論文 - 益崎　裕章

Two Cases of Plasmablastic Myeloma Mimicking Plasmablastic Lymphoma With In-Depth Review of Literature.

Kitamura S, Morichika K, Nakachi S, Hanashiro T, Miyagi R, Nakajima T, Nishi Y, Tamaki K, Fukushima T, Masuzaki H

Cancer reports (Hoboken, N.J.) ( Cancer Reports )  8 ( 2 ) e70094   2025年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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[Intramuscular abscess and multiple lymphadenitis due to Nocardia asiatica infection requiring differential diagnosis from smoldering adult T-cell leukemia/lymphoma].

Yamashiro M, Nakajima T, Irei Y, Miyagi R, Kitamura S, Tamaki K, Nishi Y, Morichika K, Nakachi S, Maehara H, Fukushima T, Masuzaki H

[Rinsho ketsueki] The Japanese journal of clinical hematology ( 一般社団法人 日本血液学会 )  66 ( 2 ) 121 - 126   2025年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p>左上腕三頭筋の腫瘤を主訴に来院した72歳男性。切開術を施行し排膿を認めた。病理検査で悪性所見はなく起因微生物の同定にも到らずcefazolinも無効であった。追加のCT検査で全身性リンパ節腫脹を，血液検査でHTLV-1抗体を検出。末梢血単核球でHTLV-1プロウイルスのモノクロナリティを確認した。左腋窩リンパ節の再生検でも異常細胞は確認されず成人T細胞白血病・リンパ腫くすぶり型と診断。膿培養の延長を行い<i>Nocardia</i> sp.を検出。16S rRNA解析で<i>Nocardia asiatica</i>を同定。薬剤感受性試験の結果を踏まえてST合剤とminocyclineを開始し，3ヶ月で全身性リンパ節腫脹は改善した。多発リンパ節腫脹を呈する<i>Nocardia asiatica</i>感染症の報告は極めて稀であるが免疫能低下を背景とした全身性リンパ節腫脹の鑑別診断で考慮することが重要である。</p>

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A Rare Case of Autoimmune-Mediated Lecithin:Cholesterol Acyltransferase Insufficiency Manifesting as the Acute Onset of Extremely Hypo-High-Density Lipoprotein-Cholesterolemia and Spontaneous Improvement: A Case Report with a Review of the Literature.

Tamaki A, Kuroda M, Yonaha K, Ishiki Y, Uehara M, Nakayama Y, Honma KI, Chinen R, Uema T, Okamoto S, Miyoshi J, Kirinashizawa M, Sato K, Aohara T, Yamamoto M, Maezawa Y, Yokote K, Masuzaki H

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  advpub ( 0 )   2024年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A 59-year-old Japanese woman was referred for an extremely low level of circulating high-density lipoprotein cholesterol (HDL-C). The serum HDL-C level had long been within the normal range but suddenly decreased asymptomatically to 7 mg/dL. She had no typical symptoms associated with familial lecithin, cholesterol acyltransferase deficiency (FLD), including proteinuria, anemia, and corneal opacity. The circulating level of ApoA-1 was also markedly decreased at 48 mg/dL, and the proportion of esterified cholesterol to free cholesterol was irregularly low at 26%. Whole-genome sequencing revealed no apparent pathological mutations in the LCAT gene. Notably, anti-LCAT antibodies were detected in the serum at 146±1.7 ng/mL, resulting in her being diagnosed with acquired LCAT insufficiency (ALCATI) caused by anti-LCAT antibodies. Five years after her HDL-C levels spontaneously decreased, they increased without any identifiable cause. To our knowledge, only six cases of ALCATI caused by anti-LCAT antibodies have been reported to date. In contrast to the present case, previously reported cases of ALCATI manifested proteinuria that improved with steroid therapy. The unique clinical course in the present case highlights the heterogeneity of ALCATI, warranting further research to clarify the molecular pathophysiology of FLD and ALCATI.

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Machine learning-based reproducible prediction of type 2 diabetes subtypes.

Tanabe H, Sato M, Miyake A, Shimajiri Y, Ojima T, Narita A, Saito H, Tanaka K, Masuzaki H, Kazama JJ, Katagiri H, Tamiya G, Kawakami E, Shimabukuro M

Diabetologia ( Diabetologia )  67 ( 11 ) 2446 - 2458   2024年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Young-onset type 2 diabetes mellitus enhances proteinuria, but not glomerular filtration rate decline: A Japanese cohort study.

Saito H, Tanabe H, Hirai H, Higa M, Tanaka K, Yamaguchi S, Maimaituxun G, Masuzaki H, Kazama JJ, Shimabukuro M

Journal of diabetes investigation ( Journal of Diabetes Investigation )  15 ( 10 ) 1444 - 1456   2024年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Gut microbiota-based prediction for the transition from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) in a remote island cohort study.

Uema T, Tsukita M, Okamoto S, Uehara M, Honma KI, Nakayama Y, Tamaki A, Miyazato M, Ashikari A, Maeda S, Imamura M, Matsushita M, Nakamura K, Masuzaki H

Diabetes research and clinical practice ( Diabetes Research and Clinical Practice )  213   111747 - 111747   2024年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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AIM: The present cohort study explored whether specific gut microbiota (GM) profile would predict the development of impaired glucose tolerance (IGT) in individuals with normal glucose tolerance (NGT). METHODS: A total of 114 study subjects with NGT in Kumejima island, Japan participated in the present study and underwent 75 g oral glucose tolerance tests at baseline and one year later. We compared the profile of GM at baseline between individuals who consistently maintained NGT (NRN, n = 108) and those who transitioned from NGT to IGT (NTI, n = 6). RESULTS: Within-individual bacterial richness and evenness as well as inter-individual bacterial composition showed no significant differences between NRN and NTI. Of note, however, partial least squares discriminant analyses revealed distinct compositions of GM between groups, with no overlap in their 95 % confidence interval ellipses. Multi-factor analyses at the genus level demonstrated that the proportions of CF231, Corynebacterium, Succinivibrio, and Geobacillus were significantly elevated in NTI compared to NRN (p < 0.005, FDR < 0.1, respectively) after adjusting for age, sex, HbA1c level, and BMI. CONCLUSIONS: Our data suggest that increased proportion of specific GM is linked to the future deterioration of glucose tolerance, thereby serving as a promising predictive marker for type 2 diabetes mellitus.

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Impact of the transition from radioimmunoassay (RIA) to chemiluminescent enzyme immunoassay (CLEIA) for the measurement of plasma aldosterone concentration (PAC) on the diagnosis of primary aldosteronism (PA) via retrospective analyses in Okinawa, Japan.

Honma KI, Nakayama Y, Tamaki A, Uehara M, Teruya T, Yabiku T, Ishiki Y, Yonaha K, Chinen R, Uema T, Okamoto S, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 895 - 906   2024年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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In Japan, the traditional method for measuring plasma aldosterone concentration (PAC) was radioimmunoassay (RIA), which had several challenges, including poor traceability of certified reference materials and reduced detection sensitivity at low concentrations. To overcome these issues, a chemiluminescent enzyme immunoassay (CLEIA) for PAC measurement was introduced in April 2021 and the Japan Endocrine Society published new guidelines for primary aldosteronism (PA). This study aimed to evaluate the impact of the transition from RIA to CLEIA for PAC measurement on PA diagnosis. Data from 190 patients admitted to the Second Department of Internal Medicine, University of the Ryukyus Hospital, between April 2012 and March 2021 were analyzed. Patients who were diagnosed with PA underwent adrenal venous sampling. The PAC measured by RIA (PAC(RIA)) was converted to the estimated PAC measured by CLEIA (ePAC(CLEIA)) using a conversion formula. The present study evaluated the discordance rates in diagnoses based on screening (SC), captopril challenge test (CCT), saline infusion test (SIT), and diagnosis of PA between results judged by PAC(RIA) according to the previous guidelines and those judged by ePAC(CLEIA) according to the new guidelines. The results revealed discordant diagnosis rates of 6.4% for SC and 10.1% for CCT, with no discordance for SIT. The discordant diagnosis rate for PA was 3.7%. Our study reveals the challenges in establishing appropriate diagnostic criteria for PA using PAC(CLEIA) and highlights the demand for further research on provisionally positive categories.

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座談会 高尿酸血症と合併症～CVD残余リスクとして薬剤介入を考える～

益崎 裕章, 今田 恒夫, 田中 敦史

診断と治療 ( 診断と治療社 )  112 ( 6 ) 773 - 778   2024年06月

掲載種別: 研究論文（学術雑誌）

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Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report with review of literature.

Ishiki Y, Tamaki A, Honma KI, Yonaha K, Yabiku T, Teruya T, Uehara M, Nakayama Y, Chinen R, Uema T, Nakachi S, Okamoto S, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 817 - 824   2024年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Post-traumatic pituitary stalk transection syndrome (PSTS) is an extremely rare cause of combined pituitary hormone deficiency (CPHD), affecting approximately 9 per 100,000 cases of traumatic brain injury. In contrast, pituitary stalk interruption syndrome (PSIS) is also a rare cause of CPHD. Importantly, these conditions are often confused due to their similar names and resembling findings on magnetic resonance imaging (MRI). PSIS has been thought to be a prenatal developmental event resulting from a couple of genetic aberrations. In typical PSIS, anterior pituitary hormone deficiencies are restricted to growth hormone (GH) and gonadotropin during the pediatric age, gradually and generally progressing to panhypopituitarism in most cases. In contrast, global deficiencies of the anterior pituitary hormones in PSTS are temporally associated with trauma. To the best of our knowledge, no case reports of PSTS combined with acute traumatic spinal cord injury have been reported. A 34-year-old female was transferred to our hospital after jumping from the fourth building floor. She was diagnosed as an acute traumatic spinal cord injury and underwent the operation of elective posterior spinal fusion. On postoperative day 7, the blood tests revealed considerable hyperkalemia, hyponatremia and eosinophilia. Notably, menstruation stopped after falling from a height. Pituitary function tests revealed GH deficiency, hypogonadism, hypothyroidism and hypoadrenocorticism. MRI revealed loss of the pituitary stalk, whilst the hyperintense signal from distal axon of hypothalamus was still identified. Based on these findings, she was diagnosed as PSTS. Our case highlights endocrinological landscape of transection of the pituitary stalk by acute trauma.

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幼若期のニコチン曝露により誘導される成獣期肥満の病態モデルマウスの樹立と新規脳ドパミン作用機構の探索

根本 雄飛, 岡本 士毅, 照屋 太輝, 上間 次己, 本間 健一郎, 玉城 啓太, 島袋 充生, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  100 ( 1 ) 319 - 319   2024年05月

掲載種別: 研究論文（その他学術会議資料等）

成人T細胞白血病リンパ腫(ATL)リンパ腫型と鑑別を要したNocardia asiaticaによる多発リンパ節炎

山城 真人, 中島 知, 上間 道仁, 横田 雄太郎, 宮城 理子, 北村 紗希子, 玉城 啓太, 森近 一穂, 森島 聡子, 仲地 佐和子, 前原 博樹, 福島 卓也, 益崎 裕章

臨床血液 ( (一社)日本血液学会-東京事務局 )  65 ( 5 ) 447 - 447   2024年05月

掲載種別: 研究論文（その他学術会議資料等）

超難治性血液がんの糖代謝特性と分子制御に注目した新規治療法の可能性

仲地 佐和子, 岡本 士毅, 玉城 啓太, 森近 一穂, 上間 次己, 玉城 敦子, 本間 健一郎, 福島 卓也, 益崎 裕章

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  59回   55 - 55   2024年04月

掲載種別: 研究論文（その他学術会議資料等）

超難治性血液がんの糖代謝特性と分子制御に注目した新規治療法の可能性

仲地 佐和子, 岡本 士毅, 玉城 啓太, 森近 一穂, 上間 次己, 玉城 敦子, 本間 健一郎, 福島 卓也, 益崎 裕章

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  59回   55 - 55   2024年04月

掲載種別: 研究論文（その他学術会議資料等）

Role of perirenal adiposity in renal dysfunction among CKD individuals with or without diabetes: a Japanese cross-sectional study.

Kono T, Maimaituxun G, Tanabe H, Higa M, Saito H, Tanaka K, Masuzaki H, Sata M, Kazama JJ, Shimabukuro M

BMJ open diabetes research & care ( BMJ Open Diabetes Research and Care )  12 ( 2 )   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

INTRODUCTION: It remains unclear whether increased perirenal fat (PRF) accumulation is equally related to renal involvement in patients with and without diabetes mellitus (DM). We evaluated the association between PRF volume (PRFV) and low glomerular filtration rate (GFR) and proteinuria in people with or without type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of 473 individuals without T2DM (non-DM, n=202) and with T2DM (DM, n=271). PRFV (cm3), obtained from non-contrast CT, was indexed as PRF index (PRFV/body surface area, cm3/m2). Multivariate-adjusted models were used to determine the ORs of PRFV and PRFV index for detecting estimated GFR (eGFR) decrease of <60 mL/min/1.73 m2 proteinuria onset, or both. RESULTS: Although body mass index (BMI), visceral fat area, and waist circumference were comparable between the non-DM and DM groups, kidney volume, PRFV, and PRFV index were higher in individuals with T2DM than in those without T2DM. In the multivariate analysis, after adjusting for age, sex, BMI, hypertension, smoking history, and visceral fat area ≥100 cm2, the cut-off values of PRFV index were associated with an eGFR<60 in individuals with DM (OR 6.01, 95% CI 2.20 to 16.4, p<0.001) but not in those without DM. CONCLUSIONS: PRFV is associated with low eGFR in patients with T2DM but not in those without T2DM. This suggests that PRF accumulation is more closely related to the onset and progression of diabetic kidney disease (DKD) than non-DKD. Clarifying the mechanisms through which PRF influences DKD development could pave the way for novel prevention and treatment strategies.

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4．まとめ

益崎 裕章

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  113 ( 3 ) 402 - 403   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Impact of coronavirus disease 2019 on medical practice in endocrine and metabolic diseases in Japan: a nationwide surveillance study conducted by the Japan Endocrine Society.

Manaka K, Kato S, Sakamoto R, Yamakage H, Uema T, Kawai S, Shibata M, Hiratsuka I, Nakachi S, Onoue T, Tsuchiya T, Fukui M, Hashimoto K, Suzuki A, Makita N, Ogawa Y, Arima H, Satoh-Asahara N, Masuzaki H

Endocrine journal ( 一般社団法人 日本内分泌学会 )  advpub ( 0 ) 499 - 514   2024年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>We investigated the impact of the Coronavirus disease 2019 (COVID-19) pandemic on the management of endocrine and metabolic disorders in Japan. We conducted a cross-sectional nationwide questionnaire survey targeting board-certified endocrinologists under the auspices of the Japan Endocrine Society. The questionnaire consisted of multiple-choice questions and open-ended responses. Out of approximately 2,700 specialists, 528 (19.5%) opted to participate, suggesting a high level of interest in COVID-19 management among endocrinologists. The study found that almost half of participants had encountered cases of endocrine and metabolic disorders following COVID-19 infection or vaccination. Conditions related to thyroid diseases, glucose metabolism disorders/diabetes, and hypothalamic-pituitary disorders were particularly prevalent. Diabetes and obesity were identified as having high rates of severe cases or fatalities due to COVID-19. The study also highlighted challenges in routine diagnosis and treatment, emphasizing the potential benefits of combining remote consultations with in-person visits to optimize the frequency of examinations and check-ups during infectious disease outbreak which disrupts access to healthcare providers. The insights obtained from this survey are expected to contribute to ensuring appropriate healthcare provision for patients with endocrine and metabolic disorders by using flexible consultation formats, particularly even in the conditions where medical access may be limited due to future outbreaks of emerging or re-emerging infectious diseases.</p>

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超加工食品・ゼロカロリー食品の代謝・健康への影響

益崎 裕章, 上間 次己, 岡本 士毅

Diabetes Journal: 糖尿病と代謝 ( (公財)日本糖尿病財団 )  51 ( 1 ) 9 - 15   2024年03月

掲載種別: 研究論文（その他学術会議資料等）

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現代人の日常にあふれる食品の中には天然食材には存在しない栄養成分の配合比率を有し,調理済みで加工度の高い食べ物や飲料が多く含まれており,知らず知らずの間にそれらの摂取量・摂取頻度が高まっている.わが国においては種々の食品は「農林物資の規格化及び品質表示の適正化に関する法律」(JAS法)により,生鮮食料品,加工食品,食品添加物の3種類に分類され,品質表示基準のもとに管理されている.これに対し,超加工食品(ultra-processed foods:UPF)は従来の食品加工の概念を超え,精製加工度が高い食成分や添加物を工業的に組み合わせ,より簡便に,より多く摂取され,より多く購入・消費されることを重視して作製された一連の食品群を指している.世界的規模で超加工食品の摂取量が増加するに伴い,健康や社会経済に関する諸問題が提起されるようになり,一連の前向きコホート研究や基礎研究の結果から,超加工食品の摂取過剰が,癌,うつ,肥満症,認知機能障害,死亡リスクの上昇,妊婦が過剰摂取した場合の次世代の肥満への影響など,現代人の健康を脅かす核心的な疾病群の発症・進展リスクに深く関連していることが注目されるようになった.本稿では超加工食品の代謝や健康への影響をめぐる最近の知見を紹介するとともに,種々の超加工食品群に配合される機会が多く,やはり世界的規模で摂取量・供給量が増加している,いわゆる"ゼロカロリー食品"が代謝や健康に及ぼす潜在的影響に関しても概説したい.(著者抄録)

Sex differences in the association between epicardial adipose tissue volume and left atrial volume index.

Yamaguchi S, Maeda M, Oba K, Maimaituxun G, Arasaki O, Yagi S, Kusunose K, Soeki T, Yamada H, Fukuda D, Masuzaki H, Sata M, Shimabukuro M

BMC cardiovascular disorders ( BMC Cardiovascular Disorders )  24 ( 1 ) 46 - 46   2024年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: Sex disparities in the association between epicardial adipose tissue volume (EATV) and cardiovascular disease have been reported. The sex-dependent effects of EATV on left atrial (LA) size have not been elucidated. METHODS: Consecutive 247 subjects (median 65 [interquartile range 57, 75] years; 67% of men) who underwent multi-detector computed tomography without significant coronary artery disease or moderate to severe valvular disease were divided into two groups: patients with sinus rhythm (SR) or atrial fibrillation (AF). Sex differences in the association between the EATV index (EATVI) (mL/m2) and LA volume index (LAVI) in 63 SR (28 men and 35 women) and 184 AF (137 men and 47 women) patients were evaluated using univariate and multivariate regression analyses. RESULTS: In overall that includes both men and women, the relationship between EATVI and LAVI was not significantly correlated for patients with SR and AF. The relationship between EATVI and LAVI differed between men and women in both SR and AF groups. In SR patients, there was a positive relationship between EATVI and LAVI in men, but not in women. In contrast, in patients with AF, a negative relationship was found between EATVI and LAVI in women, whereas no association was found in men. CONCLUSIONS: We evaluated sex differences in the association between EATVI and LAVI in patients with either SR or AF, and found a positive relationship in men with SR and a negative relationship in women with AF. This is the first report to evaluate sex differences in the relationship between EATVI and LAVI, suggesting that EAT may play a role, at least in part, in sex differences in the etiology of AF.

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Impact of treatment cessation on incidence and progression of retinopathy in Japanese patients with type 2 diabetes mellitus: a retrospective cohort study

Shinzato Y.

Diabetology International ( Diabetology International )  15 ( 3 ) 535 - 543   2024年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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超加工食品・ゼロカロリー食品の代謝・健康への影響

益崎 裕章, 岡本 士毅

Diabetes Journal   51   9   2024年

掲載種別: 研究論文（学術雑誌）

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