Published Papers - Koizumi Hideki

Hearing characteristics of Branchio-oto-renal syndrome in Japan

Goto, SI; Sasaki, A; Nishio, SY; Morita, SY; Ogasawara, N; Kobayashi, Y; Amano, A; Shinkawa, C; Oda, K; Wada, T; Ikezono, T; Matsuda, H; Fujisaka, M; Nagai, K; Yoshimura, H; Kashio, A; Nishiyama, N; Ito, T; Tajima, S; Oka, SI; Kaga, K; Takeda, H; Kobayashi, M; Sano, H; Arai, Y; Nakanishi, H; Koizumi, H; Obara, N; Yoshida, T; Esaki, T; Takeuchi, K; Yamazaki, H; Horie, R; Ohta, Y; Morimoto, C; Uehara, N; Naito, Y; Maeda, Y; Ishino, T; Egusa, K; Sugahara, K; Teraoka, M; Kondo, E; Tsuchihashi, N; Kihara, C; Kanda, Y; Nakamura, T; Miyanohara, I; Kondo, S; Usami, SI

ACTA OTO-LARYNGOLOGICA     1 - 10   2026.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Impact of Reticular Pseudodrusen on Clinical and Ocular Characteristics and Progression Rate of Geographic Atrophy in Japanese Patients

Ueda-Arakawa, N; Sato, Y; Miyake, M; Takahashi, A; Mori, Y; Miyara, Y; Hara, C; Kitajima, Y; Maruko, R; Kawai, M; Ohnaka, M; Koizumi, H; Maruyama-Inoue, M; Yanagi, Y; Iida, T; Kondo, M; Sakamoto, T; Tsujikawa, A

OPHTHALMOLOGY SCIENCE ( Ophthalmology Science )  6 ( 2 ) 100984   2026.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Intravitreal aflibercept 8 mg in patients from Japan with neovascular age-related macular degeneration: 48-week subgroup analysis of the PULSAR trial

Koizumi, H; Honda, S; Yasukawa, T; Kishino, G; Sekiryu, T; Schulze, A; Yamashita, T; Schmidt-Ott, U; Zhao, M; Zhang, X; Berliner, AJ; Chu, KW; Reed, K; Cheng, YC; Bhore, R; Vitti, R; Fujita, I; Leal, S; Iida, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  70 ( 1 ) 139 - 149   2026.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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International consensuses and guidelines on central serous chorioretinopathy (CSC) by the Asia Pacific Vitreo-retina Society (APVRS), the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and the Academia Retina Internationalis (ARI).

Radke NV, van Dijk EHC, Spaide RF, Holz FG, Koizumi H, Freund KB, Subhi Y, Lange C, Singh SR, Chen H, Chen LJ, Chen SN, Chhablani J, Behar-Cohen F, Das T, Fung AT, Gomi F, Kim M, Lai CC, Lai TYY, Lee CS, Lotery A, Sivaprasad S, Zhao M, Lam DSC, Boon CJF

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) ( Asia Pacific Journal of Ophthalmology )  14 ( 5 ) 100252   2025.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy Accompanied by Keratoconus

Forte, P; Feo, A; Koizumi, H; Borrelli, E; Manocchio, R; Di Cello, L; Biagini, F; Macocco, F; Drago, G; Forte, G; Vagge, A; Gianoglio, C; Fontana, V; Jester, M; Nicolo, M; Romano, MR; Bonzano, C

OPHTHALMOLOGY SCIENCE ( Ophthalmology Science )  5 ( 5 ) 100808   2025.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Reply to the Comment on Scleral Thickness in Simple Versus Complex Central Serous

Imanaga, N; Koizumi, H

AMERICAN JOURNAL OF OPHTHALMOLOGY ( American Journal of Ophthalmology )  271   509 - 510   2025.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Pre-clinical and clinical evaluation of a surface plasmon field-enhanced fluorescence spectroscopy (SPFS) antigen test for detecting SARS-CoV-2

Ashizawa, N; Takazono, T; Ota, K; Ito, Y; Hirayama, T; Takeda, K; Ide, S; Iwanaga, N; Fujita, A; Tashiro, M; Hosogaya, N; Akamatsu, N; Kosai, K; Tanaka, T; Kobayashi, H; Yamauchi, R; Segawa, C; Koizumi, H; Taka, N; Hishigaki, H; Yamamoto, K; Izumikawa, K; Yanagihara, K; Mukae, H

JOURNAL OF INFECTION AND CHEMOTHERAPY ( Journal of Infection and Chemotherapy )  31 ( 1 ) 102504   2025.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Efficacy, durability, and safety of faricimab up to every 16 weeks in patients with neovascular age-related macular degeneration: 1-year results from the Japan subgroup of the phase 3 TENAYA trial (vol 67, pg 301, 2023)

Mori, R; Honda, S; Gomi, F; Tsujikawa, A; Koizumi, H; Ochi, H; Ohsawa, S; Okada, AA; TENAYA and LUCERNE Investigators

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  67 ( 3 ) 311 - 311   2023.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Scleral Thickness in Central Serous Chorioretinopathy

Imanaga, N; Terao, N; Nakamine, S; Tamashiro, T; Wakugawa, S; Sawaguchi, K; Koizumi, H

OPHTHALMOLOGY RETINA ( Ophthalmology Retina )  5 ( 3 ) 285 - 291   2021.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To evaluate scleral thickness in central serous chorioretinopathy (CSC) using anterior segment (AS) OCT. DESIGN: Retrospective, comparative study. PARTICIPANTS: Forty-seven eyes of 40 patients with CSC and 53 eyes of 47 age- and gender-matched normal control participants. METHODS: Spherical equivalent, axial length, subfoveal choroidal thickness, and scleral thickness were compared between the CSC and control groups. Scleral thickness was measured by AS OCT 6 mm posterior to the scleral spur in 4 directions. MAIN OUTCOME MEASURE: Scleral thickness in CSC eyes. RESULTS: No differences were found between the 2 groups in age, gender, spherical equivalent, or axial length. Subfoveal choroidal thickness was significantly greater in CSC eyes than in normal control eyes (424.0 ± 101.4 μm vs. 324.3 ± 91.8 μm; P < 0.001). Scleral thickness was significantly greater in CSC eyes than in normal control eyes at the superior (429.4 ± 50.3 μm vs. 395.2 ± 55.4 μm; P = 0.005), temporal (447.7 ± 45.7 μm vs. 396.5 ± 64.1 μm; P < 0.001), inferior (455.7 ± 81.2 μm vs. 437.8 ± 46.9 μm; P = 0.022), and nasal (454.9 ± 44.7 μm vs. 416.6 ± 51.2 μm; P = 0.001) points. CONCLUSIONS: Scleral thickness measured by AS OCT was significantly greater in CSC eyes than in normal control eyes, although no differences were found in spherical equivalent or axial length. Thick sclera may have a role in the pathogenesis of CSC.

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Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus

Nakayama, Y; Yamaguchi, S; Shinzato, Y; Okamoto, S; Millman, JF; Yamashiro, K; Takemoto, N; Uema, T; Arakaki, K; Higa, M; Koizumi, H; Shimabukuro, M; Masuzaki, H

ENDOCRINE JOURNAL ( 一般社団法人 日本内分泌学会 )  68 ( 6 ) 655 - 669   2021

Type of publication: Research paper (scientific journal)

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<p>Gender differences in risks for macrovascular complications in type 2 diabetes mellitus (T2DM) have been well established. However, the impact of gender differences on diabetic retinopathy (DR) has not been fully elucidated. We therefore retrospectively explored gender-specific determinants for DR in patients with T2DM in a small sized Japanese cohort in Okinawa. There were 214 patients who were diagnosed as no DR (<i>n</i> = 142) and non-proliferative DR (<i>n</i> = 72) in 2009. During the follow-up of median 7 years, 41/142 of incidence, 26/72 of progression, and 67/214 of incidence and progression were observed, respectively. DR was assessed using the modified international clinical DR severity scales. The risks for incidence, progression as well as incidence and progression of DR were comparable between men and women, respectively. Cox proportional hazard models in multivariate analyses demonstrated that the only common determinant in both men and women for DR was the duration of T2DM. Regarding gender-specific determinants, lower level of serum albumin in men as well as higher HbA1c, lower level of estimated glomerular filtration rate, and lower level of serum uric acid in women were extracted, respectively. Although precise mechanisms for such gender-specific determinants of DR still remain unsolved, the present study would highlight a couple of factors associated with gender-specific determinants for DR in a limited numbers of Japanese cohort. Prospective observational studies on gender-specific determinants of DR in a large scale cohort are warranted to further clarify underlying mechanisms.</p>

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Short axial length and hyperopic refractive error are risk factors of central serous chorioretinopathy

Terao, N; Koizumi, H; Kojima, K; Kusada, N; Nagata, K; Yamagishi, T; Yoneda, K; Yoshii, K; Kinoshita, S; Sotozono, C

BRITISH JOURNAL OF OPHTHALMOLOGY ( British Journal of Ophthalmology )  104 ( 9 ) 1260 - 1265   2020.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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BACKGROUND/AIMS: To evaluate the axial length (AL) and refractive status in central serous chorioretinopathy (CSC). METHODS: This retrospective observational case series involved 140 patients with CSC (180 eyes) and 78 age-matched and gender-matched control subjects. A detailed ophthalmic examination was performed, including an interferometer measurement of AL. Multimodal imaging comprised colour fundus photography, fluorescein angiography, indocyanine green angiography, fundus autofluorescence photography and spectral domain optical coherence tomography. RESULTS: Eighty eyes of 40 patients were categorised into the bilateral-CSC (b-CSC) group and 100 eyes of 100 patients were categorised into the unilateral-CSC (u-CSC) group. AL of the b-CSC (23.19 mm) and u-CSC (23.75 mm) groups was significantly shorter than that of the control (24.85 mm) group (p<0.001 for both). Moreover, AL was significantly shorter in the b-CSC group than in the u-CSC group (p=0.020). Spherical equivalent (SE) in the b-CSC (0.25 D) group was significantly greater than in the u-CSC (-0.81 D) and control (-1.38 D) groups (p<0.001 for both). Gender (male; OR 4.55; 95% CI 1.13 to 18.40; p=0.033), AL (OR 0.38; 95% CI 0.23 to 0.63; p<0.001), area of choroidal vascular hyperpermeability (OR 1.08; 95% CI 1.03 to 1.13; p=0.002) and presence of descending tract (OR 7.22; 95% CI 1.86 to 28.00; p=0.004) were the variables found to be significantly associated with b-CSC via multiple regression analyses. CONCLUSION: Anatomical features, such as shorter AL and greater SE, may be associated with the pathogenesis of CSC.

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Two-Year Outcomes of Treat-and-Extend Intravitreal Aflibercept for Exudative Age-Related Macular Degeneration: A Prospective Study.

Maruko I, Ogasawara M, Yamamoto A, Itagaki K, Hasegawa T, Arakawa H, Nakayama M, Koizumi H, Okada AA, Sekiryu T, Iida T

Ophthalmology. Retina ( Ophthalmology Retina )  4 ( 8 ) 767 - 776   2020.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To report the 2-year outcomes of intravitreal aflibercept injections (IAIs) in Japanese patients with neovascular age-related macular degeneration (AMD) using a 1-month adjusted treat-and-extend (TAE) regimen. DESIGN: Multicenter, prospective, nonrandomized, interventional study. PARTICIPANTS: Ninety-seven eyes of 97 patients with treatment-naive AMD were studied at 3 tertiary ophthalmological institutions. METHODS: The patients were treated with 3 consecutive monthly IAIs followed by the TAE regimen with a 1-month adjustment for a maximum of 3 months. Our TAE regimen allowed us to shorten and extend the treatment intervals even after a 3-month or 1-month treatment interval, or both, were reached. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and subfoveal choroidal thickness (SCT) were analyzed. MAIN OUTCOME MEASURES: The mean changes in the BCVA, CRT, and SCT from the baseline to 2 years after initiating the treatment were determined. In addition, the number of injections also was determined. RESULTS: The mean BCVA significantly improved from 0.27 logarithm of the minimum angle of resolution (logMAR) units to 0.14 logMAR at 2 years (P < 0.01). The mean CRT decreased significantly from 307±132 μm to 202±76 μm at 2 years (P < 0.01). The mean SCT decreased significantly from 247±106 μm to 203±96 μm at 2 years (P < 0.01). Seventy eyes (72.2%) showed a dry macula at 2 years. The treatment interval at 2 years was 1 month in 20 eyes (20.6%), 2 months in 18 eyes (18.6%), and 3 months in 59 eyes (60.8%). In 49 (50.5%) eyes with a 3-month treatment interval immediately after the loading phase, no fluid was seen in 25 eyes (51.0%) for the duration of this study. The rest had switched to a more frequent scheme. The mean number of injections during the 2-year period was 13.0±3.9. CONCLUSIONS: Intravitreal aflibercept injections with a 1-month adjusted TAE regimen significantly improved the BCVA and CRT with a reduced number of injections at 2 years. The treatment interval was adjusted to extend to 3 months in 60% and to shorten to 1 month in 20% of the eyes at 2 years.

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Macular atrophy after aflibercept therapy for neovascular age-related macular degeneration: outcomes of Japanese multicenter study

Koizumi, H; Yamamoto, A; Ogasawara, M; Maruko, I; Hasegawa, T; Itagaki, K; Sekiryu, T; Okada, AA; Iida, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  64 ( 4 ) 338 - 345   2020.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To evaluate the development and rate of growth in macular atrophy after intravitreal injections of aflibercept (IVAs) for neovascular age-related macular degeneration (AMD) over a 2-year period. STUDY DESIGN: Retrospective, interventional, consecutive case series. METHODS: This study included 94 eyes of 92 patients with treatment-naïve AMD involving the foveal center treated with IVAs at 3 university hospitals in Japan. The patients underwent IVAs bimonthly after 3 initial monthly doses in the first year. The protocol was converted to a treat-and-extend regimen in the second year. The incidence and growth rate of macular atrophy were quantified based on hypoautofluorescence detected by fundus autofluorescence images. Additionally, possible background factors related to the development and rate of growth of macular atrophy were investigated. RESULTS: Of 94 eyes, 39 (41.5%) had typical AMD and 55 (58.5%) had polypoidal choroidal vasculopathy. Ten eyes (10.6%) had macular atrophy at the baseline. Of the remaining 84 eyes, 14 (16.7%) had developed new macular atrophy at 2 years, the square root of the growth rate of atrophy was 0.52 mm/year. In multivariate analyses, a poorer best-corrected visual acuity (P = 0.01) and the presence of intraretinal fluid (P = 0.04) at baseline were found to be the independent predictors for the development of macular atrophy. No factors were found that were significantly related to the growth rate of the macular atrophy. CONCLUSIONS: Our study determined the incidence and rate of growth of macular atrophy after IVAs for neovascular AMD in clinical settings. Eyes with vision reduction and intraretinal fluid at the baseline develop macular atrophy more frequently after IVAs for neovascular AMD.

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Latest Developments in Polypoidal Choroidal Vasculopathy: Epidemiology, Etiology, Diagnosis, and Treatment

Chaikitmongkol, V; Cheung, CMG; Koizumi, H; Govindahar, V; Chhablani, J; Lai, TYY

ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY ( Asia Pacific Journal of Ophthalmology )  9 ( 3 ) 260 - 268   2020.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Polypoidal choroidal vasculopathy (PCV) is a condition characterized by multiple, recurrent, serosanguineous pigment epithelial detachments, and neurosensory retinal detachments due to abnormal aneurysmal neovascular lesions. It is generally considered as a variant of neovascular age-related macular degeneration, but there are some differences between the clinical presentation, natural history, and treatment response between patients with PCV and typical neovascular age-related macular degeneration patients. Over the past decade, new research and technological advancements have greatly improved our understanding of the PCV disease process and the management of PCV. This review aims to summarize the recent research findings to highlight the epidemiology, pathogenesis, genetics, the application of various diagnostic tools for PCV, and the available treatment options for PCV.

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QUANTIFICATION OF CHOROIDAL VASCULATURE BY HIGH-QUALITY STRUCTURE EN FACE SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY IMAGES IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY

Ogawa, Y; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  40 ( 3 ) 529 - 536   2020.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To determine the density of the choroidal vasculature by high-quality structure en face optical coherence tomography (OCT) scanned at the same time as OCT angiography in eyes with central serous chorioretinopathy (CSC). METHODS: Thirty-five eyes of 30 patients with CSC (20 men and 10 women; average age, 48.4 years) were studied. Volume scans (12 × 12 mm-square) were obtained at the same time as OCT angiographic scans (Plex Elite 9000; Swept-Source OCT, Zeiss). High-quality structure en face images were flattened at Bruch membrane and binarized to identify and quantify the choroidal vascular density by the Bernsen method of the segmentation slab of one-half of the choroidal thickness. Similarly, high-quality structure en face choroidal images of 35 healthy eyes of 29 patients (18 men and 11 women; average age, 51.7 years) were binarized and analyzed as controls. The en face images were cropped to exclude the optic disk. RESULTS: The mean cropped image size was 9.57 mm × 9.57 mm in the eyes with CSC and 9.48 mm × 9.48 mm in the healthy eyes (P = 0.41). In the eyes with CSC, the choroidal vascular density was 61.6 ± 7.5% of the choroid, which was significantly greater than that in the healthy eyes at 49.4 ± 7.5% (P < 0.01). CONCLUSION: High-quality structure en face OCT can be used to assess the density of the choroidal vessels quantitatively and noninvasively in eyes with CSC.

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【自発蛍光で読み解く 眼底疾患】加齢黄斑変性と眼底自発蛍光

今永 直也, 古泉 英貴

眼科グラフィック ( (株)メディカ出版 )  8 ( 5 ) 547 - 559   2019.10

Type of publication: Research paper (other science council materials etc.)

【いちばんやさしいOCTの撮りセツ】疾患別OCT画像の撮り方,見方 まずはこれだけ3疾患 加齢黄斑変性

冨山 亜季子, 古泉 英貴

眼科ケア ( (株)メディカ出版 )  21 ( 10 ) 1016 - 1025   2019.10

Type of publication: Research paper (other science council materials etc.)

高齢者糖尿病における糖尿病性網膜症の発症及び悪化要因に関する臨床疫学的後方視解析

新里 幸子, 中山 良朗, 比嘉 盛丈, 新垣 孝一郎, 島袋 充生, 古泉 英貴, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  62 ( 9 ) 611 - 611   2019.09

Type of publication: Research paper (other science council materials etc.)

原発開放隅角緑内障および高眼圧症に対するオミデネパグイソプロピルの短期成績

宮平 大輝, 酒井 寛, 大橋 和広, 力石 洋平, 新垣 淑邦, 酒井 美也子, 古泉 英貴

日本緑内障学会抄録集 ( 日本緑内障学会 )  30回   85 - 85   2019.09

Type of publication: Research paper (other science council materials etc.)

Untitled Reply

Hasegawa, T; Kawano, T; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  39 ( 6 ) E23 - E24   2019.06 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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