Mekaru Keiko

写真a

Researcher Number(JSPS Kakenhi)

30444912
2 6 5 5 4
To the head of this page.▲

External Career 【 display / non-display 】

  • 2006.08
    　
    　

     

  • 2006.08
    -
    2013.03

    University of the Ryukyus, Faculty of Medicine, University Hospital, Research Associate  

  • 2013.04
    -
    2019.11

     

  • 2013.04
    -
    2019.11

     

  • 2019.12
    　
    　

     

To the head of this page.▲

Affiliated academic organizations 【 display / non-display 】

  • 　
    　
    　
     

    Japan society of obstetrics and gynecology 

To the head of this page.▲

Research Interests 【 display / non-display 】

  • 生殖内分泌,不妊症,体外受精・胚移植,腹腔鏡手術,子宮内膜症

  • 腹腔鏡手術

  • 生殖内分泌

  • 子宮内膜症

  • 周産期

display all >>

To the head of this page.▲

Research Areas 【 display / non-display 】

  • Life Science / Obstetrics and gynecology

To the head of this page.▲

Published Papers 【 display / non-display 】

  • Diffusion lacunae: a novel MR imaging finding on diffusion-weighted imaging for diagnosing placenta accreta spectrum.

    Iraha Y, Fujii S, Tsuchiya N, Azama K, Yonamine E, Mekaru K, Kinjo T, Sekine M, Nishie A

    Japanese journal of radiology     2024.09 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Out-of-pocket fertility preservation expenses: data from a Japanese nationwide multicenter survey.

    Ono M, Takai Y, Harada M, Horie A, Dai Y, Kikuchi E, Miyachi M, Yamamoto T, Fujii N, Kajiyama H, Manabe A, Yasuoka T, Katsuragi S, Mekaru K, Maezawa T, Horage Y, Kataoka S, Nakayama R, Nakajima TE, Kimura F, Shimizu C, Sugimoto K, Takae S, Yumura Y, Nishi H, Furui T, Morishige KI, Watanabe C, Osuga Y, Suzuki N

    International journal of clinical oncology ( International Journal of Clinical Oncology )    2024.09 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    • Access this article
      DOI
    • Search related information
      PubMed

  • How Effective Is Cervical Ripening Using the Controlled-Release Dinoprostone Vaginal Delivery System for Primiparas with Unruptured Membranes?

    Yoshino Kinjyo* , Yukiko Chinen, Tadatsugu Kinjo, Shuko Chinen, Keiko Mekaru

    Open Journal of Obstetrics and Gynecology     2024.08 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    　View Summary

    Background: Labor induction has a low success rate, especially in primiparas with unruptured membranes. Previous studies focused on pregnant women with unruptured membranes, but none specifically targeted primiparas. Aims: To compare the effectiveness of a controlled-release dinoprostone vaginal delivery system for cervical dilatation (PROPESS) with that of mechanical dilation for labor induction in primiparous women with unruptured membranes. Materials and Methods: We retrospectively analyzed the data of 90 primiparas with unruptured membranes (41 and 49 in the PROPESS and mechanical dilation groups, respectively). The primary outcome was the cesarean section (CS) rate. The secondary outcomes were the prevalence of vaginal delivery within 12 or 24 h after the initial insertion, oxytocin usage rate, chorioamnionitis, additional use of mechanical dilation in the PROPESS group, and neonatal outcomes. Results: The CS rate was significantly lower in the PROPESS group than in the mechanical dilation group (p = 0.02). A total of 13 patients (31.7%) delivered within 24 h with PROPESS alone, indicating a significantly higher rate of delivery within 24 h in the PROPESS group (p = 0.02). Fewer patients required additional oxytocin in the PROPESS group than in the mechanical dilation group (p = 0.001). However, 14 (34%) patients in the PROPESS group required additional mechanical cervical dilation, resulting in a longer time to delivery than mechanical dilation. Conclusions: PROPESS significantly reduced CS rates and increased delivery rates 24 h after the initial insertion in primiparas with unruptured membranes compared to mechanical dilatation. However, failure to respond to PROPESS resulted in an overall longer delivery time than that of the conventional mechanical dilation group; therefore, identifying predictors of response to PROPESS is necessary.

  • Relationship between the serum creatinine concentrations of preterm neonates within 24 h of birth and their mothers before delivery

    Shimabukuro, W; Nakada, S; Shimada, K; Tsukayama, M; Hamada, K; Goya, H; Kinjo, N; Yoshida, T; Mekaru, K; Nakanishi, K

    CLINICAL AND EXPERIMENTAL NEPHROLOGY ( Clinical and Experimental Nephrology )  28 ( 4 ) 293 - 299   2024.04 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

    • Access this article
      DOI
    • Search related information
      PubMed

  • Perinatal Morbidity, Mortality, and Neurodevelopmental Outcomes of Neonates with Fetal Growth Restriction

    Natsuki Tamashiro, Shuko Chinen, Yoshino Kinjyo, Yukiko Chinen, Tadatsugu Kinjo, Keiko Mekaru

    Open Journal of Obstetrics and Gynecology     2024.03 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

display all >>

To the head of this page.▲

Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Effects of polyunsaturated fatty acids on fertilization and embryonic development

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2016.04  -  2020.03 

    Investigator(s): Mekaru Keiko 

    Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

    　View Summary

    Objective is to clarify the concentration of polyunsaturated fatty acids (PUFAs) in the follicular fluid affect fertilization and the quality of embryos. A prospective study was conducted on 28 women eligible for in-vitro fertilization and embryo transfer between August 2016 and December 2017. Twenty-eight serum and 140 follicle fluid samples were collected and analysed. PUFAs fractions from the serum and follicular fluid were analysed using gas chromatography. Two milliliters of follicular fluid was collected from six consecutive follicles of each patient. Each individual follicle was aspirated independently and matched to an oocyte gr owing in this particular follicular milieu. Certain PUFAs showed significantly higher or lower levels depending on fertilization. There was no significant difference in the concentration of PUFAS in the follicular fluid between good and poor quality blastocyst. The concentration of PUFAs in the follicular fluid plays an important role in fertilization.

  • Effects of polyunsaturated fatty acids on fertilization and embryonic development

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2016.04  -  2020.03 

    Investigator(s): Mekaru Keiko 

    Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

    　View Summary

    Objective is to clarify the concentration of polyunsaturated fatty acids (PUFAs) in the follicular fluid affect fertilization and the quality of embryos. A prospective study was conducted on 28 women eligible for in-vitro fertilization and embryo transfer between August 2016 and December 2017. Twenty-eight serum and 140 follicle fluid samples were collected and analysed. PUFAs fractions from the serum and follicular fluid were analysed using gas chromatography. Two milliliters of follicular fluid was collected from six consecutive follicles of each patient. Each individual follicle was aspirated independently and matched to an oocyte gr owing in this particular follicular milieu. Certain PUFAs showed significantly higher or lower levels depending on fertilization. There was no significant difference in the concentration of PUFAS in the follicular fluid between good and poor quality blastocyst. The concentration of PUFAs in the follicular fluid plays an important role in fertilization.

  • Effects of polyunsaturated fatty acids on fertilization and embryonic development

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2016.04  -  2020.03 

    Investigator(s): Mekaru Keiko 

    Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

    　View Summary

    Objective is to clarify the concentration of polyunsaturated fatty acids (PUFAs) in the follicular fluid affect fertilization and the quality of embryos. A prospective study was conducted on 28 women eligible for in-vitro fertilization and embryo transfer between August 2016 and December 2017. Twenty-eight serum and 140 follicle fluid samples were collected and analysed. PUFAs fractions from the serum and follicular fluid were analysed using gas chromatography. Two milliliters of follicular fluid was collected from six consecutive follicles of each patient. Each individual follicle was aspirated independently and matched to an oocyte gr owing in this particular follicular milieu. Certain PUFAs showed significantly higher or lower levels depending on fertilization. There was no significant difference in the concentration of PUFAS in the follicular fluid between good and poor quality blastocyst. The concentration of PUFAs in the follicular fluid plays an important role in fertilization.

  • Effects of polyunsaturated fatty acids on fertilization and embryonic development

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2016.04  -  2020.03 

    Investigator(s): Mekaru Keiko 

    Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

    　View Summary

    Objective is to clarify the concentration of polyunsaturated fatty acids (PUFAs) in the follicular fluid affect fertilization and the quality of embryos. A prospective study was conducted on 28 women eligible for in-vitro fertilization and embryo transfer between August 2016 and December 2017. Twenty-eight serum and 140 follicle fluid samples were collected and analysed. PUFAs fractions from the serum and follicular fluid were analysed using gas chromatography. Two milliliters of follicular fluid was collected from six consecutive follicles of each patient. Each individual follicle was aspirated independently and matched to an oocyte gr owing in this particular follicular milieu. Certain PUFAs showed significantly higher or lower levels depending on fertilization. There was no significant difference in the concentration of PUFAS in the follicular fluid between good and poor quality blastocyst. The concentration of PUFAs in the follicular fluid plays an important role in fertilization.

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2016.04  -  2019.03 

    Direct: 3,600,000 (YEN)  Overheads: 1,080,000 (YEN)  Total: 4,680,000 (YEN)

display all >>

To the head of this page.▲

SDGs 【 display / non-display 】

  • 女性研究者のキャリア教育、小児・若年がん患者の妊孕性温存療法、女性のヘルスケア

To the head of this page.▲

Social Activity 【 display / non-display 】

  • 2023.05
    　
    　

  • 2024.07
    　
    　

  • 2019.12
    　
    　

  • 2019.12
    　
    　

  • 2019.12
    　
    　

To the head of this page.▲

Media Coverage 【 display / non-display 】

  • 産まれるいのちをどう守る？特定妊婦支援  TV or radio program

    NHK  ハートネットTV  2024.4

    Author： Other 

    　View Summary

    妊産婦等生活援助事業「おにわ」と琉球大学病院周産母子センターの連携について

To the head of this page.▲