interval ellipses. Multi-factor analyses at the genus level demonstrated that the proportions of CF231, Corynebacterium, Succinivibrio, and Geobacillus were significantly elevated in NTI compared to NRN (p < 0.005, FDR < 0.1, respectively) after adjusting for age, sex, HbA1c level, and BMI. CONCLUSIONS: Our data suggest that increased proportion of specific GM is linked to the future deterioration of glucose tolerance, thereby serving as a promising predictive marker for type 2 diabetes mellitus.

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Impact of the transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for the measurement of plasma aldosterone concentration (PAC) on the diagnosis of primary aldosteronism (PA) via retrospective analyses in Okinawa, Japan.

Honma KI, Nakayama Y, Tamaki A, Uehara M, Teruya T, Yabiku T, Ishiki Y, Yonaha K, Chinen R, Uema T, Okamoto S, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 895 - 906   2024年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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In Japan, the traditional method for measuring plasma aldosterone concentration (PAC) was radioimmunoassay (RIA), which had several challenges, including poor traceability of certified reference materials and reduced detection sensitivity at low concentrations. To overcome these issues, a chemiluminescent enzyme immunoassay (CLEIA) for PAC measurement was introduced in April 2021 and the Japan Endocrine Society published new guidelines for primary aldosteronism (PA). This study aimed to evaluate the impact of the transition from RIA to CLEIA for PAC measurement on PA diagnosis. Data from 190 patients admitted to the Second Department of Internal Medicine, University of the Ryukyus Hospital, between April 2012 and March 2021 were analyzed. Patients who were diagnosed with PA underwent adrenal venous sampling. The PAC measured by RIA (PAC(RIA)) was converted to the estimated PAC measured by CLEIA (ePAC(CLEIA)) using a conversion formula. The present study evaluated the discordance rates in diagnoses based on screening (SC), captopril challenge test (CCT), saline infusion test (SIT), and diagnosis of PA between results judged by PAC(RIA) according to the previous guidelines and those judged by ePAC(CLEIA) according to the new guidelines. The results revealed discordant diagnosis rates of 6.4% for SC and 10.1% for CCT, with no discordance for SIT. The discordant diagnosis rate for PA was 3.7%. Our study reveals the challenges in establishing appropriate diagnostic criteria for PA using PAC(CLEIA) and highlights the demand for further research on provisionally positive categories.

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座談会 高尿酸血症と合併症～CVD残余リスクとして薬剤介入を考える～

益崎 裕章, 今田 恒夫, 田中 敦史

診断と治療 ( 診断と治療社 )  112 ( 6 ) 773 - 778   2024年06月

掲載種別: 研究論文（学術雑誌）

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Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report with review of literature.

Ishiki Y, Tamaki A, Honma KI, Yonaha K, Yabiku T, Teruya T, Uehara M, Nakayama Y, Chinen R, Uema T, Nakachi S, Okamoto S, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 817 - 824   2024年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Post-traumatic pituitary stalk transection syndrome (PSTS) is an extremely rare cause of combined pituitary hormone deficiency (CPHD), affecting approximately 9 per 100,000 cases of traumatic brain injury. In contrast, pituitary stalk interruption syndrome (PSIS) is also a rare cause of CPHD. Importantly, these conditions are often confused due to their similar names and resembling findings on magnetic resonance imaging (MRI). PSIS has been thought to be a prenatal developmental event resulting from a couple of genetic aberrations. In typical PSIS, anterior pituitary hormone deficiencies are restricted to growth hormone (GH) and gonadotropin during the pediatric age, gradually and generally progressing to panhypopituitarism in most cases. In contrast, global deficiencies of the anterior pituitary hormones in PSTS are temporally associated with trauma. To the best of our knowledge, no case reports of PSTS combined with acute traumatic spinal cord injury have been reported. A 34-year-old female was transferred to our hospital after jumping from the fourth building floor. She was diagnosed as an acute traumatic spinal cord injury and underwent the operation of elective posterior spinal fusion. On postoperative day 7, the blood tests revealed considerable hyperkalemia, hyponatremia and eosinophilia. Notably, menstruation stopped after falling from a height. Pituitary function tests revealed GH deficiency, hypogonadism, hypothyroidism and hypoadrenocorticism. MRI revealed loss of the pituitary stalk, whilst the hyperintense signal from distal axon of hypothalamus was still identified. Based on these findings, she was diagnosed as PSTS. Our case highlights endocrinological landscape of transection of the pituitary stalk by acute trauma.

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幼若期のニコチン曝露により誘導される成獣期肥満の病態モデルマウスの樹立と新規脳ドパミン作用機構の探索

根本 雄飛, 岡本 士毅, 照屋 太輝, 上間 次己, 本間 健一郎, 玉城 啓太, 島袋 充生, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  100 ( 1 ) 319 - 319   2024年05月

掲載種別: 研究論文（その他学術会議資料等）

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成人T細胞白血病リンパ腫(ATL)リンパ腫型と鑑別を要したNocardia asiaticaによる多発リンパ節炎

山城 真人, 中島 知, 上間 道仁, 横田 雄太郎, 宮城 理子, 北村 紗希子, 玉城 啓太, 森近 一穂, 森島 聡子, 仲地 佐和子, 前原 博樹, 福島 卓也, 益崎 裕章

臨床血液 ( (一社)日本血液学会-東京事務局 )  65 ( 5 ) 447 - 447   2024年05月

掲載種別: 研究論文（その他学術会議資料等）

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超難治性血液がんの糖代謝特性と分子制御に注目した新規治療法の可能性

仲地 佐和子, 岡本 士毅, 玉城 啓太, 森近 一穂, 上間 次己, 玉城 敦子, 本間 健一郎, 福島 卓也, 益崎 裕章

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  59回   55 - 55   2024年04月

掲載種別: 研究論文（その他学術会議資料等）

アジア型糖尿病は存在するか?遺伝的および疫学的特徴から 日本人糖尿病のクラスター分類の試み

島袋 充生, 川辺 隼人, 田中 健一, 益崎 裕章, 風間 順一郎, 片桐 秀樹, 川上 英良, 田宮 元

糖尿病 ( (一社)日本糖尿病学会 )  67 ( Suppl.1 ) S - 45   2024年04月

掲載種別: 研究論文（その他学術会議資料等）

Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study.

Kono T, Maimaituxun G, Tanabe H, Higa M, Saito H, Tanaka K, Masuzaki H, Sata M, Kazama JJ, Shimabukuro M

BMJ open diabetes research & care ( BMJ Open Diabetes Research and Care )  12 ( 2 )   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

INTRODUCTION: It remains unclear whether increased perirenal fat (PRF) accumulation is equally related to renal involvement in patients with and without diabetes mellitus (DM). We evaluated the association between PRF volume (PRFV) and low glomerular filtration rate (GFR) and proteinuria in people with or without type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of 473 individuals without T2DM (non-DM, n=202) and with T2DM (DM, n=271). PRFV (cm3), obtained from non-contrast CT, was indexed as PRF index (PRFV/body surface area, cm3/m2). Multivariate-adjusted models were used to determine the ORs of PRFV and PRFV index for detecting estimated GFR (eGFR) decrease of <60 mL/min/1.73 m2 proteinuria onset, or both. RESULTS: Although body mass index (BMI), visceral fat area, and waist circumference were comparable between the non-DM and DM groups, kidney volume, PRFV, and PRFV index were higher in individuals with T2DM than in those without T2DM. In the multivariate analysis, after adjusting for age, sex, BMI, hypertension, smoking history, and visceral fat area ≥100 cm2, the cut-off values of PRFV index were associated with an eGFR<60 in individuals with DM (OR 6.01, 95% CI 2.20 to 16.4, p<0.001) but not in those without DM. CONCLUSIONS: PRFV is associated with low eGFR in patients with T2DM but not in those without T2DM. This suggests that PRF accumulation is more closely related to the onset and progression of diabetic kidney disease (DKD) than non-DKD. Clarifying the mechanisms through which PRF influences DKD development could pave the way for novel prevention and treatment strategies.

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4．まとめ

益崎 裕章

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  113 ( 3 ) 402 - 403   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Impact of coronavirus disease 2019 on medical practice in endocrine and metabolic diseases in Japan: a nationwide surveillance study conducted by the Japan Endocrine Society.

Manaka K, Kato S, Sakamoto R, Yamakage H, Uema T, Kawai S, Shibata M, Hiratsuka I, Nakachi S, Onoue T, Tsuchiya T, Fukui M, Hashimoto K, Suzuki A, Makita N, Ogawa Y, Arima H, Satoh-Asahara N, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 499 - 514   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>We investigated the impact of the Coronavirus disease 2019 (COVID-19) pandemic on the management of endocrine and metabolic disorders in Japan. We conducted a cross-sectional nationwide questionnaire survey targeting board-certified endocrinologists under the auspices of the Japan Endocrine Society. The questionnaire consisted of multiple-choice questions and open-ended responses. Out of approximately 2,700 specialists, 528 (19.5%) opted to participate, suggesting a high level of interest in COVID-19 management among endocrinologists. The study found that almost half of participants had encountered cases of endocrine and metabolic disorders following COVID-19 infection or vaccination. Conditions related to thyroid diseases, glucose metabolism disorders/diabetes, and hypothalamic-pituitary disorders were particularly prevalent. Diabetes and obesity were identified as having high rates of severe cases or fatalities due to COVID-19. The study also highlighted challenges in routine diagnosis and treatment, emphasizing the potential benefits of combining remote consultations with in-person visits to optimize the frequency of examinations and check-ups during infectious disease outbreak which disrupts access to healthcare providers. The insights obtained from this survey are expected to contribute to ensuring appropriate healthcare provision for patients with endocrine and metabolic disorders by using flexible consultation formats, particularly even in the conditions where medical access may be limited due to future outbreaks of emerging or re-emerging infectious diseases.</p>

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超加工食品・ゼロカロリー食品の代謝・健康への影響

益崎 裕章, 上間 次己, 岡本 士毅

Diabetes Journal: 糖尿病と代謝 ( (公財)日本糖尿病財団 )  51 ( 1 ) 9 - 15   2024年03月

掲載種別: 研究論文（その他学術会議資料等）

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現代人の日常にあふれる食品の中には天然食材には存在しない栄養成分の配合比率を有し,調理済みで加工度の高い食べ物や飲料が多く含まれており,知らず知らずの間にそれらの摂取量・摂取頻度が高まっている.わが国においては種々の食品は「農林物資の規格化及び品質表示の適正化に関する法律」(JAS法)により,生鮮食料品,加工食品,食品添加物の3種類に分類され,品質表示基準のもとに管理されている.これに対し,超加工食品(ultra-processed foods:UPF)は従来の食品加工の概念を超え,精製加工度が高い食成分や添加物を工業的に組み合わせ,より簡便に,より多く摂取され,より多く購入・消費されることを重視して作製された一連の食品群を指している.世界的規模で超加工食品の摂取量が増加するに伴い,健康や社会経済に関する諸問題が提起されるようになり,一連の前向きコホート研究や基礎研究の結果から,超加工食品の摂取過剰が,癌,うつ,肥満症,認知機能障害,死亡リスクの上昇,妊婦が過剰摂取した場合の次世代の肥満への影響など,現代人の健康を脅かす核心的な疾病群の発症・進展リスクに深く関連していることが注目されるようになった.本稿では超加工食品の代謝や健康への影響をめぐる最近の知見を紹介するとともに,種々の超加工食品群に配合される機会が多く,やはり世界的規模で摂取量・供給量が増加している,いわゆる"ゼロカロリー食品"が代謝や健康に及ぼす潜在的影響に関しても概説したい.(著者抄録)

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Sex differences in the association between epicardial adipose tissue volume and left atrial volume index.

Yamaguchi S, Maeda M, Oba K, Maimaituxun G, Arasaki O, Yagi S, Kusunose K, Soeki T, Yamada H, Fukuda D, Masuzaki H, Sata M, Shimabukuro M

BMC cardiovascular disorders ( BMC Cardiovascular Disorders )  24 ( 1 ) 46 - 46   2024年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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BACKGROUND: Sex disparities in the association between epicardial adipose tissue volume (EATV) and cardiovascular disease have been reported. The sex-dependent effects of EATV on left atrial (LA) size have not been elucidated. METHODS: Consecutive 247 subjects (median 65 [interquartile range 57, 75] years; 67% of men) who underwent multi-detector computed tomography without significant coronary artery disease or moderate to severe valvular disease were divided into two groups: patients with sinus rhythm (SR) or atrial fibrillation (AF). Sex differences in the association between the EATV index (EATVI) (mL/m2) and LA volume index (LAVI) in 63 SR (28 men and 35 women) and 184 AF (137 men and 47 women) patients were evaluated using univariate and multivariate regression analyses. RESULTS: In overall that includes both men and women, the relationship between EATVI and LAVI was not significantly correlated for patients with SR and AF. The relationship between EATVI and LAVI differed between men and women in both SR and AF groups. In SR patients, there was a positive relationship between EATVI and LAVI in men, but not in women. In contrast, in patients with AF, a negative relationship was found between EATVI and LAVI in women, whereas no association was found in men. CONCLUSIONS: We evaluated sex differences in the association between EATVI and LAVI in patients with either SR or AF, and found a positive relationship in men with SR and a negative relationship in women with AF. This is the first report to evaluate sex differences in the relationship between EATVI and LAVI, suggesting that EAT may play a role, at least in part, in sex differences in the etiology of AF.

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Impact of treatment cessation on incidence and progression of retinopathy in Japanese patients with type 2 diabetes mellitus: a retrospective cohort study

Shinzato Y.

Diabetology International ( Diabetology International )  15 ( 3 ) 535 - 543   2024年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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AIMS: This cohort study investigated the association between treatment cessation and incidence/progression of diabetic retinopathy (DR) in Japanese patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Data were extracted from electronic medical records at the University of the Ryukyu Hospital and the Tomishiro Central Hospital of Okinawa, Japan. We enrolled 417 diabetic patients without DR (N = 281) and with nonproliferative DR (N = 136) at the baseline. Treatment cessation was defined as failing to attend outpatient clinics for at least twelve months prior to the baseline. After a median follow-up of 7 years, we compared the incidence/progression rate of DR including nonproliferative and proliferative DR between patients with and without treatment cessation and calculated the odds ratio (OR) in the treatment cessation group using a logistic regression model. RESULTS: The overall prevalence of treatment cessation was 13% in patients with T2DM. Characteristics of treatment cessation included relative youth (57 ± 11 years vs. 63 ± 12 years, P < 0.01). Treatment cessation was tightly associated with the incidence of DR (OR 4.20 [95% confidence interval [CI] 1.46-12.04, P < 0.01) and also incidence/progression of DR (OR 2.70 [1.28-5.69], P < 0.01), even after adjusting for age, sex, BMI, duration of T2DM, and HbA1c level. CONCLUSIONS: By considering major confounding factors, the present study demonstrates an independent association between treatment cessation and incidence of DR in patients with T2DM, highlighting treatment cessation as an independent risk for DR in T2DM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-024-00724-7.

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超加工食品・ゼロカロリー食品の代謝・健康への影響

益崎 裕章, 岡本 士毅

Diabetes Journal   51   9   2024年

掲載種別: 研究論文（学術雑誌）

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令和５年度 日本肥満学会学会賞の受賞にあたって：私の肥満症研究の歩み ～脂肪組織科学・分子栄養学・依存的行動嗜癖の脳科学からのチャレンジと社会実装～

益崎 裕章

肥満研究   30   4 - 10   2024年

掲載種別: 研究論文（その他学術会議資料等）

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デジタルヘルスが拓くスマート社会とプレシジョンヘルスの未来 ～沖縄県久米島デジタルヘルスプロジェクトからの学びと展望～

益崎 裕章

メディカルビューポイント   45   1 - 2   2024年

掲載種別: 研究論文（学術雑誌）

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2人に1人が100歳の時代？/ 動物性脂肪は麻薬と同じか？

益崎 裕章

The Way Forward   25   16 - 18   2024年

掲載種別: 研究論文（学術雑誌）

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玄米に特有の機能成分 γ-オリザノールの脳機能改善効果

益崎 裕章

New Diet Therapy   40   55 - 57   2024年

掲載種別: 研究論文（学術雑誌）

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２型糖尿病の食事療法・運動療法の効果を左右する腸内細菌のパワー

益崎 裕章

べんちのーと   134   12 - 13   2024年

掲載種別: 研究論文（学術雑誌）

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超加工食品・ゼロカロリー食品の代謝・健康への影響

益崎 裕章, 岡本 士毅

Diabetes Journal   51   9 - 15   2024年

掲載種別: 研究論文（学術雑誌）

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腸脳力を活かしたQOL向上アプローチ：運動欲求・身体活動パフォーマンスに影響する腸内細菌の新知見

益崎 裕章, 岡本 士毅

アロスエルゴン   3   1350 - 1356   2024年

掲載種別: 研究論文（学術雑誌）

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肥満の診断に必要な１１の健康障害

益崎 裕章

日本臨牀 特集：肥満症２０２４ -診断・治療の最新動向-   82   1583 - 1587   2024年

掲載種別: 研究論文（学術雑誌）

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肥満と肥満症

益崎 裕章

日本臨牀 特集4号：動脈・静脈の疾患2024:最新の診断・治療動向   82   32 - 38   2024年

掲載種別: 研究論文（学術雑誌）

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【神経が司る 代謝・炎症制御と生体恒常性 臓器ネットワークを理解し、疾患予防・治療へ繋ぐ】(第2章)摂食 摂食行動制御を司る新規神経回路と肥満における変化

岡本 士毅, 益崎 裕章, 箕越 靖彦

実験医学 ( (株)羊土社 )  41 ( 20 ) 3321 - 3328   2023年12月

掲載種別: 研究論文（その他学術会議資料等）

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摂食行動は生存に必須の本能行動である.電気的破壊実験によって視床下部に満腹中枢と摂食中枢が存在することが発見されて以来,摂食行動制御にかかわる神経ネットワークの解明は飛躍的に進み,近年では中脳や大脳辺縁系などの脳領域にも拡大している.さまざまな摂食行動調節因子が発見され,栄養素別の選択摂食メカニズムや摂食直前から直後における神経活動が無麻酔・無拘束下においても制御可能となり,摂食行動制御にかかわる詳細なメカニズムが次々と明らかとなっている.本稿では,食行動を変化させる分子メカニズムを概説し,食事誘導性肥満動物モデルから得られた知見をもとに,肥満による食行動変容のメカニズムについても考察する.(著者抄録)

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糖尿病クラスター分類と食事要因 福島DEMコホート研究

佐藤 雅紘, 田辺 隼人, 齋藤 悠, 益崎 裕章, 島袋 充生

肥満研究 ( (一社)日本肥満学会 )  29 ( 合同学術集会抄録集 ) 321 - 321   2023年11月

掲載種別: 研究論文（その他学術会議資料等）

臓器連関の観点から肥満を考える 肥満が腸・脳連関に与える影響と機能性食品による改善の可能性

岡本 士毅, 島袋 充生, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  29 ( 合同学術集会抄録集 ) 182 - 182   2023年11月

掲載種別: 研究論文（その他学術会議資料等）

肺原発節外性NK/T細胞リンパ腫の一例

宮城 理子, 仲地 佐和子, 上間 道仁, 横田 雄太郎, 中島 知, 北村 紗希子, 玉城 啓太, 森近 一穂, 西 由希子, 森島 聡子, 福島 卓也, 益崎 裕章

日本血液学会学術集会 ( (一社)日本血液学会 )  85回   1165 - 1165   2023年10月

掲載種別: 研究論文（その他学術会議資料等）

遺伝子異常を伴わないPAI-1欠乏症が疑われた1例

森島 聡子, 岩城 孝行, 浦野 哲盟, 宮城 理子, 中島 知, 北村 紗希子, 花城 多恵子, 西 由希子, 玉城 啓太, 森近 一穂, 仲地 佐和子, 益崎 裕章

日本血液学会学術集会 ( (一社)日本血液学会 )  85回   609 - 609   2023年10月

掲載種別: 研究論文（その他学術会議資料等）

第1土曜特集 人生100年時代を見据えて　がんと生活習慣病(心疾患/糖尿病/CKD/MAFLD)を再考する──共通リスク因子,予防・治療の最新アプローチ はじめに

益崎 裕章

医学のあゆみ ( 医歯薬出版 )  286 ( 10 ) 755 - 756   2023年09月

掲載種別: 研究論文（学術雑誌）

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第1土曜特集 人生100年時代を見据えて　がんと生活習慣病(心疾患/糖尿病/CKD/MAFLD)を再考する──共通リスク因子,予防・治療の最新アプローチ トピックス Metabolic Oncology

仲地 佐和子, 岡本 士毅, 益崎 裕章

医学のあゆみ ( 医歯薬出版 )  286 ( 10 ) 867 - 874   2023年09月

掲載種別: 研究論文（学術雑誌）

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食事からみた先制医療の実践

益崎 裕章, 上間 次己, 本間 健一郎, 玉城 敦子, 岡本 士毅

糖尿病・内分泌代謝科 ( (有)科学評論社 )  57 ( 3 ) 352 - 359   2023年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

食品・サプリメントと認知機能 効果のエビデンスを探る(第7回) 腸内フローラと脳機能にフォーカスする沖縄スタイルのPrecision Nutrition

上間 次己, 岡本 士毅, 益崎 裕章

保健の科学 ( (株)杏林書院 )  65 ( 7 ) 483 - 488   2023年07月

掲載種別: 研究論文（その他学術会議資料等）

食品・サプリメントと認知機能 効果のエビデンスを探る(第7回) 腸内フローラと脳機能にフォーカスする沖縄スタイルのPrecision Nutrition

上間 次己, 岡本 士毅, 益崎 裕章

保健の科学 ( (株)杏林書院 )  65 ( 7 ) 483 - 488   2023年07月

掲載種別: 研究論文（その他学術会議資料等）

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医療従事者における肥満スティグマの調査とアドボカシー活動

呉屋 秀憲, 上間 次己, 仲地 健, 糸数 ちえみ, 益崎 裕章

肥満症治療学展望 ( 日本肥満症治療学会 )  11 ( 2 ) 27 - 28   2023年07月

掲載種別: 研究論文（その他学術会議資料等）

特集にあたって

益崎 裕章

糖尿病 ( 一般社団法人 日本糖尿病学会 )  66 ( 6 ) 459 - 459   2023年06月

掲載種別: 研究論文（学術雑誌）

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コミュニティヘルスケアにおけるアンチエイジング ビッグデータ活用によるアンチエイジング社会実現 沖縄県における試み

益崎 裕章, 上間 次己

日本抗加齢医学会総会プログラム・抄録集 ( (一社)日本抗加齢医学会 )  23回   177 - 177   2023年06月

掲載種別: 研究論文（その他学術会議資料等）

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抗LCAT抗体の出現に伴い著明な低HDL-C血症を来した症例

玉城 敦子, 伊敷 洋平, 本間 健一郎, 屋比久 賢光, 上原 盛幸, 山城 清人, 中山 良朗, 前澤 善朗, 黒田 正幸, 横手 幸太郎, 益崎 裕章

日本内分泌学会雑誌 ( 一般社団法人 日本内分泌学会 )  99 ( S.Update ) 70 - 73   2023年05月

掲載種別: 研究論文（学術雑誌）

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マウス脂肪肝形成に対する玄米由来機能成分γ-オリザノールの抑制メカニズム解析

岡本 士毅, 島袋 省吾, 島袋 康貴, 照屋 太輝, 根本 雄飛, 玉城 啓太, 上間 次己, 本間 健一郎, 島袋 充生, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  99 ( 1 ) 333 - 333   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

玄米由来成分γ-オリザノール含有ナノ粒子製剤を用いた老齢マウスの認知機能改善効果と海馬における神経新生促進効果の検証

照屋 太輝, 島袋 康貴, 上間 次己, 本間 健一郎, 根本 雄飛, 玉城 啓太, 岡本 士毅, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  99 ( 1 ) 321 - 321   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

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クラスター分析による糖尿病新分類とグルカゴンの関連性

田辺 隼人, 島尻 佳典, 佐藤 雅紘, 山口 瑞希, 滝口 善規, 堀田 悠貴, 齋藤 悠, 鴻野 央征, 平井 裕之, 比嘉 盛丈, 田中 健一, 益崎 裕章, 風間 順一郎, 島袋 充生

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  99 ( 1 ) 376 - 376   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

マウス脂肪肝形成に対する玄米由来機能成分γ-オリザノールの抑制メカニズム解析

岡本 士毅, 島袋 省吾, 島袋 康貴, 照屋 太輝, 根本 雄飛, 玉城 啓太, 上間 次己, 本間 健一郎, 島袋 充生, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  99 ( 1 ) 333 - 333   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

玄米由来成分γ-オリザノール含有ナノ粒子製剤を用いた老齢マウスの認知機能改善効果と海馬における神経新生促進効果の検証

照屋 太輝, 島袋 康貴, 上間 次己, 本間 健一郎, 根本 雄飛, 玉城 啓太, 岡本 士毅, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  99 ( 1 ) 321 - 321   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

玄米機能成分γ-オリザノールのマウス海馬における神経新生促進・認知機能改善効果

照屋 太輝, 島袋 康貴, 上間 次己, 本間 健一郎, 玉城 啓太, 岡本 士毅, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( 5 ) 424 - 424   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

代謝的に健康な肥満者と不健康な肥満者を特徴付ける腸内細菌と血清代謝物

上間 次己, 山城 清人, 仲村 武裕, 上原 盛幸, 本間 健一郎, 岡本 士毅, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( 5 ) 402 - 402   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

玄米発酵飲料がメタボリックシンドローム保有者の腸内フローラに及ぼすインパクト

赤嶺 ゆかり, Millman Jasmine Frances, 上間 次己, 岡本 士毅, 上原 盛幸, 小塚 智沙代, 要 匡, 島袋 充生, 満田 昌代, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( 5 ) 451 - 452   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

腸脳連関とメトホルミン作用

益崎 裕章, 上間 次己, 中山 良朗, 山城 清人, 照屋 太輝, 本間 健一郎, 岡本 士毅

糖尿病 ( (一社)日本糖尿病学会 )  66 ( 5 ) 373 - 374   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

糖尿病・肥満症の脳 中枢神経系におけるエネルギー代謝制御と精神疾患

岡本 士毅, 島袋 充生, 箕越 靖彦, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( 5 ) 390 - 390   2023年05月

掲載種別: 研究論文（その他学術会議資料等）

特集 プライマリケア医に必要な情報をまるっと整理 くすりの使い方便利帳 第6章　代謝系に作用する薬剤 [糖尿病治療薬] チアゾリジン誘導体

本間 健一郎, 益崎 裕章

内科 ( 南江堂 )  131 ( 4 ) 806 - 810   2023年04月

掲載種別: 研究論文（学術雑誌）

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Effect of dapagliflozin on 24-hour glycemic variables in Japanese patients with type 2 diabetes mellitus receiving basal insulin supported oral therapy (DBOT): a multicenter, randomized, open-label, parallel-group study.

Kudo A, Machii N, Ono T, Saito H, Oshiro Y, Takahashi R, Oshiro K, Taneda Y, Higa M, Nakachi K, Yagi S, Masuzaki H, Sata M, Shimabukuro M

BMJ open diabetes research & care ( BMJ Open Diabetes Research and Care )  11 ( 2 )   2023年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

INTRODUCTION: This study aimed to evaluate the impacts of dapagliflozin on 24-hour glucose variability and diabetes-related biochemical variables in Japanese patients with type 2 diabetes who had received basal insulin supported oral therapy (BOT). RESEARCH DESIGN AND METHODS: Changes in mean daily blood glucose level before and after 48-72 hours of add-on or no add-on of dapagliflozin (primary end point) and diabetes-related biochemical variables and major safety variables during the 12 weeks (secondary end point) were evaluated in the multicenter, randomized, two-arm, open-label, parallel-group comparison study. RESULTS: Among 36 participants, 18 were included in the no add-on group and 18 were included in the dapagliflozin add-on group. Age, gender, and body mass index were comparable between the groups. There were no changes in continuous glucose monitoring metrics in the no add-on group. In the dapagliflozin add-on group, mean glucose (183-156 mg/dL, p=0.001), maximum glucose (300-253, p<0.01), and SD glucose (57-45, p<0.05) decreased. Time in range increased (p<0.05), while time above the range decreased in the dapagliflozin add-on group but not in the no add-on group. After 12-week treatment with dapagliflozin add-on, 8-hydroxy-2'-deoxyguanosine (8OHdG), as well as hemoglobin A1c (HbA1c), decreased. CONCLUSIONS: This study showed that the mean daily blood glucose and other daily glucose profiles were amended after 48-72 hours of dapagliflozin add-on in Japanese patients with type 2 diabetes who received BOT. The diabetes-related biochemical variables such as HbA1c and urinary 8OHdG were also obtained during the 12 weeks of dapagliflozin add-on without major adverse events. A preferable 24-hour glucose profile in 'time in ranges' and an improvement in reactive oxygen species by dapagliflozin warrant us to evaluate these benefits in larger clinical studies. TRIAL REGISTRATION NUMBER: UMIN000019457.

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マウス脂肪肝形成に対する玄米由来機能成分γ-オリザノールの抑制メカニズム

岡本 士毅, 島袋 省吾, 島袋 康貴, 照屋 太輝, 根本 雄飛, 玉城 啓太, 上間 次己, 本間 健一郎, 島袋 充生, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( Suppl.1 ) S - 301   2023年04月

掲載種別: 研究論文（その他学術会議資料等）

玄米由来機能成分γ-オリザノール含有ナノ粒子製剤による老齢マウスの認知機能改善効果及び海馬における神経新生促進効果

照屋 太輝, 島袋 康貴, 上間 次己, 本間 健一郎, 根本 雄飛, 玉城 啓太, 岡本 士毅, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( Suppl.1 ) S - 194   2023年04月

掲載種別: 研究論文（その他学術会議資料等）

玄米由来機能成分γ-オリザノール含有ナノ粒子製剤による老齢マウスの認知機能改善効果及び海馬における神経新生促進効果

照屋 太輝, 島袋 康貴, 上間 次己, 本間 健一郎, 根本 雄飛, 玉城 啓太, 岡本 士毅, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( Suppl.1 ) S - 194   2023年04月

掲載種別: 研究論文（その他学術会議資料等）

マウス脂肪肝形成に対する玄米由来機能成分γ-オリザノールの抑制メカニズム

岡本 士毅, 島袋 省吾, 島袋 康貴, 照屋 太輝, 根本 雄飛, 玉城 啓太, 上間 次己, 本間 健一郎, 島袋 充生, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( Suppl.1 ) S - 301   2023年04月

掲載種別: 研究論文（その他学術会議資料等）

A Comprehensive Study of the Immunophenotype and its Clinicopathological Significance in Adult T-cell Leukemia/Lymphoma.

Tamaki T, Karube K, Sakihama S, Tsuruta Y, Awazawa R, Hayashi M, Nakada N, Matsumoto H, Yagi N, Ohshiro K, Nakazato I, Kitamura S, Nishi Y, Miyagi T, Yamaguchi S, Nakachi S, Morishima S, Masuzaki H, Takahashi K, Fukushima T, Wada N

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ( Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc )  36 ( 8 ) 100169 - 100169   2023年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). The typical ATLL immunophenotypes are described in the 2017 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues (positive: CD2, CD3, CD5, CD4, and CD25; negative: CD7, CD8, and cytotoxic markers; and partially positive: CD30, CCR4, and FOXP3). However, limited studies are available on the expression of these markers, and their mutual relationship remains unknown. Furthermore, the expression status of novel markers associated with T-cell lymphomas, including Th1 markers (T-bet and CXCR3), Th2 markers (GATA3 and CCR4), T follicular helper markers (BCL6, PD1, and ICOS), and T-cell receptor (TCR) markers, and their clinicopathologic significance is unclear. In this study, we performed >20 immunohistochemical stains in 117 ATLL cases to determine the comprehensive immunophenotypic profile of ATLL, which were compared on the basis of clinicopathologic factors, including morphologic variants (pleomorphic vs anaplastic), biopsy locations, treatments, Shimoyama classification-based clinical subtype, and overall survival. CD3+/CD4+/CD25+/CCR4+ was considered a typical immunophenotype of ATLL, but approximately 20% of cases did not conform to this pattern. Simultaneously, the following new findings were obtained: (1) most cases were negative for TCR-β and TCR-δ (104 cases, 88.9%), indicating the usefulness of negative conversion of TCR expression to provide differentiation from other T-cell tumors; (2) the positivity of CD30 and CD15 and the negativity of FOXP3 and CD3 were significantly associated with anaplastic morphology; and (3) atypical cases, such as T follicular helper marker-positive (12 cases, 10.3%) and cytotoxic molecule-positive cases (3 cases, 2.6%), were identified. No single markers could predict the overall survival among patients with acute/lymphoma subtypes of ATLL. The results of this study illustrate the diversity of ATLL phenotypes. In T-cell tumors occurring in HTLV-1 carriers, the possibility of ATLL should not be eliminated even when the tumor exhibits an atypical phenotype, and the confirmation of HTLV-1 in the tissue is recommended.

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代謝的に健康な肥満者と不健康な肥満者を特徴付ける腸示細菌と血清代謝物

上間 次己, 山城 清人, 仲村 武裕, 上原 盛幸, 本間 健一郎, 岡本 士毅, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  98 ( 5 ) 1568 - 1568   2023年03月

掲載種別: 研究論文（その他学術会議資料等）

代謝的に健康な肥満者と不健康な肥満者を特徴付ける腸内細菌と血清代謝物

上間 次己, 山城 清人, 仲村 武裕, 上原 盛幸, 本間 健一郎, 岡本 士毅, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  98 ( 5 ) 1568 - 1568   2023年03月

掲載種別: 研究論文（その他学術会議資料等）

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Markers for obese and non-obese Type 2 diabetes identified using whole blood metabolomics.

Teruya T, Sunagawa S, Mori A, Masuzaki H, Yanagida M

Scientific reports ( Scientific Reports )  13 ( 1 ) 2460 - 2460   2023年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Definitive differences in blood metabolite profiles between obese and non-obese Type 2 diabetes (T2D) have not been established. We performed an LC-MS-based non-targeted metabolomic analysis of whole blood samples collected from subjects classified into 4 types, based on the presence or absence of obesity and T2D. Of the 125 compounds identified, 20, comprising mainly nucleobases and glucose metabolites, showed significant increases or decreases in the T2D group. These included cytidine, UDP-glucuronate, UMP, 6-phosphogluconate, and pentose-phosphate. Among those 20 compounds, 11 enriched in red blood cells (RBCs) have rarely been studied in the context of diabetes, indicating that RBC metabolism is more extensively disrupted than previously known. Correlation analysis revealed that these T2D markers include 15 HbA1c-associated and 5 irrelevant compounds that may reflect diabetic conditions by a different mechanism than that of HbA1c. In the obese group, enhanced protein and fatty acid catabolism causes increases in 13 compounds, including methylated or acetylated amino acids and short-chain carnitines. Our study, which may be considered a pilot investigation, suggests that changes in blood metabolism due to obesity and diabetes are large, but essentially independent.

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Fatal acquired coagulation factor V deficiency after hepatectomy for advanced hepatocellular carcinoma as a possible immune checkpoint inhibitor-related adverse event: a case report.

Arakaki S, Ono S, Kawamata F, Ishino S, Uesato Y, Nakajima T, Nishi Y, Morishima S, Arakaki S, Maeshiro T, Souri M, Ichinose A, Masuzaki H, Takatsuki M

Surgical case reports ( SpringerOpen )  9 ( 1 ) 16 - 7   2023年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background Atezolizumab plus bevacizumab therapy was recently introduced as the first line for unresectable advanced hepatocellular carcinoma (HCC), but immune-related adverse events (IrAEs) due to atezolizumab are a great concern. Here, we report the case of a patient who developed fatal acquired coagulation factor deficiency after hepatectomy for HCC, treated with atezolizumab and bevacizumab before surgery. Case presentation A 70-year-old man received right trisegmentectomy of the liver with hepaticojejunostomy for advanced HCC with bile duct invasion, after atezolizumab and bevacizumab therapy. The patient suffered the sudden onset of severe multiple coagulation factor deficiency (II, V, VII, VIII, IX, X, XI and XII) immediately following reoperation for anastomotic leakage of hepaticojejunostomy, 7 days after hepatectomy. The coagulation factor deficiency did not reverse even with intensive treatment, and the patient died of uncontrollable bleeding 32 days after hepatectomy. An IrAE due to atezolizumab was suspected because the patient had developed the possible IrAE of enthesitis of the right gastrocnemius muscle before surgery, and specific inhibitors against factor V and anti-factor V autoantibodies were detected, leading to an ultimate diagnosis of autoimmune FV/5 deficiency (AiF5D). Conclusion Severe acquired coagulopathy should be recognized as a possible life-threatening IrAE when using atezolizumab and bevacizumab for HCC.

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「肥満する脳」と「肥満した脳」 糖尿病・肥満症の病態における新しい脳の役割

岡本 士毅, 島袋 充生, 箕越 靖彦, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  66 ( 1 ) 42 - 42   2023年01月

掲載種別: 研究論文（その他学術会議資料等）

A nutritional assessment tool, GNRI, predicts sarcopenia and its components in type 2 diabetes mellitus: A Japanese cross-sectional study.

Shiroma K, Tanabe H, Takiguchi Y, Yamaguchi M, Sato M, Saito H, Tanaka K, Masuzaki H, Kazama JJ, Shimabukuro M

Frontiers in nutrition ( Frontiers in Nutrition )  10   1087471 - 1087471   2023年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: There are few reports evaluating the relationship between undernutrition and the risk of sarcopenia in type 2 diabetes mellitus (T2DM) patients. OBJECTIVE: We investigated whether undernutritional status assessed by the geriatric nutritional risk index (GNRI) and controlling nutritional status (CONUT) were associated with the diagnosis of sarcopenia. METHODS: This was a cross-sectional study of Japanese individuals with T2DM. Univariate or multivariate logistic regression analysis was performed to assess the association of albumin, GNRI, and CONUT with the diagnosis of sarcopenia. The optimal cut-off values were determined by the receiver operating characteristic (ROC) curve to diagnose sarcopenia. RESULTS: In 479 individuals with T2DM, the median age was 71 years [IQR 62, 77], including 264 (55.1%) men. The median duration of diabetes was 17 [11, 23] years. The prevalence of sarcopenia was 41 (8.6%) in all, 21/264 (8.0%) in men, and 20/215 (9.3%) in women. AUCs were ordered from largest to smallest as follows: GNRI > albumin > CONUT. The cut-off values of GNRI were associated with a diagnosis of sarcopenia in multiple logistic regression analysis (odds ratio 9.91, 95% confidential interval 5.72-17.2), P < 0.001. The superiority of GNRI as compared to albumin and CONUT for detecting sarcopenia was also observed in the subclasses of men, women, body mass index (BMI) < 22, and BMI ≥ 22. CONCLUSIONS: Results showed that GNRI shows a superior diagnostic power in the diagnosis of sarcopenia. Additionally, its optimal cut-off points were useful overall or in the subclasses. Future large and prospective studies will be required to confirm the utility of the GNRI cut-off for undernutrition individuals at risk for sarcopenia.

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食事からみた先制医療の実践

益崎 裕章, 岡本 士毅

糖尿病・内分泌代謝内科   57   352 - 359   2023年

掲載種別: 研究論文（学術雑誌）

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超難治性血液がんの糖代謝特性に注目した糖尿病治療薬SGLT2阻害剤の抗腫瘍効果の発見

岡本 士毅, 益崎 裕章

細胞   55   65   2023年

掲載種別: 研究論文（学術雑誌）

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腸脳力を活かしたQOL 向上アプローチ：運動欲求・身体活動パフォーマンスに影響する腸内細菌の新知見

益崎 裕章, 岡本 士毅

特集/腸内フローラのバランス異常と疾患との関わり　アロスエルゴン   3   2023年

掲載種別: 研究論文（学術雑誌）

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腸内フローラと脳機能にフォーカスする沖縄スタイルのPrecision Nutrition

岡本 士毅, 益崎 裕章

保健の科学   65   483   2023年

掲載種別: 研究論文（学術雑誌）

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生活習慣病をめぐるInterdisciplinary Medicine: 病態解明と治療の進歩

益崎 裕章

日本内科学会雑誌   112   2010 - 2011   2023年

掲載種別: 研究論文（学術雑誌）

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玄米機能成分をめぐる脳科学と分子栄養学

益崎 裕章, 岡本 士毅

実験医学   41   123 - 129   2023年

掲載種別: 研究論文（学術雑誌）

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玄米機能成分をめぐる脳科学と分子栄養学

益崎 裕章, 岡本 士毅

実験医学　増刊健康と疾患を制御する精密栄養学」　食行動を司る生体恒常性維持システム」   41   123   2023年

掲載種別: 研究論文（学術雑誌）

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沖縄県の離島，久米島コホート研究における腸内フローラ・血清メタボローム解析による代謝的不健康肥満者 (MUO) の分析とPrecision Nutrition の展開

岡本 士毅, 益崎 裕章

特集/腸内フローラのバランス異常と疾患との関わり　アロスエルゴン   3   2023年

掲載種別: 研究論文（学術雑誌）

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摂食行動制御を司る新規神経回路と肥満における変化

岡本 士毅, 益崎 裕章

実験医学　増刊「神経系を介した臓器ネットワーク―代謝、摂食、免疫、運動、生体リズム、冬眠」   41   115   2023年

掲載種別: 研究論文（学術雑誌）

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Analysis of spot urine biomarkers and association with body weight in Japanese elementary schoolchildren.

Takemoto N, Millman J, Uema T, Yamakawa F, Okamoto S, Mori M, Mori H, Nakamura K, Yamori Y, Masuzaki H

European journal of pediatrics ( European Journal of Pediatrics )  181 ( 11 ) 3879 - 3888   2022年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Childhood obesity is rapidly increasing worldwide and is largely the consequence of adoption of unhealthy diets excessive in calories and salt (NaCl) as well as devoid in pivotal micronutrients such as potassium (K) and magnesium (Mg). Education-based programs aiming to encourage healthy food knowledge and behaviors are crucial at a young age, and for this purpose, convenient ways to assess daily dietary intake are warranted. We therefore attempted to evaluate the dietary intake of Okinawan schoolchildren in Japan by analyzing a series of biomarkers in morning spot urine samples and explore whether these biomarkers correlate with body weight and a series of metabolic parameters. We enrolled 98 third-grade elementary schoolchildren in Okinawa, Japan. Morning spot urine samples were collected and analyzed using high-performance liquid chromatography (HPLC) to assess dietary intake. We found that estimated daily NaCl intake was higher in obese/overweight children as compared to healthy-weight children (p = 0.0001). There was also a significant positive correlation between body mass index (BMI) and NaCl intake (Spearman) (ρ = 0.45, p < 0.0001) and a negative correlation between BMI and Mg/Cr (ρ =  -0.27, p = 0.01). Furthermore, Na/K ratio was higher in samples collected on Monday (weekend) as compared to samples collected on Thursday or Friday (weekday) (p < 0.0001). CONCLUSION: Via the use of morning spot urine analyses, our results show that NaCl intake was associated with obesity, and Mg excretion negatively correlated with BMI in Japanese schoolchildren, highlighting the potential role of these micronutrients in maintaining a healthy body weight. WHAT IS KNOWN: •Overweight and obesity are largely due to excessive consumption of calories and positively correlated with salt (NaCl) intake. •Spot urine methods are convenient for assessing the nutritional needs and targeting prevention programs in children. WHAT IS NEW: •Utilizing morning spot urine analyses, estimated NaCl intake is positively correlated and Mg/Cr negatively correlated with BMI in Okinawan schoolchildren. •As estimated via morning spot urine samples, a greater proportion of children likely exceeds the recommended NaCl intake on the weekend as compared to weekday.

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栄養評価ツールGNRIは2型糖尿病患者のサルコペニア予測因子である 福島DEMコホート

城間 かおり, 田辺 隼人, 佐藤 雅紘, 根本 雄飛, 山口 瑞希, 滝口 義規, 堀田 悠貴, 齋藤 悠, 平井 裕之, 益崎 裕章, 島袋 充生

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 322 - 322   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

糖尿病クラスター分類によるサルコペニアリスクの検出 前向きコホート研究

田辺 隼人, 平井 裕之, 齋藤 悠, 田中 健一, 益崎 裕章, 風間 順一郎, 島袋 充生

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 291 - 291   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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早朝第一スポット尿の解析による沖縄県小学3年生児童の食習慣と肥満の実態把握と学校給食の意義

竹本 のぞみ, 上間 次己, 山川 房江, 岡本 士毅, 森 真理, 森 英樹, 家森 幸男, 中村 幸志, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 288 - 288   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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玄米由来機能成分γ-オリザノールはマウスの肝細胞増殖を促進し脂肪肝形成を抑制する

島袋 省吾, 岡本 士毅, 島袋 康貴, 照屋 太輝, 根本 雄飛, 玉城 啓太, 上間 次己, 本間 健一郎, 島袋 充生, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 290 - 290   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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玄米由来機能成分γ-オリザノールのマウス海馬における神経新生促進及び認知機能改善効果の解析

照屋 太輝, 島袋 康貴, 上間 次己, 本間 健一郎, 玉城 啓太, 岡本 士毅, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 292 - 292   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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減量・代謝改善手術前後の食嗜好変化の解析

中島 貴子, 大城 ちか子, 中山 良朗, 山城 清人, 中村 陽二, 呉屋 太造, 名嘉 太郎, 高江洲 義和, 照屋 秀侍, 仲嵩 緑, 山城 ゆかり, 伊集 裕子, 儀間 優佳, 城間 圭美, 小橋川 広樹, 上間 次己, 高槻 光寿, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 331 - 331   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

琉球大学病院における減量・代謝改善手術後の減量効果不良要因の探索

中山 良朗, 大城 俊貴, 伊敷 洋平, 玉城 敦子, 本間 健一郎, 屋比久 賢光, 照屋 太輝, 上原 盛幸, 山城 清人, 中村 陽二, 上間 次己, 岡本 士毅, 高槻 光寿, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 329 - 329   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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離島住民における代謝的に健康な肥満者と不健康な肥満者を特徴付ける腸内細菌と血清代謝物の解析

上間 次己, 山城 清人, 上原 盛幸, 本間 健一郎, 岡本 士毅, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 293 - 293   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

肥満症予防・改善に携わる全国スタッフの集い～地域の健診・レセプトデータから読み解く肥満症の実態と解決課題～ 琉球大学病院で実践している栄養コンサルテーション『制限から選択へ』

中島 貴子, 照屋 秀侍, 伊集 裕子, 儀間 優佳, 山城 ゆかり, 仲嵩 緑, 城間 圭美, 小橋川 広樹, 大城 ちか子, 上間 次己, 中山 良朗, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 233 - 233   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

注目される肥満症の併存疾患:病態解明と診療の最前線 肥満脳とアルコール依存脳の病態分子クロストーク

岡本 士毅, 島袋 充生, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  28 ( Suppl. ) 176 - 176   2022年11月

掲載種別: 研究論文（その他学術会議資料等）

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Profile of gut microbiota and serum metabolites associated with metabolic syndrome in a remote island most afflicted by obesity in Japan.

Uema T, Millman JF, Okamoto S, Nakamura T, Yamashiro K, Uehara M, Honma KI, Miyazato M, Ashikari A, Saito S, Maeda S, Imamura M, Ishida H, Matsushita M, Nakamura K, Masuzaki H

Scientific reports ( Scientific Reports )  12 ( 1 ) 17292 - 13   2022年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Abstract Numerous studies have revealed distinct differences in the profiles of gut microbiota between non-obese and obese individuals. To date, however, little is known if any disparities in the community of gut microbiota exist between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) subjects. We therefore aimed to comprehensively characterize the gut microbiota and circulating metabolites in serum from both MHO and MUO residing in the remote island, Kumejima, where the prevalence of obesity is one of the highest in Japan, and explored possible correlations between the gut microbiota profile and markers of metabolic syndrome. Results revealed that MUO showed significantly higher levels of genera such as g_Succinivibrio, g_Granulicatella, g_Brachyspira, g_Oribacterium and g_Atopobium in comparison to MHO. Moreover, abundance of g_Succinivibrio, g_Brachyspira and g_Atopobium were positively correlated with value of fasting insulin, HOMA-R, circulating triglycerides, diastolic blood pressure, BMI, body weight, waist circumference and HbA1c. In addition, MUO compared to MHO showed an imbalance of serum metabolites, with a significant elevation in 2-oxoisovaleric acid, pyruvic acid, 2-hydroxybutyric acid, and creatine. Our data highlight unmet needs in precision approaches for the treatment of obesity, targeting the gut microbiota profile and serum metabolites in a distinct population affected by obesity.

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Metabolism, clinical and experimental: seventy years young and growing.

Polyzos SA, Hill MA, Fuleihan GE, Gnudi L, Kim YB, Larson S, Masuzaki H, Matarese G, Sanoudou D, Tena-Sempere M, Mantzoros CS

Metabolism: clinical and experimental ( Metabolism: Clinical and Experimental )  137   155333 - 155333   2022年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Amyloid beta clearance and microglia: Effects of glycative stress and melatonin

Yonei Yoshikazu, Taira Toshio, Otaka Shino, Sekiguchi Shizuko, Mamun-or-Rashid ANM, Yagi Masayuki, Masuzaki Hiroaki

Glycative Stress Research ( 一般社団法人 糖化ストレス研究会 )  9 ( 3 ) 135 - 145   2022年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The physiological role of amyloid-β (Aβ) is unknown, while it plays an important role in the onset and progression of Alzheimer's disease (AD). Aβ polymerization leads to enhanced neurotoxicity, persistent degradation, and deposition in the brain, resulting in decreased Aβ clearance. Diabetes mellitus and poor sleep quality are representative risk factors for the development of AD. Methylglyoxal (MGO) and acrolein are increased in diabetic patients, a representative disease with high glycative stress, and melatonin secretion is decreased during poor sleep quality. In this study, we focused on the Aβ phagocytosis of microglia, which plays a role in Aβ clearance, and examined the effects of Aβ glycation and melatonin. Glycated Aβ was prepared by MGO or acrolein treatment. Fluorescently labeled TAMRA-Aβ and primary rat microglial cells (Cosmo Bio) were used in the experiments. Several new findings were obtained from this experiment. First, microglia phagocytose Aβ, while their phagocytic capacity for glycated Aβ was markedly reduced. Second, Aβ phagocytosis was enhanced by melatonin. Concurrently, spontaneous death of cultured microglia was greater when Aβ was not added than when Aβ was. These findings suggest that prevention of Aβ glycation by countermeasures against glycative stress and prevention of AD progression by lifestyle, <i>i.e.</i>, improvement of sleep quality, are important, rather than elimination of Aβ as has been conventionally practiced.

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AIと医工連携が拓く排尿障害の新たな治療展開 排尿モニタリング装置による診断システムの開発(久米島デジタルヘルスプロジェクト)

芦刈 明日香, 宮里 実, 中村 幸志, 山城 清人, 仲村 武裕, 上間 次己, 上原 盛幸, 益崎 裕章, 斎藤 誠一, 前田 士郎, 石田 肇, 松下 正之

日本排尿機能学会誌 ( (一社)日本排尿機能学会 )  33 ( 1 ) 118 - 118   2022年09月

掲載種別: 研究論文（その他学術会議資料等）

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Clinically Amyopathic Dermatomyositis Manifested After the Allogeneic Hematopoietic Stem Cell Transplantation: Case Presentation and Literature Review.

Miyagi R, Nakachi S, Tamaki Y, Doi M, Nakajima T, Kitamura S, Tomori S, Hanashiro T, Tamaki K, Morichika K, Nishi Y, Morishima S, Fukushima T, Masuzaki H

Modern rheumatology case reports ( Modern Rheumatology Case Reports )  7 ( 1 ) 102 - 107   2022年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: Clinically amyopathic dermatomyositis (CADM) lacks muscle symptoms, associating with rapidly progressive interstitial lung disease (RPILD). Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody has been identified as a disease-labeling autoantibody. We report two cases of CADM manifested after the allogeneic hematopoietic stem cell transplantation (allo-HSCT). CASE SERIES: Case 1: A 56-year-old man with acute leukemia received the allo-HSCT. Case 2: A 45-year-old female patient with lymphoma received the allo-HSCT. She received donor lymphocyte infusion (DLI) because of a post-transplant relapse. After allo-HSCT or DLI, Gottron papules emerged, and both patients were diagnosed as CADM based on dermatological findings coupled with the positivity of anti-MDA-5 antibody, accompanied by interstitial shadows consistent with ILD on chest CT. Case 2 was initially diagnosed as a kind of chronic graft versus host disease. Their symptoms were improved by the combination of immunosuppressive agents with a concomitant decrease in anti-MDA-5 antibody levels. For Case 2, Rituximab was subsequently started for relapse of lymphoma, resulting in a substantial decrease in level of anti-MDA-5 antibody and improvement in rash and ILD. CONCLUSION: Our cases raise a possibility that CADM emerges after the HSCT, highlighting the importance of early diagnosis to avoid fated progression into ILD.

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Detecting Sarcopenia Risk by Diabetes Clustering: A Japanese Prospective Cohort Study.

Tanabe H, Hirai H, Saito H, Tanaka K, Masuzaki H, Kazama JJ, Shimabukuro M

The Journal of clinical endocrinology and metabolism ( The Journal of clinical endocrinology and metabolism )  107 ( 10 ) 2729 - 2736   2022年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

CONTEXT: Previous studies have assessed the usefulness of data-driven clustering for predicting complications in patients with diabetes mellitus. However, whether the diabetes clustering is useful in predicting sarcopenia remains unclear. OBJECTIVE: To evaluate the predictive power of diabetes clustering for the incidence of sarcopenia in a prospective Japanese cohort. DESIGN: Three-year prospective cohort study. SETTING AND PATIENTS: We recruited Japanese patients with type 1 or type 2 diabetes mellitus (n = 659) between January 2018 and February 2020 from the Fukushima Diabetes, Endocrinology, and Metabolism cohort. INTERVENTIONS: Kaplan-Meier and Cox proportional hazards models were used to measure the predictive values of the conventional and clustering-based classification of diabetes mellitus for the onset of sarcopenia. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia (AWGS) 2019 consensus update. MAIN OUTCOME MEASURES: Onset of sarcopenia. RESULTS: Cluster analysis of a Japanese population revealed 5 diabetes clusters: cluster 1 [severe autoimmune diabetes (SAID)], cluster 2 [severe insulin-deficient diabetes (SIDD)], cluster 3 (severe insulin-resistant diabetes, cluster 4 (mild obesity-related diabetes), and cluster 5 (mild age-related diabetes). At baseline, 38 (6.5%) patients met the AWGS sarcopenia criteria, and 55 had newly developed sarcopenia within 3 years. The SAID and SIDD clusters were at high risk of developing sarcopenia after correction for known risk factors. CONCLUSIONS: This study reveals that among the 5 diabetes clusters, the SAID and SIDD clusters are at a high risk for developing sarcopenia. Clustering-based stratification may be beneficial for predicting and preventing sarcopenia in patients with diabetes.

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体質医学からみたこれからの先制医療 腸脳連関と生活習慣病

益崎 裕章, Millman Jasmine F., 上間 次己, 根本 雄飛, 岡本 士毅

日本体質医学会雑誌 ( 日本体質医学会 )  84 ( 2 ) 97 - 105   2022年06月

掲載種別: 研究論文（その他学術会議資料等）

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Obesity and Voiding Parameters in a Community-Based Population of Okinawa, Japan: Kumejima Digital Health Project (KDHP).

Ashikari A, Miyazato M, Nakamura K, Yamashiro K, Nakamura T, Uema T, Uehara M, Masuzaki H, Saito S, Maeda S, Ishida H, Matsushita M

Metabolites ( Metabolites )  12 ( 5 ) 468 - 468   2022年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

(1) Background: Evidence has accumulated regarding the etiology of lower urinary tract symptoms associated with obesity and metabolic syndrome. Therefore, the present study aimed to identify which subjectively and objectively measured voiding parameters were associated with obesity in a community-based population. (2) Methods: Voiding parameters on a self-administered questionnaire and a digital self-health monitoring system for urine excretion (s-HMSU) were compared between participants with and without obesity, defined as a body mass index ≥ 25 kg/m2 (n = 30 and 29, respectively), from a community in Okinawa, Japan. Logistic regression analysis was employed to calculate the odds ratios of abnormalities in voiding parameters for the obese group, with the non-obese group serving as a reference. (3) Results: The obese group had odds ratios of 5.17 (95% confidence interval: 1.33-20.0) for shortened hours of undisturbed sleep (&lt;302 min) by s-HMSU and 7.65 (1.88-31.1) for nighttime urinary frequency by a questionnaire after adjusting for age and sex. In addition, the obese group had an adjusted odds ratio of 2.27 (0.76-6.78) for decreased maximum bladder capacity (&lt;212 mL) by s-HMSU. (4) Conclusion: the results of the present study suggest that nocturia and shortened hours of undisturbed sleep are signs of obesity.

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Fermented brown rice beverage distinctively modulates the gut microbiota in Okinawans with metabolic syndrome: A randomized controlled trial.

Akamine Y, Millman JF, Uema T, Okamoto S, Yonamine M, Uehara M, Kozuka C, Kaname T, Shimabukuro M, Kinjo K, Mitsuta M, Watanabe H, Masuzaki H

Nutrition research (New York, N.Y.) ( Nutrition Research )  103   68 - 81   2022年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Accumulating evidence to date suggests that brown rice is superior to white rice in regard to its beneficial impact on a number of risk factors of the metabolic syndrome (MetS). However, little is known about the influence of fermented brown rice beverage on the gut microbiota in humans. We therefore hypothesized that its impact would beneficially alter the gut microbiota composition of patients with MetS. Using a 4-week randomized, single-arm study design, subjects (n = 40) were advised to consume a daily fermented brown rice beverage (BA) or fermented white rice beverage (WA) as a replacement of their main meal. Clinical and anthropometric measurements as well as fecal samples were collected at baseline and immediately after completion of the intervention. Gut microbiota was analyzed using 16S ribosomal RNA sequencing and capillary electrophoresis-time-of-flight mass spectrometry was used to measure plasma short-chain fatty acids. Interestingly, ingestion of BA in contrast to WA resulted in a unique elevation in the abundance of number of beneficial species belonging to the Clostridia class, associated with reduced inflammation, and increased short-chain fatty acid production: Lactobacillales bacterium DJF B280 (P = .005), Butyrate producing bacterium A2 207 (P = .012), and Firmicutes bacterium DJF VP44 (P = .038). This study demonstrates that consumption of BA is effective to beneficially modulate the gut microbiota compared with WA in patients with MetS.

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Elevation of the Plasma Levels of TNF Receptor 2 in Association with Those of CD25, OX40, and IL-10 and HTLV-1 Proviral Load in Acute Adult T-Cell Leukemia.

Kato M, Imaizumi N, Tanaka R, Mizuguchi M, Hayashi M, Miyagi T, Uchihara J, Ohshiro K, Todoroki J, Karube K, Masuzaki H, Tanaka Y, Fukushima T

Viruses ( Viruses )  14 ( 4 ) 751 - 751   2022年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Adult T-cell leukemia/lymphoma (ATL) cells express TNF receptor type-2 (TNFR2) on their surface and shed its soluble form (sTNFR2). We previously reported that sTNFR2 levels were highly elevated in the plasma of patients with acute ATL. To investigate whether its quantitation would be helpful for the diagnosis or prediction of the onset of acute ATL, we examined the plasma levels of sTNFR2 in a large number of specimens obtained from a cohort of ATL patients and asymptomatic human T-cell leukemia virus type 1 (HTLV-1) carriers (ACs) and compared them to those of other candidate ATL biomarkers (sCD25, sOX40, and IL-10) by enzyme-linked immunosorbent assays (ELISA) and HTLV-1 proviral loads. We observed that sTNFR2 levels were significantly elevated in acute ATL patients compared to ACs and patients with other types of ATL (chronic, smoldering, and lymphoma). Importantly, sTNFR2 levels were significantly correlated with those of sCD25, sOX40, and IL-10, as well as proviral loads. Thus, the present study confirmed that an increase in plasma sTNFR2 levels is a biomarker for the diagnosis of acute ATL. Examination of plasma sTNFR2 alone or in combination with other ATL biomarkers may be helpful for the diagnosis of acute ATL.

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沖縄県、長野県、徳島県の非糖尿病患者におけるインスリンAUCと腹部肥満との連関

比嘉 盛丈, 渡邊 桐子, 澤紙 亜希子, 長谷川 吉正, 佐田 政隆, 益崎 裕章, 島袋 充生

糖尿病 ( (一社)日本糖尿病学会 )  65 ( Suppl.1 ) S - 290   2022年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

沖縄県、長野県、徳島県の非糖尿病者におけるインスリンAUCと腹部肥満との連関

比嘉 盛丈, 渡邊 桐子, 澤紙 亜希子, 長谷川 吉正, 佐田 政隆, 益崎 裕章, 島袋 充生

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  98 ( 1 ) 373 - 373   2022年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

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耐糖能異常のリスク上昇に関わる腸内細菌叢組成の探索的解析

上間 次己, 山城 清人, 仲村 武裕, 本間 健一郎, 上原 盛幸, 岡本 士毅, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  98 ( 1 ) 323 - 323   2022年04月

掲載種別: 研究論文（その他学術会議資料等）

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若年発症2型糖尿病の蛋白尿の出現にはHbA1cが時間依存的に関与する

齋藤 悠, 猪狩 翔吾, 佐藤 恵, 佐藤 雅紘, 根本 雄飛, 山口 瑞希, 滝口 善規, 渡邊 桐子, 堀田 悠貴, 田辺 隼人, 岩崎 麻里子, 平井 裕之, 山口 怜, 比嘉 盛丈, 益崎 裕章, 田中 健一, 旭 浩一, 風間 順一郎, 島袋 充生

糖尿病 ( (一社)日本糖尿病学会 )  65 ( Suppl.1 ) S - 269   2022年04月

掲載種別: 研究論文（その他学術会議資料等）

糖尿病患者における循環器疾患の予防と治療を考える 糖尿病クラスター分類から見た循環器疾患の診断と治療

島袋 充生, 田辺 隼人, 齋藤 悠, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  65 ( Suppl.1 ) S - 39   2022年04月

掲載種別: 研究論文（その他学術会議資料等）

Impact of anti-diabetic sodium-glucose cotransporter 2 inhibitors on tumor growth of intractable hematological malignancy in humans.

Nakachi S, Okamoto S, Tamaki K, Nomura I, Tomihama M, Nishi Y, Fukushima T, Tanaka Y, Morishima S, Imamura M, Maeda S, Tsutsui M, Matsushita M, Masuzaki H

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie ( Biomedicine and Pharmacotherapy )  149   112864 - 112864   2022年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Under the dysfunction of mitochondria, cancer cells preferentially utilize both glycolytic and pentose phosphate pathways rather than electron transport chains to desperately generate adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH), classically recognized as the Warburg effect. Based on this background, the present study tested the hypothesis that anti-diabetic sodium-glucose cotransporter 2 (SGLT2) inhibitors would exert a tumor-suppressive impact on intractable human hematological malignancies via the modulation of glucose metabolism within cells and cell cycles. The level of mRNA for SGLT2 was remarkably elevated in leukemic cells from patients with adult T-cell leukemia (ATL), one of the most intractable blood cancers in humans, and as well as in two kinds of ATL cell lines (MT-1 and MT-2). Two kinds of SGLT2 inhibitors, Luseogliflozin and Tofogliflozin substantially suppressed the proliferation of MT-1 and MT-2 cells in both adherent and anchorage-independent culture conditions. Such a suppressive effect on tumor cell growth was reproduced by Luseogliflozin in leukemic cells in peripheral blood from patients with ATL. In MT-2 cells, both of SGLT2 inhibitors considerably attenuated glucose uptake, intracellular ATP levels, and NADPH production, resultantly enhancing cell cycle arrest at the G0/G1 phase. From the standpoint of metabolic oncology, the present study suggests that SGLT2 inhibitors would be a promising adjunctive option for the treatment of the most intractable human hematological malignancies like ATL.

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The power of gut-brain interaction as a promising target for healthy longevity

Masuzaki Hiroaki, Uema Tsugumi, Okamoto Shiki

Glycative Stress Research ( 一般社団法人 糖化ストレス研究会 )  9 ( 1 ) 1 - 6   2022年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Hippocrates, the sage of medicine, famously said, "All disease begins in the gut," The gut-brain axis plays an extremely important role in a high-quality strategy for anti-aging throughout the roughly 100-year life span of humans. When the gut-brain axis is functioning properly, it is possible to maintain a healthy body, mind, and cognitive function, while dysfunction in the gut-brain axis can lead to increased risks of a variety of diseases and subsequent deterioration. From this point of view, we call the unlimited power of the gut-brain interaction "gut-brain axis power" and have focused our attention on the molecular medicine of diet and exercise to enhance gut-brain axis power. The degree of gut-brain power varies greatly from person to person, and the power of gut-brain axis is greatly affected by one's lifestyle, including diet, exercise habits, sleep quality, and stress management. Based on this notion, gut brain power is highlighted as a possible factor X to explain individual and constitutional differences in the development and worsening of complications as well as differences in response to diet, exercise, and drug therapy, all of which have occasionally been overlooked in preventive and clinical medicine. The ingested dietary contents are sensed by enteroendocrine cells (EECs) as nutrients, bile acids, or fermentation metabolites of gut microbiota, and are involved in the regulation of secretion of gut-derived peptide hormones, i.e. CCK, GLP-1, PYY, and ghrelin. These gastrointestinal hormones then act on the central nervous system (brain) to exert a considerable influence on the control of appetite and food preference. In addition to sensing by EEC, the various bioactive substances in the gastrointestinal tracts send information to the brain via blood and lymph flow or directly via spinal afferents, and determine all modes of behaviour, including eating habits and physical activity, whether consciously or unconsciously. The ultimate key to the "behaviour modification" that is being discussed in various aspects of society can be said to be gut brain axis power.

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【食の謎にせまる】オリーブオイルの謎

Millman Jasmine F., 岡本 士毅, 野村 育美, 上間 次己, 益崎 裕章

消化器病学サイエンス ( (株)先端医学社 )  6 ( 1 ) 38 - 42   2022年03月

掲載種別: 研究論文（その他学術会議資料等）

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地中海食の主要な要素であるエクストラバージンオリーブオイル(Extra Virgin Olive Oil:EVOO)はオレイン酸などの一価不飽和脂肪酸やポリフェノール化合物を高濃度に含有し、心血管病や認知症の予防に寄与することが広く知られている。興味深いことに、EVOOは腸内フローラのバランスや質の改善、消化管免疫機能の向上にも有用であることが明らかになっており、分子メカニズム解明の進展が大きな注目を集めている。本稿ではEVOOの栄養学的特徴、心血管病や認知症の予防効果、腸内環境に与えるインパクトをめぐる最新知見を概観する。(著者抄録)

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Psycho-Metabolism-その基礎と臨床-(精神心理代謝連関) 肥満症と精神疾患に共通する病態メカニズム

岡本 士毅, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  27 ( Suppl. ) 169 - 169   2022年03月

掲載種別: 研究論文（その他学術会議資料等）

Specific Expression of KCC2 in the α Cells of Normal and Type 1 Diabetes Model Mouse Pancreatic Islets.

Shimizu-Okabe C, Okada S, Okamoto S, Masuzaki H, Takayama C

Acta histochemica et cytochemica ( 日本組織細胞化学会 )  55 ( 1 ) 47 - 56   2022年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the mature brain; however, it acts excitatory during development. This difference in action depends on the intra­cellular chloride ion concentration, primarily regulated by potassium chloride co-transporter2 (KCC2). Sufficient KCC2 expression results in its inhibitory action. GABA is also abundant in pancreatic islets, where it acts differentially on the islet cells, and is involved in carbohydrate metabolism. However, the mechanisms underlying the differential action remain unknown. We performed immunohistochemistry for glutamic acid decarboxylase (GAD), a synthetic enzyme for GABA, and KCC2 in normal adult islets. GAD was co-localized with insulin in β cells, whereas KCC2 was expressed in glucagon-positive α cells. These results are in line with previous observations that GABA decreases glucagon release but increases insulin release, and suggest that GABA and insulin may work together in reducing blood glucose levels under hyperglycemia. Next, we examined the streptozotocin-induced type1 diabetes mellitus mouse model. GAD and insulin expression levels were markedly decreased. KCC2 was expressed in glucagon-positive cells, whereas insulin- and somatostatin-positive cells were KCC2-negative. These findings suggest that in diabetes model, reduced GABA release may cause disinhibition of glucagon release, resulting in increased blood sugar levels and the maintenance of hyperglycemic state.</p>

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Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity.

Sasaki A, Yokote K, Naitoh T, Fujikura J, Hayashi K, Hirota Y, Inagaki N, Ishigaki Y, Kasama K, Kikkawa E, Koyama H, Masuzaki H, Miyatsuka T, Nozaki T, Ogawa W, Ohta M, Okazumi S, Shimabukuro M, Shimomura I, Nishizawa H, Saiki A, Seki Y, Shojima N, Tsujino M, Ugi S, Watada H, Yamauchi T, Yamaguchi T, Ueki K, Kadowaki T, Tatsuno I, Joint Committee in the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, the Japan Society for the Study of Obesity.

Diabetology international ( Diabetology International )  13 ( 1 ) 1 - 30   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Bariatric surgery has been shown to have a variety of metabolically beneficial effects for patients with type 2 diabetes (T2D), and is now also called metabolic surgery. At the 2nd Diabetes Surgery Summit held in 2015 in London, the indication for bariatric and metabolic surgery was included in the "algorithm for patients with type T2D". With this background, the Japanese Society for Treatment of Obesity (JSTO), the Japan Diabetes Society (JDS) and the Japan Society for the Study of Obesity (JASSO) have formed a joint committee to develop a consensus statement regarding bariatric and metabolic surgery for the treatment of Japanese patients with T2D. Eventually, the consensus statement was announced at the joint meeting of the 38th Annual Meeting of JSTO and the 41st Annual Meeting of JASSO convened in Toyama on March 21, 2021. In preparing the consensus statement, we used Japanese data as much as possible as scientific evidence to consider the indication criteria, and set two types of recommendation grades, "recommendation" and "consideration", for items for which recommendations are possible. We hope that this statement will be helpful in providing evidence-based high-quality care through bariatric and metabolic surgery for the treatment of obese Japanese patients with T2D. Supplementary Information: The online version contains supplementary material available at 10.1007/s13340-021-00551-0.

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Correction to: Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity.

Sasaki A, Yokote K, Naitoh T, Fujikura J, Hayashi K, Hirota Y, Inagaki N, Ishigaki Y, Kasama K, Kikkawa E, Koyama H, Masuzaki H, Miyatsuka T, Nozaki T, Ogawa W, Ohta M, Okazumi S, Shimabukuro M, Shimomura I, Nishizawa H, Saiki A, Seki Y, Shojima N, Tsujino M, Ugi S, Watada H, Yamauchi T, Yamaguchi T, Ueki K, Kadowaki T, Tatsuno I, Joint Committee in the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, the Japan Society for the Study of Obesity.

Diabetology international ( Diabetology International )  13 ( 1 ) 31 - 32   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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[This corrects the article DOI: 10.1007/s13340-021-00551-0.].

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Correction to: Metabolic surgery in treatment of obese Japanese patients with type 2 diabetes: a joint consensus statement from the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, and the Japan Society for the Study of Obesity.

Sasaki A, Yokote K, Naitoh T, Fujikura J, Hayashi K, Hirota Y, Inagaki N, Ishigaki Y, Kasama K, Kikkawa E, Koyama H, Masuzaki H, Miyatsuka T, Nozaki T, Ogawa W, Ohta M, Okazumi S, Shimabukuro M, Shimomura I, Nishizawa H, Saiki A, Seki Y, Shojima N, Tsujino M, Ugi S, Watada H, Yamauchi T, Yamaguchi T, Ueki K, Kadowaki T, Tatsuno I, Joint Committee in the Japanese Society for Treatment of Obesity, the Japan Diabetes Society, the Japan Society for the Study of Obesity.

Diabetology international ( Diabetology International )  13 ( 1 ) 33 - 34   2022年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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[This corrects the article DOI: 10.1007/s13340-021-00551-0.].

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Maternal Urinary Cotinine Concentrations During Pregnancy Predict Infant BMI Trajectory After Birth: Analysis of 89617 Mother-Infant Pairs in the Japan Environment and Children's Study.

Hirai H, Okamoto S, Masuzaki H, Murata T, Ogata Y, Sato A, Horiuchi S, Shinohara R, Shinoki K, Nishigori H, Fujimori K, Hosoya M, Yasumura S, Hashimoto K, Yamagata Z, Shimabukuro M, JECS Group.

Frontiers in endocrinology ( Frontiers in Endocrinology )  13   850784 - 13   2022年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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BACKGROUND: Clinical or epidemiological conclusions remain undecided on the direct effects of active and second-hand smoking during pregnancy on childhood obesity. Urinary cotinine (UC) concentration, an accurate and quantitative marker for smoking, may elucidate the dose-dependent relationship between smoking during pregnancy and childhood obesity. To analyze the relationship between UC concentration and smoking questionnaire (SQ) classes for active and second-hand smoking in pregnant mothers and trajectory of infant Kaup index (body mass index: BMI). METHODS: This multicenter prospective cohort study was conducted using a list-wise complete set of 35829 among 89617 mother-infant singleton pairs, recruited between 2011 and 2014, in the Japan Environment and Children's Study (JECS). Pairs were categorized according to UC levels (1 to 4 classes) or SQ (0 to 4 classes). RESULTS: Maternal BMI at delivery was the highest in UC class 4 (highest). Maternal and paternal education of ≥16 years and annual household income were lowest in UC class 4. Infant BMI was lower at birth, but trends in BMI and ΔBMI were higher from six to 36 months step-wise in the UC classes. The above tendency was observed in the list-wise complete dataset but was emphasized after multiple imputations and corrections of cofounders. UC concentration in five SQ classes largely fluctuated, and the relationship between SQ classes and trends in BMI and ΔBMI was not statistically significant. CONCLUSION: Infants from high UC mothers had a low BMI at birth, increasing from six to 36 months of age. UC concentrations, but not smoking questionnaire classes, predict infant BMI trajectory, suggesting that active and second-hand smoking affect child obesity in a dose-dependent manner.

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A protective role of HTLV-1 gp46-specific neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies in progression to adult T-cell leukemia (ATL).

Tanaka Y, Tanaka R, Imaizumi N, Mizuguchi M, Takahashi Y, Hayashi M, Miyagi T, Uchihara J, Ohshiro K, Masuzaki H, Fukushima T

Frontiers in immunology ( Frontiers in Immunology )  13   921606 - 921606   2022年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Human T-cell leukemia virus type-1 (HTLV-1) establishes a long-term persistent infection in humans and causes malignant T-cell leukemia, adult T-cell leukemia (ATL). HTLV-1-specific cytotoxic T lymphocytes have been suggested to play a major role in the immunosurveillance of HTLV-1-infected T cells. However, it remains unclear whether HTLV-1-specific functional antibodies are also involved in the host defense. To explore the role of antibodies in the course of HTLV-1 infection, we quantitated HTLV-1-specific neutralizing and antibody-dependent cellular cytotoxicity (ADCC)-inducing antibody levels in plasma from asymptomatic carriers (ACs) and ATL patients. The levels of neutralizing antibodies, as determined by a syncytium inhibition assay, were significantly lower in acute and chronic ATL patients than in ACs. The levels of ADCC-inducing activity were tested using an autologous pair of HTLV-1-producing cells and cultured natural killer (NK) cells, which showed that the ADCC-inducing activity of IgG at a concentration of 100 µg/ml was comparable between ACs and acute ATL patients. The anti-gp46 antibody IgG levels, determined by ELISA, correlated with those of the neutralizing and ADCC-inducing antibodies. In contrast, the proviral loads did not correlate with any of these antibody levels. NK cells and a monoclonal anti-gp46 antibody reduced the number of HTLV-1 Tax-expressing cells in cultured peripheral blood mononuclear cells from patients with aggressive ATL. These results suggest a protective role for HTLV-1 neutralizing and ADCC-inducing antibodies during the course of HTLV-1 infection.

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化学療法抵抗性ATLに対する同種造血幹細胞移植前のモガムリズマブの意義

仲地 佐和子, 益崎 裕章

内科学会雑誌   111   183   2022年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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公益社団法人日本麻酔科学会第68回学術集会講演特集号 招待講演 人生100年時代の健康脳を創る　脳科学・分子栄養学からの学び

益崎 裕章, 岡本 士毅

麻酔 ( 克誠堂出版(株) )  70 ( 13 ) S138 - S148   2021年11月

掲載種別: 研究論文（学術雑誌）

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Spontaneous pulmonary emphysema in mice lacking all three nitric oxide synthase isoforms.

Kato K, Tsutsui M, Noguchi S, Iha Y, Naito K, Ogoshi T, Nishida C, Tahara M, Yamashita H, Wang KY, Toyohira Y, Yanagihara N, Masuzaki H, Shimokawa H, Tanimoto A, Yatera K

Scientific reports ( Scientific Reports )  11 ( 1 ) 22088 - 22088   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The roles of endogenous nitric oxide (NO) derived from the entire NO synthases (NOSs) system have yet to be fully elucidated. We addressed this issue in mice in which all three NOS isoforms were deleted. Under basal conditions, the triple n/i/eNOSs-/- mice displayed significantly longer mean alveolar linear intercept length, increased alveolar destructive index, reduced lung elastic fiber content, lower lung field computed tomographic value, and greater end-expiratory lung volume as compared with wild-type (WT) mice. None of single NOS-/- or double NOSs-/- genotypes showed such features. These findings were observed in the triple n/i/eNOSs-/- mice as early as 4 weeks after birth. Cyclopaedic and quantitative comparisons of mRNA expression levels between the lungs of WT and triple n/i/eNOSs-/- mice by cap analysis of gene expression (CAGE) revealed that mRNA expression levels of three Wnt ligands and ten Wnt/β-catenin signaling components were significantly reduced in the lungs of triple n/i/eNOSs-/- mice. These results provide the first direct evidence that complete disruption of all three NOS genes results in spontaneous pulmonary emphysema in juvenile mice in vivo possibly through down-regulation of the Wnt/β-catenin signaling pathway, demonstrating a novel preventive role of the endogenous NO/NOS system in the occurrence of pulmonary emphysema.

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特集 糖尿病性腎臓病(DKD) DKDの治療　AI・IoT活用による肥満症予防とDKD　沖縄県久米島デジタルヘルスプロジェクトの試み

益崎 裕章, 上間 次己, 仲村 武裕, 山城 清人, 岡本 士毅

腎と透析 ( (株)東京医学社 )  91 ( 4 ) 737 - 742   2021年10月

掲載種別: 研究論文（学術雑誌）

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Full-length HLA sequencing in adult T cell leukemia-lymphoma uncovers multiple gene alterations.

Tamaki K, Morishima S, Suzuki S, Shigenari A, Nomura I, Yokota Y, Morichika K, Nishi Y, Nakachi S, Okamoto S, Fukushima T, Shiina T, Masuzaki H

Leukemia ( Leukemia )  35 ( 10 ) 2998 - 3001   2021年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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【糖尿病性腎臓病(DKD)】DKDの治療 AI・IoT活用による肥満症予防とDKD 沖縄県久米島デジタルヘルスプロジェクトの試み

益崎 裕章, 上間 次己, 仲村 武裕, 山城 清人, 岡本 士毅

腎と透析 ( (株)東京医学社 )  91 ( 4 ) 737 - 742   2021年10月

掲載種別: 研究論文（その他学術会議資料等）

Novel strategies for glycaemic control and preventing diabetic complications applying the clustering-based classification of adult-onset diabetes mellitus: A perspective.

Tanabe H, Masuzaki H, Shimabukuro M

Diabetes research and clinical practice ( Diabetes Research and Clinical Practice )  180   109067 - 109067   2021年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Diabetes mellitus results from an interplay between insulin resistance and β-cell dysfunction. Since their relative contributions to its pathogenesis are difficult to quantify, therapeutic strategies for glycaemic control are determined primarily based on two limited metrics: plasma glucose and haemoglobin A1c. Recent attempts have been made to subclassify diabetes mellitus to better predict its associated pathology and plan appropriate therapeutic strategies. These classifications are based on data-driven cluster analysis using autoimmunity, age, obesity (metabolically unhealthy and healthy phenotypes), insulin secretory capacity and resistance, and ethnicity. This review addresses potential therapeutic strategies for the cluster-based classifications of adult-onset diabetes mellitus to achieve better glycaemic control and prevent or at least delay the concomitant complications.

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【高齢者肥満症と循環器疾患】運動と食事に関する分子医学

益崎 裕章, 上間 次己, 岡本 士毅

循環器内科 ( (有)科学評論社 )  90 ( 3 ) 270 - 276   2021年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

加齢に伴う摂食低下のメカニズム

益崎 裕章, 根本 雄飛, 照屋 太輝, 島袋 康貴, 上間 次己, 仲地 佐和子, 島袋 充生, 岡本 士毅

老年内科 ( (有)科学評論社 )  4 ( 3 ) 276 - 281   2021年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

日本人の肥満2型糖尿病患者に対する減量・代謝改善手術に関するコンセンサスステートメント

佐々木 章, 内藤 剛, 横手 幸太郎, 稲垣 暢也, 益崎 裕章, 綿田 裕孝, 小川 渉, 下村 伊一郎, 山内 敏正, 石垣 泰, 笠間 和典, 野崎 剛弘, 島袋 充生, 藤倉 純二, 宮塚 健, 庄嶋 伸浩, 西澤 均, 廣田 勇士, 卯木 智, 太田 正之, 岡住 慎一, 吉川 絵梨, 小山 英則, 齋木 厚人, 関 洋介, 辻野 元祥, 林 果林, 山口 崇, 龍野 一郎, 植木 浩二郎, 門脇 孝, 日本肥満症治療学会, 日本糖尿病学会, 日本肥満学会, 日本人の肥満2型糖尿病患者に対する減量・代謝改善手術の適応基準に関する3学会合同委員会

肥満研究 ( (一社)日本肥満学会 )  27 ( 2 ) 1 - 74   2021年08月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

日本人の肥満2型糖尿病患者に対する減量・代謝改善手術に関するコンセンサスステートメント

佐々木 章, 内藤 剛, 横手 幸太郎, 稲垣 暢也, 益崎 裕章, 綿田 裕孝, 小川 渉, 下村 伊一郎, 山内 敏正, 石垣 泰, 笠間 和典, 野崎 剛弘, 島袋 充生, 藤倉 純二, 宮塚 健, 庄嶋 伸浩, 西澤 均, 廣田 勇士, 卯木 智, 太田 正之, 岡住 慎一, 吉川 絵梨, 小山 英則, 齋木 厚人, 関 洋介, 辻野 元祥, 林 果林, 山口 崇, 龍野 一郎, 植木 浩二郎, 門脇 孝, 日本肥満症治療学会, 日本糖尿病学会, 日本肥満学会, 日本人の肥満2型糖尿病患者に対する減量・代謝改善手術の適応基準に関する3学会合同委員会

肥満研究 ( (一社)日本肥満学会 )  27 ( 2 ) 1 - 74   2021年08月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

書評 -石井 均　編-誰も教えてくれなかった糖尿病患者の感染症診療-感染症合併例はココに気をつけて!

益崎 裕章

medicina ( 株式会社医学書院 )  58 ( 8 ) 1185 - 1185   2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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  CiNii Research

High FIB4 index is an independent risk factor of diabetic kidney disease in type 2 diabetes.

Saito H, Tanabe H, Kudo A, Machii N, Higa M, Yamaguchi S, Maimaituxun G, Abe K, Takahashi A, Tanaka K, Asahi K, Masuzaki H, Ohira H, Kazama JJ, Shimabukuro M

Scientific reports   11 ( 1 ) 11753 - 11753   2021年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) may be linked to development of chronic kidney diseases (CKD). The FIB4 index, a noninvasive liver fibrosis score, has been reported to predict CKD in non-diabetic patients, but there are no reports yet in diabetic cases. Therefore, we evaluated the prognostic impact of FIB4 index on the risk of developing diabetic kidney disease (DKD) in Japanese patients with type 2 diabetes in a retrospective cohort study. We assessed patients with type 2 diabetes with an eGFR ≥ 60 mL/min/1.73 m2 and without dipstick positive proteinuria (≥ 1 +) at their first visit to our department. Participants were divided into two groups based on the FIB4 index at their first visit: FIB4 index > 1.3 and FIB4 index ≤ 1.3. The primary endpoint was defined as a decrease in eGFR < 60 mL/min/1.73 m2 or the onset of proteinuria during the course of treatment. The average age of all 584 type 2 diabetic participants (360 [61.6%] men) was 55 ± 11 years. There were 187 patients in the FIB4 index group > 1.3 (32.0%) and the median observation period was 6.0 (3.8-11.0) years. Kaplan-Meier survival analysis indicated that the risks of developing DKD, eGFR < 60 and proteinuria were all higher in FIB4 index > 1.3 patients than in FIB4 ≤ 1.3 patients. In the Cox regression analysis, an FIB4 index > 1.3 was a significant predictor for onset of DKD (HR 1.54, 95% CI 1.15-2.08) and proteinuria (HR 1.55, 95% CI 1.08-2.23), but not for an eGFR < 60 (HR 1.14, 95% CI 0.79-1.99). To the best of our knowledge, this is the first study to demonstrate that an FIB4 index > 1.3 has a prognostic impact on the development of CKD and proteinuria in type 2 diabetic patients. This warrants further investigation of the prognostic impact of the development of DKD or proteinuria.

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The Positivity of Phosphorylated STAT3 Is a Novel Marker for Favorable Prognosis in Germinal Center B-Cell Type of Diffuse Large B-Cell Lymphoma.

Morichika K, Karube K, Sakihama S, Watanabe R, Kawaki M, Nishi Y, Nakachi S, Okamoto S, Takahara T, Satou A, Shimada S, Shimada K, Tsuzuki T, Fukushima T, Morishima S, Masuzaki H

The American journal of surgical pathology ( American Journal of Surgical Pathology )  45 ( 6 ) 832 - 840   2021年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

On the basis of immunohistochemistry, diffuse large B-cell lymphoma (DLBCL) is categorized as a germinal center B-cell (GCB) or non-GCB subtype. Recent integrated genomic analyses have highlighted the importance of the JAK-STAT3 pathway in the molecular pathogenesis of DLBCL. However, its relevance to clinical outcomes remains controversial. Therefore, we evaluated the extent of the nuclear expression of phosphorylated STAT3 (pSTAT3), a surrogate marker of signal transducer and activator of transcription 3 (STAT3) activation, by immunohistochemistry. We also analyzed the potential relationship between pSTAT3 positivity (defined as ≥40% positive neoplastic cells) and clinicopathologic characteristics in 294 patients with DLBCL. pSTAT3 was detected in 122 patients (42%), with a higher rate in the non-GCB subtype than in the GCB subtype (57% vs. 28%, P<0.001). Factors potentially activating STAT3, MYD88L265P, and Epstein-Barr virus-encoded small RNA were identified in the pSTAT3-positive non-GCB subtype, whereas the pSTAT3-positive GCB subtype often showed STAT3 mutations and lacked EZH2 mutations and the rearrangements of BCL2 and MYC. Multivariate analyses revealed that the pSTAT3-positive GCB subtype showed a favorable prognosis (HR: 0.17; 95% confidence interval, 0.04-0.7; P=0.014). These findings suggest that pSTAT3 positivity may have a unique impact on the clinicopathologic characteristics of DLBCL, making it a promising novel marker for the favorable prognosis of patients with the GCB subtype.

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沖縄県久米島デジタルヘルスプロジェクト IoTとAIによる体重減少・HbA1c改善効果

仲村 武裕, 山城 清人, 上原 盛幸, 上間 次己, 宮里 実, 中村 幸志, 松下 正之, 石田 肇, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  64 ( Suppl.1 ) I - 4   2021年05月

掲載種別: 研究論文（その他学術会議資料等）

Effect of a mobile digital intervention to enhance physical activity in individuals with metabolic disorders on voiding patterns measured by 24-h voided volume monitoring system: Kumejima Digital Health Project (KDHP).

Miyazato M, Ashikari A, Nakamura K, Nakamura T, Yamashiro K, Uema T, Uehara M, Masuzaki H, Saito S, Maeda S, Ishida H, Matsushita M

International urology and nephrology ( International Urology and Nephrology )  53 ( 8 ) 1497 - 1505   2021年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: To evaluate the effect of a mobile digital intervention on voiding patterns, we performed 24-h voided volume monitoring in individuals with metabolic disorders. METHODS: Participants with metabolic disorders were grouped into either the intervention group (n = 17), who had access to a smartphone app (CARADA), or the non-intervention group (n = 11), who did not. Urine monitoring was conducted for 24 h using a novel digital self-health monitoring system for urine excretion (s-HMSU). Body weight, abdominal circumference, blood pressure, and biomarkers were measured. RESULTS: Physical findings and blood test results at baseline and 6 months indicated no significant between-group differences. Night-time frequency did not change between baseline and 6 months in the intervention group but significantly worsened at 6 months in the non-intervention group, as compared to baseline (1.0 ± 0.7 vs. 1.5 ± 0.5, p < 0.05). The change in night-time frequency over 6 months did not differ between the intervention and non-intervention groups. Furthermore, the change in hours of undisturbed sleep over 6 months did not differ between the two groups. However, compared with baseline, nocturnal polyuria index tended to worsen at 6 months in the non-intervention group. CONCLUSION: Our study results suggest that mobile digital intervention might be useful for behavioral therapy to improve night-time frequency and urine production and that s-HMSU might be beneficial for confirming the prevention of progress in individuals with metabolic disorders, which can aid in modifying lifestyle.

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グルコース要求性が高い難治性血液腫瘍に対する糖代謝制御を介するSGLT2阻害剤の新たな治療的意義

仲地 佐和子, 岡本 士毅, 野村 育美, 富浜 真美子, 玉城 啓太, 森近 一穂, 西 由希子, 福島 卓也, 森島 聡子, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  97 ( 1 ) 319 - 319   2021年04月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

沖縄県久米島デジタルヘルスプロジェクト IoTとAIによる体重減少・HbA1c改善効果

仲村 武裕, 山城 清人, 上原 盛幸, 上間 次己, 宮里 実, 中村 幸志, 松下 正之, 石田 肇, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  97 ( 1 ) 276 - 276   2021年04月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

沖縄県久米島デジタルヘルスプロジェクト IoTと機械学習を用いた体重減少と糖尿病予防効果の検討

仲村 武裕, 山城 清人, 上原 盛幸, 上間 次己, 宮里 実, 中村 幸志, 松下 正之, 石田 肇, 益崎 裕章

日本遠隔医療学会雑誌 ( (一社)日本遠隔医療学会 )  16 ( 補刊号 ) 12 - 12   2021年04月

掲載種別: 研究論文（その他学術会議資料等）

2）IoT・AIを活用する生活習慣病診療

益崎 裕章

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  110 ( 3 ) 427 - 434   2021年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Genetic profile of adult T-cell leukemia/lymphoma in Okinawa: Association with prognosis, ethnicity, and HTLV-1 strains.

Sakihama S, Morichika K, Saito R, Miyara M, Miyagi T, Hayashi M, Uchihara J, Tomoyose T, Ohshiro K, Nakayama S, Nakachi S, Morishima S, Sakai K, Nishio K, Masuzaki H, Fukushima T, Karube K

Cancer science ( Cancer Science )  112 ( 3 ) 1300 - 1309   2021年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Genetic alterations in adult T-cell leukemia/lymphoma (ATLL), a T-cell malignancy associated with HTLV-1, and their clinical impacts, especially from the perspective of viral strains, are not fully elucidated. We employed targeted next-generation sequencing and single nucleotide polymorphism array for 89 patients with ATLL in Okinawa, the southernmost islands in Japan, where the frequency of HTLV-1 tax subgroup-A (HTLV-1-taxA) is notably higher than that in mainland Japan, where most ATLL cases have HTLV-1-taxB, and compared the results with previously reported genomic landscapes of ATLL in mainland Japan and the USA. Okinawan patients exhibited similar mutation profiles to mainland Japanese patients, with frequent alterations in TCR/NF-ĸB (eg, PRKCB, PLCG1, and CARD11) and T-cell trafficking pathways (CCR4 and CCR7), in contrast with North American patients who exhibited a predominance of epigenome-associated gene mutations. Some mutations, especially GATA3 and RHOA, were detected more frequently in Okinawan patients than in mainland Japanese patients. Compared to HTLV-1-taxB, HTLV-1-taxA was significantly dominant in Okinawan patients with these mutations (GATA3, 34.1% vs 14.6%, P = .044; RHOA, 24.4% vs 6.3%, P = .032), suggesting the contribution of viral strains to these mutation frequencies. From a clinical viewpoint, we identified a significant negative impact of biallelic inactivation of PRDM1 (P = .027) in addition to the previously reported PRKCB mutations, indicating the importance of integrated genetic analysis. This study suggests that heterogeneous genetic abnormalities in ATLL depend on the viral strain as well as on the ethnic background. This warrants the need to develop therapeutic interventions considering regional characteristics.

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沖縄県久米島デジタルヘルスプロジェクト IoTとAIによる体重減少・HbA1c改善効果

仲村 武裕, 山城 清人, 上原 盛幸, 上間 次己, 宮里 実, 中村 幸志, 松下 正之, 石田 肇, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  64 ( 3 ) 259 - 259   2021年03月

掲載種別: 研究論文（その他学術会議資料等）

Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health.

Millman JF, Okamoto S, Teruya T, Uema T, Ikematsu S, Shimabukuro M, Masuzaki H

Nutrition reviews ( Oxford University Press (OUP) )  79 ( 12 ) 1362 - 1374   2021年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<jats:title>Abstract</jats:title> <jats:p>Extra-virgin olive oil (EVOO), a popular functional food and major source of fat in the Mediterranean diet, possesses a variety of healthful components, including monounsaturated fatty acids and bioactive phenolic compounds that, individually and collectively, exert beneficial effects on cardiometabolic markers of health and act as neuroprotective agents through their anti-inflammatory and antioxidant activities. The gut microbiota and health of the intestinal environment are now considered important factors in the development of obesity, metabolic disease, and even certain neurodegenerative conditions via the gut-brain axis. Recently, data are emerging which demonstrate that the health-promoting benefits of EVOO may also extend to the gut microbiota. In this review, we aimed to examine findings from recent studies regarding the impact of EVOO on gut microbiota and intestinal health and explore how modulations in composition of gut microbiota, production of microbially produced products, and activity and functioning of the mucosal immune system may lead to favorable outcomes in cardiovascular, metabolic, and cognitive health.</jats:p>

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Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus.

Nakayama Y, Yamaguchi S, Shinzato Y, Okamoto S, Millman JF, Yamashiro K, Takemoto N, Uema T, Arakaki K, Higa M, Koizumi H, Shimabukuro M, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  68 ( 6 ) 655 - 669   2021年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p>Gender differences in risks for macrovascular complications in type 2 diabetes mellitus (T2DM) have been well established. However, the impact of gender differences on diabetic retinopathy (DR) has not been fully elucidated. We therefore retrospectively explored gender-specific determinants for DR in patients with T2DM in a small sized Japanese cohort in Okinawa. There were 214 patients who were diagnosed as no DR (<i>n</i> = 142) and non-proliferative DR (<i>n</i> = 72) in 2009. During the follow-up of median 7 years, 41/142 of incidence, 26/72 of progression, and 67/214 of incidence and progression were observed, respectively. DR was assessed using the modified international clinical DR severity scales. The risks for incidence, progression as well as incidence and progression of DR were comparable between men and women, respectively. Cox proportional hazard models in multivariate analyses demonstrated that the only common determinant in both men and women for DR was the duration of T2DM. Regarding gender-specific determinants, lower level of serum albumin in men as well as higher HbA1c, lower level of estimated glomerular filtration rate, and lower level of serum uric acid in women were extracted, respectively. Although precise mechanisms for such gender-specific determinants of DR still remain unsolved, the present study would highlight a couple of factors associated with gender-specific determinants for DR in a limited numbers of Japanese cohort. Prospective observational studies on gender-specific determinants of DR in a large scale cohort are warranted to further clarify underlying mechanisms.</p>

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Novel STAR gene variant in a patient with classic lipoid congenital adrenal hyperplasia and combined pituitary hormone deficiency.

Higa M, Zaha A, Takushi A, Morishima N, Majikina T, Touma T, Shimabukuro M, Masuzaki H, Honda M, Hasegawa T

Human genome variation ( Human Genome Variation )  8 ( 1 ) 6 - 6   2021年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

We report the first case of classic lipoid congenital adrenal hyperplasia and combined pituitary hormone deficiency. We identified pathogenic variants in the STAR gene: a novel variant of c.126_127delCCinsG, namely, p.Thr44Profs*2 and an already reported variant of c.634C>T, namely, p.Gln212*. The association with combined pituitary hormone deficiency might be just a coincidence.

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沖縄県久米島デジタルヘルスプロジェクト IoTと機械学習を用いた体重減少と糖尿病予防効果の検討

仲村 武裕, 山城 清人, 上原 盛幸, 上間 次己, 宮里 実, 中村 幸志, 松下 正之, 石田 肇, 益崎 裕章

日本遠隔医療学会学術大会プログラム・抄録集 ( (一社)日本遠隔医療学会 )  24回   175 - 175   2021年02月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Clinicopathological features of adult T-cell leukemia/lymphoma with HTLV-1-infected Hodgkin and Reed-Sternberg-like cells.

Karube K, Takatori M, Sakihama S, Tsuruta Y, Miyagi T, Morichika K, Kitamura S, Nakada N, Hayashi M, Tomori S, Nakazato I, Ohshiro K, Imaizumi N, Kikuti YY, Nakamura N, Morishima S, Masuzaki H, Fukushima T

Blood advances ( Blood Advances )  5 ( 1 ) 198 - 206   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Hodgkin and Reed-Sternberg (HRS) cells, a hallmark of classic Hodgkin lymphoma (CHL), are occasionally detected in non-Hodgkin lymphomas, including adult T-cell leukemia/lymphoma (ATLL), a lymphoid neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). HRS-like cells associated with ATLL have been described to be of B-cell lineage and infected with Epstein-Barr virus (EBV), not HTLV-1. We herein describe clinicopathological findings in 8 cases (4 males and 4 females; median age, 73 years [range, 55-81 years]) of ATLL with HTLV-1-infected HRS-like cells identified by ultrasensitive RNA in situ hybridization for HTLV-1 basic leucine zipper factor (HBZ-ISH), a specific viral transcript of HTLV-1. All patients showed nodal or mediastinal lesions, and 5 of the 8 patients were at an advanced disease stage. HRS-like cells were positive for CD30, CD15, MUM1, CD25, and HBZ-ISH and negative for B-cell markers, including PAX5, pan-T-cell antigens, and EBV in all cases. Five cases were positive for CD4, and 6 cases were positive for fascin. HBZ was identified in both HRS-like cells and surrounding lymphoid cells in 1 case with an aggressive clinical course and only HRS-like cells in 7 cases, most of whom showed a clinical response regardless of the chemotherapeutic regimen. Even though the definitive lineage typing of the HTLV-1-infected HRS cells is one of the limitations of this study in the absence of single-cell microdissection for polymerase chain reaction analysis, the combination of diffuse HBZ-ISH positivity and negativity for PAX5 and EBV deemed these cases distinct from CHL arising in HTLV-1 carriers.

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Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13.

Suzumori N, Sekizawa A, Takeda E, Samura O, Sasaki A, Akaishi R, Wada S, Hamanoue H, Hirahara F, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Nakayama S, Kamei Y, Namba A, Murotsuki J, Yamaguchi M, Tairaku S, Maeda K, Kaji T, Okamoto Y, Endo M, Ogawa M, Kasai Y, Ichizuka K, Yamada N, Ida A, Miharu N, Kawaguchi S, Hasuo Y, Okazaki T, Ichikawa M, Izumi S, Kuno N, Yotsumoto J, Nishiyama M, Shirato N, Hirose T, Sago H

European journal of obstetrics, gynecology, and reproductive biology   256   75 - 81   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Risk factors for cerebral palsy in neonates due to placental abruption.

Ichizuka K, Toyokawa S, Ikenoue T, Satoh S, Hasegawa J, Ikeda T, Tamiya N, Nakai A, Fujimori K, Maeda T, Kanayama N, Masuzaki H, Iwashita M, Suzuki H, Takeda S

The journal of obstetrics and gynaecology research   47 ( 1 ) 159 - 166   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Regional Variations of Insulin Secretion and Insulin Sensitivity in Japanese Participants With Normal Glucose Tolerance.

Watanabe K, Higa M, Hasegawa Y, Kudo A, Allsopp RC, Willcox BJ, Willcox DC, Sata M, Masuzaki H, Shimabukuro M

Frontiers in nutrition ( Frontiers in Nutrition )  8   632422 - 632422   2021年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Purpose: Regional differences in dietary patterns in Asian countries might affect the balance of insulin response and sensitivity. However, this notion is yet to be validated. To clarify the regional differences in the insulin response and sensitivity and their relationship to nutrients, we compared the insulin secretory response during an oral glucose tolerance test in Japanese participants. Methods: This observational retrospective cohort study analyzed the data from participants with normal glucose tolerance (NGT) from four distinct areas of Japan with regard to the food environment: Fukushima, Nagano, Tokushima, and Okinawa based on data available in the Japanese National Health Insurance database. Results: Although the glucose levels were comparable among the four regions, the insulin responses were significantly different among the regions. This difference was observed even within the same BMI category. The plot between the insulin sensitivity index (Matsuda index) and insulinAUC/glucoseAUC or the insulinogenic index showed hyperbolic relationships with variations in regions. The indices of insulin secretion correlated positively with fat intake and negatively with the intake of fish, carbohydrate calories, and dietary fiber. Conclusions: We found that significant regional differences in insulin response and insulin sensitivity in Japanese participants and that nutritional factors may be linked to these differences independently of body size/adiposity. Insulin response and insulin sensitivity can vary among adult individuals, even within the same race and the same country, and are likely affected by environmental/lifestyle factors as well as genetic traits.

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選択的静脈サンプリング検査が有用だった甲状腺内副甲状腺腫の一例

玉城 敦子, 中山 良朗, 益崎 裕章, 久高 将太, 照屋 理子, 本間 健一郎, 屋比久 賢光, 照屋 太輝, 吉村 蘭, 上原 盛幸, 山城 清人

日本内分泌学会雑誌 ( 一般社団法人 日本内分泌学会 )  97 ( 0 ) 56 - 58   2021年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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  CiNii Research

Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus

Nakayama Yoshiro, Yamaguchi Satoshi, Shinzato Yukiko, Okamoto Shiki, Millman Jasmine F., Yamashiro Kiyoto, Takemoto Nozomi, Uema Tsugumi, Arakaki Koichiro, Higa Moritake, Koizumi Hideki, Shimabukuro Michio, Masuzaki Hiroaki

ENDOCRINE JOURNAL   68 ( 6 ) 655 - 669   2021年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

特集 動脈硬化進行予防のための肥満・脂質異常診療戦略 動脈硬化の病態・早期診断法・リスク　動脈硬化のリスクとしての肥満症・メタボリックシンドロームの臨床的位置づけ

益崎 裕章, 山城 清人, 竹本 のぞみ

診断と治療 ( (株)診断と治療社 )  108 ( 10 ) 1293 - 1297   2020年10月

掲載種別: 研究論文（学術雑誌）

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  CiNii Research

Ovarian reserve after three-step laparoscopic surgery for endometriomas utilizing dienogest: A pilot study.

Kitajima M, Matsumoto K, Murakami N, Harada A, Kitajima Y, Masuzaki H, Miura K

Reproductive medicine and biology   19 ( 4 ) 425 - 431   2020年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Weekend and off-hour effects on the incidence of cerebral palsy: contribution of consolidated perinatal care.

Toyokawa S, Hasegawa J, Ikenoue T, Asano Y, Jojima E, Satoh S, Ikeda T, Ichizuka K, Takeda S, Tamiya N, Nakai A, Fujimori K, Maeda T, Masuzaki H, Suzuki H, Ueda S

Environmental health and preventive medicine   25 ( 1 ) 52   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Metabolically and immunologically beneficial impact of extra virgin olive and flaxseed oils on composition of gut microbiota in mice.

Millman J, Okamoto S, Kimura A, Uema T, Higa M, Yonamine M, Namba T, Ogata E, Yamazaki S, Shimabukuro M, Tsutsui M, Matsushita M, Ikematsu S, Masuzaki H

European journal of nutrition ( European Journal of Nutrition )  59 ( 6 ) 2411 - 2425   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: Extra virgin olive oil (EVOO) and flaxseed oil (FO) contain a variety of constituents beneficial for chronic inflammation and cardio-metabolic derangement. However, little is known about the impact of EVOO and FO on dysbiosis of gut microbiota, intestinal immunity, and barrier. We, therefore, aimed to assess the impact of EVOO and FO on gut microbiota, mucosal immunity, barrier integrity, and metabolic health in mice. METHODS: C57BL/6 J mice were exposed to a low-fat (LF), lard (HF), high fat-extra virgin olive oil (HF-EVOO), or high fat-flaxseed oil (HF-FO) diet for 10 weeks. Gut microbiota assessment was undertaken using 16S rRNA sequencing. Levels of mRNA for genes involved in intestinal inflammation and barrier maintenance in the intestine and bacterial infiltration in the liver were measured by qPCR. RESULTS: HF-EVOO or HF-FO mice showed greater diversity in gut microbiota as well as a lower abundance of the Firmicutes phylum in comparison with HF mice (P < 0.05). The qPCR analyses revealed that mRNA level of FoxP3, a transcription factor, and IL-10, an inducer of regulatory T cells, was significantly elevated in the intestines of mice-fed HF-EVOO in comparison with mice-fed HF (P < 0.05). The mRNA level of the antimicrobial peptide, RegӀӀӀγ, was markedly elevated in the intestines of HF-EVOO and HF-FO compared with HF group (P < 0.05). CONCLUSIONS: Our data suggest that the consumption of EVOO or FO can beneficially impact gut microbiota, enhance gut immunity, and assist in the preservation of metabolic health in mice.

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血液悪性腫瘍の増殖抑制におけるSGLT2阻害剤のインパクトと作用機構

仲地 佐和子, 岡本 士毅, 野村 育美, 富浜 真美子, 玉城 啓太, 森近 一穂, 西 由希子, 福島 卓也, 森島 聡子, 益崎 裕章

日本抗加齢医学会総会プログラム・抄録集 ( (一社)日本抗加齢医学会 )  20回   214 - 214   2020年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

マウスにおいてエクストラヴァージンオリーブオイルとアマニ油は腸内細菌叢に影響を及ぼして粘膜免疫と代謝的健康を促進する(Extra virgin olive and flaxseed oils impact gut microbiota, enhancing mucosal immunity and metabolic health in mice)

ミルマン・ジャスミン, 岡本 士毅, 上間 次己, 比嘉 萌子, 難波 豊隆, 山崎 聡, 島袋 充生, 池松 真也, 益崎 裕章

日本抗加齢医学会総会プログラム・抄録集 ( (一社)日本抗加齢医学会 )  20回   223 - 223   2020年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan.

Okuma K, Kuramitsu M, Niwa T, Taniguchi T, Masaki Y, Ueda G, Matsumoto C, Sobata R, Sagara Y, Nakamura H, Satake M, Miura K, Fuchi N, Masuzaki H, Okayama A, Umeki K, Yamano Y, Sato T, Iwanaga M, Uchimaru K, Nakashima M, Utsunomiya A, Kubota R, Ishitsuka K, Hasegawa H, Sasaki D, Koh KR, Taki M, Nosaka K, Ogata M, Naruse I, Kaneko N, Okajima S, Tezuka K, Ikebe E, Matsuoka S, Itabashi K, Saito S, Watanabe T, Hamaguchi I

Retrovirology   17 ( 1 ) 26   2020年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1.

Takatori M, Sakihama S, Miyara M, Imaizumi N, Miyagi T, Ohshiro K, Nakazato I, Hayashi M, Todoroki J, Morishima S, Masuzaki H, Fukushima T, Karube K

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ( Modern Pathology )  34 ( 1 ) 51 - 58   2020年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Histopathological distinction between adult T-cell leukemia/lymphoma (ATLL) and other T-cell neoplasms is often challenging. The current gold standard for the accurate diagnosis of ATLL is the Southern blot hybridization (SBH) assay, which detects clonal integration of human T-cell leukemia virus type I (HTLV-1) provirus. However, SBH cannot be performed with small biopsy or formalin-fixed paraffin-embedded (FFPE) tissue samples because this assay requires a large amount of DNA without degradation. Here we developed a new diagnostic algorithm for the accurate diagnosis of ATLL using FFPE samples. This method combines two HTLV-1 detection assays, namely, ultrasensitive RNA in situ hybridization using RNAscope for HTLV-1 bZIP factor (HBZ-RNAscope), and quantitative PCR targeting the tax gene (tax-qPCR). We analyzed 119 FFPE tissue specimens (62 ATLL, and 57 non-ATLL, including 41 HTLV-1 carriers) and compared them with the SBH results using the corresponding fresh-frozen samples. As a result, tax-qPCR had a higher ATLL identification rate than HBZ-RNAscope (88% [52/59], and 63% [39/62], respectively). However, HBZ-RNAscope clearly visualized the localization of HTLV-1-infected tumor cells and its identification rate increased to 94% (17/18) when the analysis was limited to samples up to 2 years old, indicating its usefulness in the daily diagnosis. The diagnostic algorithm combining these two assays successfully evaluated 94% (112/119) of samples and distinguished ATLL from non-ATLL cases including HTLV-1 carriers with 100% sensitivity and specificity. This method is expected to replace SBH and increase the accuracy of the diagnosis of ATLL.

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糖尿病腎症ステージ毎の血糖変動指標の検討

澤紙 亜希子, 比嘉 盛丈, 盛島 菜美, 座覇 明子, 眞境名 豊文, 當眞 武, 渡邊 桐子, 田辺 隼人, 待井 典剛, 益崎 裕章, 島袋 充生

糖尿病 ( (一社)日本糖尿病学会 )  63 ( Suppl.1 ) S - 343   2020年08月

掲載種別: 研究論文（その他学術会議資料等）

子宮体がん術後の検査で偶然、発見された高Na血症を契機に判明した中枢性尿崩症の一例

本間 健一郎, 中山 良朗, 久高 将太, 玉城 敦子, 照屋 理子, 安澤 由香利, 屋比久 賢光, 長谷川 千穂, 吉村 蘭, 山城 清人, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  96 ( 1 ) 289 - 289   2020年08月

掲載種別: 研究論文（その他学術会議資料等）

発性アルドステロン症(PA)とサブクリニカルクッシング症候群(SCS)を併発した原発性大結節性副腎皮質過形成(PMAH)の一例

久高 将太, 中山 良朗, 玉城 敦子, 照屋 理子, 安澤 由香利, 本間 健一郎, 屋比久 賢光, 長谷川 千穂, 吉村 蘭, 山城 清人, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  96 ( 1 ) 299 - 299   2020年08月

掲載種別: 研究論文（その他学術会議資料等）

尿中カテコラミン上昇なく123-MIBGシンチグラフィー陰性で摘出病理で確定診断に到った褐色細胞腫の一例

山城 清人, 中山 良朗, 玉城 敦子, 久高 将太, 照屋 理子, 安澤 由香利, 本間 健一郎, 屋比久 賢光, 長谷川 千穂, 吉村 蘭, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  96 ( 1 ) 337 - 337   2020年08月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Walking Speed is the Sole Determinant Criterion of Sarcopenia of Mild Cognitive Impairment in Japanese Elderly Patients with Type 2 Diabetes Mellitus.

Machii N, Kudo A, Saito H, Tanabe H, Iwasaki M, Hirai H, Masuzaki H, Shimabukuro M

Journal of clinical medicine ( Journal of Clinical Medicine )  9 ( 7 ) 1 - 17   2020年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Diabetes mellitus is a risk factor for mild cognitive impairment (MCI) and dementia. However, how the clinical characteristics of MCI patients with type 2 diabetes mellitus are linked to sarcopenia and/or its criteria remain to be elucidated. Japanese patients with type 2 diabetes mellitus were categorized into the MCI group for MoCA-J (the Japanese version of the Montreal cognitive assessment) score <26, and into the non-MCI group for MoCA-J ≥26. Sarcopenia was defined by a low skeletal mass index along with low muscle strength (handgrip strength) or low physical performance (walking speed <1.0 m/s). Univariate and multivariate-adjusted odds ratio models were used to determine the independent contributors for MoCA-J <26. Among 438 participants, 221 (50.5%) and 217 (49.5%) comprised the non-MCI and MCI groups, respectively. In the MCI group, age (61 ± 12 vs. 71 ± 10 years, p < 0.01) and duration of diabetes mellitus (14 ± 9 vs. 17 ± 9 years, p < 0.01) were higher than those in the non-MCI group. Patients in the MCI group exhibited lower hand grip strength, walking speed, and skeletal mass index, but higher prevalence of sarcopenia. Only walking speed (rather than muscle loss or muscle weakness) was found to be an independent determinant of MCI after adjusting for multiple factors, such as age, gender, body mass index (BMI), duration of diabetes mellitus, hypertension, dyslipidemia, smoking, drinking, estimated glomerular filtration rate (eGFR), HbA1c, and history of coronary heart diseases and stroke. In subgroup analysis, a group consisting of male patients aged ≥65 years, with BMI <25, showed a significant OR for walking speed. This study showed that slow walking speed is a sole determinant criterion of sarcopenia of MCI in patients with type 2 diabetes mellitus. It was suggested that walking speed is an important factor in the prediction and prevention of MCI development in patients with diabetes mellitus.

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Factors Associated with Risk of Diabetic Complications in Novel Cluster-Based Diabetes Subgroups: A Japanese Retrospective Cohort Study.

Tanabe H, Saito H, Kudo A, Machii N, Hirai H, Maimaituxun G, Tanaka K, Masuzaki H, Watanabe T, Asahi K, Kazama J, Shimabukuro M

Journal of clinical medicine   9 ( 7 )   2020年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Diabetes is a complex and heterogeneous disease, making the prediction of the risks of diabetic complications challenging. Novel adult-onset diabetes subgroups have been studied using cluster analysis, but its application in East Asians remains unclear. We conducted a retrospective cohort study to elucidate the clinical utility of cluster-based subgroup analysis in the Japanese population. Cluster analysis based on anti-glutamate decarboxylase antibody (GAD antibody) levels, age at diagnosis, body mass index (BMI), hemoglobin A1c (A1c), and homeostatic model assessment 2 estimates of β-cell function and insulin resistance was performed in 1520 diabetic patients. The risk of developing diabetic complications was analyzed using Kaplan-Meier analysis and the Cox proportional hazards model. By cluster analysis, we identified five distinct subgroups of adult-onset diabetes in the Japanese population. The risk of diabetic complications varied greatly among the clusters. Patients with severe autoimmune diabetes or severe insulin deficiency diabetes were at an increased risk of diabetic retinopathy, and those with severe insulin resistant diabetes (SIRD) had the highest risk of developing diabetic kidney disease (DKD). After adjusting for uncorrectable and correctable risk factors, SIRD was found to be an independent risk factor for DKD. In conclusion, we identified five subgroups of adult-onset diabetes and the risk factors for diabetic complications in the Japanese population. This new classification system can be effective in predicting the risk of diabetic complications and for providing optimal treatment.

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満足できない肥満脳のメカニズム解析

岡本 士毅, 箕越 靖彦, 益崎 裕章

メタボリックシンドローム ( 高尿酸血症・メタボリックシンドロームリサーチフォーラム )  16 ( 1 ) 2 - 5   2020年07月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Carboplatin(CBDCA)+Etoposido(VP-16)療法が著効した原発臓器不明の神経内分泌がん(NEC)の1例

長谷川 千穂, 中山 良朗, 玉城 敦子, 屋比久 賢光, 吉村 蘭, 山城 清人, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  96 ( Suppl.Update ) 137 - 140   2020年07月

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

65歳男。食思不振を主訴に近医を受診し、肝胆道系酵素の高値と低Na血症を認められ、当院に救急搬送された。腹部造影CTで13cm大の右後腹膜腫瘍を認め、入院となった。腫瘍マーカーは、CEA、NSE、SLX、ProGRPが高値であった。諸検査の結果から原発臓器不明のNECと診断し、内分泌学的には非機能性の腫瘍と診断した。手術不能のため、肺小細胞がんの治療に準じてCBDCA+VP-16療法を施行した。6コース終了時に腫瘍のサイズは4cmまで縮小し、腫瘍マーカー値も低下し、退院となった。退院9週後に肺炎を発症し、再入院となった。このとき右後腹膜腫瘍が9.5cmに増大しており、肺炎の治療を行ったが呼吸不全が進行し、再入院後第19病日に死亡した。

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  J-GLOBAL

ヒト生検検体を用いた腎臓周囲と皮下の脂肪組織におけるアディポネクチン発現量とその決定因子(Levels of Adiponectin Expression in Peri-Renal and Subcutaneous Adipose Tissue and Its Determinants in Human Biopsied Samples)

Maimaituxun Gulinu, 福田 大受, 井崎 博文, 平田 陽一郎, 金山 博臣, 益崎 裕章, 佐田 政隆, 島袋 充生

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  57回   75 - 75   2020年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

耐糖能障害を来した筋強直性ジストロフィー患者に対するメトホルミン療法の有効性

山城 清人, 照屋 太輝, 中山 良朗, 玉城 敦子, 屋比久 賢光, 長谷川 千穂, 吉村 蘭, 難波 豊隆, 山崎 聡, 池間 朋己, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  63 ( 4 ) 291 - 292   2020年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

マウスにて、エクストラヴァージンオリーブオイルと亜麻仁オイルは粘膜と代謝の健全性を促進し、腸内細菌叢を調節する(Extra virgin olive and flaxseed oils modulate gut microbiota, enhancing mucosal and metabolic health in mice)

ミルマン・ジャスミン, 岡本 士毅, 木村 碧樹, 上間 次己, 比嘉 萌子, 難波 豊隆, 山崎 聡, 島袋 充生, 池松 真也, 益崎 裕章

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  57回   64 - 64   2020年04月

掲載種別: 研究論文（その他学術会議資料等）

Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL.

Guerrero CLH, Yamashita Y, Miyara M, Imaizumi N, Kato M, Sakihama S, Hayashi M, Miyagi T, Karimata K, Uchihara J, Ohshiro K, Todoroki J, Nakachi S, Morishima S, Karube K, Tanaka Y, Masuzaki H, Fukushima T

Blood advances ( Blood Advances )  4 ( 6 ) 1062 - 1071   2020年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T-cell leukemia/lymphoma (ATL) is a human T-cell leukemia virus type 1 (HTLV-1)-associated T-cell malignancy with generally poor prognosis. Although only ∼5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. In this study, we analyzed blood plasma profiles of asymptomatic HTLV-1 carriers (ACs); untreated ATL patients, including acute, lymphoma, smoldering, and chronic types; and ATL patients in remission. Through SOMAscan, expression levels of 1305 plasma proteins were analyzed in 85 samples (AC, n = 40; ATL, n = 40; remission, n = 5). Using gene set enrichment analysis and gene ontology, overrepresented pathways in ATL vs AC included angiogenesis, inflammation by cytokines and chemokines, interleukin-6 (IL-6)/JAK/STAT3, and notch signaling. In selecting candidate biomarkers, we focused on soluble tumor necrosis factor 2 (sTNFR2) because of its active role in enriched pathways, extreme significance (Welch's t test P < .00001), high discrimination capacity (area under the curve >0.90), and novelty in ATL research. Quantification of sTNFR2 in 102 plasma samples (AC, n = 30; ATL, n = 68; remission, n = 4) using enzyme-linked immunosorbent assay showed remarkable elevations in acute ATL, at least 10 times those of AC samples, and return of sTNFR2 to AC state levels after achieving remission. Flow cytometry and immunostaining validated the expression of TNFR2 in ATL cells. No correlation between sIL-2 and sTNFR2 levels in acute ATL was found, suggesting the possibility of sTNFR2 as an independent biomarker. Our findings represent the first extensive blood-based proteomic analysis of ATL, suggesting the potential clinical utility of sTNFR2 in diagnosing acute ATL.

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糞線虫症はアグレッシブ成人T細胞白血病リンパ腫に影響を与えるか? 沖縄県アグレッシブATLデータベースの解析

玉城 啓太, 森島 聡子, 野村 尚吾, 西 由希子, 仲地 佐和子, 福島 卓也, 益崎 裕章

沖縄県医師会報 ( (一社)沖縄県医師会 )  56 ( 3 ) 202 - 207   2020年03月

掲載種別: 研究論文（その他学術会議資料等）

　概要を見る

播種性糞線虫症は成人T細胞白血病リンパ腫(ATL)における致死的合併症のひとつであり、ATLの予後不良因子と見做されてきたが、病態的意義の詳細は明らかでなかった。ATLの予後因子としての糞線虫症の意義と既存の二つの予後指標(ATL-PI、JCOG-PI)の有用性を沖縄県アグレッシブATLデータベースから抽出した433例で後方視的に検証した。主要評価項目は全生存期間(OS)とし、ログランク検定やCox回帰分析を用いて糞線虫症のOSへの影響を評価した。糞線虫症は便検査で診断した。全体の生存期間中央値は0.5年、3年生存割合は12.3%であった。糞線虫症は陽性55例、陰性378例であった。単変量解析で糞線虫症はOSに影響せず(ハザード比1.22;95%信頼区間0.90-1.66)、3年生存割合でも差を認めなかった(陽性群:8.2% vs 陰性群:13.0%、P=0.20)。本研究により、ATL-PIがリスク層別化に優れていること、初期の予想に反して糞線虫症はアグレッシブATLの予後に影響しない可能性が示唆された。(著者抄録)

Qualitative investigation of the factors that generate ambivalent feelings in women who give birth after receiving negative results from non-invasive prenatal testing.

Yotsumoto J, Sekizawa A, Inoue S, Suzumori N, Samura O, Yamada T, Miura K, Masuzaki H, Sawai H, Murotsuki J, Hamanoue H, Kamei Y, Endo T, Fukushima A, Katagiri Y, Takeshita N, Ogawa M, Nishizawa H, Okamoto Y, Tairaku S, Kaji T, Maeda K, Matsubara K, Ogawa M, Osada H, Ohba T, Kawano Y, Sasaki A, Sago H, Japan NIPT Consortium

BMC pregnancy and childbirth   20 ( 1 ) 112   2020年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 高血圧診療Update-「高血圧治療ガイドライン2019」で何が変わるのか? 他疾患を合併する高血圧 肥満症・メタボリックシンドローム

山崎 聡, 尾形 絵美, 岡本 士毅, 島袋 充生, 益崎 裕章

内科 ( 南江堂 )  125 ( 2 ) 227 - 230   2020年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The Incidence of Dichorionic Diamniotic Twin Pregnancy After Single Blastocyst Embryo Transfer and Zygosity: 8 Years of Single-Center Experience.

Konno H, Murakoshi T, Miura K, Masuzaki H

Twin research and human genetics : the official journal of the International Society for Twin Studies   23 ( 1 ) 51 - 54   2020年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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血漿交換により救命出来た多臓器不全を合併した甲状腺クリーゼの一例

照屋 理子, 中山 良朗, 久高 将太, 玉城 敦子, 安澤 由香利, 本間 健一郎, 屋比久 賢光, 照屋 太輝, 吉村 蘭, 山城 清人, 長谷川 千穗, 竹本 のぞみ, 難波 豊隆, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 4 ) 1361 - 1361   2020年02月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction.

Maimaituxun G, Yamada H, Fukuda D, Yagi S, Kusunose K, Hirata Y, Nishio S, Soeki T, Masuzaki H, Sata M, Shimabukuro M

Circulation journal : official journal of the Japanese Circulation Society ( 一般社団法人 日本循環器学会 )  84 ( 2 ) 203 - 216   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p><b><i>Background:</i></b>Although full-volume quantification of epicardial adipose tissue (EAT) is a predictor of LV diastolic dysfunction (LVDD), how localized EAT depots are linked to LVDD remains unclear. We evaluated the effect of local EAT depots on LV diastolic function parameters in patients with preserved LV ejection fraction (LVEF).</p><p><b><i>Methods and Results:</i></b>From 423 consecutive patients who underwent cardiac CT angiography, we recruited 252 with sinus rhythm and normal LVEF. The EAT volume index (EATV/body surface area) and the localized EAT thickness around the right coronary artery (EAT_RCA), left anterior descending artery (EAT_LAD), left circumflex artery (EAT_LCX), right ventricle (EAT_RV), left ventricle (EAT_LV), right atrium (EAT_RA), and left atrium (EAT_LA) were measured using cardiac CT. In the LVDD group (n=71), the EATV index (75±30 vs. 64±28 mL/m², P=0.010), EAT_LCX(10.7±3.8 vs. 9.4±3.4 mm, P=0.008), and EAT_LV(2.6±1.6 vs. 2.1±1.4 mm, P=0.024) were greater than in the non-LVDD group (n=181). In contrast, EAT_LCXand EAT_LVwere markedly associated with decreased lateral e' and increased lateral E/e'. Multiple regression analysis indicated that EAT_LCXand EAT_LVwere strongly associated with LV diastolic function parameters.</p><p><b><i>Conclusions:</i></b>Localized EAT depots are linked to altered mitral annular motion. Further study is warranted to clarify whether localized EAT depots are functionally linked to the clinical manifestations of LVDD.</p>

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Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction

Gulinu Maimaituxun, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Kenya Kusunose, Yukina Hirata, Susumu Nishio, Takeshi Soeki, Hiroaki Masuzaki, Masataka Sata, Michio Shimabukuro

Circulation Journal ( Japanese Circulation Society )  84 ( 2 ) 203 - 216   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice.

Guo T, Tanaka T, Matsumoto M, Kaneko K, Unzai T, Ogino Y, Aotani D, Kusakabe T, Iwakura H, Miyazawa T, Sawamoto K, Minokoshi Y, Masuzaki H, Inagaki N, Nakao K

Neuroscience letters ( Neuroscience Letters )  714   134550 - 134550   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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BACKGROUND: Cannabinoid receptor 1 (CB1R) is a GPCR expressed widely in the brain as well as in peripheral metabolic organs. Although pharmacological blockade of CB1R has been effective for the treatment of obesity and tobacco addiction, precise distribution of CB1R within the brain and potential changes by obesity or nicotine exposure have not been thoroughly addressed. METHODS: To examine CB1R distribution within the central energy center, we performed immunostaining and qPCR analysis of micro-dissected hypothalamic nuclei from male C57BL/6 mice. To address the effect of nicotine on food intake and body weight, and on potential changes of CB1R levels in the hypothalamus, mice kept on a high fat diet (HFD) for four weeks were challenged with nicotine intraperitoneally. RESULTS: Validity of the micro-dissected samples was confirmed by the expression of established nucleus-enriched genes. The expression levels of CB1R in the arcuate and lateral nuclei of the hypothalamus were higher than paraventricular and ventral-dorsal medial nuclei. Nicotine administration led to a significant suppression of food intake and body weight either under standard or high fat diet. Neither HFD nor nicotine alone altered CB1R levels in any nucleus tested. By contrast, treatment of HFD-fed mice with nicotine led to a significant increase in CB1R levels in the arcuate, paraventricular and lateral nuclei. CONCLUSIONS: CB1R was widely distributed in multiple hypothalamic nuclei. The expression of CB1R was augmented only when mice were treated with HFD and nicotine in combination. These data suggest that the exposure to nicotine may provoke an enhanced endocannabinoid response in diet-induced obesity.

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Transplant-related complications are impediments to the success of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia patients in non-complete remission.

Tomori S, Morishima S, Nishi Y, Nakachi S, Tamaki K, Morichika K, Tedokon I, Shimabukuro N, Hanashiro T, Kitamura S, Uchibori S, Miyagi R, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tomoyose T, Karube K, Fukushima T, Masuzaki H

Bone marrow transplantation ( Bone Marrow Transplantation )  55 ( 1 ) 233 - 241   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with adult T cell leukemia/lymphoma (ATL) are not satisfactory, particularly in patients in non-complete remission at transplantation (Pt-non-CR). We conducted a regional retrospective study in the ATL endemic area of Okinawa, Japan. Of 62 ATL patients, 21 received allo-HSCT in CR and 41 in non-CR. The 3-year overall survival (3yOS) rate and median survival time for the whole cohort was 25.6% and 7.7 months, respectively. The 3yOS of Pt-non-CR was significantly lower than that of patients in CR (Pt-CR) (16.8% vs. 43.6%, P = 0.005). Transplant-related mortality (TRM) was significantly higher in Pt-non-CR than in Pt-CR (46.3% vs. 15.7%, P = 0.025), while there was no significant difference in disease-associated mortality (DAM) between Pt-non-CR and Pt-CR. Multivariable analysis for Pt-non-CR revealed that poor performance status (poor-PS) and higher sIL-2R level (high sIL-2R) adversely affected OS. Poor-PS was associated with higher TRM, but not with higher DAM in Pt-non-CR. High sIL-2R did not affect TRM or DAM in Pt-non-CR. Overall, high TRM rates rather than DAM contribute to the poor outcomes of Pt-non-CR, suggesting that not only disease control but also management of transplant-related complications is required for allo-HSCT in ATL patients.

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Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes.

Horie I, Haraguchi A, Ito A, Nozaki A, Natsuda S, Akazawa S, Mori Y, Ando T, Higashijima A, Hasegawa Y, Yoshida A, Miura K, Masuzaki H, Kawakami A, Abiru N

Journal of diabetes investigation   11 ( 1 ) 232 - 240   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Significance of p53-Binding Protein 1 Nuclear Foci in Cervical Squamous Intraepithelial Lesions: Association With High-Risk Human Papillomavirus Infection and P16(INK4a) Expression.

Kawashita S, Matsuda K, Kondo H, Kitajima Y, Hasegawa Y, Shimada T, Kitajima M, Miura K, Nakashima M, Masuzaki H

Cancer control : journal of the Moffitt Cancer Center   27 ( 1 ) 1073274819901170   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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ペムブロリズマブ投与後に視床下部性のACTH単独欠損症を発症した一例

屋比久 賢光, 中山 良朗, 玉城 敦子, 久高 将太, 本間 健一郎, 吉村 蘭, 長谷川 千穂, 山城 清人, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 3 ) 1251 - 1251   2020年01月

掲載種別: 研究論文（その他学術会議資料等）

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人生100年時代の健康長寿の展望と課題:～沖縄クライシスからのレッスン～

益崎 裕章

理学療法学Supplement ( 公益社団法人 日本理学療法士協会 )  47 ( 0 ) G - 10-G-10   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>　世界に冠たる健康長寿を誇ってきた沖縄県は現在，2型糖尿病や肥満症が蔓延し，65歳までに死亡する割合（早逝率）や糖尿病患者の血液透析導入率は全国トップレベルにあります。2017年の47都道府県平均寿命ランキングでは沖縄県の男性が36位，女性が7位にまで後退しており，この驚くべき現実を私達，琉球大学第二内科で"沖縄クライシス"と命名し，この10年間，その実態解明と啓発に取り組んできました。日本で最後の国立大学医学部として琉球大学医学部が新設された1980年当時の80歳台，90歳台の沖縄県民患者の解剖所見によると，大動脈や冠状動脈の粥状動脈硬化や石灰化が殆ど認められず，血管年齢の若々しさに病理医たちが驚嘆した様子が記録されています。戦後の沖縄県民の脂肪エネルギー摂取比率は常に全国平均よりも5%以上上回っており，動脈硬化症の温床となる肥満症，糖尿病，脂質異常症の蔓延と平均寿命ランキングの降下が見事な好対照をなしています。</p><p>　健康に良くないと理屈ではわかっていても食べ過ぎや運動不足から脱却できないのはなぜでしょう？ 私達は2型糖尿病や肥満症の発症基盤にある"脳機能の異常"に注目し，脳科学と分子栄養学を用いて食事・運動療法の実効性を高める行動変容の分子基盤の解明に取り組んでいます。動物性脂肪の過剰摂取は脳をハッキングし，自らが必要とするエネルギー量や栄養成分を判断できない脳に変えてしまいます。このメカニズムには食欲中枢である視床下部における小胞体ストレスの上昇や幸せや歓びを受け取る報酬系におけるゲノム修飾というイヴェントが深く関わっています（Diabetologia 2017, Diabetes 2012）。また，肥満や動物性脂肪の過剰摂取に伴う脂肪細胞ホルモン，レプチンの作用不全（レプチン抵抗性）は脳内報酬系のドパミン神経に発現するレプチン受容体シグナルを介して運動欲求を低下させ，体重が増えていくほど，運動する意欲が減退してしまい，ますます太りやすくなります。運動嫌いな患者さんの脳の中ではこのようなことが生じていると考えられます。</p><p>　本講演では運動や食事と生活習慣病との関わりをめぐる最新の医学エビデンスを御紹介し，効果的な行動変容を実現するための理学療法の重要性に言及したいと思います。</p>

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Chest Computed Tomography Abnormalities and Their Relationship to the Clinical Manifestation of Respiratory Syncytial Virus Infection in a Genetically Confirmed Outbreak.

Nabeya D, Kinjo T, Parrott GL, Nakachi S, Yamashiro T, Ikemiyagi N, Arakaki W, Masuzaki H, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  59 ( 2 ) 247 - 252   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>Studies reporting chest images of respiratory syncytial virus (RSV)-induced lower respiratory tract infection (LRTI) in an outbreak setting and their relationship to the clinical manifestation are limited. During a genetically confirmed RSV outbreak, eight patients underwent both chest X-ray and computed tomography (CT). Among these, 5 cases had newly appearing abnormalities on CT, although chest X-ray was able to detect abnormalities in only 2 cases (40%). Although bronchial wall thickening was common, other findings and their distribution were variable, even in an outbreak setting. All patients with both a history of anticancer chemotherapy against hematological cancer and lower respiratory symptoms, such as wheezing, sputum, and hypoxemia, had abnormalities on CT, suggesting that these two factors might be important for predicting the existence of LRTI in RSV-infected patients. </p>

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Safety and efficacy of nanoparticulated brown rice germ extract on reduction of body fat mass and improvement of fuel metabolism in both pre-obese and mild obese subjects without excess of visceral fat accumulation.

Masuzaki Hiroaki, Fukuda Kotaro, Ogata Mika, Kinjo Ayano, Matsuo Takeru, Nishihira Jun

Glycative Stress Research ( 一般社団法人 糖化ストレス研究会 )  7 ( 1 ) 1 - 12   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Beneficial effects on obesity and dysmetabolism of a variety of functional ingredients contained in brown rice have attracted academic as well as clinical attention. On the other hand, it is noteworthy that the absorption efficiency of some of the functional ingredients derived from brown rice from the digestive tract is significantly low. Based on these backgrounds, we developed the “nanoparticulated brown rice germ extract” by encapsulating brown rice germ extract containing γ-oryzanol, one of the functional ingredients abundantly and specifically in brown rice (rice bran), in nanoparticles, and conducted safety and efficacy tests in humans. The present study was performed appropriately after the approval from the ethics committee of Hokkaido Information University. Japanese men and women whose BMI is 23 kg/m² or more and less than 25 kg/m², or 25 kg/m² or more and less than 30 kg/m², and whose visceral fat area is less than 100 cm² when measured by bioelectric-impedance methods were recruited for the study. We conducted a placebo-controlled, randomized, double-blind, parallel-group comparative study targeting approximately 78 people who met the eligible criteria, and examined metabolic improvements when the “nanoparticulated brown rice germ extract” tablets were ingested once-a-day continuously for 12 weeks. Although a decreasing trend was observed in the abdominal visceral fat area, which is a primary endpoint, there were no significant differences among the ingestion groups of test food (low dose group: 5 mg, and medium-dose group: 10 mg). Among the secondary endpoints, plasma LDL-cholesterol (LDL-C) level showed a marginally significant decrease in the medium and low dose (5 mg) groups compared to the control group (placebo ingestion) after 8 weeks of ingestion (p = 0.078, p = 0.098). The plasma lipid ratio (LDL-C/HDL-C) showed a significant decrease in the low dose group compared to the control group after 4 and 8 weeks of ingestion (p = 0.016, p = 0.018). The plasma non-HDL-C level showed a marginally significant or significant decrease in the medium and low dose groups compared to the control group after 8 weeks of ingestion (p = 0.099, p = 0.031). Blood level of HbA1c also showed a significant decrease in the medium-dose group compared to the control group after 4, 8, and 12 weeks of ingestion (p = 0.029, p = 0.011, p = 0.011). Furthermore, plasma level of adiponectin, which has potent anti-atherosclerotic actions, showed a marked increase in the high, medium, and low dose groups (p = 0.012, p = 0.039, p = 0.017) after 4 weeks of ingestion compared to the control group, and also showed a marginally significant or significant increase after 8 and 12 weeks of ingestion. During the hospital visit, problematic changes were not observed in blood pressure, pulse rate, general blood tests, liver and kidney functions, and urinalysis, and adverse events suggesting a causal relationship with the test food were not observed. This clinical intervention study confirmed the safety of ingestion of the “nanoparticulated brown rice germ extract”, which was also proven to improve the atherogenic lipid profile, reduce HbA1c level, and increase plasma adiponectin concentration. Results obtained tempt us to expect that nanoparticulated brown rice germ extract is well eligible for practical use.

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「他疾患に合併する高血圧：肥満症・メタボリックシンドローム特集：高血圧診療Update:高血圧治療ガイドライン2019で何が変わるのか？」

岡本 士毅, 益崎 裕章

内科   125   227 - 230   2020年

掲載種別: 研究論文（学術雑誌）

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「特集/心血管疾患の残余リスクとしてのキサンチンオキシダーゼ(XO) XOR, XOの尿酸代謝・酸化ストレス生成における役割と病態意義―血中のXO活性と血清尿酸値との関連性をめぐる最近の知見―」

益崎 裕章, 岡本 士毅

循環器内科   87   4 - 10   2020年

掲載種別: 研究論文（学術雑誌）

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「特集/新しい時代の高血圧診療　合併症を伴う高血圧症の治療　脂質異常症・肥満症・高尿酸血症」

岡本 士毅, 益崎 裕章

臨床と研究   97   72 - 77   2020年

掲載種別: 研究論文（学術雑誌）

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「特集　食と腸内環境γ-オリザノールの多彩な作用と腸内環境へのインパクト」

益崎 裕章, 岡本 士毅

アグリバイオ   3   20 - 25   2020年

掲載種別: 研究論文（学術雑誌）

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肥満外科手術後早期の減量効果に寄与する要因の探索

岡本 士毅, 益崎 裕章

肥満研究   26   254 - 262   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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肥満症に伴う認知機能障害ー脳科学基礎研究の動向

益崎 裕章, 岡本 士毅

肥満研究   26   238 - 244   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Deleterious Effects of Epicardial Adipose Tissue Volume on Global Longitudinal Strain in Patients With Preserved Left Ventricular Ejection Fraction.

Maimaituxun G, Kusunose K, Yamada H, Fukuda D, Yagi S, Torii Y, Yamada N, Soeki T, Masuzaki H, Sata M, Shimabukuro M

Frontiers in cardiovascular medicine ( Frontiers in Cardiovascular Medicine )  7   607825 - 607825   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: It is known that epicardial adipose tissue (EAT) volume is linked to cardiac dysfunction. However, it is unclear whether EAT volume (EATV) is closely linked to abnormal LV strain. We examined the relationship between EATV and global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in patients with preserved LV function. Methods: Notably, 180 consecutive subjects (68 ± 12 years; 53% men) underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into coronary artery disease (CAD) (≥1 coronary artery branch stenosis ≥50%) and non-CAD groups. GLS, GCS, and GRS were evaluated by 2-dimensional speckle tracking in patients with preserved left ventricular (LV) ejection fraction (LVEF) ≥50%. Results: First, GLS, but not GRS and GCS, was lower in the high EATV group though the LVEF was comparable to the low EATV group. Frequency of GLS ≤18 was higher in the high EATV group. Second, multiple regression model showed that EATV, age, male sex, and CAD, were determinants of GLS. Third, the cutoff points of EATV were comparable (~116-117 mL) in both groups. The cutoff of EATV ≥116 showed a significant correlation with GLS ≤18 in overall subjects. Conclusions: Increasing EATV was independently associated with global longitudinal strain despite the preserved LVEF and lacking obstructive CAD. Our findings suggest an additional role of EAT on myocardial systolic function by impaired LV longitudinal strain.

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AMH Concentrations in Peritoneal Fluids of Women With and Without Endometriosis.

Kitajima M, Matsumoto K, Murakami N, Kajimura I, Harada A, Kitajima Y, Masuzaki H, Miura K

Frontiers in surgery   7   600202   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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フローサイトメトリーを用いたATL患者由来腫瘍細胞におけるProgram Death Ligand 1とHuman Leukocyte Antigenの発現解析系の構築

座覇 理子, 森島 聡子, 西 由希子, 玉城 啓太, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  39 ( 1-4 ) 86 - 86   2020年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

末梢血メタボロームデータを活用したうつと肥満症・2型糖尿病の病態連関に関する臨床研究 久米島デジタルヘルスプロジェクトのコホート解析から

町田 香菜子, 山城 清人, 上間 次己, 岡本 士毅, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  39 ( 1-4 ) 83 - 83   2020年

掲載種別: 研究論文（その他学術会議資料等）

Huge uterine fibroid arising from primary uterine cervical diverticulum: a case report and review of the literatures.

Noguchi M, Kitajima M, Abe S, Murakami N, Kitajima Y, Miura K, Masuzaki H

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology   39 ( 8 ) 1186 - 1187   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Somatic Mutations and Loss of Heterozygosity of HLA Genes Are Frequently Occurred and Tightly Associated with Poor Prognosis in Adult T Cell Leukemia-Lymphoma

Tamaki, K; Morishima, S; Suzuki, S; Shigenari, A; Nomura, I; Yokota, Y; Morichika, K; Nishi, Y; Nakachi, S; Okamoto, S; Karube, K; Fukushima, T; Shiina, T; Masuzaki, H

BLOOD ( AMER SOC HEMATOLOGY )  134   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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0

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  DOI

特集 冠動脈疾患のリスク管理のフロントライン Ⅱ.冠動脈疾患リスクファクターをどう管理する? 肥満の是正はどうする?

島袋 充生, 益崎 裕章

循環器ジャーナル ( 株式会社　医学書院 )  67 ( 4 ) 619 - 623   2019年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay.

Hokama N, Shirakura T, Sunagawa S, Morishima S, Nakachi S, Nishi Y, Murayama Y, Matsui C, Hase N, Tamura M, Okamoto S, Shimabukuro M, Nakamura K, Masuzaki H

Hematological oncology ( Hematological Oncology )  37 ( 4 ) 527 - 530   2019年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Extra virgin oliveおよび亜麻仁油は腸内細菌叢を調節しマウス粘膜および代謝の正常化を促す(Extra virgin olive and flaxseed oil modulate gut microbiota, enhancing mucosal & metabolic health in mice)

Frances Millman Jasmine, 岡本 士毅, 山崎 聡, 上間 次己, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 260 - 260   2019年10月

掲載種別: 研究論文（その他学術会議資料等）

沖縄県在住の若年健康成人における腸内フローラのバランスと食嗜好性との関連性

上間 次己, Frances Millman Jasmine, 岡本 士毅, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 281 - 281   2019年10月

掲載種別: 研究論文（その他学術会議資料等）

術後3ヵ月における肥満外科治療の効果と減量に関連する要因

久場 美鈴, 岡本 士毅, 上間 次己, 安里 恵美子, 加島 ひとみ, 仲地 佐和子, 難波 豊隆, 稲嶺 進, 山崎 聡, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 255 - 255   2019年10月

掲載種別: 研究論文（その他学術会議資料等）

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma.

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer science ( Cancer Science )  110 ( 9 ) 2982 - 2991   2019年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK-STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P < .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression-free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.

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高齢者糖尿病における糖尿病性網膜症の発症及び悪化要因に関する臨床疫学的後方視解析

新里 幸子, 中山 良朗, 比嘉 盛丈, 新垣 孝一郎, 島袋 充生, 古泉 英貴, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  62 ( 9 ) 611 - 611   2019年09月

掲載種別: 研究論文（その他学術会議資料等）

Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube KN, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant immunology ( Transplant Immunology )  55   101205 - 101205   2019年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5.1) splenocytes without conditioning irradiation or chemotherapy. AD-MSCs from C3H mice were injected intravenously via tail veins. GVHD was assessed using flowcytometry analysis of peripheral blood cells and histopathologic analysis of target organs. Histopathological analyses revealed that AD-MSCs markedly suppressed the infiltration of lymphocytes into liver as well as the aplasia in bone marrow. This study is the first to clarify the effectiveness of AD-MSCs against bone marrow aplasia in GVHD, supporting a rationale of AD-MSCs for ameliorating bone marrow suppression and infectivity after allo-HSCT in human clinics.

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A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly-sensitive assay

Hokama N, Shirakura T, Sunagawa S, Morishima S, Nakachi S, Nishi Y, Murayama Y, Matsui C, Hase N, Tamura M, Okamoto S, Shimabukuro M, Nakamura K, Masuzaki H

Hematological Oncology   37 ( 4 ) 527 - 530   2019年08月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women.

Murakami N, Kitajima M, Ohyama K, Aibara N, Taniguchi K, Wei M, Kitajima Y, Miura K, Masuzaki H

Clinica chimica acta; international journal of clinical chemistry   495   545 - 551   2019年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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  PubMed

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma: Possible role of STAT3 phosphorylation in clinical subtype, progression, and prognosis

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer Sci   110 ( 9 ) 2982 - 2991   2019年07月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Validation of a novel digital health monitoring system to measure the volume of voided urine.

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourology and urodynamics ( Neurourology and Urodynamics )  38 ( 4 ) 1106 - 1110   2019年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

AIM: To validate a novel digital health monitoring system to measure the volume of voided urine. METHODS: Micturition volume was calculated using our novel digital self-health monitoring system of urine excretion (s-HMSU) in 18 participants (16 women and 2 men; average age, 40.8 years), without a history of voiding symptoms. Participants completed a self-reported questionnaire regarding their medical history and water intake during the period of observation, as well as the Core Lower Urinary Tract Symptom Score (CLSS) questionnaire. To assess the reliability of the voided volumes measured using the s-HMSU, the intraclass correlation coefficient (ICC) was calculated between the volume and the change in body weight before and after micturition. RESULTS: The CLSS questionnaire confirmed the absence of urinary system diseases in all participants. The medical history was also negative with the exception of hypertension in one participant. The ICC (1,1) between the measured volume of urine excretion using the s-HMSU and the change in body weight was 0.972 (95% confidence interval, 0.957-0.982). CONCLUSIONS: The s-HMSU system provides a reliable measure of voiding volume and is appropriate for home use. It has the potential to facilitate large-scale clinical research to examine the relationship between medical diseases and voiding dysfunction.

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Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube K, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant Immunology   55   101205   2019年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

久米島デジタルヘルスプロジェクトにおけるトイレ後付け型自動排尿モニタリングシステムの検証

宮里 実, 米本 孝二, 芦刈 明日香, 山城 清人, 上原 盛幸, 益崎 裕章, 石田 肇, 松下 正之, 斎藤 誠一

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  107回   PP2 - 351   2019年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

日本国内における耐糖能の地域性 沖縄県,長野県,徳島県,福島県での比較

下地 桐子, 齋藤 悠, 五十嵐 彩華, 田辺 隼人, 鴻野 央征, 金成 文平, 岩崎 麻里子, 待井 典剛, 工藤 明宏, 比嘉 盛丈, 長谷川 吉正, 佐田 政隆, 益崎 裕章, 島袋 充生

糖尿病 ( (一社)日本糖尿病学会 )  62 ( Suppl.1 ) S - 317   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

玄米由来生理活性物質を活用した高脂肪食肥満・糖尿病予防

小塚 智沙代, 井上 梓, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 1 ) 317 - 317   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

肥満症患者に対する減量入院治療後の腸内フローラ・発酵代謝産物の解析

難波 豊隆, 上間 次己, 岡本 士毅, 照屋 理子, 本間 健一郎, 屋比久 賢光, 照屋 太輝, 國場 司, 仲村 武裕, 中山 良朗, 砂川 澄人, 池間 朋己, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  62 ( Suppl.1 ) S - 260   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

ストレス・情動応答を介する生体の恒常性維持 ストレス後の食嗜好性変化を制御する恒常性維持機構 ストレス後に甘いものが欲しくなる脳内メカニズムに迫る

岡本 士毅, 與那嶺 正人, 箕越 靖彦, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 1 ) 224 - 224   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

特集 肥満と消化器 4 .肥満の治療(1) 食事・運動療法-メタボリック症候群の治療を目的とした肥満解消の食事療法・運動療法

山崎 聡, 尾形 絵美, 益崎 裕章

臨床消化器内科 ( 日本メディカルセンター )  34 ( 4 ) 431 - 436   2019年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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  CiNii Research

Validation of a novel digital health monitoring system to measure the volume of voided urine

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourol Urodyn   38 ( 4 ) 1106 - 1110   2019年03月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Levels of Adiponectin Expression in Peri-Renal and Subcutaneous Adipose Tissue and Its Determinants in Human Biopsied Samples.

Maimaituxun G, Fukuda D, Izaki H, Hirata Y, Kanayama HO, Masuzaki H, Sata M, Shimabukuro M

Frontiers in endocrinology ( Frontiers in Endocrinology )  10   897 - 897   2019年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: The interactions of adipose tissue with the kidney are hypothesized to affect kidney function. Also, excessive peri-renal fat may increase the risk of cardiometabolic risk. However, the role(s) of peri-renal fat adipocytokine has never been evaluated. Objectives: To elucidate levels of adiponectin expression in peri-renal and subcutaneous adipose tissue and its determinants in human biopsied samples. Methods: A pair of subcutaneous and perirenal fat tissue samples were collected from 80 patients (men: 54; women: 26) who underwent urological operations. Subcutaneous adipose tissue (SAT) area, visceral adipose tissue (VAT) area and peri-renal adipose tissue (RAT) volume were quantified on abdominal computed tomography. Cytokine/adipocytokine expression was evaluated by real-time semi-quantitative polymerase chain reaction (qPCR). Probability was considered significant if P < 0.05. Results: Current study evaluated determinants of plasma adiponectin levels and expression levels of adiponectin in SAT and RAT in human samples. We found that: first, plasma adiponectin levels were correlated with VAT area but not with BMI, waist circumference, SAT area, and RAT volume; second, expression levels of adiponectin in SAT were correlated with BMI, waist circumference, and SAT area but not with VAT area and RAT volume; and third, expression levels of adiponectin in RAT were correlated with all adiposity indices including BMI, waist circumference, SAT area, VAT area, and RAT volume. Conclusion: This study evaluated levels of adiponectin expression in RAT and SAT and its determinants in patients who underwent urological operation. Levels of adiponectin mRNA in RAT were negatively correlated with remote fat mass in SAT and VAT and also with local fat mass in RAT, while level of adiponectin in SAT was not correlated with RAT volume. Further studies are warranted to evaluate roles of peri-renal fat mass accumulation and its pathophysiological machineries.

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Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Maemoto H, Ariga T, Kusada T, Heianna J, Manabe Y, Miyakawa A, Nakachi S, Morishima S, Iraha S, Ganaha F, Masuzaki H, Murayama S

Japanese journal of clinical oncology ( Japanese Journal of Clinical Oncology )  49 ( 2 ) 153 - 159   2019年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma. METHODS: We retrospectively reviewed 46 courses of radiotherapy administered to 15 consecutive patients with adult T-cell leukaemia/lymphoma (acute, n = 7; lymphoma, n = 7; smouldering, n = 1) who received mogamulizumab before or during radiotherapy at three institutions between 2012 and 2017. RESULTS: During 43 of the 46 radiotherapy courses, patients developed Grade ≤1 radiation-induced dermatitis. No patient developed Grade ≥3 radiation-induced dermatitis. No patient was prescribed ointments as prophylactic treatment for radiation-induced dermatitis. Development of radiation-induced dermatitis was not significantly associated with the number of days since the administration of mogamulizumab prior to radiotherapy (P = 0.85), frequency of administration of mogamulizumab before/during radiotherapy (P = 0.33), administration of mogamulizumab during radiotherapy (P = 0.41) or types of lesions in adult T-cell leukaemia/lymphoma cases (cutaneous vs. non-cutaneous, P = 0.74). Development of radiation-induced dermatitis was significantly related to the total cutaneous dose (mean, 31.9 Gy [95% confidence interval: 26.6-37.1 Gy] vs. 19.7 Gy [95% confidence interval: 16.2-23.2 Gy], P = 0.0004) and total prescribed dose (mean, 31.5 Gy [95% confidence interval: 26.2-36.8 Gy] vs. 18.5 Gy [95% confidence interval: 15.0-22.0 Gy], P = 0.0002). CONCLUSION: None of the 15 patients who received moderate-dose radiotherapy developed severe radiation-induced dermatitis during the 46 courses of radiotherapy after mogamulizumab administration.

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Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma.

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama S

Journal of radiation research ( Journal of Radiation Research )  60 ( 1 ) 98 - 108   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that occurs only in patients with human T-cell leukemia virus type 1. No large study or randomized trial investigating radiotherapy (RT) for ATL has been performed. We retrospectively reviewed 55 courses of RT for 41 consecutive patients with ATL who underwent RT between 2000 and 2016 at our institutions. The results showed that RT for local ATL lesions can achieve symptomatic improvement in 92% of cases. Local remission, either complete remission (CR) or partial response (PR), was achieved in 100% of the patients (CR: 89%, PR: 11%) with ≥40 Gy irradiation. CR or PR was achieved in 71% (CR: 29%, PR: 43%) with 30-39 Gy and in 73% (CR: 6.7%, PR: 67%) with ≤29 Gy irradiation. The mean total radiation dose in the CR and PR groups differed significantly (38 vs 25 Gy, P = 0.0002). The maximum acute toxicity was Grade 0-2 in all patients, except for one patient experienced Grade 3 radiation dermatitis. In-field relapses occurred in 36% of patients, and the frequency of in-field relapses was 11%, 30% and 71% among those who achieved CR, PR and SD, respectively. All 9 patients who received total skin irradiation experienced cutaneous relapses, with a median of 63 days (range, 7-210 days). Almost all (39 of 41) patients with ATL experienced out-of-field progression after RT. In conclusion, RT was confirmed to be effective and safe for palliative treatment of local ATL lesions.

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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 94 - 103   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans.

Masuzaki H, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 18 - 25   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

J Diabetes Investig   10 ( 1 ) 94 - 103   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Brown rice-specific -oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans

Masuzaki H (senior, corresponding author, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

J Diabetes Investig   10 ( 1 ) 18 - 25   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lumphoma

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama M

Journal of Radiation Research   60 ( 1 ) 98 - 108   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT.

Suzumori N, Sekizawa A, Takeda E, Samura O, Sasaki A, Akaishi R, Wada S, Hamanoue H, Hirahara F, Kuriki H, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Yamashita T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Endo M, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Nagamatsu T, Watanabe A, Nishikawa N, Hamajima N, Shirato N, Yotsumoto J, Nishiyama M, Koide K, Hirose T, Sago H

Prenatal diagnosis   39 ( 2 ) 100 - 106   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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メタボリックシンドロームと腸内細菌」

岡本 士毅, 益崎 裕章

カレントテラピー   37   65 - 70   2019年

掲載種別: 研究論文（学術雑誌）

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「健康長寿社会に求められる食と行動の科学」

益崎 裕章, 岡本 士毅

日本体質医学会雑誌   81   48 - 54   2019年

掲載種別: 研究論文（学術雑誌）

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「特集　代謝疾患と精神神経疾患の交点（サイコメタボリズム）「脳内炎症と過食・動物性脂肪依存」」

益崎 裕章, 岡本 士毅

Medical Science Digest   45   652 - 655   2019年

掲載種別: 研究論文（学術雑誌）

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「玄米機能成分を活用する脳機能改善～人生100年時代を生き抜く健康脳づくりのアプローチ～生物工学」

益崎 裕章, 岡本 士毅

日本生物工学会誌   97   14 - 17   2019年

掲載種別: 研究論文（学術雑誌）

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Adult T-cell leukemia/lymphoma(ATL)の悪性度と末梢血リンパ球におけるCell adhesion molecule 1(CADM1)発現との関連性

横田 雄太郎, 玉城 啓太, 野村 育美, 森島 聡子, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  37 ( 1-4 ) 132 - 132   2018年12月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

視床下部室傍核に存在するCRHニューロン内のAMPK活性化が、炭水化物嗜好性の誘導において必要十分である

岡本 士毅, 與那嶺 正人, 箕越 靖彦, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  94 ( 4 ) 1558 - 1558   2018年12月

掲載種別: 研究論文（その他学術会議資料等）

Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation.

Maeda M, Oba K, Yamaguchi S, Arasaki O, Sata M, Masuzaki H, Shimabukuro M

The American journal of cardiology ( American Journal of Cardiology )  122 ( 10 ) 1694 - 1700   2018年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with post-ablation atrial fibrillation (AF), ranges of EATV predictive of post-ablation recurrence of AF remain unclear. In this study, we evaluated: (1) relationships between EATV and characteristics of AF, (2) impact of EATV on recurrent AF after radiofrequency ablation; , and (3) cut-off point for recurrent AF using a receiver operating characteristic curve. In 218 consecutive symptomatic patients undergoing who underwent ablation for AF (143 paroxysmal AF; 78 persistent AF), the EATV index (EATVI: EATV/body surface area, mL/m2) was measured using 320-row multidetector computed tomography. The high EATV group showed specific cardiometabolic derangements as well as left atrial dilatation and left ventricular dysfunction. Multivariate regression analysis showed that the EATVI was an independent predictor of recurrent AF after catheter ablation. High EATV (EATVI ≥ 85 mL/m2) or EATVI cutoff ≥116 mL/m2 can predict recurrent AF after catheter ablation, independent of other risk factors. In conclusion, EATVI was an independent predictor of recurrent AF after catheter ablation; a high EATV tertile or EATVI cutoff may be useful for prediction of recurrent AF after catheter ablation. Future studies should determine the utility of the EATVI in the clinical setting of AF ablation.

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Correction: Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.

Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K

Journal of human genetics   63 ( 11 ) 1195   2018年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele.

Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky RL, Morris BJ, Lim E, Allsopp RC, Willcox BJ

The journals of gerontology. Series A, Biological sciences and medical sciences ( Journals of Gerontology - Series A Biological Sciences and Medical Sciences )  73 ( 11 ) 1448 - 1452   2018年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Minimal shortening of leukocyte telomere length across age groups in a cross-sectional study for carriers of a longevity-associated FOXO3 allele

Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky R, Morris BJ, Lim E, Allsopp RC, Willcox BJ

J Gerontol A Biol Sci Med Sci   73 ( 11 ) 1448 - 1452   2018年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Usefulness of epicardial adipose tissue volume to predict recurrent atrial fibrillation after radiofrequency catheter ablation

Maeda M, Oba K, Yamaguchi S, Arasaki O, Sata M, Masuzaki H, Shimabukuro M

Am J Cardiol   122 ( 10 ) 1694 - 1700   2018年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior

Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C

Neurosci Res   134   39 - 48   2018年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior.

Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C

Neuroscience research ( Neuroscience Research )  134   39 - 48   2018年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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高悪性度成人T細胞白血病/リンパ腫の予後予測におけるFDG-PET/CTの有用性(Clinical usefulness of FDG-PET/CT for predicting prognosis of aggressive ATL)

仲地 佐和子, 森島 聡子, 岡田 真広, 東江 ゆりか, 内堀 幸恵, 北村 紗希子, 友利 昌平, 花城 多恵子, 島袋 奈津紀, 玉城 啓太, 手登根 伊織, 森近 一穂, 西 由希子, 加留部 謙之輔, 福島 卓也, 益崎 裕章

臨床血液 ( (一社)日本血液学会-東京事務局 )  59 ( 9 ) 1597 - 1597   2018年09月

掲載種別: 研究論文（その他学術会議資料等）

若年健常成人における野菜類・肉類の嗜好性と腸内フローラとの関連性

上間 次己, 難波 豊隆, 岡本 士毅, 與那嶺 正人, 砂川 澄人, 中山 良朗, 土井 基嗣, 竹本 のぞみ, 玉城 泰太郎, 仲村 武裕, 照屋 太輝, 屋比久 賢光, 本間 健一郎, 照屋 理子, ミルマン・ジャスミン, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  24 ( Suppl. ) 211 - 211   2018年09月

掲載種別: 研究論文（その他学術会議資料等）

食餌性肥満後に減量させたマウスにおける絶食後の食嗜好性変化に関わる脳内分子メカニズムの解明

與那嶺 正人, 岡本 士毅, ミルマン・ジャスミン, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  24 ( Suppl. ) 237 - 237   2018年09月

掲載種別: 研究論文（その他学術会議資料等）

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マウス系統差が及ぼす食餌嗜好性への影響と視床下部室傍核AMPKの調節作用

岡本 士毅, 與那嶺 正人, ミルマン・ジャスミン, 難波 豊隆, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  24 ( Suppl. ) 185 - 185   2018年09月

掲載種別: 研究論文（その他学術会議資料等）

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Protective Role of Myelocytic Nitric Oxide Synthases against Hypoxic Pulmonary Hypertension in Mice.

Ogoshi T, Tsutsui M, Kido T, Sakanashi M, Naito K, Oda K, Ishimoto H, Yamada S, Wang KY, Toyohira Y, Izumi H, Masuzaki H, Shimokawa H, Yanagihara N, Yatera K, Mukae H

American journal of respiratory and critical care medicine ( American Journal of Respiratory and Critical Care Medicine )  198 ( 2 ) 232 - 244   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Evaluation of two prognostic indices for adult T-cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan.

Tamaki K, Morishima S, Nomura S, Nishi Y, Nakachi S, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Taira N, Tomoyose T, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tamaki K, Hayashi M, Uchihara JN, Ohshiro K, Asakura Y, Kuba-Miyara M, Karube K, Fukushima T, Masuzaki H

Cancer science ( Cancer Science )  109 ( 7 ) 2286 - 2293   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Evaluation of two prognostic indices for adult T cell leukemia/lymphoma in the subtropical endemic area, Okinawa, Japan

Tamaki K, Morishima S, Nomura S, Nishi Y, Nakachi S, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Taira N, Tomoyose T, Takashi Miyagi T, Karimata K, Ohama M, Yamanoha A, Tamaki K, Hayashi M, Uchihara J, Ohshiro K, Asakura Y, Kuba-Miyara M, Karube K, Fukushima T, Masuzaki H

Cancer Sci   109 ( 7 ) 2286 - 2293   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Protective Role of Myelocytic Nitric Oxide Synthases Against Hypoxic Pulmonary Hypertension in Mice

Ogoshi T, Tsutsui M, Kido T, Sakanashi M, Naito K, Oda K, Ishimoto H, Yamada S, Wang KY, Toyohira Y, Izumi H, Masuzaki H, Shimokawa H, Yanagihara N, Yatera K, Mukae H

Am J Respir Crit Care Med   198 ( 2 ) 232 - 244   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus.

Ichinose K, Sato S, Kitajima Y, Horai Y, Fujikawa K, Umeda M, Fukui S, Nishino A, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Yasuhi I, Masuzaki H, Kawakami A

Lupus   27 ( 8 ) 1312 - 1320   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Effect of the Epicardial Adipose Tissue Volume on the Prevalence of Paroxysmal and Persistent Atrial Fibrillation.

Oba K, Maeda M, Maimaituxun G, Yamaguchi S, Arasaki O, Fukuda D, Yagi S, Hirata Y, Nishio S, Iwase T, Takao S, Kusunose K, Yamada H, Soeki T, Wakatsuki T, Harada M, Masuzaki H, Sata M, Shimabukuro M

Circulation journal : official journal of the Japanese Circulation Society ( 一般社団法人 日本循環器学会 )  82 ( 7 ) 1778 - 1787   2018年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p><b><i>Background:</i></b>Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with atrial fibrillation (AF), it is controversial whether there is a dose-response relationship of increasing EATV along the continuum of AF. We evaluated the effect of the EATV on the prevalence of paroxysmal AF (PAF) and persistent AF (PeAF) and the relationships with cardiac structure and functional remodeling.</p><p><b><i>Methods and Results:</i></b>Subjects who underwent multidetector computed tomography (MDCT) coronary angiography because of symptoms suggestive of coronary artery disease were divided into sinus rhythm (SR) (n=112), PAF (n=133), and PeAF (n=71) groups. The EATV index (EATV/body surface area, mL/m²) was strongly associated with the prevalence of PAF and PeAF on the model adjusted for known AF risk factors. The effect of the EATV index on the prevalence of PeAF, but not on that of PAF, was modified by the left atrial (LA) dimension, suggesting that extension of the LA dimension is related to EATV expansion in PeAF. The cutoff value of the EATV index for the prevalence was higher in PeAF than in PAF (64 vs. 55 mL/m², P<0.01).</p><p><b><i>Conclusions:</i></b>The EATV index is associated with the prevalence of PAF and PeAF, and its cutoff values are predictive for PAF and PeAF development independently of other AF risk factors.</p>

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Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy.

Suzumori N, Sekizawa A, Ebara T, Samura O, Sasaki A, Akaishi R, Wada S, Hamanoue H, Hirahara F, Izumi H, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Yamashita T, Okai T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Nagamatsu T, Watanabe A, Shirato N, Yotsumoto J, Nishiyama M, Hirose T, Sago H

European journal of obstetrics, gynecology, and reproductive biology   224   165 - 169   2018年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Two consecutive successful live birth in woman with 17α hydroxylase deficiency by frozen-thaw embryo transfer under hormone replacement endometrium preparation.

Kitajima M, Miura K, Inoue T, Murakami Y, Kitajima Y, Murakami N, Taniguchi K, Yoshiura KI, Masuzaki H

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology   34 ( 5 ) 381 - 384   2018年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Reference values for circulating pregnancy-associated microRNAs in maternal plasma and their clinical usefulness in uncomplicated pregnancy and hypertensive disorder of pregnancy.

Murakami Y, Miura K, Sato S, Higashijima A, Hasegawa Y, Miura S, Yoshiura KI, Masuzaki H

The journal of obstetrics and gynaecology research   44 ( 5 ) 840 - 851   2018年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Natural Course of Human T-Cell Leukemia Virus Type 1 Proviral DNA Levels in Carriers During Pregnancy.

Fuchi N, Miura K, Tsukiyama T, Sasaki D, Ishihara K, Tsuruda K, Hasegawa H, Miura S, Yanagihara K, Masuzaki H

The Journal of infectious diseases   217 ( 9 ) 1383 - 1389   2018年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Relevant obstetric factors associated with fetal heart rate monitoring for cerebral palsy in pregnant women with hypertensive disorder of pregnancy.

Hasegawa J, Ikeda T, Toyokawa S, Jojima E, Satoh S, Ichizuka K, Tamiya N, Nakai A, Fujimori K, Maeda T, Masuzaki H, Takeda S, Suzuki H, Ueda S, Ikenoue T, Prevention Recurrence Committee, Japan Obstetric Compensation System for Cerebral Palsy

The journal of obstetrics and gynaecology research   44 ( 4 ) 647 - 654   2018年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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SGLT2阻害剤による血液悪性腫瘍における抗腫瘍効果のメカニズム解析

仲地 佐和子, 森島 聡子, 岡本 士毅, 与那嶺 正人, 内堀 幸恵, 北村 紗希子, 友利 昌平, 花城 多恵子, 島袋 奈津紀, 玉城 啓太, 森近 一穂, 西 由希子, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  94 ( 1 ) 323 - 323   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

マウスにおいて亜麻仁油とエクストラヴァージンオリーブオイルの食餌摂取は消化管細菌叢を調節して肥満と代謝機能障害を予防する(Dietary flaxseed and extra virgin olive oils modulate gut microbiota, protecting against obesity and metabolic dysfunction in mice)

ミルマン・ジャスミン, 岡本 士毅, 上間 次己, 與那嶺 正人, 難波 豊隆, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  94 ( 1 ) 316 - 316   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

亜麻仁油とextra virgin olive oilは腸内細菌叢、腸バリア、免疫機能に影響を及ぼし健全な代謝を維持する(Flaxseed and extra virgin olive oils impact gut microbiota, gut barrier and immune function, supporting metabolic health)

Millman Frances Jasmine, 岡本 士毅, 上間 次己, 與那嶺 正人, 難波 豊隆, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  61 ( Suppl.1 ) S - 266   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

野菜摂取量が少ない20歳代、30歳代健康成人における腸内フローラ解析と食事嗜好の関連性

上間 次己, 難波 豊隆, 池間 朋己, 知念 玲, 砂川 澄人, 中山 良朗, 仲村 英昭, 上原 盛幸, 與那嶺 正人, 仲村 武裕, 國場 司, 照屋 太輝, 本間 健一郎, 安澤 由香利, 岡本 士毅, 池松 智子, ミルマンフランシス・ジャスミン, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  94 ( 1 ) 440 - 440   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

野菜摂取量が少ない20歳代、30歳代健康成人における腸内細菌叢解析と食事嗜好の関連性

上間 次己, 難波 豊隆, 池間 朋己, 知念 玲, 砂川 澄人, 中山 良朗, 仲村 英昭, 上原 盛幸, 與那嶺 正人, 仲村 武裕, 國場 司, 照屋 太輝, 本間 健一郎, 安澤 由香利, 岡本 士毅, 池松 智子, ミルマン・ジャスミン, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  61 ( Suppl.1 ) S - 314   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

中枢神経におけるインスリン抵抗性と糖代謝制御

益崎 裕章, 與那嶺 正人, 岡本 士毅, 田仲 秀明, 島袋 充生, 箕越 靖彦

糖尿病 ( (一社)日本糖尿病学会 )  61 ( Suppl.1 ) S - 117   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

視床下部室傍核に存在するCRHニューロン内のAMPK活性化が、炭水化物嗜好性の誘導において必要十分である

岡本 士毅, 益崎 裕章, 箕越 靖彦

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  55回   75 - 75   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.

Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y

Cell reports ( Cell Reports )  22 ( 3 ) 706 - 721   2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) remains unknown. Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons in the rostral region of the paraventricular hypothalamus (PVH) induces selection of an HCD over an HFD in mice during refeeding after fasting, resulting in a rapid recovery from the change in ketone metabolism. These neurons manifest activation of AMP-activated protein kinase (AMPK) during food deprivation, and this activation is necessary and sufficient for selection of an HCD over an HFD. Furthermore, this effect is mediated by carnitine palmitoyltransferase 1c (CPT1c). Thus, our results identify the specific neurons and intracellular signaling pathway responsible for regulation of the complex behavior of selection between an HCD and an HFD. VIDEO ABSTRACT.

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Association between ovarian endometrioma and ovarian reserve.

Kitajima M, Khan KN, Harada A, Taniguchi K, Inoue T, Kaneuchi M, Miura K, Masuzaki H

Frontiers in bioscience (Elite edition)   10 ( 1 ) 92 - 102   2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Corrigendum: Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Fuchi N, Miura K, Doi H, Li TS, Masuzaki H

Scientific reports   7   46922   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Adrenal venous sampling in patients with primary aldosteronism: Which is the best evaluation method for laterality assessments?

Azama K, Okada M, Yogi A, Koga T, Iraha Y, Heianna J, Nakamura H, Masuzaki H, Murayama S

Open Journal of Radiology   7 ( 4 ) 219 - 227   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

食欲・食嗜好の分子・神経基盤 視床下部AMPKは炭水化物嗜好性を制御する

岡本 士毅, 箕越 靖彦, 益崎 裕章

生命科学系学会合同年次大会 ( 生命科学系学会合同年次大会運営事務局 )  2017年度   [4AW08 - 5]   2017年12月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K, Masuzaki H

Drug delivery ( Drug Delivery )  24 ( 1 ) 558 - 568   2017年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Our previous works demonstrated that brown rice-specific bioactive substance, gamma-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)induced obese diabetic mice. However, extremely low absorption efficiency from intestine of gamma-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of gamma-oryzanol with super-high lipophilicity, we encapsulated gamma-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the bestknown severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude (similar to 1000-fold lower dose) compared with regular gamma-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward gamma-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

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特集 臓器炎症からみた糖尿病および糖尿病性合併症 脳における炎症と糖尿病

益崎 裕章, 岡本 士毅, 小塚 智沙代

糖尿病診療マスター ( 株式会社医学書院 )  15 ( 10 ) 825 - 830   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Clinical usefulness of FDG-PET/CT for the evaluation of various types of adult T-cell leukemia.

Nakachi S, Okada M, Morishima S, Agarie Y, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tamaki K, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Murayama S, Masuzaki H

Hematology (Amsterdam, Netherlands) ( TAYLOR & FRANCIS LTD )  22 ( 9 ) 536 - 543   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Purpose: The aim was to explore undefined useful indices for clinically grading adult T-cell leukemia (ATL) using [F-18] 2-fluoro-2-deoxyglucose (FDG) - positron emission tomography/computed tomography (PET/CT). Methods: A total of 28 patients with ATL (indolent, 9; aggressive, 19) were enrolled; all patients with aggressive ATL underwent FDG-PET/CT before chemotherapy. Patients with indolent ATL underwent FDG-PET/CT at the time of suspected disease progression and/or transformation; some received lymph node biopsy. The quantitative parameters maximum standardized uptake values (SUVmax), and mean and peak SUV, metabolic tumor volume (MTV), and volume-based total lesion glycolysis were calculated with the margin threshold as 25%, and 50% of the SUVmax for all lesions. Results: All parameters except for MTV-25% showed significant differences (P0.05) in differentiating the aggressive type from the indolent type of ATL. Areas under the curve for receiver-operating characteristic (ROC) analysis regarding the series of parameters investigated ranged from 0.75 to 0.92; this indicated relatively high accuracy in distinguishing the aggressive type from the indolent type. No malignant findings were detected in lymph node biopsies in indolent ATL patients with lymphadenopathy. Discussion: We performed evaluation of a line of parameters of FDG-PET, thereby demonstrating their significantly high accuracy for grading malignancy in ATL patients. In particular, low accumulation of FDG in indolent ATL patients with lymphadenopathy might predict that it is not a sign of disease transformation, but rather a reactive manifestation. Conclusion: FDG-PET/CT findings could be useful for clinically grading ATL.

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Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphom

Morichika K, Uchihara JN, Morishima S, Karube KN, Tanaka Y, Masuzaki H, Fukushima T

Leuk Res   61   18 - 24   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Increased expression of 11β-hydroxysteroid dehydrogenase type 1 in experimental periodontitis induced by lipopolysaccharide from Porphyromonas gingivalis

Fujita A, Nakata T, Umeda M, Masuzaki H, Sawai H

Open Journal of Stomatology   7 ( 10 ) 429 - 438   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

Sakihama S, Saito M, Kuba-Miyara M, Tomoyose T, Taira N, Miyagi T, Hayashi M, Kinjo S, Nakachi S, Tedokon I, Nishi Y, Tamaki K, Morichika K, Uchihara JN, Morishima S, Karube KN, Tanaka Y, Masuzaki H, Fukushima T

Leukemia research ( Leukemia Research )  61   18 - 24   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fetiform teratoma was a parthenogenetic tumor arising from a mature ovum.

Miura K, Kurabayashi T, Satoh C, Sasaki K, Ishiguro T, Yoshiura KI, Masuzaki H

Journal of human genetics   62 ( 9 ) 803 - 808   2017年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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食嗜好性を制御する脳内分子機構とその破綻 肥満症の病態解明を目指す新機軸 視床下部AMPKは炭水化物嗜好性を制御する

岡本 士毅, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  23 ( Suppl. ) 131 - 131   2017年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice.

Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H

Diabetologia ( Diabetologia )  60 ( 8 ) 1502 - 1511   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit.

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

Journal of medical virology ( Journal of Medical Virology )  89 ( 8 ) 1364 - 1372   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

J Med Virol   89 ( 8 ) 1364 - 1372   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Impact of Brown Rice-Specific -Oryzanol on Epigenetic Modulation of Dopamine D2 Receptor in Brain Striatum of High Fat Diet-Induced Obese Mice

Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H

Diabetologia   60 ( 8 ) 1502 - 1511   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Current status of non-invasive prenatal testing in Japan.

Samura O, Sekizawa A, Suzumori N, Sasaki A, Wada S, Hamanoue H, Hirahara F, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Nakayama S, Okai T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Kido Y, Fukao T, Miharu N, Nagamatsu T, Watanabe A, Hamajima N, Hirose M, Sanui A, Shirato N, Yotsumoto J, Nishiyama M, Hirose T, Sago H

The journal of obstetrics and gynaecology research   43 ( 8 ) 1245 - 1255   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 糖尿病と遺伝-患者さんからの質問に的確にこたえるために Ⅱ各論 ゲノム修飾(エピゲノム)と糖尿病

益崎 裕章, 河本 絵里子, 小塚 智沙代

糖尿病診療マスター ( 株式会社医学書院 )  15 ( 7 ) 590 - 596   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 腸内細菌-糖尿病・肥満にまつわる10 topics II各論 -トピック4-食事と腸内細菌-全身疾患との関わり

益崎 裕章, 與那嶺 正人, Millman Jasmine, 小塚 智沙代

糖尿病診療マスター ( 株式会社医学書院 )  15 ( 6 ) 484 - 490   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.

Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M

Diabetologia ( SPRINGER )  60 ( 6 ) 1138 - 1151   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Nitric oxide (NO) is synthesised not only from l-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, but whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency would induce the metabolic syndrome in mice. To this end, we prepared a low-nitrite/nitrate diet (LND) consisting of an amino acid-based low-nitrite/nitrate chow, in which the contents of l-arginine, fat, carbohydrates, protein and energy were identical with a regular chow, and potable ultrapure water. Nitrite and nitrate were undetectable in both the chow and the water. Three months of the LND did not affect food or water intake in wild-type C57BL/6J mice compared with a regular diet (RD). However, in comparison with the RD, 3 months of the LND significantly elicited visceral adiposity, dyslipidaemia and glucose intolerance. Eighteen months of the LND significantly provoked increased body weight, hypertension, insulin resistance and impaired endothelium-dependent relaxations to acetylcholine, while 22 months of the LND significantly led to death mainly due to cardiovascular disease, including acute myocardial infarction. These abnormalities were reversed by simultaneous treatment with sodium nitrate, and were significantly associated with endothelial NOS downregulation, adiponectin insufficiency and dysbiosis of the gut microbiota. These results provide the first evidence that long-term dietary nitrite/nitrate deficiency gives rise to the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice, indicating a novel pathogenetic role of the exogenous NO production system in the metabolic syndrome and its vascular complications.

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Carbon dioxide angiography and arterial embolization could successfully control postpartum uterine hemorrhage for the patient with hypersensitivity to iodine compound.

Kawashita S, Kaneuchi M, Nakayama D, Fuchi N, Murakami Y, Miura K, Masuzaki H

Radiology case reports   12 ( 2 ) 261 - 264   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<i>FOXO3</i> GENOTYPE PROTECTS AGAINST TELOMERE SHORTENING WITH AGE

Davy, PMC; Morris, BJ; Willcox, DC; Shimabukaro, M; Donlon, TA; Suzuki, M; Higa, M; Masuzaki, H; Sata, M; Chen, R; He, Q; Murkofsky, R; Lim, E; Allsopp, RC; Willcox, BJ

HYPERTENSION   69 ( 6 ) E30 - E31   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Fuchi N, Miura K, Doi H, Li TS, Masuzaki H

Scientific reports   7   46220   2017年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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An Atypical Case of Late-Onset Systemic Lupus Erythematosus with Systemic Lymphadenopathy and Severe Autoimmune Thrombocytopenia/Neutropenia Mimicking Malignant Lymphoma

Tamaki K, Morishima S, Nakachi S, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Masuzaki H

Int J Hematol   105 ( 4 ) 526 - 531   2017年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

An atypical case of late-onset systemic lupus erythematosus with systemic lymphadenopathy and severe autoimmune thrombocytopenia/neutropenia mimicking malignant lymphoma.

Tamaki K, Morishima S, Nakachi S, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Masuzaki H

International journal of hematology ( International Journal of Hematology )  105 ( 4 ) 526 - 531   2017年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 糖尿病食事療法の指導技術パワーアップ-現代日本人に伝えたい和食の知恵 動物脂肪の過剰摂取が誘導する視床下部の小胞体ストレスと動物脂肪依存,これに対する玄米食の改善効果

益崎 裕章, 小塚 智沙代, 島袋 充生

糖尿病診療マスター ( 株式会社医学書院 )  15 ( 3 ) 216 - 221   2017年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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[Programs for Continuing Medical Education 2016: A Session: 4. Obesity Disease and Metabolic Syndrome: Clinical Progress and Future Outlook].

Masuzaki H, Shimabukuro M

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   106 ( 3 ) 477 - 83   2017年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Brown Rice-Specific -Oryzanol-Based Novel Approach toward Lifestyle-Related Brain Dysfunction and Impaired Glucose Metabolism

Masuzaki H (senior, corresponding author, Kozuka C, Yonamine M, Shimabukuro M

Glycative Stress Research   4 ( 1 ) 58 - 66   2017年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Purification of Two Novel Sugar Acid-binding Lectins from Haplomitrium Mnioides (bryophyte, Plantae) and their Preliminary Characterization.

Masuzaki H, Hosono M, Nitta K

Applied biochemistry and biotechnology   181 ( 1 ) 65 - 82   2017年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Two novel sugar acid-binding lectins were purified from Haplomitrium mnioides (Lindb.) Schust. using a procedure consisting of ammonium sulfate precipitation, G-50 gel filtration, hydroxyapatite chromatography, and HW-50 gel filtration. We reported their partial physicochemical properties: molecular weight, affinity for carbohydrates and organic acids, pH stability, and dependence of their hemagglutination activity on metal ions. We also determined their N-terminal amino acid sequences. H. mnioides lectins (HMLs) were monomers (one with a molecular weight of approximately 27 kDa, and the other with a molecular weight of approximately 105 kDa) under both nonreducing and reducing conditions. They were named HML27 and HML105, respectively. Both HMLs had an affinity for N-acetylneuraminic acid, D-glucuronic acid, D-glucaric acid, bovine submaxillary mucin, heparin, and organic acids, such as citrate, 2-oxoglutaric acid, and D-2-hydroxyglutarate. Furthermore, HML27 had an affinity for α-D-galacturonic acid, D-malate, L-malate, and pyruvate, while HML105 had an affinity for D-gluconic acid. HML27 and HML105 are novel plant lectins: they have an affinity for sugar acids and organic acids and specifically recognize the carboxyl group, and there is no homology between their N-terminal amino acid sequences and those of the previously described lectins and agglutinins.

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Circulating Levels of Pregnancy-Associated, Placenta-Specific microRNAs in Pregnant Women With Placental Abruption.

Miura K, Higashijima A, Murakami Y, Fuchi N, Tsukamoto O, Abe S, Hasegawa Y, Miura S, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   24 ( 1 ) 148 - 155   2017年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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4．肥満症とメタボリックシンドローム：最近の知見と展望

益崎 裕章, 島袋 充生

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  106 ( 3 ) 477 - 483   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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孤立性脊髄硬膜外顆粒球肉腫で発症した急性骨髄性白血病の1例

北村 紗希子, 益崎 裕章, 森島 聡子, 玉城 啓太, 仲地 佐和子, 手登根 伊織, 島袋 奈津紀, 花城 多恵子, 玉城 智子, 福島 卓也

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  106 ( 10 ) 2214 - 2221   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p>28歳，男性．7カ月持続する臀部痛と左下腿運動麻痺があり，MRI（magnetic resonance imaging）で脊柱管内に腫瘤性病変を認め，精査で孤立性顆粒球肉腫の診断に至ったが，治療開始直前に急性骨髄性白血病に移行した．寛解導入療法後に分子遺伝学的寛解に到達し，地固め療法後に既往の統合失調症が増悪し治療中断となったが，22カ月経過した現在も完全寛解を維持している．顆粒球肉腫は急性骨髄性白血病に準じた治療が必要とされ，正確な診断と早期の治療介入が重要である．</p>

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Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior

Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C

Neurosci Res   17   30313 - 30319   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Brown Rice-Specific γ-Oryzanol-Based Novel Approach toward Lifestyle-Related Brain Dysfunction and Impaired Glucose Metabolism

益崎 裕章

Glycative Stress Research   4   58 - 66   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Round ligament varicosities diagnosed as inguinal hernia during pregnancy: A case report and series from two regional hospitals in Japan.

Mine Y, Eguchi S, Enjouji A, Fukuda M, Yamaguchi J, Inoue Y, Fujita F, Tsukamoto O, Masuzaki H

International journal of surgery case reports   36   122 - 125   2017年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan.

Yotsumoto J, Sekizawa A, Suzumori N, Yamada T, Samura O, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Endo T, Fukushima A, Namba A, Osada H, Kasai Y, Watanabe A, Katagiri Y, Takeshita N, Ogawa M, Okai T, Izumi S, Hamanoue H, Inuzuka M, Haino K, Hamajima N, Nishizawa H, Okamoto Y, Nakamura H, Kanegawa T, Yoshimatsu J, Tairaku S, Naruse K, Masuyama H, Hyodo M, Kaji T, Maeda K, Matsubara K, Ogawa M, Yoshizato T, Ohba T, Kawano Y, Sago H, Japan NIPT Consortium

Journal of human genetics   61 ( 12 ) 995 - 1001   2016年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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HLA一致同胞間骨髄移植後の再発に対して非血縁者間骨髄移植を行った骨髄異形成症候群の1例

本間 健一郎, 島袋 奈津紀, 花城 多恵子, 内堀 幸恵, 北村 紗希子, 友利 昌平, 玉城 啓太, 手登根 伊織, 森近 一穂, 西 由希子, 仲地 佐和子, 森島 聡子, 益崎 裕章

沖縄医学会雑誌 ( 沖縄県医師会医学会 )  55 ( 3 ) 77 - 77   2016年12月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

リハビリ・運動療法を活用した高齢腎不全患者の栄養管理 高齢腎不全・透析患者への栄養指導の実際　食欲、ADLが低下している患者

山川 房江, 力石 幸枝, 仲嵩 緑, 山城 ゆかり, 仲村 英昭, 益崎 裕章

臨床透析 ( 日本メディカルセンター )  32 ( 12 ) 1509 - 1514   2016年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1 -deficient mice

Yoshiro Ishimaru, Shota Ushiama, Masataka Narukawa, Misako Yoshioka, Chisayo Kozuka, Naoki Watanabe, Makoto Tsunoda, Naomi Osakabe, Tomiko Asakura, Hiroaki Masuzaki, Keiko Abe

CHEMICAL SENSES ( OXFORD UNIV PRESS )  41 ( 9 ) E218 - E218   2016年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats.

Nakata T, Umeda M, Masuzaki H, Sawai H

BMC oral health ( BMC Oral Health )  16 ( 1 ) 108   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Characterization of patients with aggressive adult T-cell leukemia-lymphoma in Okinawa, Japan: a retrospective analysis of a large cohort

Nishi Y, Fukushima T, Nomura S, Tomoyose T, Nakachi S, Morichika K, Tedokon I, Tamaki K, Shimabukuro N, Taira N, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tamaki K, Hayashi M, Arakaki H, Uchihara JN, Ohshiro K, Asakura Y, Kuba-Miyara M, Karube K, Masuzaki H

Int J Hematol   104 ( 4 ) 468 - 475   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Characterization of patients with aggressive adult T-cell leukemia-lymphoma in Okinawa, Japan: a retrospective analysis of a large cohort.

Nishi Y, Fukushima T, Nomura S, Tomoyose T, Nakachi S, Morichika K, Tedokon I, Tamaki K, Shimabukuro N, Taira N, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tamaki K, Hayashi M, Arakaki H, Uchihara JN, Ohshiro K, Asakura Y, Kuba-Miyara M, Karube K, Masuzaki H

International journal of hematology ( International Journal of Hematology )  104 ( 4 ) 468 - 75   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats

Nakata T, Umeda M, Masuzaki H, Sawai H

BMC Oral Health   16 ( 1 ) 108   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.

Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K

Journal of human genetics   61 ( 10 ) 879 - 884   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Long-term effect of sitagliptin on endothelial function in type 2 diabetes: A sub-analysis of the PROLOGUE study

Maruhashi T.

Cardiovascular Diabetology ( Cardiovascular Diabetology )  15 ( 1 )   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.

Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M

The Journal of nutritional biochemistry ( ELSEVIER SCIENCE INC )  35   66 - 73   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD + Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD + E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8 weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4 beta-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4 beta-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 413-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function. (C) 2016 Elsevier Inc. All rights reserved.

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A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population.

Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe S, Higashijima A, Fuchi N, Miura S, Yoshiura K, Masuzaki H

Journal of human genetics   61 ( 9 ) 793 - 6   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Adipocyte size distribution and depot-specific modulation of pro- and anti-atherosclerotic adipocytokines and innate immune molecules in human adipose tissue

Shimabukuro, M; Sato, H; Izaki, H; Fukuda, D; Uematsu, E; Hirata, Y; Yagi, S; Soeki, T; Sakaue, H; Kanayama, H; Masuzaki, H; Sata, M

EUROPEAN HEART JOURNAL   37   183 - 183   2016年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.

Shirakura T, Nomura J, Matsui C, Kobayashi T, Tamura M, Masuzaki H

Naunyn-Schmiedeberg's archives of pharmacology ( SPRINGER )  389 ( 8 ) 831 - 8   2016年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO produces considerable amount of oxidative stress throughout the body. To date, however, its pathophysiologic role in hypertension and endothelial dysfunction still remains controversial. To explore the possible involvement of XO-derived oxidative stress in the pathophysiology of vascular dysfunction, by use of a selective XO inhibitor, febuxostat, we investigated the impact of pharmacological inhibition of XO on hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats (SHRs). Sixteen-week-old SHR and normotensive Wistar-Kyoto (WKY) rats were treated with tap water (control) or water containing febuxostat (3 mg/kg/day) for 6 weeks. Systolic blood pressure (SBP) in febuxostat-treated SHR (220 +/- 3 mmHg) was significantly (P &lt; 0.05) decreased compared with the control SHR (236 +/- 4 mmHg) while SBP in febuxostat-treated WKY was constant. Acetylcholine-induced endothelium-dependent relaxation in aortas from febuxostat-treated SHR was significantly (P &lt; 0.05) improved compared with the control SHR, whereas relaxation in response to sodium nitroprusside was not changed. Vascular XO activity and tissue nitrotyrosine level, a representative indicator of local oxidative stress, were considerably elevated in the control SHR compared with the control WKY, and this increment was abolished by febuxostat. Our results suggest that exaggerated XO activity and resultant increase in oxidative stress in this experimental model contribute to the hypertension and endothelial dysfunction, thereby supporting a notion that pharmacological inhibition of XO is valuable not only for hyperuricemia but also for treating hypertension and related endothelial dysfunction in human clinics.

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Biological differences between functionalis and basalis endometria in women with and without adenomyosis.

Khan KN, Fujishita A, Kitajima M, Masuzaki H, Nakashima M, Kitawaki J

European journal of obstetrics, gynecology, and reproductive biology   203   49 - 55   2016年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients.

Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama HO, Masuzaki H, Sata M

BioFactors (Oxford, England) ( WILEY-BLACKWELL )  42 ( 4 ) 397 - 406   2016年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Gender difference in obesity-associated cardiovascular complication could be derived from divergent chronic inflammation. We evaluated depot- and gender-specific regulation of the innate immune system in human adipose tissues. Pair samples were obtained from subcutaneous (SAT) and visceral adipose tissue (VAT) during elective surgery (Male: 35; Female: 27). Expressions of pro- and anti-inflammatory adipocytokines were evaluated by semi-quantitative qPCR. Adipose cell-size distribution was obtained from tissue samples fixed in osmium tetroxide and analyzed by Beckman Coulter Multisizer. Levels of adiponectin were higher in SAT and VAT of female than those of male (P&lt;0.001 and P=0.011, respectively). NLRP3, IL1-IL18, TLR2 were comparable in SAT and VAT between genders. However, TLR4 and TLR9 were increased in female SAT and VAT and HMGB1 in female VAT. Levels of adiponectin were not correlated with mean diameter of adipocyte (phi, m) in SAT and VAT of male, but negatively well correlated in those of female (r=-0.392 and r=-0.616). Such negative correlations were also observed between levels of TLR2, TLR4, and HMGB1 and phi in female. Levels of NLRP3 and IL1 were positively correlated with phi in male, but not in female. In conclusion, Innate signals were differentially expressed in male and female adipose tissues, suggesting that the depot- and gender-specific signals could be related to gender difference in chronic inflammation. (c) 2016 BioFactors, 42(4):397-406, 2016

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Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy.

Suzumori N, Ebara T, Yamada T, Samura O, Yotsumoto J, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Saldivar JS, Dharajiya N, Sago H, Sekizawa A, Japan NIPT Consortium

Journal of human genetics   61 ( 7 ) 647 - 52   2016年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Three-dimensional saline-infusion sonohysterography is useful for the identification of endometrial polyp.

Inoue T, Kitajima M, Taniguchi K, Masuzaki H

The journal of obstetrics and gynaecology research   42 ( 7 ) 855 - 9   2016年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 食事療法Revisit 食べること-なぜ,適量で止まらないのか.なぜ,食べ物に対する依存が生じるのか

益崎 裕章

糖尿病診療マスター ( 株式会社医学書院 )  14 ( 6 ) 413 - 417   2016年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice.

Ushiama S, Ishimaru Y, Narukawa M, Yoshioka M, Kozuka C, Watanabe N, Tsunoda M, Osakabe N, Asakura T, Masuzaki H, Abe K

EBioMedicine ( ELSEVIER SCIENCE BV )  8   60 - 71   2016年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis. This system is referred to as the gut-brain axis. Here we show that both brush cells and type II taste cells are eliminated in the gastrointestinal tract of transcription factor Skn-1 knockout (KO) mice. Despite unaltered food intake, Skn-1 KO mice have reduced body weight with lower body fat due to increased energy expenditure. In this model, 24-h urinary excretion of catecholamines was significantly elevated, accompanied by increased fatty acid beta-oxidation and fuel dissipation in skeletal muscle and impaired insulin secretion driven by glucose. These results suggest the existence of brain-mediated energy homeostatic pathways originating from brush cells and type II taste cells in the gastrointestinal tract and ending in peripheral tissues, including the adrenal glands. The discovery of food-derived factors that regulate these cells may open new avenues the treatment of obesity and diabetes. Research Context: Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis along the gut-brain axis. We propose the concept that taste-receiving cells in the oral cavity and/or food-borne chemicals-receiving brush cells in the gut are involved in regulation of the body weight and adiposity via the brain. The discovery of food-derived factors that regulate these cells may open new avenues for the treatment of obesity and diabetes. (C) 2016 The Authors. Published by Elsevier B.V.

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HLA抗体を有する急性骨髄性白血病患者の非血縁間同種造血幹細胞移植において計画的なHLA適合血小板輸血を行った1例

島袋 奈津紀, 花城 多恵子, 内堀 幸恵, 北村 紗希子, 友利 昌平, 玉城 啓太, 手登根 伊織, 森近 一穂, 西 由希子, 仲地 佐和子, 友寄 毅昭, 加留部 謙之輔, 福島 卓也, 益崎 裕章

日本輸血細胞治療学会誌 ( (一社)日本輸血・細胞治療学会 )  62 ( 3 ) 534 - 534   2016年06月

掲載種別: 研究論文（その他学術会議資料等）

Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.

Shimabukuro M, Higa N, Masuzaki H, Sata M, Ueda S

Cardiovascular diabetology ( Cardiovascular Diabetology )  15 ( 1 ) 77   2016年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Impact of indivisual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men

M. Shimabukuro, N. Higa, H. Masuzaki, M. Sata, S. Ueda

Cardiovasc Diabetology   15   77   2016年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Recurrence of psoriasis vulgaris accompanied by the treatment with C-C chemokine receptor type 4 (CCR4) antibody (Mogamulizumab) therapies in a patient with adult T cell leukemia/ lymphoma: Insight into autoinflammatory syndrome

K. Morichika, T. Tomoyose, T. Hanashiro, N. Shimabukuro, K. Tamaki, I. Tedokon, Y. Nishi, T. S.Nakachi, K. Karube, T. Fukushima, H. Masuzaki

Intern Med   55 ( 10 ) 1345 - 1349   2016年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Influenza 2014-2015 among pregnant Japanese women: primiparous vs multiparous women.

Yamada T, Kawakami S, Yoshida Y, Kawamura H, Ohta S, Abe K, Hamada H, Dohi S, Ichizuka K, Takita H, Baba Y, Matsubara S, Mochizuki J, Unno N, Maegawa Y, Maeda M, Inubashiri E, Akutagawa N, Kubo T, Shirota T, Oda Y, Yamada T, Yamagishi E, Nakai A, Fuchi N, Masuzaki H, Urabe S, Kudo Y, Nomizo M, Sagawa N, Maeda T, Kamitomo M, Kawabata K, Kataoka S, Shiozaki A, Saito S, Sekizawa A, Minakami H

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology   35 ( 4 ) 665 - 71   2016年04月 [ 査読有り ]

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Survey of prenatal testing for genetic disorders in Japan: Recent report.

Nobuzane T, Yamada T, Miura K, Sawai H, Masuzaki H, Kudo Y

The journal of obstetrics and gynaecology research   42 ( 4 ) 375 - 9   2016年04月 [ 査読有り ]

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Molecular detection of intrauterine microbial colonization in women with endometriosis.

Khan KN, Fujishita A, Masumoto H, Muto H, Kitajima M, Masuzaki H, Kitawaki J

European journal of obstetrics, gynecology, and reproductive biology   199   69 - 75   2016年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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玄米由来機能成分γ-オリザノールによるドパミン受容体シグナルを介するグルコース応答性インスリン分泌増強の新規メカニズム

小塚 智沙代, 砂川 澄人, 植田 玲, 比嘉 盛丈, 池間 朋己, 田仲 秀明, 清水 千草, 高山 千利, 松下 正之, 中田 正範, 矢田 俊彦, 親泊 政一, 島袋 充生, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  59 ( Suppl.1 ) S - 457   2016年04月

掲載種別: 研究論文（その他学術会議資料等）

Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier.

Fuchi N, Miura K, Imaizumi Y, Hasegawa H, Yanagihara K, Miyazaki Y, Masuzaki H

The journal of obstetrics and gynaecology research   42 ( 3 ) 336 - 40   2016年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Novel molecular mechanisms of brown rice-derived bioactive substance on anti-obesity and anti-diabetic properties

Kozuka, C; Masuzaki, H

JOURNAL OF PHARMACOLOGICAL SCIENCES   130 ( 3 ) S69 - S69   2016年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.

Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS

Scientific reports   6   18844   2016年01月 [ 査読有り ]

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目指せ!肥満症のトータルケア-減量に苦戦する患者について考える 肥満症の疫学 日本における肥満症の現状と対策

河本 絵里子, 益崎 裕章

内科 ( 南江堂 )  117 ( 1 ) 11 - 14   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The Increased Ratio of 11β-Hydroxysteroid Dehydrogenase Type 1 versus Type 2 in Chronic Periodontitis Irrespective of Obesity

T. Nakata, A. Fujita, M. Umeda, H. Yoshida, K. Inami, H. Masuzaki, H. Sawai

SpringerPlus   5   40   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.

Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K

Early human development   92   33 - 6   2016年01月 [ 査読有り ]

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CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.

Kitamoto A, Kitamoto T, Nakamura T, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Hotta K

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  23 ( 3 ) 309 - 19   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<b><i>Aim</i></b><b>: </b>Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (<i>CDH13</i>) gene that are associated with adiponectin levels.<br><b><i>Methods</i></b><b>: </b>We investigated whether single nucleotide polymorphisms (SNPs) in <i>CDH13</i> was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals.<br><b><i>Results</i></b><b>:</b> We found that three <i>CDH13</i> SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (<i>P</i>＜1×10 ^－14), even after adjustment for VFA. However, these adiponectin-inducing alleles of <i>CDH13</i> SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment–insulin resistance (HOMA-IR) scores, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels.<br><b><i>Conclusion</i></b><b>: </b>These results suggested that <i>CDH13</i> SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

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CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass

Aya Kitamoto, Takuya Kitamoto, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ikuo Mineo, Jun Wada, Yuji Ogawa, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kikuko Hotta

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS ( JAPAN ATHEROSCLEROSIS SOC )  23 ( 3 ) 309 - 319   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Aim: Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (CDH13) gene that are associated with adiponectin levels. Methods: We investigated whether single nucleotide polymorphisms (SNPs) in CDH13 was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals. Results: We found that three CDH13 SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (P &lt; 1 x 10(-14)), even after adjustment for VFA. However, these adiponectin-inducing alleles of CDH13 SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment-insulin resistance (HOMA-IR) scores, and triglycerides and lower highdensity lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels. Conclusion: These results suggested that CDH13 SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma: Insight into Autoinflammatory Diseases.

Morichika K, Tomoyose T, Hanashiro T, Shimabukuro N, Tamaki K, Tedokon I, Nishi Y, Nakachi S, Karube KN, Fukushima T, Katoh T, Ohshima K, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 10 ) 1345 - 9   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T cell leukemia / lymphoma (ATL) is one of the most aggressive hematological malignancies caused by human T-lymphotropic virus type-I (HTLV-1). Mogamulizumab is a new defucosylated humanized monoclonal antibody agent which targets C-C chemokine receptor type 4 (CCR4) expressed occasionally on the surface of ATL cells. However, adverse events such as drug eruptions have also been highlighted, at least in part, via the dysfunction of regulatory T cells (Tregs). We herein report a pronounced recurrence of systemic psoriasis vulgaris accompanied by the treatment of mogamulizumab in a patient with ATL. Pathological examinations may suggest a mechanistic link between the recurrence of autoinflammatory diseases and anti-CCR4 antibody therapies.<br>

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Thromboembolism Supervened on Eosinophilia Induced by Mycoplasma Pneumonia.

Morichika K, Nakachi S, Tomoyose T, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 18 ) 2741 - 2   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity.

Nakata T, Fujita A, Umeda M, Yoshida H, Inami K, Masuzaki H, Sawai H

SpringerPlus ( SpringerPlus )  5 ( 1 ) 40 - 7   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Screening of Coronary Artery Disease in Diabetic Patients: Who and How? - Reply.

Shimabukuro M, Saito T, Masuzaki H, Sata M

Circulation journal : official journal of the Japanese Circulation Society ( 一般社団法人 日本循環器学会 )  80 ( 2 ) 544 - 544   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<b><i>Background:</i></b>Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients.<b><i>Methods and Results:</i></b>In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50–74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75–89% stenosis), Grade 5 (severe stenosis/atherosclerosis, ≥90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3–5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA_1c≥7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.<b><i>Conclusions:</i></b>The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization. (<i>Circ J</i> 2015; <b>79:</b> 2422–2429)

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Relevant Obstetric Factors for Cerebral Palsy: From the Nationwide Obstetric Compensation System in Japan.

Hasegawa J, Toyokawa S, Ikenoue T, Asano Y, Satoh S, Ikeda T, Ichizuka K, Tamiya N, Nakai A, Fujimori K, Maeda T, Masuzaki H, Suzuki H, Ueda S, Prevention Recurrence Committee, Japan Obstetric Compensation System for Cerebral Palsy

PloS one   11 ( 1 ) e0148122   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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いま知っておきたい!　内科最新トピックス (第10章)代謝・栄養 肥満を科学し,臨床に活かす

益崎 裕章, 小塚 智沙代, 島袋 充生

内科 ( 南江堂 )  116 ( 6 ) 1198 - 1202   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Authors' reply re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series.

Nishijima K, Orisaka M, Takahashi J, Yamamoto M, Nakago S, Yoshida A, Masuzaki H, Kotsuji F, Yoshida Y

BJOG : an international journal of obstetrics and gynaecology   122 ( 13 ) 1844 - 5   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation.

Hasegawa Y, Miura K, Higashijima A, Abe S, Miura S, Yoshiura K, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   22 ( 12 ) 1569 - 76   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab.

Tamaki K, Kinjo T, Aoyama H, Tomoyose T, Nakachi S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Taira N, Fujita J, Yoshimi N, Fukushima T, Masuzaki H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  21 ( 11 ) 820 - 3   2015年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab

K. Tamaki, T. T. Kinjo, H. Aoyama, Tomoyose, S. Nakachi, T. Hanashiro, N. Shimabukuro, I. Todokon, K. Morichika, Y. Nishi, N. Taira, J. Fujita, N. Yoshimi, T.Fukushima, H. Masuzaki

J Infect Chemother   21 ( 11 ) 820 - 823   2015年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Circulating chromosome 19 miRNA cluster microRNAs in pregnant women with severe pre-eclampsia.

Miura K, Higashijima A, Murakami Y, Tsukamoto O, Hasegawa Y, Abe S, Fuchi N, Miura S, Kaneuchi M, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 10 ) 1526 - 32   2015年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D₂ receptor signalling in mouse islet.

Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H

British journal of pharmacology ( British Journal of Pharmacology )  172 ( 18 ) 4519 - 4534   2015年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background and Purpose gamma-Oryzanol, derived from unrefined rice, attenuated the preference for dietary fat in mice, by decreasing hypothalamic endoplasmic reticulum stress. However, no peripheral mechanisms, whereby -oryzanol could ameliorate glucose dyshomeostasis were explored. Dopamine D-2 receptor signalling locally attenuates insulin secretion in pancreatic islets, presumably via decreased levels of intracellular cAMP. We therefore hypothesized that -oryzanol would improve high-fat diet (HFD)-induced dysfunction of islets through the suppression of local D-2 receptor signalling. Experimental Approach Glucose metabolism and regulation of molecules involved in D-2 receptor signalling in pancreatic islets were investigated in male C57BL/6J mice, fed HFD and treated with gamma-oryzanol . In isolated murine islets and the beta cell line, MIN6 , the effects of gamma-oryzanol on glucose-stimulated insulin secretion (GSIS) was analysed using siRNA for D-2 receptors and a variety of compounds which alter D-2 receptor signalling. Key Results In islets, -oryzanol enhanced GSIS via the activation of the cAMP/PKA pathway. Expression of molecules involved in D-2 receptor signalling was increased in islets from HFD-fed mice, which were reciprocally decreased by -oryzanol. Experiments with siRNA for D-2 receptors and D-2 receptor ligands in vitro suggest that gamma-oryzanol suppressed D-2 receptor signalling and augmented GSIS. Conclusions and Implications gamma-Oryzanol exhibited unique anti-diabetic properties. The unexpected effects of gamma-oryzanol on D-2 receptor signalling in islets may provide a novel; natural food-based, approach to anti-diabetic therapy.

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Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multi-detector computed tomography

M. Shimabukuro, T. Saito, T. Higa, K. Nakamura, H. Masuzaki, M. Sata

Circ J   79   2422 - 2429   2015年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Subclinical Carotid Atherosclerosis Burden in the Japanese: Comparison between Okinawa and Nagano Residents.

Shimabukuro M, Hasegawa Y, Higa M, Amano R, Yamada H, Mizushima S, Masuzaki H, Sata M

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  22 ( 8 ) 854 - 68   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<b><i>Aim</i></b><b>: </b>The prevalence of overweight and a change in atherosclerotic lipid profiles may be linked to region-specific differences in atherosclerotic diseases. We evaluated whether the lipid phenotype could be linked to region- and sex-specific differences in the degree of atherosclerosis.<br><b><i>Methods</i></b><b>: </b>Non-diabetic subjects included Okinawa (<i>n</i>=1674) and Nagano (<i>n</i>=1392) residents aged 30–75 years who underwent carotid ultrasonography for the measurement of maximum intima-media thickness (max IMT).<br><b><i>Results</i></b><b>: </b>Average max IMT was higher in Okinawa men and women, and the increase in max IMT with age was enhanced in men. Multiple regression analysis showed that in addition to age and systolic blood pressure, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol were IMT determinants only in men for both Okinawa and Nagano. Meanwhile, HDL-cholesterol was a determinant for Okinawa men and women, but not for Nagano men and women.<br><b><i>Conclusions</i></b><b>: </b>This is the first report to show region- and sex-specific differences in the determinants for max IMT in a Japanese population. The evaluation of the relationship between lipid profile patterns and region- and sex-specific differences in carotid atherosclerosis burden may be required.

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Estrogen deficiency heterogeneously affects tissue specific stem cells in mice.

Kitajima Y, Doi H, Ono Y, Urata Y, Goto S, Kitajima M, Miura K, Li TS, Masuzaki H

Scientific reports   5   12861   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: Two case reports and review of the literature

Miyagi T.

Transplant Infectious Disease ( Transplant Infectious Disease )  17 ( 4 ) 593 - 598   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Successful treatment of toxoplasmic encephalitis quickly diagnosed by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two cases reports and review of the literature

T. Miyagi, H. Itonaga, F. Aosai, J. Taguchi, K. Norose, K. Mochiduki, H. Fujii, A. Furumoto, M. Ohama, K. Karimata, A. Yamanoha, H.Taniguchi, S. Sato, N. Taira, Y. Moriuchi, T. Fukushima, H. Masuzaki, Y. Miyazaki

Transpl Infect Dis   17 ( 4 ) 593 - 598   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Experience with recombinant activated factor VII for severe post-partum hemorrhage in Japan, investigated by Perinatology Committee, Japan Society of Obstetrics and Gynecology.

Murakami M, Kobayashi T, Kubo T, Hata T, Takeda S, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 8 ) 1161 - 8   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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National survey of fibrinogen concentrate usage for post-partum hemorrhage in Japan: investigated by the Perinatology Committee, Japan Society of Obstetrics and Gynecology.

Makino S, Takeda S, Kobayashi T, Murakami M, Kubo T, Hata T, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 8 ) 1155 - 60   2015年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 糖のホメオスターシス-最近の知見 食習慣・食の嗜好性と糖ホメオスターシス

益崎 裕章, 小塚 智沙代

糖尿病診療マスター ( 株式会社医学書院 )  13 ( 5 ) 370 - 376   2015年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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17β-estradiol and lipopolysaccharide additively promote pelvic inflammation and growth of endometriosis.

Khan KN, Kitajima M, Inoue T, Fujishita A, Nakashima M, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   22 ( 5 ) 585 - 94   2015年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Pregnancy-associated microRNAs in plasma as potential molecular markers of ectopic pregnancy.

Miura K, Higashijima A, Mishima H, Miura S, Kitajima M, Kaneuchi M, Yoshiura K, Masuzaki H

Fertility and sterility   103 ( 5 ) 1202 - 8.e1   2015年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight.

Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Kaneuchi M, Yoshiura K, Masuzaki H

Prenatal diagnosis   35 ( 5 ) 509 - 11   2015年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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[Discussion Meeting on Care and Treatment of Obesity Syndrome: Latest Approach through Nutrition, Diets, Exercise, Lifestyle Modification and Psychological Aspects].

Masuzaki H, Yabe D, Onishi Y, Matsuzawa Y, Matsuda Y

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine ( 一般社団法人 日本内科学会 )  104 ( 4 ) 748 - 62   2015年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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γ-Oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice.

Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki J, Oyadomari S, Shimabukuro M, Masuzaki H

Endocrinology ( Endocrinology )  156 ( 4 ) 1242 - 50   2015年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Endoplasmic reticulum (ER) stress is profoundly involved in dysfunction of beta-cells under high-fat diet and hyperglycemia. Our recent study in mice showed that gamma-oryzanol, a unique component of brown rice, acts as a chemical chaperone in the hypothalamus and improves feeding behavior and diet-induced dysmetabolism. However, the entire mechanism whereby gamma-oryzanol improves glucose metabolism throughout the body still remains unclear. In this context, we tested whether gamma-oryzanol reduces ER stress and improves function and survival of pancreatic beta-cells using murine beta-cell line MIN6. In MIN6 cells with augmented ER stress by tunicamycin, gamma-oryzanol decreased exaggerated expression of ER stress-related genes and phosphorylation of eukaryotic initiation factor-2 alpha, resulting in restoration of glucose-stimulated insulin secretion and prevention of apoptosis. In islets from high-fat diet-fed diabetic mice, oral administration of gamma-oryzanol improved glucose-stimulated insulin secretion on following reduction of exaggerated ER stress and apoptosis. Furthermore, we examined the impact of gamma-oryzanol on low-dose streptozotocin-induced diabetic mice, where exaggerated ER stress and resultant apoptosis in beta-cells were observed. Also in this model, gamma-oryzanol attenuated mRNA level of genes involved in ER stress and apoptotic signaling in islets, leading to amelioration of glucose dysmetabolism. Taken together, our findings demonstrate that gamma-oryzanol directly ameliorates ER stress-induced beta-cell dysfunction and subsequent apoptosis, highlighting usefulness of gamma-oryzanol for the treatment of diabetes mellitus.

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Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy.

Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Masuzaki H

European journal of obstetrics, gynecology, and reproductive biology   187   6 - 13   2015年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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ADIPOQ polymorphisms are associated with insulin resistance in Japanese women

A. Kitamoto, T. Kitamoto, R. So, T. Matsuo, Y. Nakata, H. Hyogo, H. Ochi, T. Nakamura, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, Y. Ogawa, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, H. Masuzaki, T. Ueno, K. Chayama, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, T. Sakata, K. Tanaka, Y. Matsuzawa, K. Hotta

Endocrine J   62 ( 6 ) 513 - 521   2015年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Vaccination during the 2013-2014 influenza season in pregnant Japanese women.

Yamada T, Abe K, Baba Y, Inubashiri E, Kawabata K, Kubo T, Maegawa Y, Fuchi N, Nomizo M, Shimada M, Shiozaki A, Hamada H, Matsubara S, Akutagawa N, Kataoka S, Maeda M, Masuzaki H, Sagawa N, Nakai A, Saito S, Minakami H

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology   34 ( 3 ) 543 - 8   2015年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects.

Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M

Journal of pharmacological sciences ( JAPANESE PHARMACOLOGICAL SOC )  127 ( 2 ) 217 - 22   2015年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects. A double-blind, placebo-controlled, crossover study was performed in 27 healthy volunteers. A cup of either caffeinated or decaffeinated coffee was drunk by the subjects, and reactive hyperemia of finger blood flow was assessed by laser Doppler flowmetry. In an interval of more than 2 days, the same experimental protocol was repeated with another coffee in a crossover manner. Caffeinated coffee intake slightly but significantly elevated blood pressure and decreased finger blood flow as compared with decaffeinated coffee intake. There was no significant difference in heart rate between caffeinated and decaffeinated coffee intake. Importantly, caffeinated coffee intake significantly enhanced post-occlusive reactive hyperemia of finger blood flow, an index of microvascular endothelial function, compared with decaffeinated coffee intake. These results provide the first evidence that caffeine contained in a cup of coffee enhances microvascular function in healthy individuals. (C) 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

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Authors' reply.

Nishijima K, Takahashi J, Orisaka M, Kurokawa T, Tamamura C, Yoshida A, Masuzaki H, Sekiya T, Yoshida Y, Kotsuji F

BJOG : an international journal of obstetrics and gynaecology   122 ( 3 ) 448 - 9   2015年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Involvement of hepatocyte growth factor-induced epithelial-mesenchymal transition in human adenomyosis.

Khan KN, Kitajima M, Hiraki K, Fujishita A, Nakashima M, Masuzaki H

Biology of reproduction   92 ( 2 ) 35   2015年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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沖縄県の造血幹細胞移植におけるc-D-indexの有用性に関する後方視的解析

友寄 毅昭, 仲地 佐和子, 森近 一穂, 西 由希子, 手登根 伊織, 玉城 啓太, 花城 多恵子, 島袋 奈津紀, 福島 卓也, 益崎 裕章

日本内科学会雑誌 ( (一社)日本内科学会 )  104 ( Suppl. ) 227 - 227   2015年02月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

The intractable intra-abdominal hemorrhage with unknown etiology in a patient with severe hemophilia A

K.Morichika, T.Hanashiro, N.Shimabukuro, K.Tamaki, I.Tedokon, Y.Nishi, S.Nakachi, T.Tomoyose, T.Fukushima, H. Masuzaki

Am J Emerg Med   33 ( 1 ) 129 - e1-3   2015年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The intractable intra-abdominal hemorrhage with unknown etiology in a patient with severe hemophilia A.

Morichika K, Tomoyose T, Nishi Y, Nakachi S, Fukushima T, Masuzaki H

The American journal of emergency medicine ( American Journal of Emergency Medicine )  33 ( 1 ) 129.e1 - 3   2015年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Effect of labor on plasma concentrations and postpartum clearance of cell-free, pregnancy-associated, placenta-specific microRNAs.

Morisaki S, Miura K, Higashijima A, Abe S, Miura S, Hasegawa Y, Yoshida A, Kaneuchi M, Yoshiura K, Masuzaki H

Prenatal diagnosis   35 ( 1 ) 44 - 50   2015年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A Case with falsely elevated HbAlc concentration caused by unknown modified hemoglobin

Shimajiri Y.

Journal of the Japan Diabetes Society ( Journal of the Japan Diabetes Society )  58 ( 12 ) 915 - 922   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

ADIPOQ polymorphisms are associated with insulin resistance in Japanese women.

Kitamoto A, Kitamoto T, So R, Matsuo T, Nakata Y, Hyogo H, Ochi H, Nakamura T, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Hotta K

Endocrine journal ( 一般社団法人 日本内分泌学会 )  62 ( 6 ) 513 - 21   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Visceral fat accumulation contributes to the development of insulin resistance, leading to metabolic syndrome. Adiponectin provides a link between visceral fat accumulation and insulin resistance. In addition to environmental factors, genetic factors play important roles in visceral fat accumulation and circulating adiponectin levels. Genome-wide association studies (GWASs) have identified genetic variations in the adiponectin, C1Q and collagen domain containing (<i>ADIPOQ</i>) gene that are associated with adiponectin levels. In this study, we investigated whether <i>ADIPOQ</i> single nucleotide polymorphisms (SNPs) were associated with visceral fat accumulation and insulin resistance. We measured the visceral fat area (VFA) by computed tomography (CT) and examined the presence of the insulin resistance-related phenotype (fasting plasma glucose, fasting insulin, and homeostasis model assessment-insulin resistance [HOMA-IR]) in a set of Japanese individuals (731 men and 864 women) who were genotyped for seven <i>ADIPOQ</i> SNPs reported by recent GWASs (namely, rs6810075, rs10937273, rs1648707, rs864265, rs182052, rs17366568, and rs6773957). SNPs associated with the phenotype (<i>P</i> < 0.05) were then evaluated by association analysis using a second set of the study participants (383 men and 510 women). None of the SNPs was associated with body mass index (BMI) or VFA in men or women. However, the adiponectin-decreasing alleles of rs10937273 and rs1648707 were significantly associated with HOMA-IR (<i>P</i> = 0.0030 and <i>P</i> = 0.00074, respectively) in women, independently of BMI. These SNPs were significantly associated with decreased adiponectin levels in women. Our results suggested that rs10937273 and rs1648707 may affect insulin sensitivity by regulating adiponectin production by adipose tissue in women.

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Giant Septic Lymphadenitis with Marked Gas Formation Caused by Bacteroides fragilis in a Patient with Adult T-cell Leukemia/lymphoma.

Tomoyose T, Nakachi S, Nishi Y, Morichika K, Tedokon I, Tamaki K, Shimabukuro N, Hanashiro T, Samura H, Fukushima T, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 22 ) 2919 - 22   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T-cell leukemia/lymphoma (ATL) sometimes causes opportunistic infections. A 53-year-old woman with systemic lymphadenopathies was diagnosed with ATL by inguinal lymph node biopsies and underwent oral chemotherapy. Two months later, high grade fever, lower abdominal pain and lymphadenopathy recurred. Computed tomography revealed the presence of lymphadenopathy with marked gas formation in the pelvic lesion. Blood cultures were suggestive of septic lymphadenitis by <i>Bacteroides fragilis</i> (<i>BF</i>). This represents the first demonstration of giant lymphadenitis with gas formation caused by <i>BF</i> in a patient with ATL. Notably, septic lymphadenitis is pivotal in the differential diagnosis of systemic lymphadenopathy in ATL.<br>

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著明な両側眼瞼腫脹を生じた皮下脂肪織炎様 T 細胞リンパ腫の 1 例

林 健太郎, 益崎 裕章, 上里 博, 宮城 拓也, 園崎 哲, 山口 さやか, 山本 雄一, 高橋 健造, 西 由希子, 仲地 佐和子, 友寄 毅昭

西日本皮膚科 ( 日本皮膚科学会西部支部 )  77 ( 5 ) 487 - 491   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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患者は 24 歳，女性。発熱と体幹，四肢に多発する紅斑や関節痛があり，病初期には自己免疫疾患との鑑別に苦慮していた。経過中に著明な両眼瞼腫脹を生じ，皮膚筋炎や原発性皮膚リンパ腫を疑った。ゴットロン徴候や爪囲紅斑，筋関連酵素の上昇はなく，再検した病理組織で，脂肪細胞を取り囲んで浸潤する異型細胞を認め，いわゆる rimming 像を呈していた。免疫染色で異型細胞は CD3，CD8，T cell restricted intercellular antigen (TIA-1) が 陽 性であり，CD4，CD30，CD56，EBV-encoded small RNA (EBER)は陰性であった。また異型細胞は T 細胞受容体 <i>αβ</i> 鎖が陽性で，<i>γδ</i> 鎖は陰性だった。以上の結果から，皮下脂肪織炎様 T 細胞リンパ腫(subcutaneous panniculitis-like T-cell lymphoma ; SPTCL)と診断した。自験例は血球貪食症候群も合併していたため，治療は多剤併用化学療法を開始した。その結果，病変は消失し，治療終了後2年間再発はない。眼瞼腫脹を生じた SPTCL の報告は少なく，眼瞼腫脹はSPTCL では稀な皮膚症状と思われる。一方，眼窩悪性リンパ腫の半数が眼瞼腫脹を初発症状とし，自験例のように眼瞼腫脹を契機に診断された眼窩悪性リンパ腫の報告もあるため，眼瞼腫脹の鑑別に悪性リンパ腫も念頭におくべきであると考えた。

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原因不明の修飾ヘモグロビンのためにHbA1cが偽高値を示した1例

島尻 佳典, 與那嶺 正人, 友寄 毅昭, 益崎 裕章, 三家 登喜夫, 原野 恵子, 和田 芳直, 古賀 正史

糖尿病 ( 一般社団法人 日本糖尿病学会 )  58 ( 12 ) 915 - 922   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

修飾ヘモグロビン（Hb）のためにHbA1cが偽高値を示した症例を経験したので報告する．症例は72歳男性．糖尿病精査を希望にて当院を受診．OGTTにて境界型，グリコアルブミンは16.4 %であったが，HbA1c（HPLC法）は8.1 %と高値を示し，そのクロマトグラムで異常ピークを認めた．一方，免疫法，酵素法で測定したHbA1cは各々2.8 %，4.0 %といずれも低値であった．高分離HPLC（KO500）法にて不安定HbA1c近傍およびHbAとHbA1cの間に2つの異常ピークを認めたが，グロビン遺伝子（<i>α</i>鎖および<i>β</i>鎖）に変異を認めなかった．高分離HPLCで認めた2つの異常ピークを質量分析にて解析した結果，両分画はともに<i>β</i>グロビンに88 Daの分子修飾を認めた．修飾分子の詳細は不明であるが，分子量から既知の修飾Hbは該当せず，新規の修飾Hbであった．HbA1cが偽高値を示す新たな原因の可能性がある．

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Subclinical Carotid Atherosclerosis Burden in the Japanese: Comparison between Okinawa and Nagano Residents

Michio Shimabukuro, Yoshimasa Hasegawa, Moritake Higa, Rie Amano, Hirotsugu Yamada, Shunsaku Mizushima, Hiroaki Masuzaki, Masataka Sata

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS ( JAPAN ATHEROSCLEROSIS SOC )  22 ( 8 ) 854 - 868   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Aim: The prevalence of overweight and a change in atherosclerotic lipid profiles may be linked to region-specific differences in atherosclerotic diseases. We evaluated whether the lipid phenotype could be linked to region-and sex-specific differences in the degree of atherosclerosis. Methods: Non-diabetic subjects included Okinawa (n=1674) and Nagano (n=1392) residents aged 30-75 years who underwent carotid ultrasonography for the measurement of maximum intima-media thickness (max IMT). Results: Average max IMT was higher in Okinawa men and women, and the increase in max IMT with age was enhanced in men. Multiple regression analysis showed that in addition to age and systolic blood pressure, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol were IMT determinants only in men for both Okinawa and Nagano. Meanwhile, HDL-cholesterol was a determinant for Okinawa men and women, but not for Nagano men and women. Conclusions: This is the first report to show region-and sex-specific differences in the determinants for max IMT in a Japanese population. The evaluation of the relationship between lipid profile patterns and region-and sex-specific differences in carotid atherosclerosis burden may be required.

Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multidetector computed tomography.

Shimabukuro M, Saito T, Higa T, Nakamura K, Masuzaki H, Sata M, Fukuoka diabetologists group.

Circulation journal : official journal of the Japanese Circulation Society ( 一般社団法人 日本循環器学会 )  79 ( 11 ) 2422 - 9   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<b><i>Background:</i></b>Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients.<b><i>Methods and Results:</i></b>In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50–74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75–89% stenosis), Grade 5 (severe stenosis/atherosclerosis, ≥90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3–5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA_1c≥7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.<b><i>Conclusions:</i></b>The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization. (<i>Circ J</i> 2015; <b>79:</b> 2422–2429)

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玄米と高脂肪食

益崎 裕章, 小塚 智沙代, 島袋 充生

Annual Review 糖尿病・代謝・内分泌2015   1   38 - 44   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Dietary supplementation with sodium nitrite can exert neuroprotective effects on global cerebral ischemia/reperfusion in mice

Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H

J Anesth   29   609 - 617   2015年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Genetic Variation in the CYP17A1 and NT5C2 Genes are Associated with a Reduction in Visceral and Subcutaneous Fat Areas in Japanese Women.

K. Hotta, A. Kitamoto, T. Kitamoto, S. Mizusawa, H. Teranishi, T. Matsuo,Y. Nakata, H. Hyogo, H. Ochi, T. Nakamura, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A, Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, H. Masuzaki, T. Ueno, K. Chayama, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, T. Sakata, K. Tanaka, Y. Matsuzawa, K. Nakao, A. Sekine.

J. Hum. Genet ( その他の出版社 )  57 ( 1 ) 46 - 51   2012年

掲載種別: 研究論文（その他学術会議資料等）

Telmisartan Ameriorates Insulin Sensitivity by Activating the AMPK / SIRT1 Pathway in Skeletal Muscle of Obese db/db Mice.

A. Shiota, M. Shimabukuro, D. Fukuda, T. Soeki, H. Sato, E. Umetsu, Y. Hirata,H. Sakaue, H. Kurobe, N. Maeda, H. Masuzaki, I. Shimomura, M. Sata.

J Pharmacol Exp Ther ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Activation of AMPK-Sirt1 Pathway by Telmisartan in White Adipose Tissue: A Possible Link to Anti-metabolic Effects

A. Shiota, M. Shimabukuro, D. Fukuda, T. Soeki, H. Sato, E. Umetsu, Y. Hirata, H. Kurobe, H. Sakaue, Y. Nakaya, H. Masuzaki, M. Sata.

Eur J Pharmacol ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Miglitol, α-glycosidase Inhibitor, Reduces Visceral Fat Accumulation and Cardiovascular Risk Factors in Subjects with the Metabolic Syndrome: A randomized comparable study

M. Shimabukuro, M. Higa, K. Yamakawa, H. Masuzaki, M. Sata.

Int J Cardiol ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Exposure to Artificial Sweets in Juvenile Mice Intensifies Addiction to High Fat Diet and Aggravates Die-induced Obesity in Adulthood

K. Yabiku, Y. Ohshiro, C. Kozuka, S. Sunagawa, R. Ueda, S. Taira, K. Yamakawa, M. Higa, M.Shimabukuro, S. Oyadomari, C. Takayama, M. Matsushita, H. Masuzaki

その他の掲載誌 ( その他の出版社 )    Manuscript submitted   2012年

掲載種別: 研究論文（その他学術会議資料等）

Eicosapentaenoic acid (EPA) supplementation corrects endothelial dysfunction in hyperlipidemic patients through a mechanism of fatty acid recomposition

K.Yamakawa, N. Higa, T. Asahi, K. Ohba, O. Arasaki, M. Higa, Y. Oshiro, H. Yoshida, T. Higa, K. T. Saito, S. Ueda, H. Masuzaki, M. Sata, M. Shimabukuro

Nutrition and Metabolism ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Urinary Aldosterone Excretion Is Increased in Association with Subcutaneous, not Visceral, Adipose Tissue in Obese Individuals - A possible Manifestation of the Dysfunctional Subcutaneous Adipose Tissue and of an Ectopic Lipid Accumulation in the Adrenal Gland

E. Harada, Y. Mizuno, D. Katoh, Y. Nakayama, M. Yoshimura, H. Masuzaki, Y. Saito, H. Yasue

Obesity ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Lipid Deposition in Various Sites of Skeletal Muscle and Liver Shows Correlations with Visceral Fat Accunulation in Middle-Aged Male Patients with Metabolic Syndrome

S. Taira, M. Shimabukuro, M. Higa, K. Yabiku, C. Kozuka, R. Ueda, S. Sunagawa, E. Kawamoto,Y. Nakayama, H. Nakamura, T. Iha, T. Ikema, K. Yamakawa, H. Masuzaki

Diabetes Care ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Brown rice and its components, -orizanol, attenuate the preference for high fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice

C. Kozuka, K. Yabiku, S. Sunagawa, R. Ueda, S. Taira, H. Ohshiro, T. Ikema, K. Yamakawa, M. Higa, H. Tanaka, C. Takayama, M. Matsushita, S. Oyadomari, M.Shimabukuro, H. Masuzaki

Diabetes ( その他の出版社 )    in press   2012年

掲載種別: 研究論文（その他学術会議資料等）

Association between Type 2 Diabetes Genetic Susceptibility Loci and Visceral and Subcutaneous Fat Area as Determined by Computed Tomography.

K. Hotta, T. Kitamoto, A. Kitamoto, S. Mizusawa, H. Teranishi, T. Matsuo, Y. Nakata, H. Hyogo, H. Ochi, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K.Tokunaga, H. Masuzaki, T. Ueno, K. Chayama, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, T. Sakata, K. Tanaka, Y. Matsuzawa, K. Nakao, A. Sekine.

J. Hum. Genet ( その他の出版社 )  57   305 - 310   2012年

掲載種別: 研究論文（その他学術会議資料等）

Intensive Glucose Lowering in Cardiovascular Risk Reduction: Unsolve dQuestions.

M. Shimabukuro, H. Masuzaki, M. Sata.

Circ. J. ( その他の出版社 )  76   593 - 595   2012年

掲載種別: 研究論文（その他学術会議資料等）

Distinct Effects of Pitavastation and Atorvastatin on Lipoprotein Subclasses in Patients with Type 2 Diabetes Mellitus.

M. Shimabukuro, M. Higa, H. Tanaka, T. Shimabukuro, K. Yamakawa, H. Masuzaki.

Diabetic Med. ( その他の出版社 )  28   856 - 864   2011年

掲載種別: 研究論文（その他学術会議資料等）

Computed Tomography Analysis of the Association between the SH2B1 rs7498665 Single-Nucleotide Polymorphismand Visceral Fat Area.

K. Hotta, T. Kitamoto, S. Mizusawa, T. Matsuo, Y. Nakata, H. Hyogo, H. Ochi, S. Kamohara, N. Miyatake, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, H. Masuzaki, T. Ueno, K. Hamaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, T. Sakata, K. Tanaka, Y. Matsuzawa, K. Nakao, A. Sekine.

J. Hum. Genet ( その他の出版社 )  56   716 - 719   2011年

掲載種別: 研究論文（その他学術会議資料等）

Increasing Dihydrobiopterin Causes Dysfunction of Endothelial Nitric Oxide Synthase in Rats In Vivo.

K. Noguchi, N. Hamadate, T. Matsuzaki, M. Sakanashi, J. Nakasone, T. Uchida, K. Arakaki, H. Kubota, S. Ishiuchi, H. Masuzaki, K. Sugahara, Y. Ohya, M. Sakanashi, M. Tsutsui.

Am. J. Physiol. (Heart and Circulatrory Physiology) ( その他の出版社 )  301   H721-H729   2011年

掲載種別: 研究論文（その他学術会議資料等）

Association of Variations in the FTO, SCG3 and MTMR9 Genes with Metabolic Syndrome in a Japanese Population.

K. Hotta, T. Kitamoto, A. Kitamoto, S. Mizusawa, T. Matsuo, Y. Nakata, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, H. Masuzaki, T. Ueno, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, T. Sakata, Y. Matsuzawa, K. Nakao, A. Sekine.

J. Hum. Genet ( その他の出版社 )  56   647 - 651   2011年

掲載種別: 研究論文（その他学術会議資料等）

Serum Levels of B-cell Activating Factor of TNF Family (BAFF) in Patients with Graves' Diseases: Correlation between Serum BAFF level and Disease Activity of Graves' Disease.

S. Sunagawa, S. Taira, R. Uedda, K. Yabiku, T. Kouki, T. Ikema, A. Nakachi, C. Kozuka, M. Higa, K. Yamakawa, M. Shimabukuro, H. Masuzaki.

J. Endocrinol. Metab. ( その他の出版社 )  1   73 - 78   2011年

掲載種別: 研究論文（その他学術会議資料等）

Impact of Pacing and High-Pass Filter Settings on Ventricular Bipolar Electrograms in Implantable Cardioverter Defibrillator Systems: Implication of Predictors for Inappropriate Therapy Caused By Oversensing of Repolarization Electrograms.

A. Maesato, S. Higa, YJ. Lin, I. Chinen, S. Ishigaki, M. Yajima, H. Masuzaki, S. Chen.

Circ. J. ( その他の出版社 )  75   2095 - 2104   2011年

掲載種別: 研究論文（その他学術会議資料等）

Effective Prediction of Response to Cardiac Resynchronization Therapy Using a Novel Program of Gated Myocardial Perfusion SPECT.

K. Nakamura, M. Takami, M. Shimabukuro, A. Maesato, I. Chinen, S. Ishigaki, S. Higa, T. Keida, H. Masuzaki.

Europace ( その他の出版社 )  13   1731 - 1737   2011年

掲載種別: 研究論文（その他学術会議資料等）

Human T-Cell Leukemia Virus Type 1 Tax Transactivates the Matrix Metalloproteinae 7 Gene via JunD/AP-1 Signaling.

S. Nakachi, T. Nakazato, C. Ishikawa, R. Kimura, D.A. Mann, M. Senba, H. Masuzaki, N. Mori.

Biochim. Biophys. Acta. (Molecular Cell Research) ( その他の出版社 )  1813   731 - 741   2011年

掲載種別: 研究論文（その他学術会議資料等）

Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Underlies Left-Ventricular Diastolic Dysfunction.

M. Shimabukuro, N. Higa, T. Asahi, K. Yamakawa, Y. Oshiro, H. Masuzaki.

Diabetes Care ( その他の出版社 )  34   686 - 590   2011年

掲載種別: 研究論文（その他学術会議資料等）

NADPH を仲立ちとする酵素ネットワークに焦点を当てた脂肪組織機能異常の機序解明

その他の著者

研究報告書（医） ( 益崎裕章 )    2010年08月

掲載種別: 研究論文（その他学術会議資料等）

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2007年度～2009年度科学研究費補助金（基盤研究(Ｂ)）研究成果報告書 （管理者追加）リポジトリ登録情報を移行しました。確認のうえ、加除修正をしてください。

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Adipose Tissue-Specific Dysregulation of Angiotensinogen in Obese Humans and Mice - Impact of Nutritional Status and Adipocyte Hypertrophy -.

S. Yasue, H. Masuzaki, S. Okada, T. Ishii, C. Kozuka, T. Tanaka, J. Fujikura, K. Ebihara, K. Hosoda, A. Katsurada, N. Ohashi, M. Urushihara, H. Kobori, N. Morimoto, T. Kawazoe, M. Naitoh, M. Okada, H. Sakaue, S. Suzuki, K. Nakao.

Am. J. Hypertens. ( その他の出版社 )  23   425 - 431   2010年

掲載種別: 研究論文（その他学術会議資料等）

Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO, and MC4R and Their Effect on Visceral Fat Area in Japanese Population.

K. Hotta, M. Nakamura, T. Nakamura, T. Matsuo, Y. Nakata, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, M. Kawamoto, H. Masuzaki, T. Ueno, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, Y. Nakamura, N. Kamatani.

J. Hum. Genet ( その他の出版社 )  55   738 - 742   2010年

掲載種別: 研究論文（その他学術会議資料等）

Adipokine Orosomucoid Integrates Inflammatory and Metabolic Signals to Preserve Energy Homeostasis by Resolving Immoderate Inflammation.

YS. Lee, JW. Choi, JH. Lee, AY. Kim, JY. Huh, YJ. Koh, HJ. Son, H. Masuzaki, K. Hotta, GY. Koh, JB. Kim.

J. Biol. Chem. ( その他の出版社 )  285   22174 - 22185   2010年

掲載種別: 研究論文（その他学術会議資料等）

Adipose Tissue-Specific Dysregulation of Angiotensinogen by Oxidative Stress in Obesity.

S. Okada, C. Kozuka, H. Masuzaki, S. Yasue, T. Ishii-Yonemoto, T. Tanaka, Y. Yamamoto, M. Noguchi, T. Kusakabe, T. Tomita, J. Fujikura, K. Ebihara, K. Hosoda, H. Sakaue, H. Kobori, M. Ham, YS. Lee, JB. Kim, Y. Saito, K. Nakao.

Metabolism ( その他の出版社 )  59   1241 - 1251   2010年

掲載種別: 研究論文（その他学術会議資料等）

Glucocorticoid Reamplification within Cells Intensifies NFκB and MAPK Signaling and Reinforces Inflammation in Activated Preadipocytes.

T. Ishii-Yonemoto, H. Masuzaki, S. Yasue, S. Okada, C. Kozuka, T. Tanaka, M. Noguchi, T. Tomita, J. Fujikura, Y. Yamamoto, K. Ebihara, K. Hosoda, K. Nakao.

Am. J. Physiol. (Endocrinol Metab) ( その他の出版社 )  298   E930-E940   2010年

掲載種別: 研究論文（その他学術会議資料等）

The Ratio of the Blood Urea Nitrogen/CreatinineIndex in Patients with Acute Renal Failure is decreased due to Dextran or Mannitol.

T. Kouki, I. Komiya, H. Masuzaki.

Intern. Med. ( その他の出版社 )  49   223 - 226   2010年

掲載種別: 研究論文（その他学術会議資料等）

Effects of Benzbromarone and Allopurinol on Adiponectin in vivo and in vitro

T. Inokuchi, Z. Tsutsumi, S. Takahashi, T. Ka, A. Yamamoto, Y. Moriwaki, H. Masuzaki, T. Yamamoto.

Horm Metab. Res. ( その他の出版社 )  41   327 - 332   2009年

掲載種別: 研究論文（その他学術会議資料等）

Association between Obesity and Polymorphism in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2, and MC4R in a Japanese Population.

K. Hotta, M. Nakamura, T. Nakamura, T. Matsuo, Y. Nakata, S. Kamohara, N. Miyatake, K. Kotani, R. Komatsu, N. Itoh, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T. Funahashi, S. Miyazaki, K. Tokunaga, M. Kawamoto, T.Ueno, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y Matsuzawa, Y. Nakamura.

J. Hum. Genet ( その他の出版社 )  54   727 - 731   2009年

掲載種別: 研究論文（その他学術会議資料等）

Clinical Charactersitics and Efficacy of Pioglitazone in a Japanese Diabetic Patient with an Unusual Type of Famillial Partial Lipodystrophy.

M. Iwanishi, K. Ebihara, T. Kusakabe, W. Chew, J. Ito, H. Masuzaki, K. Hosoda, K. Nakao.

Metabolism ( その他の出版社 )  58   1681 - 1687   2009年

掲載種別: 研究論文（その他学術会議資料等）

Screening of 336 Single Nucleotide Polymorphisms (SNPs) in 85 Obesity-Related Genes Rrevealed McKusick-Kaufman Syndrome (MKKS) Gene Variants are Associated with Metabolic Syndrome.

K. Hotta, M. Nakamura, J. Takasaki, H. Takahashi, A. Takahashi, Y. Nakata, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, T. Funhashi, S. Miyazaki, K. Tokunaga, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, Y. Nakamura.

J. Hum. Genet ( その他の出版社 )  54   230 - 235   2009年

掲載種別: 研究論文（その他学術会議資料等）

Association Study of 11β-Hydroxysteroid Dehydrogenase Type 1 Gene Polymorphisms and Metabolic Syndrome in Urban Japanise Cohort.

Y. Miyamoto, H. Morisaki, I. Yamanaka, Y. Kokubo, H. Masuzaki, H. Tomike, Y. Yoshimasa, K. Nakao. T. Morisaki.

Diabetes. Res. Clin. Pract. ( その他の出版社 )  85   132 - 138   2009年

掲載種別: 研究論文（その他学術会議資料等）

Hypothalamic Melanocortin Signaling and Leptin Resistance - Perspective of Therapeutic Application for Obesity-Diabetes Syndrome -.

H. Masuzaki, T. Tanaka, K. Ebihara, K. Hosoda, K. Nakao.

Peptides ( その他の出版社 )  30   1383 - 1386   2009年

掲載種別: 研究論文（その他学術会議資料等）

11β-Estradiol inhibits 11β-hydroxysteroid dehydrogenase type 1 activity in rodent adipocytes.

N. Tagawa, R. Yura, S. Kubota, M. Wakabayashi, Y. Yamaguchi, N. Mori, E. Minamitani, H. Masuzaki, Y. Kobayashi.

J. Endocrinol. ( その他の出版社 )  202   131 - 139   2009年

掲載種別: 研究論文（その他学術会議資料等）

Beneficial Effects of Leptin on Glycemic and Lipid Control in a Mouse Model of Type 2 Diabetes with Increaseed Adiposity Induced by Steptozotocin and a High-Fat Diet.

T. Kusakabe, H. Tanioka, K. Ebihara, M. Hirata, L. Miyamoto, F. Miyanaga, H. Hige, D. Aotani, T. Fujisawa, H. Masuzaki, K. Hosoda, K. Nakao.

Diabetologia ( その他の出版社 )  52   675 - 683   2009年

掲載種別: 研究論文（その他学術会議資料等）

Index of Systemic Balance of End Products of Gllucocorticoid Metabolism in Fresh Urine from Humans: Its Potential Usefulness in the Evaluation of Obesity-Related Diseases.

N. Kobayashi, H. Masuzaki, T. Tanaka, S. Yasue, T. Ishii, N. Arai, T. Tomita, T. Miyawaki, T. Komeda, Y. Fukuda, N. Satoh, T. Kusakabe, M. Noguchi, J. Fujikura, F. Miyanaga, K. Ebihara, M. Hirata, K. Hosoda, H. Miyata, TS. Sato, K. Nakao.

Obes. Res. Clin. Pract. ( その他の出版社 )  3   53 - 63   2009年

掲載種別: 研究論文（その他学術会議資料等）

Neonatal Exposure to Leptin Augments Diet-induced obesity in Leptin-deficient ob/ob Mice

S. Yura, H. Itoh, N. Sagawa, H. Yamamoto, H. Masuzaki, K. Nakao, M. Kawamura, H. Mogami, Y. Ogawa, S. Fujii.

Obesity ( その他の出版社 )  16   1289 - 1295   2008年

掲載種別: 研究論文（その他学術会議資料等）

INSIG2 gene rs7566605 Polymorphism is Associated with Severe Obesity in the Japanese.

K. Hotta, M. Nakamura, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawmoto, T. Funahashi, K. Hmaguchi, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, K. Tanaka, N. Kamatani, Y. Nakamura.

J. Hum. Genet ( その他の出版社 )  53   857 - 862   2008年

掲載種別: 研究論文（その他学術会議資料等）

A Case of Cortisol Producing Adrenal Adenoma without Phenotype of Cushing's Syndrome due to Impaired 11β-Hydroxysteroid Dehydrogenase 1 Activity.

H. Arai, N. Kobayashi, Y. Nakatsuru, H. Masuzaki, T. Nanbu, K. Takaya, Y. Yamanaka, E. Kondo, G. Yamada, T. Fujii, M. Miura, Y. Komatsu, N. Kanamoto, H. Ariyasu, K. Moriyama, A. Yasoda, K. Nakao.

Endocrine J. ( その他の出版社 )  54   709 - 715   2008年

掲載種別: 研究論文（その他学術会議資料等）

Dysregulation of Adipose GPx3 in Obesity Contributes to Local and Systemic Oxidative Stress.

Y.S. Lee, A.Y. Kim, J.W. Choi, M. Kim, S. Yasue, H.J. Son, H. Masuzaki, K.S. Park, J.B. Kim.

Mol. Endocrinol. ( その他の出版社 )  9   2176 - 2189   2008年

掲載種別: 研究論文（その他学術会議資料等）

Variations in the FTO Gene are Associated with Severe Obesity in the Japanese.

K. Hotta, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Funahashi, K. Hamaguchi, K. Yamada, Y. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y.Matsuzawa, K. Tanaka, N. Kamatani, Y. Nakamura.

J. Hum. Genet ( その他の出版社 )  53   546 - 553   2008年

掲載種別: 研究論文（その他学術会議資料等）

Augmentation of 11β-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages - Role of 11β-HSD1 in pro-inflammatory properties in macrophages -

T. Ishii, H. Masuzaki, T. Tanaka, N. Arai, S. Yasue, N. Kobayashi, M. Noguchi, J. Fujikura, K. Ebihara, K. Hosoda, K. Nakao.

FEBS Lett. ( その他の出版社 )  581   349 - 354   2007年

掲載種別: 研究論文（その他学術会議資料等）

High-fat diet impaires the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle.

S. Tanaka, T. Hayashi, T. Toyoda, T. Hamada, Y. Shimizu, M. Hirata, K. Ebihara, H. Masuzaki, K. Hosoda, T. Fushiki, K. Nakao.

Metabolism ( その他の出版社 )  56   1719 - 1728   2007年

掲載種別: 研究論文（その他学術会議資料等）

Metabolic derangements in an adult patient with tetralogy of Fallot: Possible role of chronic systemic hypoxia.

E. Ebihara, H. Yasue, Y. Mizuno, T. Ito, S. Naritsugu, S. Yasue, H. Masuzaki.

Am. J. Med. Sci. ( その他の出版社 )  334   301 - 304   2007年

掲載種別: 研究論文（その他学術会議資料等）

Rbp-j Regulates Expansion of Pancreatic Epithelial Cells and Their Differentiation into Exocrine Cells during Mouse Development.

J. Fujikura, K. Hosoda, Y. Kawaguchi, M. Noguchi, H. Iwakura, S. Odori, E. Mori, T. Tomita, M. Hirata. K. Ebihara, H. Masuzaki, A. Fukuda, K. Furuyama, K. Tanigaki, D. Yabe, K. Nakao.

Dev. Dyn. ( その他の出版社 )  236   2779 - 2791   2007年

掲載種別: 研究論文（その他学術会議資料等）

Genetic and Pharmacological Inhibition of Rho-Associated Kinase II Enhances Adipogenesis.

M. Noguchi, K. Hosoda, J. Fujikura, M. Fujimoto, H. Iwakura, T. Tomita, T. Ishii, N. Arai, M. Hirata, K. Ebihara, H. Masuzaki, H. Itoh, S. Narumiya, K. Nakao.

J. Biol. Chem. ( その他の出版社 )  282   29574 - 29583   2007年

掲載種別: 研究論文（その他学術会議資料等）

Association of Single Nucleotide Polymorphism in MTMR9 Gene with Obesity.

T. Yanagiya, A. Tanabe, A. Iida, S. Saito, A. Sekine, A. Takahashi, T. Tsunoda, S. Kamohara, Y. Nakata, K. Kotani, R. Komatsu, N. Itoh, I. Mineo, J. Wada, H. Masuzaki, M. Yoneda, A. Nakajima, S. Miyazaki, K. Tokunaga, M. Kawamoto, T. Funahashi, K. Hamaguchi, K. Tanaka, K. Yamada, T. Hanafusa, S. Oikawa, H. Yoshimatsu, K. Nakao, T. Sakata, Y. Matsuzawa, N. Kamatani, Y. Nakamura, K. Hotta.

Hum Mol. Genet. ( その他の出版社 )  16   3017 - 3026   2007年

掲載種別: 研究論文（その他学術会議資料等）

Ceramide and AMP-activated Protein Kinase are Two Novel Regulators of 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Actovity in Cultured Preadipocytes.

N. Arai, H. Masuzaki, T. Tanaka, T. Ishii, S. Yasue, N. Kobayashi, T. Tomita, M. Noguchi, T. Kusakabe, H. Tanioka, H. Hige, F. Miyanaga, J. Fujikura, K. Ebihara, M. Hirata, K. Hosoda, H. Sawai, Y. Minokoshi, K. Nakao.

Endocrinology ( その他の出版社 )  148   5268 - 5277   2007年

掲載種別: 研究論文（その他学術会議資料等）

A case of secretin-responsive insulinoma with low serum C-peptide levels.

J. Fujikura, K. Hosoda, M. Noguchi, K. Ebihara, H. Masuzaki, M. Hirata, K. Fujimoto, R. Doi, M. Iwanishi, K. Nakao.

Endocrine J. ( その他の出版社 )  54   113 - 121   2007年

掲載種別: 研究論文（その他学術会議資料等）

Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphoylation in mice fed a high fat diet.

T. Tanaka, H. Masuzaki, S. Yasue, K. Ebihara, T. Shiuchi, T. Ishii, N. Arai, M. Hirata, H. Yamamoto, T. Hayashi, K. Hosoda, Y. Minokoshi, K. Nakao.

Cell Metabolism ( その他の出版社 )  5   395 - 402   2007年

掲載種別: 研究論文（その他学術会議資料等）

Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy.

K. Ebihara, T. Kusakabe, M. Hirata, H. Masuzaki, F. Miyanaga, N. Kobayashi, T. Tanaka, H. Chusho, T. Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, A.M. Depaoli, M. Fukushima, K. Nakao.

J. Clin. Endocrinol. Metab. ( その他の出版社 )  92   532 - 541   2007年

掲載種別: 研究論文（その他学術会議資料等）

Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.

L. Miyamoto, T. Toyoda, T. Hayashi, S. Yonemitsu, M. Nakano, S. Tanaka, K. Ebihara, H. Masuzaki K. Hosoda, Y. Ogawa, G. Inoue, T. Fushiki, K. Nakal.

J. Appl. Physiol. ( その他の出版社 )  102   1007 - 1013   2007年

掲載種別: 研究論文（その他学術会議資料等）

Bezafibrate regulates the expression and enzyme activity of 11β-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes.

S. Nakano, Y. Inada, H. Masuzaki, T. Tanaka, S. Yasue, T. Ishii, N. Arai, K. Ebihara, K. Hosoda, K. Maruyama, Y. Yamazaki, N. Shibata, K. Nakao.

Am. J. Physiol. (Endocrinol Metab) ( その他の出版社 )  292   E1213-E1222   2007年

掲載種別: 研究論文（その他学術会議資料等）

Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumors in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.

T. Tomita, H. Masuzaki, H. Iwakura, J. Fujikura, M. Noguchi, T. Tanaka, K. Ebihara, J. Kawamura, I. Komoto, Y. Kawaguchi, K. Fujimoto, R. Doi, H. Shimada, K. Hosoda, M. Imamura, K. Nakao.

Diabetologia ( その他の出版社 )  49   962 - 968   2006年

掲載種別: 研究論文（その他学術会議資料等）

Alpha2 isoform-specific activation of 5' adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.

M. Nakano, T. Hamada, T. Hayashi, S. Yonemitsu, L. Miyamoto, T. Toyoda, S. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, A. Otaka, T. Fushiki, K. Nakao.

Metabolism ( その他の出版社 )  55   300 - 308   2006年

掲載種別: 研究論文（その他学術会議資料等）

Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.

J. Fujikura, K. Hosoda, H. Iwakura, M. Noguchi, H. Masuzaki, K. Tanigaki, D. Yabe, T. Honjo, K. Nakao.

Cell Metabolism ( その他の出版社 )  3   1 - 7   2006年

掲載種別: 研究論文（その他学術会議資料等）

The G1057D variant of IRS-2 is associated with insulin resistance in Japanese patients with type 2 diabetes.

K. Okazawa, Y. Yoshimasa, T. Miyawaki, Y. Miyamoto, H. Masuzaki, K. Hosoda, G. Inoue, K. Nakao.

Diabetes Res Clin Pract ( その他の出版社 )  68   39 - 48   2005年

掲載種別: 研究論文（その他学術会議資料等）

Low-intensity contraction activates the α1 Isoform of 5'AMP-Activated protein kinase in rat skeletal muscle.

T. Toyoda, S. Tanaka, K. Ebihara, H. Masuzaki, K. Hosoda, K. Sato, T. Fushiki, K. Nakao, T. Hayashi.

Am. J. Physiol. (Endocrinol Metab) ( その他の出版社 )  290   E583-590   2005年

掲載種別: 研究論文（その他学術会議資料等）

Insulin-induced lipohypertrophy: Report of a case with histopathology.

J. Fujikura, M. Fujimoto, S. Yasue, M. Noguchi, H. Masuzaki, K. Hosoda, T. Tachibana, H. Sugihara, K. Nakao.

Endocrine J. ( その他の出版社 )  52   623 - 628   2005年

掲載種別: 研究論文（その他学術会議資料等）

A large amount of mRNA expression for G-protein-coupled fatty acid receptor, GPR40 in human insulinoma.

T. Tomita, H. Masuzaki, M. Noguchi, H. Iwakura, J. Fujikura, T. Tanaka, K. Ebihara, J. Kawamura, I. Komoto, Y. Kawaguchi, K. Fujimoto, R. Doi, Y. Shimada, K. Hosoda, M. Imamura, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  338   1788 - 1790   2005年

掲載種別: 研究論文（その他学術会議資料等）

Analysis of Rat Insulin II Promoter-Ghrelin Transgenic Mice and Rat Glucagon Promoter-Ghrelin Transgenic Mice.

H. Iwakura, K. Hosoa, C. Son, J. Fujikura,T. Tomita, M. Noguchi, H. Ariyasu, K. Takaya, H. Masuzaki, Y. Ogawa, T. Hayashi, G. Inoue, T. Akamizu, H. Hosoda, M. Kojima,H. Itoh, s. Toyokuni, K. Kanagawa, K. Nakao.

J. Biol. Chem. ( その他の出版社 )  280   15247 - 15256   2005年

掲載種別: 研究論文（その他学術会議資料等）

Rho-kinase is an Important Mediator of Insulin Action.

N. Furukawa, P. Ongusaha, W.J. Jahng, K. Araki, Choi C.S., H.J. Kim, Y.H. Lee, K. Kaibuchi, B.B. Kahn, H. Masuzaki, J.K. Kim, S.W. Lee, Y.B. Kim.

Cell Metabolism ( その他の出版社 )  2   119 - 129   2005年

掲載種別: 研究論文（その他学術会議資料等）

Role of Premature Leptin Surge in Obesity Resulting from Intrauterine Undernutrition.

S. Yura, H. Itoh, N. Sagawa, H. Yamamoto, H. Masuzaki, K. Nakao, M. Kawamura, M. Takemura, K. Kakui, Y. Ogawa, S. Fujii.

Cell Metabolism ( その他の出版社 )  1   371 - 378   2005年

掲載種別: 研究論文（その他学術会議資料等）

Skeletal muscle AMPK phosphorylation parallels metabolic phenotype in leptin transgenic mice under dietary modification.

T. Tanaka, S. Hidaka, H. Masuzaki, S. Yasue, Y. Minokoshi, K. Ebihara, H. Chusho, Y. Ogawa, T. Toyoda, K. Sato, F. Miyanaga, M. Fujimoto, T. Tomota, T. Kusakabe, N. Kobayashi, H. Tanioka, T. Hayashi, K. Hosoda, H. Yoshimatsu, T. Sakata, K. Nakao.

Diabetes ( その他の出版社 )  54   2365 - 2374   2005年

掲載種別: 研究論文（その他学術会議資料等）

CCAAT/enhancer binding protein α maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.

M. Fujimoto, H. Masuzaki, Y. Yamamoto, N. Norisada, M. Imori, M. Yoshimoto, T. Tomita, T. Tanaka, K. Okazawa, J. Fujikura, H. Chusho, K. Ebihara, T. Hayashi, K. Hosoda, G. Inoue, K. Nakao.

Biochem. Biophys. Acta. (Molecular Cell Research) ( その他の出版社 )  1745   38 - 47   2005年

掲載種別: 研究論文（その他学術会議資料等）

Transgenic expression of mutant peroxisome proliferator-activated receptor (PPAR) γ in liver precipitates fasting-induced steatosis but protects against high fat diet-induced stetosis in mice.

T. Tanaka, H. Masuzaki, K. Ebihara, Y. Ogawa, S. Yasue, H. Yukioka, H. Chusho, F. Miyanaga, T. Miyazawa, M. Fujimoto, T. Kusakabe, N. Kobayashi, T. Hayashi, K. Hosoda, K. Nakao.

Metabolism ( その他の出版社 )  54   1490 - 1498   2005年

掲載種別: 研究論文（その他学術会議資料等）

Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle.

C. Son, K. Hosoda, K. Ishihara, L. Bevilacqua, H. Masuzaki, T. Fushiki, M.E. Harper, K. Nakao.

Diabetologia ( その他の出版社 )  47   47 - 54   2004年

掲載種別: 研究論文（その他学術会議資料等）

Leptin Treatment on Various Kinds of Diabetes Mellitus.

H. Masuzaki, K. Ebihara, H. Chusho, T. Tanaka, K. Nakao.

International Proceedings, 12th International Congress of Endocrinology ( その他の出版社 )    257 - 261   2004年

掲載種別: 研究論文（その他学術会議資料等）

An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and Glut 4 protein expression in 3T3-L1 adipocytes.

M. Fujimoto, H. Masuzaki, T. Tanaka, S. Yasue, T. Tomita, N. Kobayashi, K. Okazawa, J. Fujikura, H. Chusho, K. Ebihara, T. Hayashi, K. Hosoda, K. Nakao.

FEBS Lett. ( その他の出版社 )  576   492 - 497   2004年

掲載種別: 研究論文（その他学術会議資料等）

Efficacy of long-term leptin replacement therapy for lipoatrophic diabetes in Japan.

K. Ebihara, H. Masuzaki, K. Nakao.

N. Eng. J. Med. ( その他の出版社 )  351   615 - 616   2004年

掲載種別: 研究論文（その他学術会議資料等）

Antidiabetic and adipogenic properties of a newly-synthesized thiazolidine derivative, FPFS-410.

N. Norisada, H. Masuzaki, M. Fujimoto, G. Inoue, K. Hosoda, T. Hayashi, M. Watanabe, S. Muraoka, F. Yoneda, K. Nakao.

Metabolism ( その他の出版社 )  53   1532 - 1537   2004年

掲載種別: 研究論文（その他学術会議資料等）

Possible involvement of the α1 Isoform of 5'AMP-Activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle.

T. Toyoda, T. Hayashi, L. Miyamoto, S. Yonemitsu, M. Nakano, S. Tanaka, K. Ebihara, H. Masuzaki, K. Hosoda, G. Inoue, A. Otaka, K. Sato, T. Fushiki, K. Nakao.

Am. J. Physiol. (Endocrinol Metab) ( その他の出版社 )  287   E166-E173   2004年

掲載種別: 研究論文（その他学術会議資料等）

Association of Ob-R gene polymorphism and insulin resistance in Japanese men.

A. Yasuno, H. Masuzaki, G. Inoue, T. Miyawaki, N. Matsuoka, Y. Ogawa, T. Hayashi, K. Hosoda, Y. Yoshimasa, K. Nakao.

Metabolism ( その他の出版社 )  53   650 - 654   2004年

掲載種別: 研究論文（その他学術会議資料等）

Gene and phenotype analysis of congenital generalized lipodystrophy in Japanese; A novel homozygous nonsense mutation in seipin gene.

K. Ebihara, T. Kusakabe, H. Masuzaki, N. Kobayashi, T. Tanaka, H. Chusho, F. Miyanaga, T. Miyazawa, T. Hayashi, K. Hosoda, Y. Ogawa, K. Nakao.

J. Clin. Endocrinol. Metab. ( その他の出版社 )  89   2360 - 2364   2004年

掲載種別: 研究論文（その他学術会議資料等）

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type-1 deficient mice.

N.M. Morton, J.M. Paterson, H. Masuzaki, M.C. Holmes, B. Staels, C. Fievet, B.R. Walker, J.S. Flier, J.J. Mullins, J.R. Seckl.

Diabetes ( その他の出版社 )  53   931 - 938   2004年

掲載種別: 研究論文（その他学術会議資料等）

Effects of obstructive sleep apnea syndrome on serum amino-transferase levels in obese patients.

K. Chin, T. Nakamura, K. Takahashi, K. Sumi, Y. Ogawa, H. Masuzaki, S. Muro, N. Hattori, H. Matsumoto, A. Niimi, T. Chiba, K. Nakao, M. Mishima, M. Ohi, T. Nakamura.

Am. J. Med. ( その他の出版社 )  114   370 - 376   2003年

掲載種別: 研究論文（その他学術会議資料等）

Leptin receptor (Ob-R) Arg223Gln polymorphism is associated withserum cholesterol elevation and ipairment of cholesterol lowering effect by simvastatin in Japanese men.

A. Takahashi-Ysuno, H. Masuzaki, T. Miyawaki, Y. Ogawa, N. Matsuoka, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, K. Nakao.

Diabetes Res. Clin. Pract. ( その他の出版社 )  62   169 - 175   2003年

掲載種別: 研究論文（その他学術会議資料等）

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

H. Masuzaki, H. Yamamoto, C.J. Kenyon, J.K. Elmquist, N.M.Morton, J.M. Paterson, H. Shinyama, M. Sharp, S. Fleming, J.J. Mullins, J.R. Seckl, J.S. Flier.

J. Clin. Invest. ( その他の出版社 )  112   83 - 90   2003年

掲載種別: 研究論文（その他学術会議資料等）

Tissue-specific glucocorticoid reactivating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). -A promising drug target for the treatment of the Metabolic Syndrome-

H. Masuzaki, J.S. Flier.

Curr. Drug Targets Immune Endocrinol. Metab. Disord. ( その他の出版社 )  3   255 - 262   2003年

掲載種別: 研究論文（その他学術会議資料等）

Regulation of melanocortin-4 receptor signaling: Agonist-mediated desensitization and internalization.

H. Shinyama, H. Masuzaki, H. Fang, J.S. Flier.

Endoclinology ( その他の出版社 )  144   1301 - 1314   2003年

掲載種別: 研究論文（その他学術会議資料等）

Leptin as an adjunct of insulin therapy in insulin-deficient diabetes.

F. Miyanaga, Y. Ogawa, K. Ebihara, S. Hidaka, T. Tanaka, S. Hayashi, H. Masuzaki, K. Nakao.

Diabetologia ( その他の出版社 )  46   1329 - 1337   2003年

掲載種別: 研究論文（その他学術会議資料等）

Characterization of short isoforms of leptin receptor in rat cerebral microvessels and of leptin uptake in mouse models of obesity.

S.M. Hileman, D.D. Pierroz, H. Masuzaki, C. Bjorbaek, K. El-Hashimi, W.A. Banks, J.S. Flier.

Endocrinology ( その他の出版社 )  143   775 - 783   2002年

掲載種別: 研究論文（その他学術会議資料等）

Possible role of placental leptin in pregnancy.

N. Sagawa, S. Yura, H. Itoh, K. Kakui, M. Tamura, M.A. Nuamah, Y. Ogawa, H. Masuzaki, K. Nakao, S. Fujii.

Endocrine J. ( その他の出版社 )  19   65 - 71   2002年

掲載種別: 研究論文（その他学術会議資料等）

Role of leptin in pregnancy- a review.

N. Sagawa, S. Yura, H. Itoh, H. Mise, K. Kakui, D. Korita, M. Takemura, M.A. Nuamah, Y. Ogawa, H. Masuzaki, K. Nakao, S. Fujii.

Placenta ( その他の出版社 )  23 ( Suppl. A ) S80-86   2002年

掲載種別: 研究論文（その他学術会議資料等）

Plasama leptin levels and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome.

K. Shimizu, K. Chin, T. Nakamura, H. Masuzaki, Y. Ogawa, R. Hosokawa, A. Niimi, N. Hattori, R. Nohara, S. Sasayama, K. Nakao, M. Mishima, T. Nakamura, M. Ohi.

Thorax ( その他の出版社 )  57   429 - 434   2002年

掲載種別: 研究論文（その他学術会議資料等）

Leptin inhibits stress-induced apoptosis of T lymphocytes.

Y. Fujita, M. Murakami, Y. Ogawa, H. Masuzaki, M. Tanaka, S. Ozaki, K. Nakao, T. Mimori.

Clin. Exp. Immunol. ( その他の出版社 )  128   21 - 26   2002年

掲載種別: 研究論文（その他学術会議資料等）

Pathophysiological role of leptin in lifestyle-related diseases. Studies with transgenic skinny mice overexpressing leptin.

Y. Ogawa, H. Masuzaki, K. Ebihara, M. Shintani, M. Aizawa-Abe, F. Miyanaga, K. Nakao.

J. Diabetes Complications ( その他の出版社 )  16   119 - 122   2002年

掲載種別: 研究論文（その他学術会議資料等）

Transgenic approach toward leptin biology - Clinical implication of leptin for the treatment of obesity-associated diabetes and obesity-related hypertension -

H. Masuzaki, Y. Ogawa, M. Aizawa-Abe, K. Nakao.

Endocrine J. ( その他の出版社 )  49   109 - 119   2002年

掲載種別: 研究論文（その他学術会議資料等）

Clinical implication of leptin and its potential humoral regulators in long-term low calorie diet therapy for obese humans.

T. Miyawaki, H. Masuzaki, Y. Ogawa, K. Hosoda, H. Nishimura, N. Azuma, A. Sugawara, I. Masuda, M. Murata, T. Matsuo, T. Hayashi, G. Inoue, Y. Yoshimasa, K. Nakao.

Eur. J. Clin. Nutr. ( その他の出版社 )  56   593 - 600   2002年

掲載種別: 研究論文（その他学術会議資料等）

Simultaneous onset of type 1 diabetes mellitus and painless thyroditis following acute pancreatitis.

G. Inoue, T. Sakurai, K. Tanaka, T. Akamizu, H. Masuzaki, K. Hosoda, T. Hayashi, Y. Yoshimasa, K. Nakao.

Intern. Med. ( その他の出版社 )  40   515 - 518   2001年

掲載種別: 研究論文（その他学術会議資料等）

A transgenic model of visceral obesity and the metabolic syndrome.

H. Masuzaki, J. Paterson, H. Shinyama, N.M. Morton, J.J. Mullins, J.R. Seckl, J.S. Flier.

Science ( その他の出版社 )  294   2166 - 2170   2001年

掲載種別: 研究論文（その他学術会議資料等）

Up-regulation of UCP3 gene expression by fatty acids and agonists for peroxisome proliferator-activated receptors in L6 myotubes.

C. Son, K. Hosoda, J. Matsuda, J. Fujikura, S. Yonemitsu, H. Iwakura, H. Masuzaki, Y. Ogawa, T. Hayashi, H. Itoh, H. Nishimura, G. Inoue, Y. Yoshimasa, Y. Yamori, K. Nakao.

Endocrinology ( その他の出版社 )  143   4189 - 4194   2001年

掲載種別: 研究論文（その他学術会議資料等）

Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin.

N. Matsuoka, Y. Ogawa, H. Masuzaki, K. Ebihara, M. Aizawa-Abe, N. Satoh, E. Ishikawa, Y. Fujisawa, A. Kosaki, K. Yamada, H. Kuzuya, K. Nakao.

Am. J. Physiol. (Endocrinol Metab) ( その他の出版社 )  280   E334-339   2001年

掲載種別: 研究論文（その他学術会議資料等）

Troglitazone induces GLUT4 translocation in L6 Myotubes.

S. Yonemitsu, H. Nishimura, M. Shintani, R. Inoue, Y. Yamamoto, H. Masuzaki, Y. Ogawa, K. Hosoda, G. Inoue, T. Hayashi, K. Nakao.

Diabetes ( その他の出版社 )  50   1093 - 1101   2001年

掲載種別: 研究論文（その他学術会議資料等）

Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.

K. Ebihara, Y. Ogawa, H. Masuzaki, M. Shintani, F. Miyanaga, M. Aizawa-Abe, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, O. Gavrilova, ML. Reitman, K. Nakao.

Diabetes ( その他の出版社 )  50 ( 6 ) 1440 - 1448   2001年

掲載種別: 研究論文（その他学術会議資料等）

Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate.

M. Shintani, H. Nishimura, S. Yonemitsu, H. Masuzaki, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, K. Naka.

Metabolism ( その他の出版社 )  49   326 - 330   2000年

掲載種別: 研究論文（その他学術会議資料等）

Disruption of klotho gene causes an abnormal energy homeostasis in mice.

K. Mori, K. Yahata, M. Mukoyama, T. Suganami, H. Makino, T. Nagae, H. Masuzaki, Y. Ogawa, A. Sugawara, Y. Nabeshima, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  278   665 - 670   2000年

掲載種別: 研究論文（その他学術会議資料等）

Constitutively active mitogen-activated protein kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes.

Y. Yamamoto, Y. Yoshimasa, M. Koh, J. Suga, H. Masuzaki, Y. Ogawa, K. Hosoda, H. Nishimura, Y. Watanabe, G. Inoue, K. Nakao.

Diabetes ( その他の出版社 )  49   332 - 339   2000年

掲載種別: 研究論文（その他学術会議資料等）

Pathophysiologic role of leptin in obesity-related hypertension.

M. Aizawa-Abe, Y. Ogawa, H. Masuzaki, K. Ebihara, N. Satoh, H. Iwai, N. Matsuoka, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa, K. Nakao.

J. Clin. Invest. ( その他の出版社 )  105   1243 - 1252   2000年

掲載種別: 研究論文（その他学術会議資料等）

Accelerated puberty and late onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin.

S. Yura, Y. Ogawa, N. Sagawa, H. Masuzaki, H. Itoh, K. Ebihara, M. Aizawa-Abe, S. Fujii, K. Nakao.

J. Clin. Invest. ( その他の出版社 )  105   749 - 755   2000年

掲載種別: 研究論文（その他学術会議資料等）

Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal Yellow agouti mutation. -Usefulness of leptin for the treatment of obesity-associated diabetes-.

H. Masuzaki, Y. Ogawa, M. Aizawa-Abe, K. Hosoda, J. Suga, K. Ebihara, N. Satoh, H. Iwai, G. Inoue, H. Nishimura, Y. Yoshimasa, K. Nakao.

Diabetes ( その他の出版社 )  48   1615 - 1622   1999年

掲載種別: 研究論文（その他学術会議資料等）

Potential usefulness of leptin for the treatment of diabetes.

K. Nakao, Y. Ogawa, H. Masuzaki, M. Aizawa-Abe, K. Ebihara, N. Matsuoka, N. Satoh, T. Hayashi, K. Hosoda, G. Inoue, Y. Yoshimasa.

Common Diabetes: Genetic and Pathogenic Aspects of Multifactorial Diseases ( その他の出版社 )    21 - 30   1999年

掲載種別: 研究論文（その他学術会議資料等）

Thyrotropin decreases leptin production in rat adipocytes.

M. Shintani, H. Nishimura, T. Akamizu, S. Yonemitsu, H. Masuzaki, Y. Ogawa, K. Hosoda, G. Inoue, Y. Yoshimasa, K. Nakao.

Metabolism ( その他の出版社 )  48   1570 - 1574   1999年

掲載種別: 研究論文（その他学術会議資料等）

Leptin is a novel placenta-derived hormone in humans

N. Sagawa, H. Mise, S. Yura, H. Itoh, T. Matsumoto, W. Liu, M.A. Nuamah, M. Fukuoka, S. Fujii, Y. Ogawa, H. Masuzaki, K. Hosoda, K. Nakao.

Taiwanese Journal of Obstetrics and Gynecology ( その他の出版社 )  38   1 - 10   1999年

掲載種別: 研究論文（その他学術会議資料等）

Leptin as a novel placenta-derived hormone in humans. -A review-

N. Sagawa, H. Itoh, T. Matsumoto, H. Mise, W. Liu, M.A. Nuamah, S. Yura, M. Fukuoka, S. Fujii, Y. Ogawa, H. Masuzaki, K. Hosoda, K. Nakao.

Trophoblast Research ( その他の出版社 )  13   25 - 34   1999年

掲載種別: 研究論文（その他学術会議資料等）

Leptin, a novel placenta-derived hormone in humans.

Y. Ogawa, N. Sagawa, H. Masuzaki, S. Yura, H. Mise, K. Ebihara, S. Fujii, K. Nakao.

Progress in Obesity Research ( その他の出版社 )  8   71 - 75   1999年

掲載種別: 研究論文（その他学術会議資料等）

Leptin as an adipocyte- and nonadipocyte- derived hormone.

Y. Ogawa, H. Masuzaki, N. Sagawa, K. Nakao.

Nutrition, Genetics, and Obesity ( その他の出版社 )  9   147 - 155   1999年

掲載種別: 研究論文（その他学術会議資料等）

Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor in leptin action.

K. Ebihara, Y. Ogawa, G. Katsuura, Y. Numata, H. Masuzaki, N. Satoh, M. Tamaki, T. Yoshioka, M. Hayase, N. Matsuoka, M. Aizawa-Abe, Y. Yoshimasa, K. Nakao.

Diabetes ( その他の出版社 )  48   2028 - 2033   1999年

掲載種別: 研究論文（その他学術会議資料等）

Clinical implication of leptin, the obese gene product.

Y. Ogawa, H. Masuzaki, K. Nakao

Intern. Med. ( その他の出版社 )  38   210 - 212   1999年

掲載種別: 研究論文（その他学術会議資料等）

Sympathetic activation of leptin via the ventromedial hypothalamus: Leptin-induced increase in catecholoamine secretion.

N. Satoh, Y. Ogawa, G. Katsuura, Y. Numata, T. Tsuji, M. Hayase, K. Ebihara, H. Masuzaki, K. Hosoda, Y. Yoshimasa, K. Nakao.

Diabetes ( その他の出版社 )  48   1787 - 1793   1999年

掲載種別: 研究論文（その他学術会議資料等）

Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy.

K. Chin, K. Shimizu, T. Nakamura, N. Narai, H. Masuzaki, Y. Ogawa, M. Mishima, T. Nakamura, K. Nakao, M. Ohi.

Circulation ( その他の出版社 )  100   706 - 712   1999年

掲載種別: 研究論文（その他学術会議資料等）

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

H. Masuzaki, Y. Ogawa, K. Hosoda, M. Abe, J. Suga, M. Suda, K. Ebihara, H. Iwai, N. Matsuoka, N. Satoh, H. Odaka, H. Kasuga, Y. Fujisawa, G. Inoue, H. Nishimura, Y. Yoshimasa, K. Nakao.

Diabetes ( その他の出版社 )  48   1822 - 1829   1999年

掲載種別: 研究論文（その他学術会議資料等）

A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth.

S. Yura, N. Sagawa, H. Mise, T. Mori, H. Masuzaki, Y. Ogawa, K. Nakao.

Am. J. Obestet. Gynecol. ( その他の出版社 )  178   926 - 930   1998年

掲載種別: 研究論文（その他学術会議資料等）

Development of a sensitive ELISA for human leptin using monoclonal antibodies.

K. Imagawa, Y. Matsumoto, Y. Numata, A. Morita, S. Kikuoka, M. Tamaki, C. Higashikubo, T. Tsuji, K. Sasakura, H. Teraoka, H. Masuzaki, K. Hosoda, Y. Ogawa, K. Nakao.

Clin. Chem. ( その他の出版社 )  44 ( 10 ) 2165 - 2171   1998年

掲載種別: 研究論文（その他学術会議資料等）

Augmentation of leptin synthesis an secretion through activation of protein kinases A and C in cultured human trophoblastic cells.

S. Yura, N. Sagawa, Y. Ogawa, H. Masuzaki, H. Mise, T. Matsumoto, K. Ebihara, S. Fujii, K. Nakao.

J. Clin. Endocrinol. Metab. ( その他の出版社 )  83   3609 - 3614   1998年

掲載種別: 研究論文（その他学術会議資料等）

Augmented placental production of leptin in pre-eclampsia: Possible involvement of placental hypoxia.

H. Mise, N. Sagawa, T. Matsumoto, S. Yura, H. Nanno, H. Itoh, T. Mori, H. Masuzaki, K. Hosoda, Y. Ogawa, K. Nakao.

J. Clin. Endocrinol. Metab. ( その他の出版社 )  83   3225 - 3229   1998年

掲載種別: 研究論文（その他学術会議資料等）

Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system.

N. Satoh, Y. Ogawa, G. Katsuura, Y. Numata, H. Masuzaki, Y. Yoshimasa, K. Nakao.

Neurosci. Lett. ( その他の出版社 )  249   107 - 110   1998年

掲載種別: 研究論文（その他学術会議資料等）

The significance of the Trp64Arg mutation of the β3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus and insulin resistance in Japanese subjects.

N. Azuma, Y. Yoshimasa, H. Nishimura, Y. Yamamoto, H. Masuzaki, J. Suga, M. Shigemoto, N. Matsuoka, T. Tanaka, N. Satoh, T. Igaki, Y. Miyamoto, H. Itoh, T. Yoshimasa, K. Hosoda, S. Nishi, K. Nakao.

Metabolism ( その他の出版社 )  47   456 - 460   1998年

掲載種別: 研究論文（その他学術会議資料等）

Glucocorticoid regulation of leptin sysnthesis and secretion in humans. - Elevated plasma leptin levels in Cushing's syndrome.-

H. Masuzaki, Y. Ogawa, K. Hosoda, T. Miyawaki, I. Hanaoka, J. Hiraoka, A. Yasuno, H. Nishimura, Y. Yoshimasa, S. Nishi, K. Nakao.

J. Clin. Endocrinol. Metab. ( その他の出版社 )  82   2542 - 2547   1997年

掲載種別: 研究論文（その他学術会議資料等）

Molecular screening of both the promoter and the protein coding regions in the human ob gene in Japanese obese subjects with non-insulin-dependent diabetes mellitus (NIDDM).

T. Tanaka, N. Azuma, H. Masuzaki, H. Nishimura, Y. Yoshimasa, K. Hosoda, K. Nakao.

Eur. J. Endocrinol. ( その他の出版社 )  137   511 - 513   1997年

掲載種別: 研究論文（その他学術会議資料等）

Identification of the human leptin 5'-flanking sequences involved in the trophoblast-specific transcription.

K. Ebihara, Y. Ogawa, N. Isse, K. Mori, N. Tamura, H. Masuzaki, K. Kohno, S. Yura, K. Hosoda, N. Sagawa, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  241   658 - 663   1997年

掲載種別: 研究論文（その他学術会議資料等）

Augmentation of obese (ob) gene expression and leptin secretion in obese spontaneously hypertensive rats (obese SHR or Koletsky rat).

J. Hiraoka, K. Hosoda, Y. Ogawa, K. Ikeda, Y. Nara, H. Masuzaki, K. Takaya, K. Nakagawa, T. Mashimo, M. Sawamura, R.J. Koletsky, Y. Yamori, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  231   582 - 585   1997年

掲載種別: 研究論文（その他学術会議資料等）

Human leptin receptor gene in obese Japanese subjects. Evidence against either obesity-causing mutations or association of sequence variants with obesity.

N. Matsuoka, Y. Ogawa, K. Hosoda, J. Matsuda, H. Masuzaki, T. Miyawaki, N. Azuma, K. Natui, H. Nishimura, Y. Yoshimasa, S. Nishi, D.B. Thompson, K. Nakao.

Diabetologia ( その他の出版社 )  40   1204 - 1210   1997年

掲載種別: 研究論文（その他学術会議資料等）

Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: Evidence for loss of its satiety effect in VMH-lesioned rats.

N. Satoh, Y. Ogawa, G. Katsuura, T. Tsuji, H. Masuzaki, J. Hiraoka, T. Okazaki, M. Tamaki, M. Hayase, Y. Yoshimasa, S. Nishi, K. Hosoda, K. Nakao.

Endocrinology ( その他の出版社 )  138   947 - 954   1997年

掲載種別: 研究論文（その他学術会議資料等）

Leptin production by hydatidiform mole.

N. Sagawa, T. Mori, H. Masuzaki, Y. Ogawa, K. Nakao.

Lancet ( その他の出版社 )  350   1518 - 1519   1997年

掲載種別: 研究論文（その他学術会議資料等）

Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans.

H. Masuzaki, Y. Ogawa, N. Sagawa, K. Hosoda, T. Matsumoto, H. Mise, H. Nishimura, Y. Yoshimasa, I. Tanaka, T. Mori, K. Nakao.

Nature Med. ( その他の出版社 )  3   1029 - 1033   1997年

掲載種別: 研究論文（その他学術会議資料等）

Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart.

H. Masuzaki, H. Jingami, N. Matsuoka, O. Nakagawa, Y. Ogawa, M. Mizuno, Y. Yoshimasa, T. Yamamoto, K. Nakao.

Circ. Res. ( その他の出版社 )  78   8 - 14   1996年

掲載種別: 研究論文（その他学術会議資料等）

Molecular cloning of rat leptin receptor isoform complementary DNAs-Identification of a missense mutation in Zucker fatty (fa/fa) rats.

K. Takaya, Y. Ogawa, N. Isse, T. Okazaki, N. Satoh, H. Masuzaki, K. Mori, N. Tamura, K. Hosoda, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  225   75 - 83   1996年

掲載種別: 研究論文（その他学術会議資料等）

Effects of gemfibrozil administration on very low density lipoprotein receptor mRNA levels in rabbits.

N. Matsuoka, H. Jingami, H. Masuzaki, M. Mizuno, S. Nakaishi, J. Suga, T. Tanaka, T. Yamamoto, K. Nakao.

Atherosclerosis ( その他の出版社 )  126   221 - 226   1996年

掲載種別: 研究論文（その他学術会議資料等）

Development of radioimmunoassay for human leptin.

K. Hosoda, H. Masuzaki, Y. Ogawa, T. Miyawaki, J. Hiraoka, I. Hanaoka, A. Yasuno, T. Nomura, Y. Fujisawa, Y. Yoshimasa, S. Nishi, Y. Yamori, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  221   234 - 239   1996年

掲載種別: 研究論文（その他学術会議資料等）

Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (fa/fa) rats.

H. Masuzaki, K. Hosoda, Y. Ogawa, M. Shigemoto, N. Satoh, K. Mori, N. Tamura, S. Nishi, Y. Yoshimasa, Y. Yamori, K. Nakao.

FEBS Lett. ( その他の出版社 )  378   267 - 271   1996年

掲載種別: 研究論文（その他学術会議資料等）

Adipose tissue-specific expression of the obese (ob) gene in rats and its marked augmentation in genetically obese-hyperglycemic Wistar fatty rats.

H. Masuzaki, Y. Ogawa, M. Shigemoto, N. Satoh, K. Mori, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, K. Nakao.

Proc. Jpn. Acad. ( その他の出版社 )  71 ( Ser. B ) 148 - 152   1995年

掲載種別: 研究論文（その他学術会議資料等）

Structural organization and chromosomal assignment of the human obese gene.

N. Isse, Y. Ogawa, N. Tamura, H. Masuzaki, K. Mori, T. Okazaki, N. Satoh, M. Shigemoto, Y. Yoshimasa, S. Nishi, K. Hosoda, J. Inazawa, K. Nakao.

J. Biol. Chem. ( その他の出版社 )  270   27728 - 27733   1995年

掲載種別: 研究論文（その他学術会議資料等）

Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats.

Y. Ogawa, H. Masuzaki, N. Isse, T. Okazaki, K. Mori, M. Shigemoto, N. Satoh, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, K. Nakao.

J. Clin. Invest. ( その他の出版社 )  96   1647 - 1652   1995年

掲載種別: 研究論文（その他学術会議資料等）

Decreased expression of the very low density lipoprotein receptor mRNA in the cardiac ventricle of spontaneously hypertensive rats.

H. Jingami, H. Masuzaki, N. Matsuoka, O. Nakagawa, Y. Ogawa, M. Mizuno, T. Yamamoto, K. Nakao.

Clin. Exp. Pharmacol. Physiol. ( その他の出版社 )  Suppl. 1   S246-S248   1995年

掲載種別: 研究論文（その他学術会議資料等）

Augmented expression of the obese gene in the adipose tissue from rats fed high-fat diet.

H. Masuzaki, Y. Ogawa, K. Hosoda, T. Kawada, T. Fushiki, K. Nakao.

Biochem. Biophys. Res. Commun. ( その他の出版社 )  216   355 - 358   1995年

掲載種別: 研究論文（その他学術会議資料等）

Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue.

H. Masuzaki, Y. Ogawa, N. Isse, N. Satoh, T. Okazaki, M. Shigemoto, K. Mori, N. Tamura, K. Hosoda, Y. Yoshimasa, H. Jingami, T. Kawada, K. Nakao.

Diabetes ( その他の出版社 )  44   855 - 858   1995年

掲載種別: 研究論文（その他学術会議資料等）

Effects of estradiol on very low density lipoprotein receptor mRNA levels in rabbit heart.

H. Masuzaki, H. Jingami, T. Yamamoto, K. Nakao.

FEBS Lett. ( その他の出版社 )  347   211 - 214   1994年

掲載種別: 研究論文（その他学術会議資料等）