論文 - 銘苅　桂子

A Phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy for para-aortic lymph node positive cervical cancer

Shimoji Y.

Anticancer Research ( Anticancer Research )  40 ( 6 ) 3565 - 3570   2020年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A Phase II Study of Neoadjuvant Chemotherapy Followed by Extended Field Concurrent Chemoradiotherapy for Para-aortic Lymph Node Positive Cervical Cancer.

Shimoji Y, Nagai Y, Toita T, Ariga T, Heianna J, Nakasone T, Taira Y, Arakaki Y, Nakamoto T, Ooyama T, Kudaka W, Kaneshima I, Nishihira K, Mekaru K, Aoki Y

Anticancer research   40 ( 6 ) 3565 - 3570   2020年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND/AIM: We conducted a phase II study of neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy in patients with cervical cancer with para-aortic node metastasis. PATIENTS AND METHODS: Thirty-seven women with stage IB1-IVA cervical cancer were enrolled. RESULTS: The median age was 52 years. Thirty-four patients other than 3 progressive disease, proceeded to extended field concurrent chemoradiotherapy. The 3-year overall survival and progression-free survival rates were 70.1% and 48.5%, respectively. The 3-year overall survival according to stages was significantly worse in stage IIIB. Twelve of the 17 patients with stage IIIB died of the disease. CONCLUSION: Neoadjuvant chemotherapy followed by extended field concurrent chemoradiotherapy may improve the prognosis of patients with stages IB and II cervical cancer with positive para-aortic node. However, new strategies should be investigated to improve a poor prognosis in stage IIIB disease with positive para-aortic node.

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Development of Vaginal Pseudoaneurysm 3 Years after Cesarean Section Possibly Induced by Anticoagulant and Antiplatelet Therapies.

Kinjo Y, Kinjo T, Mekaru K, Nitta H, Masamoto H, Aoki Y

Case reports in obstetrics and gynecology ( Case Reports in Obstetrics and Gynecology )  2020   6196575 - 6196575   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Pseudoaneurysms generally develop when an arterial puncture site is inadequately sealed. We encountered a case of vaginal pseudoaneurysm that developed 3 years after cesarean section in a 35-year-old gravida 7 para 4 woman who was prescribed with anticoagulant and antiplatelet drugs after surgeries for ventricular septal defect and aortic valve replacement. Pelvic computed tomography scan revealed a large mass, which showed a dappled contrast filling on the arterial phase, located in the posterior vaginal wall. The vaginal pseudoaneurysm was completely occluded by embolization of the left vaginal artery. Anticoagulation and antiplatelet therapies can be potential causes of spontaneous pseudoaneurysm rupture. Extrauterine pseudoaneurysm has a long period of time between cesarean section and pseudoaneurysm discovery. Considering that pseudoaneurysm shows different clinical features for each patient, we should always consider pseudoaneurysm when we assess a patient with postpartum hemorrhage.

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Impact of the one-carbon metabolism on oocyte maturation, fertilization, embryo quality, and subsequent pregnancy

Akamine K.

Reproductive Medicine and Biology ( Reproductive Medicine and Biology )  20 ( 1 ) 76 - 82   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Purpose: To investigate impact of the one-carbon metabolism (OCM) on oocyte maturity and embryo development. Methods: This prospective study analyzed 18 women who agreed to participate. We measured the OCM biomarkers' concentrations including Vitamin B12 (VB12), folic acid (FA), and homocysteine (Hcy) in serum and follicular fluid (FF), and assessed their correlation. We also evaluated the influence of such OCM biomarker concentrations in mono-FF on oocyte maturation, fertilization, embryo quality, and consequent pregnancy after embryo transfers. Results: All biomarkers showed a high concentration variability in different follicles of each woman, but their mean levels correlated with the serum levels. Among the 106 collected oocytes, 92 were mature, 59 were fertilized, and 16 yielded good-quality embryos. We performed 26 single embryo transfers, and 7 patients achieved clinical pregnancies. VB12 concentration (FF) was significantly lower in fertilized than unfertilized oocytes by univariate analysis. In multivariate logistic analysis, a significant correlation was found between FA concentration (FF) <14.25 ng/mL and good-quality embryos and between Hcy concentration (FF) <4.9 nmol/mL and clinical pregnancy. Conclusion: OCM in FF may affect fertilization, embryo quality, and clinical pregnancy.

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Tubal Pregnancy with Acute Bleeding Treated by Laparoscopic Surgery: Tips and Case Presentation

Sugiko Oishi, Keiko Mekaru, Maho Miyagi, Kozue Akamine, Chiaki Heshiki, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  10 ( 01 ) 100 - 107   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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今月の臨床 卵巣刺激・排卵誘発のすべて-どんな症例に,どのように行うのか 体外受精における卵巣刺激 long法・short法

銘苅 桂子

臨床婦人科産科 ( 株式会社医学書院 )  73 ( 7 ) 670 - 673   2019年07月

掲載種別: 研究論文（学術雑誌）

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Silicone Plate for the Prevention of Postoperative Adhesions in Patients with Asherman Syndrome.

Miyagi M, Mekaru K, Oishi S, Urasoe C, Akamine K, Aoki Y

Case reports in obstetrics and gynecology   2019   5420837   2019年

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Massive Subchorionic Thrombohematoma (Breus' Mole) Associated with Fetal Growth Restriction, Oligohydramnios, and Intrauterine Fetal Death.

Miyagi M, Kinjo T, Mekaru K, Nitta H, Masamoto H, Aoki Y

Case reports in obstetrics and gynecology   2019   9510936   2019年

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A Case of Cornelia de Lange Syndrome: Difficulty in Prenatal Diagnosis.

Kinjo T, Mekaru K, Nakada M, Nitta H, Masamoto H, Aoki Y

Case reports in obstetrics and gynecology   2019   4530491   2019年

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Fetal Congenital Peripheral Bronchial Atresia Diagnosed by Magnetic Resonance Imaging: Two Case Reports.

Kozaki M, Iraha Y, Masamoto H, Nitta H, Chinen Y, Kinjo T, Mekaru K, Aoki Y

AJP reports   8 ( 4 ) e201 - e205   2018年10月

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Comparative study of obstetric and neonatal outcomes of live births between poor- and good-quality embryo transfers.

Akamine K, Mekaru K, Gibo K, Nagata C, Oishi S, Miyagi M, Heshiki C, Kinjo T, Masamoto H, Aoki Y

Reproductive medicine and biology ( Reproductive Medicine and Biology )  17 ( 2 ) 188 - 194   2018年04月

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Multimodality imaging in secondary postpartum or postabortion hemorrhage: retained products of conception and related conditions.

Iraha Y, Okada M, Toguchi M, Azama K, Mekaru K, Kinjo T, Kudaka W, Aoki Y, Aoyama H, Matsuzaki A, Murayama S

Japanese journal of radiology ( Japanese Journal of Radiology )  36 ( 1 ) 12 - 22   2018年01月

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Rectal Injury by Inserting a Vaginal Pipe for Laparoscopic Hysterectomy

Keiko Mekaru*, Sugiko Oishi, Kozue Akamine, Chiaki Heshiki, and Yoichi Aoki

ARC Journal of Gynecology and Obstetrics     2018年01月 [ 査読有り ]

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A Case of Intrathoracic Gastric Duplication Cyst Detected on Prenatal Ultrasound Examination.

Yagi H, Kinjyo Y, Chinen Y, Nitta H, Kinjo T, Mekaru K, Masamoto H, Goya H, Yoshida T, Sanabe N, Aoki Y

Case reports in obstetrics and gynecology   2018   5346920   2018年

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Polyunsaturated fatty acid concentration in the human follicular fluid may affect fertilisation

Mekaru, K; Miyagi, M; Akamine, K; Heshiki, C; Aoki, Y

HUMAN REPRODUCTION   32   213 - 213   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Does a Vanishing Twin Affect Perinatal Outcome?

Kozue Akamine*, Keiko Mekaru, Chiaki Heshiki, Yukiko Chinen, Tadatugu Kinjyo, Hitoshi Masamoto and Yoichi Aoki

Journal of Pregnancy and Child Health     2017年03月 [ 査読有り ]

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Spontaneous Regression of Uterine Arteriovenous Malformations with Conservative Management.

Mekaru K, Oishi S, Akamine K, Heshiki C, Aoki Y

Case reports in obstetrics and gynecology   2017   6437670   2017年

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Rectal Injury by Inserting a Vaginal Pipe for Laparoscopic Hysterectomy

Keiko Mekaru, Sugiko Oishi, Kozue Akamine, Chiaki Heshiki, Yoichi Aoki

ARC Journal of Gynecology and Obstetrics ( ARC Publications Pvt Ltd. )  2 ( 2 )   2017年 [ 査読有り ]

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Cesarean Scar Pregnancy: A Report of 11 Cases and Review of the Literature Regarding Subsequent Pregnancy

Chiaki Heshiki, Keiko Mekaru, Maho Miyagi, Sugiko Oishi, Kozue Akamine, Hitoshi Sugiyama, Tadatsugu Kinjo, Hitoshi Masamoto, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  06 ( 01 ) 8 - 15   2016年 [ 査読有り ]

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The Effect of Insulin Resistance on &lt;i&gt;In-Vitro&lt;/i&gt; Fertilization-Embryo Transfer in Women without Polycystic Ovary Syndrome

Keiko Mekaru, Sugiko Oishi, Kozue Akamine, Tadatsugu Kinjo, Chiaki Heshiki, Hitoshi Masamoto, Yoichi Aoki

Open Journal of Obstetrics and Gynecology ( Scientific Research Publishing, Inc. )  06 ( 03 ) 157 - 166   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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