研究者詳細 - 安慶名　信也

論文 - 安慶名　信也

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HPV関連頭頸部癌におけるmTOR経路の検討

近藤俊輔, 安慶名信也, 平川仁, 真栄田裕行, 鈴木幹男

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 59回 O40 - 1 2021年10月

掲載種別: 研究論文（その他学術会議資料等）

HPV非関連進行咽頭癌におけるHIF1-αの発現と予後

安慶名信也, 近藤俊輔, 平川仁, 真栄田裕行, 鈴木幹男

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 59回 O40 - 3 2021年10月

掲載種別: 研究論文（その他学術会議資料等）

HPV非関連進行咽頭癌におけるHIF1-αの発現と予後

安慶名信也, 近藤俊輔, 平川仁, 真栄田裕行, 鈴木幹男

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 59回 O40 - 3 2021年10月

掲載種別: 研究論文（その他学術会議資料等）

下咽頭癌導入化学療法におけるDNA修復酵素遺伝子多型を用いた効果予測

平川仁, 池上太郎, 安慶名信也, 田中克典, 上里迅, 金城秀俊, 近藤俊輔, 真栄田裕行, 鈴木幹男

日本癌治療学会学術集会抄録集 ( (一社)日本癌治療学会 ) 59回 O40 - 2 2021年10月

掲載種別: 研究論文（その他学術会議資料等）

Prognostic significance of hypoxia-inducible factor-1α expression in advanced pharyngeal cancer without human papillomavirus infection.

Agena S, Hirakawa H, Ikegami T, Kinjyo H, Kise N, Maeda H, Uezato J, Kondo S, Kiyuna A, Yamashita Y, Hasegawa N, Suzuki M, Ganaha A

The Journal of laryngology and otology ( Journal of Laryngology and Otology ) 135 ( 7 ) 625 - 633 2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

OBJECTIVE: This study aimed to clarify the association between both hypoxia-inducible factor-1α and glucose transporter type-1 expression and survival outcome in advanced pharyngeal cancer without human papillomavirus infection. METHOD: Twenty-five oropharyngeal and 55 hypopharyngeal cancer patients without human papillomavirus infection were enrolled. All patients had stage III-IV lesions and underwent concurrent chemoradiotherapy or surgery. Hypoxia-inducible factor-1α and glucose transporter type-1 expression were investigated in primary lesions by immunohistochemistry. RESULTS: There were 41 and 39 cases with low and high hypoxia-inducible factor-1α expression, and 28 and 52 cases with low and high glucose transporter type-1 expression, respectively. There was no significant correlation between hypoxia-inducible factor-1α and glucose transporter type-1 expression. In univariate analysis, nodal metastasis, clinical stage and high hypoxia-inducible factor-1α expression, but not glucose transporter type-1 expression, predicted significantly worse prognosis. In multivariate analysis, hypoxia-inducible factor-1α overexpression was significantly correlated with poor overall survival, disease-specific survival and recurrence-free survival. CONCLUSION: High hypoxia-inducible factor-1α expression was an independent risk factor for poor prognosis for advanced human papillomavirus-unrelated pharyngeal cancer.

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摘出に難渋した咽頭微小金属異物の1例

武田翔吾, 喜瀬乗基, 金城秀俊, 上里迅, 安慶名信也, 田中克典, 真栄田裕行, 鈴木幹男

耳鼻咽喉科臨床補冊 ( 耳鼻咽喉科臨床学会 ) ( 補冊157 ) 87 - 87 2021年06月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

摘出に難渋した咽頭微小金属異物の1例

武田翔吾, 喜瀬乗基, 金城秀俊, 上里迅, 安慶名信也, 田中克典, 真栄田裕行, 鈴木幹男

耳鼻咽喉科臨床補冊 ( 耳鼻咽喉科臨床学会 ) ( 補冊157 ) 87 - 87 2021年06月

掲載種別: 研究論文（その他学術会議資料等）

胸腔鏡補助下開胸操作による肝硬変合併患者の腺腫様甲状腺腫摘出例

嘉陽祐紀, 真栄田裕行, 金城秀俊, 上里迅, 安慶名信也, 鈴木幹男

日本内分泌外科学会雑誌 ( (一社)日本内分泌外科学会 ) 38 ( Suppl.1 ) S120 - S120 2021年05月

掲載種別: 研究論文（その他学術会議資料等）

EP-HMRGを用いた頭頸部癌術中イメージング

田中克典, 池上太郎, 平川仁, 真栄田裕行, 安慶名信也, 上里迅, 金城秀俊, 鈴木幹男

頭頸部癌 ( (一社)日本頭頸部癌学会 ) 47 ( 2 ) 217 - 217 2021年05月

掲載種別: 研究論文（その他学術会議資料等）

EP-HMRGを用いた頭頸部癌術中イメージング

田中克典, 池上太郎, 平川仁, 真栄田裕行, 安慶名信也, 上里迅, 金城秀俊, 鈴木幹男

頭頸部癌 ( (一社)日本頭頸部癌学会 ) 47 ( 2 ) 217 - 217 2021年05月

掲載種別: 研究論文（その他学術会議資料等）

当科で経験したTOVS(Transoral Videolaryngoscopic Surgery)症例について

金城秀俊, 上里迅, 安慶名信也, 田中克典, 平川仁, 真栄田裕行, 鈴木幹男

頭頸部癌 ( (一社)日本頭頸部癌学会 ) 47 ( 2 ) 238 - 238 2021年05月

掲載種別: 研究論文（その他学術会議資料等）

当科で経験したTOVS(Transoral Videolaryngoscopic Surgery)症例について

金城秀俊, 上里迅, 安慶名信也, 田中克典, 平川仁, 真栄田裕行, 鈴木幹男

頭頸部癌 ( (一社)日本頭頸部癌学会 ) 47 ( 2 ) 238 - 238 2021年05月

掲載種別: 研究論文（その他学術会議資料等）

当科における腺腫様甲状腺腫手術例の検討

真栄田裕行, 嘉陽祐紀, 金城秀俊, 上里迅, 安慶名信也, 鈴木幹男

日本内分泌外科学会雑誌 ( (一社)日本内分泌外科学会 ) 38 ( Suppl.1 ) S107 - S107 2021年05月

掲載種別: 研究論文（その他学術会議資料等）

HPV非関連進行咽頭癌におけるHIF-1α発現と予後

安慶名信也, 金城秀俊, 上里迅, 田中克典, 平川仁, 真栄田裕行, 長谷川成海, 池上太郎, 鈴木幹男

日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科頭頸部外科学会 ) 124 ( 4 ) 690 - 690 2021年04月

掲載種別: 研究論文（その他学術会議資料等）

HPV非関連進行咽頭癌におけるHIF-1α発現と予後

安慶名信也, 金城秀俊, 上里迅, 田中克典, 平川仁, 真栄田裕行, 長谷川成海, 池上太郎, 鈴木幹男

日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科頭頸部外科学会 ) 124 ( 4 ) 690 - 690 2021年04月

掲載種別: 研究論文（その他学術会議資料等）

Coordinated Expression of HPV-6 Genes with Predominant E4 and E5 Expression in Laryngeal Papilloma.

Ikegami T, Hirakawa H, Tsukahara N, Murakami A, Kise N, Kiyuna A, Kosugi T, Agena S, Kinjyo H, Hasegawa N, Touyama M, Kondo S, Maeda H, Suzuki M, Ganaha A

Microorganisms ( Microorganisms ) 9 ( 3 ) 1 - 18 2021年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Laryngeal papilloma (LP) associated with human papillomavirus (HPV)-6 or -11 infection shows aggressive growth. However, the detailed molecular mechanism of virus-driven tumorigenesis has not been uncovered fully. HPV-6 viral gene expression and dynamic alterations were investigated with in situ localization of viral DNA and RNA in 13 patients with HPV-6-infected laryngeal papilloma. The average viral load was 4.80 × 105 ± 1.86 × 105 copies/ng DNA. E4, E5a, and E5b mRNAs accounted for 96% of the expression of 9 mRNAs. The alteration of viral DNA load during recurrence paralleled the mRNA expression levels, and the expression of all mRNAs showed a similar curve. E4, E5a, and E5b were expressed in the middle to upper part of the epithelium and were co-expressed in the same cells. E4 immunohistochemistry demonstrated an extensively positive reaction in the upper cell layer in accordance with E4 mRNA expression. These results suggest that individual viral genes are coordinately expressed for viral replication, virus release, and immunosurveillance avoidance. The newly developed E4-specific monoclonal antibody can be applied to further functional studies and clinical applications such as targeted molecular therapies.

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Raptor and rictor expression in patients with human papillomavirus-related oropharyngeal squamous cell carcinoma.

Kondo S, Hirakawa H, Ikegami T, Uehara T, Agena S, Uezato J, Kinjyo H, Kise N, Yamashita Y, Tanaka K, Hasegawa N, Kiyuna A, Maeda H, Suzuki M, Gahana A

BMC cancer ( BMC Cancer ) 21 ( 1 ) 87 2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

<title>Abstract</title><sec> <title>Background</title> Despite reports of a link between human papillomavirus (HPV) infection and mechanistic target of rapamycin (mTOR) signaling activation, the role of the mTOR pathway, especially raptor and rictor, in HPV-related head and neck cancer is still unclear. The aim of the present study was to elucidate the role of the mTOR pathway in HPV-related oropharyngeal squamous cell carcinoma (OPSCC). </sec><sec> <title>Methods</title> The present study involved two strategies. The first was to investigate the activity of mTOR and mTOR-related complexes in high-risk HPV-positive (UM-SCC47 and CaSki) and HPV-negative (SCC-4 and SAS) cancer cell lines. The second was to elucidate mTOR complex expression in 80 oropharyngeal cancer tissues and to examine the relationship between mTOR complex expression and survival in patients with OPSCC. </sec><sec> <title>Results</title> The UM-SCC47 and CaSki cell lines showed high gene and protein expression of raptor. They also exhibited G1/S and G2/M phase cell cycle arrest following 24 h incubation with 6 μM temsirolimus, a rapamycin analog, and temsirolimus administration inhibited their growth. HPV-related OPSCC samples showed high gene and protein expression of raptor and rictor compared with HPV-unrelated OPSCC. In addition, HPV-related OPSCC patients with high raptor and rictor expression tended to have a worse prognosis than those with low or medium expression. </sec><sec> <title>Conclusions</title> These results suggest that raptor and rictor have important roles in HPV-related OPSCC and that temsirolimus is a potential therapeutic agent for patients with HPV-related OPSCC. This is the first report to reveal the overexpression of raptor and rictor in HPV-related OPSCC. </sec>

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Availability of beaver-knife for intra-capsular enucleation of facial nerve schwannoma

Maeda Hiroyuki, Sugita Sachiko, Kise Norimoto, Kayou Yuuki, Agena Shinya, Kiyuna Asanori, Suzuki Mikio

口腔・咽頭科 ( 日本口腔・咽頭科学会 ) 34 ( 1 ) 103 - 107 2021年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

During a surgery for a parotid gland tumor, if it is determined that the case is a facial nerve schwannoma and the surgery is continued, intracapsular enucleation may be selected rather than extracapsular enucleation of the tumor to alleviate postoperative facial paralysis as much as possible. The patient is a 35-year-old woman. Initial findings revealed a hard palpable tumor with poor mobility in the anterior region of the right ear. Image findings showed a benign tumor. Although the tissue type was not revealed by cytodiagnosis, malignant findings were not observed. We determined that it was a case of facial nerve schwannoma that had developed in the main trunk. A beaver-knife was used to peel off. While aspirating and extracting the tumor capsule, the contents were peeled off from the nerve membrane little by little. As a result, while maintaining the neural capsule as much as possible, we succeeded in enucleation of most of the intracapsular contents. Although facial nerve was almost completely paralyzed immediately following surgery, this paralysis recovered to an acceptable level after 2 years. The use of a beaver knife facilitated the enucleation of the tumor and was thought to reduce the surgical damage to the facial nerve.

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癒着性中耳炎に対する一期的人工内耳手術

比嘉輝之, 我那覇章, 近藤俊輔, 親川仁貴, 安慶名信也, 平川仁, 鈴木幹男

耳鼻咽喉科臨床 ( 耳鼻咽喉科臨床学会 ) 114 ( 12 ) 909 - 916 2021年

掲載種別: 研究論文（学術雑誌）

<p>Cochlear implant surgery has been introduced successfully and is now one of the commonly performed surgeries. However, the surgical strategy of cochlear implantation in patients with chronic middle ear diseases, such as chronic otitis media and cholesteatoma, has not yet been fully established. In the present report, we describe the surgical technique adopted and prognosis of two patients with severe adhesive otitis media who underwent cochlear implant surgeries. Both underwent one-stage cochlear implantation combined with external auditory canal closure (blind-sac closure). Mastoidectomy with removal of the whole canal wall was performed to remove the otitis lesion thoroughly, and external auditory canal wall closure was performed to prevent recurrence of the lesion. A pneumatized tympanic cavity was observed and canal wall closure was maintained in both cases. Both patients acquired fair hearing ability with the cochlear implants. No severe complications have occurred until now, four years since the cochlear implantation. Although external ear canal closure destroys the natural structure of the external ear, one-stage cochlear implant surgery combined with canal closure is useful for elderly patients with systemic complications who desire shortening of hearing-deprived period.</p>

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肺癌患者における開胸肺葉切除術と頸部操作による腺腫様甲状腺腫摘出術の同時施行例

上里迅, 真栄田裕行, 金城秀俊, 安慶名信也, 平川仁, 鈴木幹男

頭頸部外科 ( (NPO)日本頭頸部外科学会 ) 30 ( 2 ) 233 - 238 2020年10月

掲載種別: 研究論文（その他学術会議資料等）

肺癌患者において開胸下の右上葉切除術と,頸部アプローチによる巨大な腺腫様甲状腺腫(AG)摘出術の同時施行例を経験したので報告する。患者は頸部圧迫感を主訴とする70歳の男性。精査の結果,右肺上葉S2区の肺癌と同時に上縦隔におよぶ右甲状腺腫瘤が発見された。甲状腺腫瘤は気道を圧排し,頸部圧迫感の主因であると考えられたため,肺癌と同時に甲状腺腫瘤摘出が計画された。AGは頸部操作のみで摘出可能であった。術後の経過は極めて順調であったが,縦隔炎や膿胸,胸骨骨髄炎など合併症の発症リスクを抑えるため,気管切開を併施せず,気管内挿管による気道管理を選択したことが理由として考えられた。(著者抄録)

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