Published Papers - Koizumi Hideki

Hearing characteristics of Branchio-oto-renal syndrome in Japan

Goto, SI; Sasaki, A; Nishio, SY; Morita, SY; Ogasawara, N; Kobayashi, Y; Amano, A; Shinkawa, C; Oda, K; Wada, T; Ikezono, T; Matsuda, H; Fujisaka, M; Nagai, K; Yoshimura, H; Kashio, A; Nishiyama, N; Ito, T; Tajima, S; Oka, SI; Kaga, K; Takeda, H; Kobayashi, M; Sano, H; Arai, Y; Nakanishi, H; Koizumi, H; Obara, N; Yoshida, T; Esaki, T; Takeuchi, K; Yamazaki, H; Horie, R; Ohta, Y; Morimoto, C; Uehara, N; Naito, Y; Maeda, Y; Ishino, T; Egusa, K; Sugahara, K; Teraoka, M; Kondo, E; Tsuchihashi, N; Kihara, C; Kanda, Y; Nakamura, T; Miyanohara, I; Kondo, S; Usami, SI

ACTA OTO-LARYNGOLOGICA     1 - 10   2026.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Impact of Reticular Pseudodrusen on Clinical and Ocular Characteristics and Progression Rate of Geographic Atrophy in Japanese Patients

Ueda-Arakawa, N; Sato, Y; Miyake, M; Takahashi, A; Mori, Y; Miyara, Y; Hara, C; Kitajima, Y; Maruko, R; Kawai, M; Ohnaka, M; Koizumi, H; Maruyama-Inoue, M; Yanagi, Y; Iida, T; Kondo, M; Sakamoto, T; Tsujikawa, A

OPHTHALMOLOGY SCIENCE ( Ophthalmology Science )  6 ( 2 ) 100984   2026.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Intravitreal aflibercept 8 mg in patients from Japan with neovascular age-related macular degeneration: 48-week subgroup analysis of the PULSAR trial

Koizumi, H; Honda, S; Yasukawa, T; Kishino, G; Sekiryu, T; Schulze, A; Yamashita, T; Schmidt-Ott, U; Zhao, M; Zhang, X; Berliner, AJ; Chu, KW; Reed, K; Cheng, YC; Bhore, R; Vitti, R; Fujita, I; Leal, S; Iida, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  70 ( 1 ) 139 - 149   2026.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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International consensuses and guidelines on central serous chorioretinopathy (CSC) by the Asia Pacific Vitreo-retina Society (APVRS), the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO) and the Academia Retina Internationalis (ARI).

Radke NV, van Dijk EHC, Spaide RF, Holz FG, Koizumi H, Freund KB, Subhi Y, Lange C, Singh SR, Chen H, Chen LJ, Chen SN, Chhablani J, Behar-Cohen F, Das T, Fung AT, Gomi F, Kim M, Lai CC, Lai TYY, Lee CS, Lotery A, Sivaprasad S, Zhao M, Lam DSC, Boon CJF

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) ( Asia Pacific Journal of Ophthalmology )  14 ( 5 ) 100252   2025.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy Accompanied by Keratoconus

Forte, P; Feo, A; Koizumi, H; Borrelli, E; Manocchio, R; Di Cello, L; Biagini, F; Macocco, F; Drago, G; Forte, G; Vagge, A; Gianoglio, C; Fontana, V; Jester, M; Nicolo, M; Romano, MR; Bonzano, C

OPHTHALMOLOGY SCIENCE ( Ophthalmology Science )  5 ( 5 ) 100808   2025.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Reply to the Comment on Scleral Thickness in Simple Versus Complex Central Serous

Imanaga, N; Koizumi, H

AMERICAN JOURNAL OF OPHTHALMOLOGY ( American Journal of Ophthalmology )  271   509 - 510   2025.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Pre-clinical and clinical evaluation of a surface plasmon field-enhanced fluorescence spectroscopy (SPFS) antigen test for detecting SARS-CoV-2

Ashizawa, N; Takazono, T; Ota, K; Ito, Y; Hirayama, T; Takeda, K; Ide, S; Iwanaga, N; Fujita, A; Tashiro, M; Hosogaya, N; Akamatsu, N; Kosai, K; Tanaka, T; Kobayashi, H; Yamauchi, R; Segawa, C; Koizumi, H; Taka, N; Hishigaki, H; Yamamoto, K; Izumikawa, K; Yanagihara, K; Mukae, H

JOURNAL OF INFECTION AND CHEMOTHERAPY ( Journal of Infection and Chemotherapy )  31 ( 1 ) 102504   2025.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Efficacy, durability, and safety of faricimab up to every 16 weeks in patients with neovascular age-related macular degeneration: 1-year results from the Japan subgroup of the phase 3 TENAYA trial (vol 67, pg 301, 2023)

Mori, R; Honda, S; Gomi, F; Tsujikawa, A; Koizumi, H; Ochi, H; Ohsawa, S; Okada, AA; TENAYA and LUCERNE Investigators

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  67 ( 3 ) 311 - 311   2023.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Scleral Thickness in Central Serous Chorioretinopathy

Imanaga, N; Terao, N; Nakamine, S; Tamashiro, T; Wakugawa, S; Sawaguchi, K; Koizumi, H

OPHTHALMOLOGY RETINA ( Ophthalmology Retina )  5 ( 3 ) 285 - 291   2021.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To evaluate scleral thickness in central serous chorioretinopathy (CSC) using anterior segment (AS) OCT. DESIGN: Retrospective, comparative study. PARTICIPANTS: Forty-seven eyes of 40 patients with CSC and 53 eyes of 47 age- and gender-matched normal control participants. METHODS: Spherical equivalent, axial length, subfoveal choroidal thickness, and scleral thickness were compared between the CSC and control groups. Scleral thickness was measured by AS OCT 6 mm posterior to the scleral spur in 4 directions. MAIN OUTCOME MEASURE: Scleral thickness in CSC eyes. RESULTS: No differences were found between the 2 groups in age, gender, spherical equivalent, or axial length. Subfoveal choroidal thickness was significantly greater in CSC eyes than in normal control eyes (424.0 ± 101.4 μm vs. 324.3 ± 91.8 μm; P < 0.001). Scleral thickness was significantly greater in CSC eyes than in normal control eyes at the superior (429.4 ± 50.3 μm vs. 395.2 ± 55.4 μm; P = 0.005), temporal (447.7 ± 45.7 μm vs. 396.5 ± 64.1 μm; P < 0.001), inferior (455.7 ± 81.2 μm vs. 437.8 ± 46.9 μm; P = 0.022), and nasal (454.9 ± 44.7 μm vs. 416.6 ± 51.2 μm; P = 0.001) points. CONCLUSIONS: Scleral thickness measured by AS OCT was significantly greater in CSC eyes than in normal control eyes, although no differences were found in spherical equivalent or axial length. Thick sclera may have a role in the pathogenesis of CSC.

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Retrospective exploratory analyses on gender differences in determinants for incidence and progression of diabetic retinopathy in Japanese patients with type 2 diabetes mellitus

Nakayama, Y; Yamaguchi, S; Shinzato, Y; Okamoto, S; Millman, JF; Yamashiro, K; Takemoto, N; Uema, T; Arakaki, K; Higa, M; Koizumi, H; Shimabukuro, M; Masuzaki, H

ENDOCRINE JOURNAL ( 一般社団法人 日本内分泌学会 )  68 ( 6 ) 655 - 669   2021

Type of publication: Research paper (scientific journal)

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<p>Gender differences in risks for macrovascular complications in type 2 diabetes mellitus (T2DM) have been well established. However, the impact of gender differences on diabetic retinopathy (DR) has not been fully elucidated. We therefore retrospectively explored gender-specific determinants for DR in patients with T2DM in a small sized Japanese cohort in Okinawa. There were 214 patients who were diagnosed as no DR (<i>n</i> = 142) and non-proliferative DR (<i>n</i> = 72) in 2009. During the follow-up of median 7 years, 41/142 of incidence, 26/72 of progression, and 67/214 of incidence and progression were observed, respectively. DR was assessed using the modified international clinical DR severity scales. The risks for incidence, progression as well as incidence and progression of DR were comparable between men and women, respectively. Cox proportional hazard models in multivariate analyses demonstrated that the only common determinant in both men and women for DR was the duration of T2DM. Regarding gender-specific determinants, lower level of serum albumin in men as well as higher HbA1c, lower level of estimated glomerular filtration rate, and lower level of serum uric acid in women were extracted, respectively. Although precise mechanisms for such gender-specific determinants of DR still remain unsolved, the present study would highlight a couple of factors associated with gender-specific determinants for DR in a limited numbers of Japanese cohort. Prospective observational studies on gender-specific determinants of DR in a large scale cohort are warranted to further clarify underlying mechanisms.</p>

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Short axial length and hyperopic refractive error are risk factors of central serous chorioretinopathy

Terao, N; Koizumi, H; Kojima, K; Kusada, N; Nagata, K; Yamagishi, T; Yoneda, K; Yoshii, K; Kinoshita, S; Sotozono, C

BRITISH JOURNAL OF OPHTHALMOLOGY ( British Journal of Ophthalmology )  104 ( 9 ) 1260 - 1265   2020.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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BACKGROUND/AIMS: To evaluate the axial length (AL) and refractive status in central serous chorioretinopathy (CSC). METHODS: This retrospective observational case series involved 140 patients with CSC (180 eyes) and 78 age-matched and gender-matched control subjects. A detailed ophthalmic examination was performed, including an interferometer measurement of AL. Multimodal imaging comprised colour fundus photography, fluorescein angiography, indocyanine green angiography, fundus autofluorescence photography and spectral domain optical coherence tomography. RESULTS: Eighty eyes of 40 patients were categorised into the bilateral-CSC (b-CSC) group and 100 eyes of 100 patients were categorised into the unilateral-CSC (u-CSC) group. AL of the b-CSC (23.19 mm) and u-CSC (23.75 mm) groups was significantly shorter than that of the control (24.85 mm) group (p<0.001 for both). Moreover, AL was significantly shorter in the b-CSC group than in the u-CSC group (p=0.020). Spherical equivalent (SE) in the b-CSC (0.25 D) group was significantly greater than in the u-CSC (-0.81 D) and control (-1.38 D) groups (p<0.001 for both). Gender (male; OR 4.55; 95% CI 1.13 to 18.40; p=0.033), AL (OR 0.38; 95% CI 0.23 to 0.63; p<0.001), area of choroidal vascular hyperpermeability (OR 1.08; 95% CI 1.03 to 1.13; p=0.002) and presence of descending tract (OR 7.22; 95% CI 1.86 to 28.00; p=0.004) were the variables found to be significantly associated with b-CSC via multiple regression analyses. CONCLUSION: Anatomical features, such as shorter AL and greater SE, may be associated with the pathogenesis of CSC.

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Two-Year Outcomes of Treat-and-Extend Intravitreal Aflibercept for Exudative Age-Related Macular Degeneration: A Prospective Study.

Maruko I, Ogasawara M, Yamamoto A, Itagaki K, Hasegawa T, Arakawa H, Nakayama M, Koizumi H, Okada AA, Sekiryu T, Iida T

Ophthalmology. Retina ( Ophthalmology Retina )  4 ( 8 ) 767 - 776   2020.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To report the 2-year outcomes of intravitreal aflibercept injections (IAIs) in Japanese patients with neovascular age-related macular degeneration (AMD) using a 1-month adjusted treat-and-extend (TAE) regimen. DESIGN: Multicenter, prospective, nonrandomized, interventional study. PARTICIPANTS: Ninety-seven eyes of 97 patients with treatment-naive AMD were studied at 3 tertiary ophthalmological institutions. METHODS: The patients were treated with 3 consecutive monthly IAIs followed by the TAE regimen with a 1-month adjustment for a maximum of 3 months. Our TAE regimen allowed us to shorten and extend the treatment intervals even after a 3-month or 1-month treatment interval, or both, were reached. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and subfoveal choroidal thickness (SCT) were analyzed. MAIN OUTCOME MEASURES: The mean changes in the BCVA, CRT, and SCT from the baseline to 2 years after initiating the treatment were determined. In addition, the number of injections also was determined. RESULTS: The mean BCVA significantly improved from 0.27 logarithm of the minimum angle of resolution (logMAR) units to 0.14 logMAR at 2 years (P < 0.01). The mean CRT decreased significantly from 307±132 μm to 202±76 μm at 2 years (P < 0.01). The mean SCT decreased significantly from 247±106 μm to 203±96 μm at 2 years (P < 0.01). Seventy eyes (72.2%) showed a dry macula at 2 years. The treatment interval at 2 years was 1 month in 20 eyes (20.6%), 2 months in 18 eyes (18.6%), and 3 months in 59 eyes (60.8%). In 49 (50.5%) eyes with a 3-month treatment interval immediately after the loading phase, no fluid was seen in 25 eyes (51.0%) for the duration of this study. The rest had switched to a more frequent scheme. The mean number of injections during the 2-year period was 13.0±3.9. CONCLUSIONS: Intravitreal aflibercept injections with a 1-month adjusted TAE regimen significantly improved the BCVA and CRT with a reduced number of injections at 2 years. The treatment interval was adjusted to extend to 3 months in 60% and to shorten to 1 month in 20% of the eyes at 2 years.

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Macular atrophy after aflibercept therapy for neovascular age-related macular degeneration: outcomes of Japanese multicenter study

Koizumi, H; Yamamoto, A; Ogasawara, M; Maruko, I; Hasegawa, T; Itagaki, K; Sekiryu, T; Okada, AA; Iida, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  64 ( 4 ) 338 - 345   2020.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To evaluate the development and rate of growth in macular atrophy after intravitreal injections of aflibercept (IVAs) for neovascular age-related macular degeneration (AMD) over a 2-year period. STUDY DESIGN: Retrospective, interventional, consecutive case series. METHODS: This study included 94 eyes of 92 patients with treatment-naïve AMD involving the foveal center treated with IVAs at 3 university hospitals in Japan. The patients underwent IVAs bimonthly after 3 initial monthly doses in the first year. The protocol was converted to a treat-and-extend regimen in the second year. The incidence and growth rate of macular atrophy were quantified based on hypoautofluorescence detected by fundus autofluorescence images. Additionally, possible background factors related to the development and rate of growth of macular atrophy were investigated. RESULTS: Of 94 eyes, 39 (41.5%) had typical AMD and 55 (58.5%) had polypoidal choroidal vasculopathy. Ten eyes (10.6%) had macular atrophy at the baseline. Of the remaining 84 eyes, 14 (16.7%) had developed new macular atrophy at 2 years, the square root of the growth rate of atrophy was 0.52 mm/year. In multivariate analyses, a poorer best-corrected visual acuity (P = 0.01) and the presence of intraretinal fluid (P = 0.04) at baseline were found to be the independent predictors for the development of macular atrophy. No factors were found that were significantly related to the growth rate of the macular atrophy. CONCLUSIONS: Our study determined the incidence and rate of growth of macular atrophy after IVAs for neovascular AMD in clinical settings. Eyes with vision reduction and intraretinal fluid at the baseline develop macular atrophy more frequently after IVAs for neovascular AMD.

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Latest Developments in Polypoidal Choroidal Vasculopathy: Epidemiology, Etiology, Diagnosis, and Treatment

Chaikitmongkol, V; Cheung, CMG; Koizumi, H; Govindahar, V; Chhablani, J; Lai, TYY

ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY ( Asia Pacific Journal of Ophthalmology )  9 ( 3 ) 260 - 268   2020.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Polypoidal choroidal vasculopathy (PCV) is a condition characterized by multiple, recurrent, serosanguineous pigment epithelial detachments, and neurosensory retinal detachments due to abnormal aneurysmal neovascular lesions. It is generally considered as a variant of neovascular age-related macular degeneration, but there are some differences between the clinical presentation, natural history, and treatment response between patients with PCV and typical neovascular age-related macular degeneration patients. Over the past decade, new research and technological advancements have greatly improved our understanding of the PCV disease process and the management of PCV. This review aims to summarize the recent research findings to highlight the epidemiology, pathogenesis, genetics, the application of various diagnostic tools for PCV, and the available treatment options for PCV.

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QUANTIFICATION OF CHOROIDAL VASCULATURE BY HIGH-QUALITY STRUCTURE EN FACE SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY IMAGES IN EYES WITH CENTRAL SEROUS CHORIORETINOPATHY

Ogawa, Y; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  40 ( 3 ) 529 - 536   2020.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To determine the density of the choroidal vasculature by high-quality structure en face optical coherence tomography (OCT) scanned at the same time as OCT angiography in eyes with central serous chorioretinopathy (CSC). METHODS: Thirty-five eyes of 30 patients with CSC (20 men and 10 women; average age, 48.4 years) were studied. Volume scans (12 × 12 mm-square) were obtained at the same time as OCT angiographic scans (Plex Elite 9000; Swept-Source OCT, Zeiss). High-quality structure en face images were flattened at Bruch membrane and binarized to identify and quantify the choroidal vascular density by the Bernsen method of the segmentation slab of one-half of the choroidal thickness. Similarly, high-quality structure en face choroidal images of 35 healthy eyes of 29 patients (18 men and 11 women; average age, 51.7 years) were binarized and analyzed as controls. The en face images were cropped to exclude the optic disk. RESULTS: The mean cropped image size was 9.57 mm × 9.57 mm in the eyes with CSC and 9.48 mm × 9.48 mm in the healthy eyes (P = 0.41). In the eyes with CSC, the choroidal vascular density was 61.6 ± 7.5% of the choroid, which was significantly greater than that in the healthy eyes at 49.4 ± 7.5% (P < 0.01). CONCLUSION: High-quality structure en face OCT can be used to assess the density of the choroidal vessels quantitatively and noninvasively in eyes with CSC.

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【自発蛍光で読み解く 眼底疾患】加齢黄斑変性と眼底自発蛍光

今永 直也, 古泉 英貴

眼科グラフィック ( (株)メディカ出版 )  8 ( 5 ) 547 - 559   2019.10

Type of publication: Research paper (other science council materials etc.)

【いちばんやさしいOCTの撮りセツ】疾患別OCT画像の撮り方,見方 まずはこれだけ3疾患 加齢黄斑変性

冨山 亜季子, 古泉 英貴

眼科ケア ( (株)メディカ出版 )  21 ( 10 ) 1016 - 1025   2019.10

Type of publication: Research paper (other science council materials etc.)

高齢者糖尿病における糖尿病性網膜症の発症及び悪化要因に関する臨床疫学的後方視解析

新里 幸子, 中山 良朗, 比嘉 盛丈, 新垣 孝一郎, 島袋 充生, 古泉 英貴, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  62 ( 9 ) 611 - 611   2019.09

Type of publication: Research paper (other science council materials etc.)

原発開放隅角緑内障および高眼圧症に対するオミデネパグイソプロピルの短期成績

宮平 大輝, 酒井 寛, 大橋 和広, 力石 洋平, 新垣 淑邦, 酒井 美也子, 古泉 英貴

日本緑内障学会抄録集 ( 日本緑内障学会 )  30回   85 - 85   2019.09

Type of publication: Research paper (other science council materials etc.)

Untitled Reply

Hasegawa, T; Kawano, T; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  39 ( 6 ) E23 - E24   2019.06 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Untitled Reply

Hasegawa, T; Kawano, T; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  39 ( 6 ) E25 - E25   2019.06 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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加齢黄斑変性と脈絡膜の密なる関係

古泉 英貴

日本眼科学会雑誌 ( (公財)日本眼科学会 )  123 ( 4 ) 369 - 371   2019.04

Type of publication: Research paper (other science council materials etc.)

【完全マスター加齢黄斑変性アップデート2019】長期経過を考えたポリープ状脈絡膜血管症治療 抗VEGF薬単独療法

玉城 環, 古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  36 ( 2 ) 181 - 189   2019.02

Type of publication: Research paper (other science council materials etc.)

【歪視の診断と治療】歪視と加齢黄斑変性

寺尾 信宏, 古泉 英貴

OCULISTA ( (株)全日本病院出版会 )  ( 71 ) 17 - 24   2019.02

Type of publication: Research paper (other science council materials etc.)

Pachychoroid disease

Cheung, CMG; Lee, WK; Koizumi, H; Dansingani, K; Lai, TYY; Freund, KB

EYE ( Eye Basingstoke )  33 ( 1 ) 14 - 33   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Pachychoroid is a relatively novel concept describing a phenotype characterized by attenuation of the choriocapillaris overlying dilated choroidal veins, and associated with progressive retinal pigment epithelium dysfunction and neovascularization. The emphasis in defining pachychoroid-related disorders has shifted away from simply an abnormally thick choroid (pachychoroid) toward a detailed morphological definition of a pathologic state (pachychoroid disease) with functional implications, which will be discussed in this review. Several clinical manifestations have been described to reside within the pachychoroid disease spectrum, including central serous chorioretinopathy, pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, polypoidal choroidal vasculopathy/aneurysmal type 1 neovascularization, focal choroidal excavation, peripapillary pachychoroid syndrome. These conditions all exhibit the characteristic choroidal alterations and are believed to represent different manifestations of a common pathogenic process. This review is based on both the current literature and the clinical experience of our individual authors, with an emphasis on the clinical and imaging features, management considerations, as well as current understanding of pathogenesis of these disorders within the context of the recent findings related to pachychoroid disease.

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RESOLUTION OF FOVEAL CYST AFTER THE RELEASE OF VITREOMACULAR ATTACHMENT IN EYE WITH MACULAR TELANGIECTASIA TYPE 2.

Kimura M, Koizumi H, Maruko I, Iida T

Retinal cases & brief reports ( Retinal Cases and Brief Reports )  13 ( 2 ) 118 - 120   2019 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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CHOROIDAL BLOOD VESSELS IN RETINAL PIGMENT EPITHELIAL ATROPHY USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Maruko I, Koizumi H, Sawaguchi S, Hasegawa T, Arakawa H, Iida T

Retinal cases & brief reports ( Retinal Cases and Brief Reports )  13 ( 1 ) 88 - 93   2019 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Anterior chamber paracentesis during intravitreal injections in observational trials: effectiveness and safety and effects.

Saxena S, Lai TY, Koizumi H, Farah ME, Ferrara D, Pelayes D, Sato T, Meyer CH, Murray T, International Pharmacokinetic Collaboration

International journal of retina and vitreous ( International Journal of Retina and Vitreous )  5 ( 1 ) 8 - 8   2019 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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A paracentesis prior to an intravitreal injection is a very safe procedure and can prevent IOP-spikes after injections. As these spikes pose the risk of inducing glaucomatous changes particularly in patients with frequent injections and/or with a risk profile, a regular paracentesis prior to an injection may be considered and discussed with the patient.

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Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy

Terao, N; Koizumi, H; Kojima, K; Yamagishi, T; Nagata, K; Kitazawa, K; Yamamoto, Y; Yoshii, K; Hiraga, A; Toda, M; Kinoshita, S; Sotozono, C; Hamuro, J

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE ( Investigative Ophthalmology and Visual Science )  59 ( 15 ) 5924 - 5931   2018.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Purpose: To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV). Methods: Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoassay, and the cytokine profiles were compared among these three groups of patients. The areas of choroidal vascular hyperpermeability (CVH) and choroidal thickness (CT), including measurement of the vascular layers, were investigated to analyze the features of choroidal abnormality in acute CSC, chronic CSC, and PNV. Additionally, associations between cytokine profiles and choroidal abnormalities were analyzed. Results: Proinflammatory cytokines, IL-6 and IL-8 were significantly upregulated in the chronic CSC group compared with the acute CSC or PNV groups. Angiogenic cytokines and VEGF-A were upregulated at levels that almost reached significance along with disease progression from acute to chronic CSC, whereas the upregulation was not significant from chronic CSC to PNV. In the chronic CSC group, strong positive correlations were confirmed between VEGF-A and placental growth factor (PlGF) (r = 0.75, P < 0.001) and IL-6 and VEGF-A (r = 0.74, P < 0.001), and angiogenesis-related cytokines were positively correlated with the typical choroidal abnormalities, areas of CVH, mean CT, and mean large choroidal vessel layer thickness. However, there was no association between these choroidal abnormality parameters and AH cytokines in the PNV group. Conclusions: The results suggest that choroidal abnormalities in chronic CSC may be associated with upregulated angiogenesis.

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未熟児網膜症診療の現状と治療,適応とタイミングは? レーザー網膜光凝固法が90%以上の症例で有効.最近,抗VEGF治療が開発された

日下 俊次, 古泉 英貴

日本医事新報 ( (株)日本医事新報社 )  ( 4932 ) 56 - 56   2018.11

Type of publication: Research paper (other science council materials etc.)

目の愛護デー(10/10)に寄せて

古泉 英貴

沖縄県医師会報 ( (一社)沖縄県医師会 )  54 ( 10 ) 1193 - 1193   2018.10

Type of publication: Research paper (other science council materials etc.)

加齢黄斑変性に対する治療法の選択と新しい治療法の可能性 コストを下げるべく,より長期作用が期待できる新規の抗VEGF薬の開発が進行中

古泉 英貴, 渡辺 彰英

日本医事新報 ( (株)日本医事新報社 )  ( 4930 ) 58 - 59   2018.10

Type of publication: Research paper (other science council materials etc.)

光干渉断層血管撮影による滲出型加齢黄斑変性の脈絡膜新生血管検出

丸子 一朗, 古泉 英貴, 河野 泰三, 長谷川 泰司, 荒川 久弥, 飯田 知弘

日本眼科学会雑誌 ( (公財)日本眼科学会 )  122 ( 10 ) 744 - 752   2018.10

Type of publication: Research paper (other science council materials etc.)

【7年前の常識は現在の非常識!-眼科診療の最新標準】網膜・硝子体疾患 診断・治療 ポリープ状脈絡膜血管症の診断と治療

古泉 英貴

臨床眼科 ( (株)医学書院 )  72 ( 11 ) 234 - 237   2018.10

Type of publication: Research paper (other science council materials etc.)

【TOPICS 2018!】Pachychoroidという疾患スペクトラム

古泉 英貴, 玉城 環, 湧川 空子

Retina Medicine ( (株)先端医学社 )  7 ( 2 ) 118 - 123   2018.10

Type of publication: Research paper (other science council materials etc.)

Comparison of subfoveal choroidal structures in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Takahashi, Y; Koizumi, H; Hasegawa, T; Izumi, T; Maruko, I; Sonoda, S; Sakamoto, T; Iida, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  62 ( 5 ) 576 - 583   2018.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To evaluate and compare the intrachoroidal structures of eyes with typical neovascular age-related macular degeneration (AMD) with those of eyes with polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective and comparative case series. METHODS: Eighty-four treatment-naïve eyes of 84 patients (22 women and 62 men) with typical neovascular AMD or PCV located in the subfoveal region were studied. Cross-sectional images of the retina and choroid were obtained by swept-source optical coherence tomography (SS-OCT). The horizontal SS-OCT images were analyzed by a manual delineation technique and by a binarization method. RESULTS: Thirty-nine eyes with typical neovascular AMD and 45 eyes with PCV were studied. Although the subfoveal choroidal thickness (SCT) did not differ significantly between the 2 subtypes (255.1 ± 86.7 µm in typical neovascular AMD and 289.2 ± 116.5 µm in PCV, P = 0.29), the ratio of the large choroidal vessel layer (LCVL) thickness to the SCT was significantly larger in the eyes with PCV than in the eyes with typical neovascular AMD (0.863 ± 0.084 vs 0.803 ± 0.125, P = 0.023). The binarization method did not find significant differences in the choroidal structure between the 2 subtypes. Multivariate logistic regression analyses found the ratio of the LCVL thickness to the SCT to be the only significantly different factor between typical neovascular AMD and PCV (P = 0.035). CONCLUSION: The intrachoroidal structures of typical neovascular AMD and PCV eyes differ significantly. In eyes with PCV, there seemed to be a greater dilation of the large choroidal vessels.

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Prognostic factors after aflibercept therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy

Ogasawara, M; Koizumi, H; Yamamoto, A; Itagaki, K; Saito, M; Maruko, I; Okada, AA; Iida, T; Sekiryu, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  62 ( 5 ) 584 - 591   2018.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To determine factors predictive of visual outcomes in eyes treated with intravitreal aflibercept injections (IAIs) for typical neovascular age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, multicenter, institutional, consecutive, interventional case series. METHODS: One hundred nine eyes (107 patients) with treatment-naïve neovascular AMD at 3 university hospitals were studied. After a loading phase of 3 monthly 2.0-mg IAIs, injections were administered every 2 months. The baseline clinical characteristics were investigated in relation to the 12-month visual outcomes. Changes in the mean best-corrected visual acuity (BCVA) were measured at 12 months after initiation of aflibercept therapy. RESULTS: Forty-five eyes (41.3%) had typical neovascular AMD, and 64 eyes (58.7%) had PCV. The changes in the mean BCVA at 12 months compared with baseline did not differ significantly (P = .737) between the 2 groups. Stepwise analysis showed that larger gains in the BCVA at 12 months were associated with poor BCVA (P < .001), no pigment epithelial detachment (P = .004), and subretinal fluid (P = .039) at baseline in eyes with typical neovascular AMD; larger gains in the BCVA were associated with poorer BCVA (P < .001), presence of choroidal vascular hyperpermeability (CVH) (P = .013), and subretinal fluid (P = .044) at baseline in eyes with PCV. CONCLUSIONS: Although poorer BCVA and the presence of subretinal fluid predicted larger gains in BCVA in both subtypes treated with aflibercept, eyes with typical neovascular AMD had greater improvement if no pigment epithelial detachment was present, while eyes with PCV had greater improvement if CVH was present.

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【主訴と所見からみた眼科 common disease】所見からみた診断の進め方 網膜硝子体 網膜剥離

今永 直也, 古泉 英貴

眼科 ( 金原出版(株) )  60 ( 10 ) 1251 - 1255   2018.09

Type of publication: Research paper (other science council materials etc.)

Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration

Terao, N; Koizumi, H; Kojima, K; Yamagishi, T; Yamamoto, Y; Yoshii, K; Kitazawa, K; Hiraga, A; Toda, M; Kinoshita, S; Sotozono, C; Hamuro, J

SCIENTIFIC REPORTS ( Scientific Reports )  8 ( 1 ) 10520 - 10520   2018.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibercept were also analysed in the PNV and nAMD groups. In the PNV group, vascular endothelial growth factor (VEGF)-A was significantly lower than in the nAMD group (p = 0.03) but was almost identical to that in the control group (p = 0.86). The nAMD group showed positive correlations between interleukin (IL)-6 and IL-8 (r = 0.78, p < 0.001), IL-6 and monocyte chemoattractant protein (MCP)-1 (r = 0.68, p = 0.002) and IL-8 and MCP-1 (r = 0.68, p = 0.002). In the nAMD group, eyes with dry maculae one month after the first aflibercept injection showed significantly lower VEGF-A and placental growth factor (PlGF) at baseline than those with wet maculae (p = 0.02 for both). However, there was no significant difference between dry and wet maculae in the PNV group. The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD.

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CLINICAL FINDINGS OF EYES WITH MACULAR EDEMA ASSOCIATED WITH BRANCH RETINAL VEIN OCCLUSION REFRACTORY TO RANIBIZUMAB

Hasegawa, T; Kawano, T; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  38 ( 7 ) 1347 - 1353   2018.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To determine the relationship between the clinical findings and the response to ranibizumab therapy in eyes with macular edema associated with branch retinal vein occlusion. METHODS: We reviewed the medical records of 68 patients with macular edema associated with a branch retinal vein occlusion. The patients were placed in the refractory group if the central foveal thickness remained more than 250 μm throughout the 6-month study period despite the ranibizumab therapy; otherwise, they were placed in the responsive group. RESULTS: Sixty (88.2%) of 68 eyes were placed in the responsive group and the other 8 eyes (11.8%) were placed in the refractory group. At the pretreatment examination, fluorescein angiography showed extensive leakage from occluded vessels in 52 (86.7%) of the 60 eyes in the responsive group and focal leakages from microaneurysms or dilated capillaries in the other 8 eyes (13.3%). In the refractory group, 7 (87.5%) of 8 eyes had only focal leakage and 1 eye (12.5%) had extensive leakage (P < 0.0001). The mean initial subfoveal choroidal thickness in the eyes with branch retinal vein occlusion in the responsive group was significantly thicker than that in the fellow eyes (278.0 ± 90.5 μm, 249.9 ± 94.4 μm; P < 0.0001). On the other hand, the mean initial subfoveal choroidal thickness in the refractory group was not significantly different from that of the fellow eyes (P = 0.4002). CONCLUSION: The dye leakage pattern in the fluorescein angiography images and choroidal thickness may be associated with response to ranibizumab therapy.

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Unmeasurable small size of foveal avascular zone without visual impairment in optical coherence tomography angiography

Yokoyama, T; Maruko, I; Koizumi, H; Ishikawa, Y; Iida, T

EYE ( Eye Basingstoke )  32 ( 6 ) 1062 - 1066   2018.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【ガイドラインに準拠 硝子体内注射の臨床手技】適応疾患と使用法および注意すべき患者背景

玉城 環, 古泉 英貴

眼科グラフィック ( (株)メディカ出版 )  7 ( 3 ) 282 - 288   2018.06

Type of publication: Research paper (other science council materials etc.)

臨床報告 En face OCTを用いた神経線維腫症1型の脈絡膜所見

渡辺 一郎, 丸子 一朗, 長谷川 泰司, 古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  60 ( 5 ) 547 - 552   2018.05

Type of publication: Research paper (other science council materials etc.)

Drusenの分類

古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  59 ( 13 ) 1587 - 1594   2017.12

Type of publication: Research paper (other science council materials etc.)

Foveal Retinal Neovascularization in Proliferative Diabetic Retinopathy: Assessment by Optical Coherence Tomography Angiography

Murakawa, S; Hasegawa, T; Koizumi, H; Maruko, I; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  37 ( 11 ) E135 - E137   2017.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【眼科救急Q&A】主訴・主要他覚所見ごとの救急疾患の鑑別診断 急に何かが飛んで見えるようになったと訴えて患者が救急外来を受診しました.鑑別すべき疾患と鑑別の方法を教えてください

寺尾 信宏, 古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  34 ( 臨増 ) 26 - 29   2017.11

Type of publication: Research paper (other science council materials etc.)

Pachychoroid spectrum diseaseの前房水サイトカイン網羅的解析

寺尾 信宏, 山岸 哲哉, 平賀 朝子, 戸田 宗豊, 山本 雄士, 北澤 耕司, 永田 健児, 小嶋 健太郎, 古泉 英貴, 羽室 淳爾, 外園 千恵

日本眼科学会雑誌 ( (公財)日本眼科学会 )  121 ( 11 ) 887 - 888   2017.11

Type of publication: Research paper (other science council materials etc.)

網膜静脈分枝閉塞症における黄斑虚血の評価

三上 侑利子, 小暮 朗子, 古泉 英貴, 新田 恵理, 小川 友紀, 飯田 知弘

臨床眼科 ( (株)医学書院 )  71 ( 10 ) 1533 - 1539   2017.10

Type of publication: Research paper (other science council materials etc.)

レーザースペックルフローグラフィを用いた網膜中心静脈閉塞症における虚血性変化の評価

小川 友紀, 小暮 朗子, 古泉 英貴, 三上 侑利子, 飯田 知弘

臨床眼科 ( (株)医学書院 )  71 ( 10 ) 1601 - 1607   2017.10

Type of publication: Research paper (other science council materials etc.)

Subthreshold 577 nm micropulse laser treatment for central serous chorioretinopathy

Maruko, I; Koizumi, H; Hasegawa, T; Arakawa, H; Iida, T

PLOS ONE ( Plos One )  12 ( 8 ) e0184112   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration

Yamashiro, K; Mori, K; Honda, S; Kano, M; Yanagi, Y; Obana, A; Sakurada, Y; Sato, T; Nagai, Y; Hikichi, T; Kataoka, Y; Hara, C; Koyama, Y; Koizumi, H; Yoshikawa, M; Miyake, M; Nakata, I; Tsuchihashi, T; Horie-Inoue, K; Matsumiya, W; Ogasawara, M; Obata, R; Yoneyama, S; Matsumoto, H; Ohnaka, M; Kitamei, H; Sayanagi, K; Ooto, S; Tamura, H; Oishi, A; Kabasawa, S; Ueyama, K; Miki, A; Kondo, N; Bessho, H; Saito, M; Takahashi, H; Tan, X; Azuma, K; Kikushima, W; Mukai, R; Ohira, A; Gomi, F; Miyata, K; Takahashi, K; Kishi, S; Iijima, H; Sekiryu, T; Iida, T; Awata, T; Inoue, S; Yamada, R; Matsuda, F; Tsujikawa, A; Negi, A; Yoneya, S; Iwata, T; Yoshimura, N

SCIENTIFIC REPORTS ( Scientific Reports )  7 ( 1 ) 9196 - 9196   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Untitled Reply

Maruko, I; Koizumi, H; Kogure-Katakura, A; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  37 ( 6 ) E84 - E84   2017.06 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Untitled Reply

Ichiro Maruko, Hideki Koizumi, Akiko Kogure-Katakura, Tomohiro Iida

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   37 ( 6 ) E84 - E84   2017.06

Type of publication: Research paper (other science council materials etc.)

Optical coherence tomographic predictor of retinal non-perfused areas in eyes with macular oedema associated with retinal vein occlusion

Hasegawa, T; Yamashita, M; Maruko, I; Koizumi, H; Kogure, A; Ogata, N; Iida, T

BRITISH JOURNAL OF OPHTHALMOLOGY ( British Journal of Ophthalmology )  101 ( 5 ) 569 - 573   2017.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy

Izumi, T; Koizumi, H; Maruko, I; Takahashi, Y; Sonoda, S; Sakamoto, T; Iida, T

BRITISH JOURNAL OF OPHTHALMOLOGY ( British Journal of Ophthalmology )  101 ( 4 ) 433 - 437   2017.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Unilateral acute idiopathic maculopathyの眼底自発蛍光および光干渉断層血管撮影 UAIMのFAFとOCT angiography

花田 真毅, 丸子 一朗, 古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  59 ( 4 ) 449 - 456   2017.04

Type of publication: Research paper (other science council materials etc.)

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35歳女.1週間前からの右眼偏視および視力低下を主訴とした.右眼視力は0.5(0.9)であった.右眼底には中心窩を含む黄斑耳側に約1.5乳頭径大の黄白色斑を認め,フルオレセインおよびインドシアニングリーン蛍光造影ではともに病変部は初期から低蛍光,その周囲は初期から後期にかけて過蛍光を呈していた.光干渉断層計(OCT)で網膜色素上皮(RPE)に肥厚と不整がありellipsoid zoneが消失していた.眼底自発蛍光(FAF)は病変部に一致して過蛍光を認め,光干渉断層血管造影(OCTA)では脈絡毛細血管板(CC)レベルで病変部に低輝度所見を認めた.自覚症状は徐々に改善し1週間後には矯正視力(1.2)となり,感染症など原因は特定されずUnilateral acute idiopathic maculopathyと診断した.OCTでRPEの肥厚範囲は縮小し3ヵ月後にはellipsoid zoneも回復し,FAFでは過蛍光所見の減弱と縮小を認めた.OCTAではCCレベルでの低輝度所見は縮小し,3ヵ月後には病変部周囲とほぼ同輝度となった.

CHOROIDAL BLOOD FLOW VISUALIZATION IN HIGH MYOPIA USING A PROJECTION ARTIFACT METHOD IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Maruko, I; Spaide, RF; Koizumi, H; Sawaguchi, S; Izumi, T; Hasegawa, T; Arakawa, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  37 ( 3 ) 460 - 465   2017.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Correspondence Reply

Maruko, I; Spaide, RF; Koizumi, H; Sawaguchi, S; Izumi, T; Hasegawa, T; Arakawa, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  37 ( 3 ) E32 - E33   2017.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【眼科における薬物療法パーフェクトガイド】網膜疾患 加齢黄斑変性

古泉 英貴

OCULISTA ( (株)全日本病院出版会 )  ( 48 ) 91 - 99   2017.03

Type of publication: Research paper (other science council materials etc.)

Correspondence Reply

Ichiro Maruko, Richard F. Spaide, Hideki Koizumi, Shota Sawaguchi, Takahiko Izumi, Taiji Hasegawa, Hisaya Arakawa, Tomohiro Iida

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   37 ( 3 ) E32 - E33   2017.03

Type of publication: Research paper (other science council materials etc.)

Optical coherence tomography angiography and fundus autofluorescence in the eyes with choroideremia.

Kato M, Maruko I, Koizumi H, Iida T

BMJ case reports ( BMJ Case Reports )  2017   2017.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Extraocular Technique of Intrascleral Intraocular Lens Fixation Using a Pair of the Shaft-Bended 27-Gauge Needles

Maruko, I; Koizumi, H; Kogure-Katakura, A; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  37 ( 1 ) 191 - 193   2017.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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MACULAR HOLE FORMATION IDENTIFIED WITH INTRAOPERATIVE OCT DURING VITRECTOMY FOR VITREOMACULAR TRACTION SYNDROME.

Sawaguchi S, Maruko I, Mikami Y, Hasegawa T, Koizumi H, Iida T

Retinal cases & brief reports ( Retinal Cases and Brief Reports )  11 ( 4 ) 380 - 382   2017 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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IMAGING AND DIAGNOSIS OF POLYPOIDAL CHOROIDAL VASCULOPATHY

Wong, RLM; Wing-Lau, H; Koizumi, H; Wong, IYH

CHOROIDAL DISORDERS ( Choroidal Disorders )    349 - 370   2017 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Detection of retrobulbar blood vessels in optical coherence tomography angiographic images in eyes with pathologic myopia.

Maruko I, Koizumi H, Hasegawa T, Iida T

American journal of ophthalmology case reports ( American Journal of Ophthalmology Case Reports )  4   74 - 77   2016.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【脈絡膜から考える網膜疾患】脈絡膜と加齢黄斑変性

古泉 英貴

臨床眼科 ( (株)医学書院 )  70 ( 13 ) 1850 - 1855   2016.12

Type of publication: Research paper (other science council materials etc.)

【加齢黄斑変性アップデート】滲出型加齢黄斑変性の診断

古泉 英貴

眼科 ( 金原出版(株) )  58 ( 13 ) 1545 - 1555   2016.12

Type of publication: Research paper (other science council materials etc.)

蛍光眼底造影クリニカルカンファレンス(第10回) 黄斑部毛細血管拡張症

古泉 英貴

臨床眼科 ( (株)医学書院 )  70 ( 10 ) 1536 - 1540   2016.10

Type of publication: Research paper (other science council materials etc.)

Reply

Hideki Koizumi, Akiko Yamamoto, Ichiro Maruko, Annabelle A. Okada, Tomohiro Iida, Mariko Kano, Masaaki Saito, Tetsuju Sekiryu, Ryo Kawasaki

American Journal of Ophthalmology ( Elsevier Inc. )  168   287 - 288   2016.08 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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蛍光眼底造影クリニカルカンファレンス(第8回) 糖尿病黄斑浮腫

小嶋 健太郎, 古泉 英貴

臨床眼科 ( (株)医学書院 )  70 ( 8 ) 1200 - 1210   2016.08

Type of publication: Research paper (other science council materials etc.)

Short-Term Changes in Choroidal Thickness After Aflibercept Therapy for Neovascular Age-Related Macular Degeneration REPLY

Hideki Koizumi, Akiko Yamamoto, Ichiro Maruko, Annabelle A. Okada, Tomohiro Iida, Mariko Kano, Masaaki Saito, Tetsuju Sekiryu, Ryo Kawasaki

AMERICAN JOURNAL OF OPHTHALMOLOGY   168   287 - 288   2016.08

Type of publication: Research paper (other science council materials etc.)

Age-Dependent Morphologic Alterations in the Outer Retinal and Choroidal Thicknesses Using Swept Source Optical Coherence Tomography

Maruko, I; Arakawa, H; Koizumi, H; Izumi, R; Sunagawa, H; Iida, T

PLOS ONE ( Plos One )  11 ( 7 ) e0159439   2016.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Subfoveal Choroidal Thickness during Aflibercept Therapy for Neovascular Age-Related Macular Degeneration

Koizumi, H; Kano, M; Yamamoto, A; Saito, M; Maruko, I; Sekiryu, T; Okada, AA; Iida, T

OPHTHALMOLOGY ( Ophthalmology )  123 ( 3 ) 617 - 624   2016.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Re: Yamamoto et al.: One-year results of intravitreal aflibercept for polypoidal choroidal vasculopathy (Ophthalmology 2015; 122: 1866-72) REPLY

Okada, AA; Yamamoto, A; Koizumi, H; Kano, M; Saito, M; Maruko, I; Sekiryu, T; Iida, T

OPHTHALMOLOGY ( Ophthalmology )  123 ( 2 ) E13 - E14   2016.02 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Re: Yamamoto et al.: One-year results of intravitreal aflibercept for polypoidal choroidal vasculopathy (Ophthalmology 2015; 122: 1866-72) REPLY

Annabelle A. Okada, Akiko Yamamoto, Hideki Koizumi, Mariko Kano, Masaaki Saito, Ichiro Maruko, Tetsuju Sekiryu, Tomohiro Iida

OPHTHALMOLOGY   123 ( 2 ) E13 - E14   2016.02

Type of publication: Research paper (other science council materials etc.)

Polypoidal Choroidal Vasculopathy A Distinct Disease or Manifestation of Many?

Balaratnasingam, C; Lee, WK; Koizumi, H; Dansingani, K; Inoue, M; Freund, KB

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  36 ( 1 ) 1 - 8   2016.01 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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【眼底自発蛍光フル活用】滲出型加齢黄斑変性と眼底自発蛍光

寺尾 信宏, 古泉 英貴

OCULISTA ( (株)全日本病院出版会 )  ( 34 ) 15 - 21   2016.01

Type of publication: Research paper (other science council materials etc.)

One-Year Results of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy

Yamamoto, A; Okada, AA; Kano, M; Koizumi, H; Saito, M; Maruko, I; Sekiryu, T; Iida, T

OPHTHALMOLOGY ( Ophthalmology )  122 ( 9 ) 1866 - 1872   2015.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Aflibercept therapy for polypoidal choroidal vasculopathy: short-term results of a multicentre study

Koizumi, H; Kano, M; Yamamoto, A; Saito, M; Maruko, I; Sekiryu, T; Okada, AA; Iida, T

BRITISH JOURNAL OF OPHTHALMOLOGY ( British Journal of Ophthalmology )  99 ( 9 ) 1284 - 1288   2015.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【眼疾患と炎症】後眼部 加齢黄斑変性 advanced AMDの観点から

古泉 英貴

別冊Bio Clinica: 慢性炎症と疾患 ( (株)北隆館 )  4 ( 3 ) 49 - 54   2015.08

Type of publication: Research paper (other science council materials etc.)

【抗VEGF薬による治療】アフリベルセプトによる加齢黄斑変性の治療

古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  32 ( 8 ) 1105 - 1111   2015.08

Type of publication: Research paper (other science council materials etc.)

Reply: To PMID 25555799.

Koizumi H, Yamamoto A, Maruko I, Okada AA, Iida T, Kano M, Saito M, Sekiryu T, Kawasaki R

American journal of ophthalmology   160 ( 1 ) 207 - 208   2015.07 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Short-Term Changes in Choroidal Thickness After Aflibercept Therapy for Neovascular Age-Related Macular Degeneration REPLY

Hideki Koizumi, Akiko Yamamoto, Ichiro Maruko, Annabelle A. Okada, Tomohiro Iida, Mariko Kano, Masaaki Saito, Tetsuju Sekiryu, Ryo Kawasaki

AMERICAN JOURNAL OF OPHTHALMOLOGY   160 ( 1 ) 207 - 208   2015.07

Type of publication: Research paper (other science council materials etc.)

抗VEGF治療セミナー 抗VEGF薬と脈絡膜厚

古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  32 ( 6 ) 839 - 840   2015.06

Type of publication: Research paper (other science council materials etc.)

En-face optical coherence tomography in the diagnosis and management of age-related macular degeneration and polypoidal choroidal vasculopathy

Tiffany Lau, Ian Y. Wong, Lawrence Iu, Jay Chhablani, Tao Yong, Koizumi Hideki, Jacky Lee, Raymond Wong

INDIAN JOURNAL OF OPHTHALMOLOGY   63 ( 5 ) 378 - 383   2015.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Short-Term Changes in Choroidal Thickness After Aflibercept Therapy for Neovascular Age-Related Macular Degeneration

Koizumi, H; Kano, M; Yamamoto, A; Saito, M; Maruko, I; Kawasaki, R; Sekiryu, T; Okada, AA; Iida, T

AMERICAN JOURNAL OF OPHTHALMOLOGY ( American Journal of Ophthalmology )  159 ( 4 ) 627 - 633   2015.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【硝子体・網膜病変の診かた-私はこう診る-】黄斑疾患 黄斑部毛細血管拡張症(idiopathic macular telangiectasia)

古泉 英貴

眼科 ( 金原出版(株) )  57 ( 4 ) 577 - 581   2015.03

Type of publication: Research paper (other science council materials etc.)

【脈絡膜と網膜疾患】脈絡膜と加齢黄斑変性

古泉 英貴

臨床眼科 ( (株)医学書院 )  69 ( 2 ) 136 - 141   2015.02

Type of publication: Research paper (other science council materials etc.)

眼科医の手引 黄斑部毛細血管拡張症

古泉 英貴

日本の眼科 ( (公社)日本眼科医会 )  85 ( 11 ) 1598 - 1599   2014.11

Type of publication: Research paper (other science council materials etc.)

ポリープ状脈絡膜血管症に関する新知見と治療への展開

古泉 英貴

日本眼科学会雑誌 ( (公財)日本眼科学会 )  118 ( 11 ) 927 - 942   2014.11

Type of publication: Research paper (other science council materials etc.)

【黄斑疾患診療の進歩】抗VEGF剤の功罪

古泉 英貴

眼科 ( 金原出版(株) )  56 ( 12 ) 1407 - 1413   2014.11

Type of publication: Research paper (other science council materials etc.)

[Polypoidal choroidal vasculopathy: new observations and therapeutic implications].

Koizumi H

Nippon Ganka Gakkai zasshi   118 ( 11 ) 927 - 942   2014.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

　View Summary

Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration characterized by peculiar polypoidal lesions seen on indocyanine green angiography (IA). However, precise pathogenesis of PCV has yet to be clearly elucidated. In addition to the conventional diagnostic tools, we evaluated the clinical characteristics of PCV by means of relatively new and noninvasive imaging methods, namely, fundus autofluorescence photography and enhanced depth imaging optical coherence tomography, and found novel observations. This article focuses especially on the relationship between the clinical characteristics of PCV and choroidal vascular hyperpermeability. Choroidal vascular hyperpermeability, which is visualized as multifocal hyperfluorescence in the middle and late phases on IA, was originally described as a characteristic finding in, central serous chorioretinopathy (CSC). Of the 89 patients with PCV in our case series, 31 patients (34.8%) demonstrated choroidal vascular hyperpermeability. The patients with PCV associated with choroidal vascular hyperpermeability demonstrated more frequently bilateral occurrence of neovascular membrane, a history of CSC, a thickened choroid and poor responses to ranibizumab therapy than those without choroidal vascular hyperpermeability. Our results provide further understanding of PCV and new therapeutic implications.

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PCV診療ガイドライン

古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  56 ( 12 ) 1439 - 1445   2014.11

Type of publication: Research paper (other science council materials etc.)

新しい治療と検査シリーズ Swept-Source OCT(SS-OCT)

古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  31 ( 10 ) 1485 - 1486   2014.10

Type of publication: Research paper (other science council materials etc.)

Latest Advances in Diagnostic Tools 滲出型加齢黄斑変性と脈絡膜断層撮影

古泉 英貴

眼科臨床紀要 ( 眼科臨床紀要会 )  7 ( 10 ) 763 - 764   2014.10

Type of publication: Research paper (other science council materials etc.)

Therapeutics 加齢黄斑変性治療の基礎知識 加齢黄斑変性診療に必要なOCTの読影

寺尾 信宏, 古泉 英貴

眼科グラフィック ( (株)メディカ出版 )  3 ( 5 ) 503 - 508   2014.10

Type of publication: Research paper (other science council materials etc.)

SUBFOVEAL CHOROIDAL THICKNESS IN RETINAL ANGIOMATOUS PROLIFERATION

Taizo Yamazaki, Hideki Koizumi, Tetsuya Yamagishi, Shigeru Kinoshita

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   34 ( 7 ) 1316 - 1322   2014.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Changes in fundus autofluorescence after treatments for polypoidal choroidal vasculopathy

Tetsuya Yamagishi, Hideki Koizumi, Taizo Yamazaki, Shigeru Kinoshita

BRITISH JOURNAL OF OPHTHALMOLOGY   98 ( 6 ) 780 - 784   2014.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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抗VEGF治療セミナー 使用方法 ノンレスポンダーへの対処方法

菅波 由花, 古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  31 ( 1 ) 67 - 68   2014.01

Type of publication: Research paper (other science council materials etc.)

Diagnostics 蛍光眼底造影写真 診断のポイント 加齢黄斑変性における蛍光眼底造影の読み方

寺尾 信宏, 古泉 英貴

眼科グラフィック ( (株)メディカ出版 )  2 ( 6 ) 581 - 588   2013.12

Type of publication: Research paper (other science council materials etc.)

【動画と写真でスイスイわかる!蛍光眼底造影の基本と見かた】蛍光眼底造影の基本を学ぼう! 検査の手順

山岸 哲哉, 古泉 英貴

眼科ケア ( (株)メディカ出版 )  15 ( 12 ) 1151 - 1156   2013.12

Type of publication: Research paper (other science council materials etc.)

【眼循環と網膜関連疾患の関与を探る】加齢黄斑変性

古泉 英貴

Retina Medicine ( (株)先端医学社 )  2 ( 2 ) 146 - 151   2013.10

Type of publication: Research paper (other science council materials etc.)

【加齢黄斑変性の新展開】加齢黄斑変性の治療 抗VEGF療法

古泉 英貴

Progress in Medicine ( (株)ライフ・サイエンス )  33 ( 10 ) 2107 - 2111   2013.10

Type of publication: Research paper (other science council materials etc.)

【加齢黄斑変性】Drusenの新概念

古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  55 ( 10 ) 1109 - 1114   2013.10

Type of publication: Research paper (other science council materials etc.)

【加齢黄斑変性に対する治療の選択】典型加齢黄斑変性

古泉 英貴

眼科手術 ( (公社)日本眼科手術学会 )  26 ( 3 ) 352 - 357   2013.07

Type of publication: Research paper (other science council materials etc.)

【こう活かそう!OCT】加齢黄斑変性

古泉 英貴

OCULISTA ( (株)全日本病院出版会 )  ( 2 ) 23 - 31   2013.05

Type of publication: Research paper (other science council materials etc.)

今さら聞けないQ&A(第2回) 眼底自発蛍光が保険収載されましたが,この検査がとくに役立つ疾患を具体的に教えてください

古泉 英貴

Retina Medicine ( (株)先端医学社 )  2 ( 1 ) 112 - 113   2013.04

Type of publication: Research paper (other science council materials etc.)

【炎症と網膜関連疾患の関与を探る】中心性漿液性脈絡網膜症

古泉 英貴, 飯田 知弘

Retina Medicine ( (株)先端医学社 )  2 ( 1 ) 61 - 65   2013.04

Type of publication: Research paper (other science council materials etc.)

増殖糖尿病網膜症に合併した滲出型加齢黄斑変性の1例

山崎 太三, 古泉 英貴, 内田 真理子, 辻本 淳子, 伴 由利子

公立南丹病院医学雑誌 ( 京都中部総合医療センター )  15 ( 1 ) 41 - 45   2013.03

Type of publication: Research paper (other science council materials etc.)

【黄斑疾患診療トピックス】眼底自発蛍光最前線

古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  30 ( 2 ) 185 - 192   2013.02

Type of publication: Research paper (other science council materials etc.)

Relationship Between Clinical Characteristics of Polypoidal Choroidal Vasculopathy and Choroidal Vascular Hyperpermeability

Hideki Koizumi, Tetsuya Yamagishi, Taizo Yamazaki, Shigeru Kinoshita

AMERICAN JOURNAL OF OPHTHALMOLOGY   155 ( 2 ) 305 - 313   2013.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【抗VEGF治療のすべて】糖尿病黄斑浮腫に対する抗VEGF治療

古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  29 ( 9 ) 1195 - 1201   2012.09

Type of publication: Research paper (other science council materials etc.)

Fundus Autofluorescence in Polypoidal Choroidal Vasculopathy

Tetsuya Yamagishi, Hideki Koizumi, Taizo Yamazaki, Shigeru Kinoshita

OPHTHALMOLOGY   119 ( 8 ) 1650 - 1657   2012.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Subfoveal Choroidal Thickness after Ranibizumab Therapy for Neovascular Age-related Macular Degeneration: 12-Month Results

Taizo Yamazaki, Hideki Koizumi, Tetsuya Yamagishi, Shigeru Kinoshita

OPHTHALMOLOGY   119 ( 8 ) 1621 - 1627   2012.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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CHOROIDAL THICKNESS IN INFERIOR STAPHYLOMA ASSOCIATED WITH POSTERIOR SEROUS RETINAL DETACHMENT

Tetsuya Yamagishi, Hideki Koizumi, Taizo Yamazaki, Shigeru Kinoshita

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   32 ( 7 ) 1237 - 1242   2012.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The inner segment/outer segment junction: what have we learnt so far?

Ian Y. Wong, Lawrence P. Iu, Hideki Koizumi, Wico W. Lai

CURRENT OPINION IN OPHTHALMOLOGY   23 ( 3 ) 210 - 218   2012.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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今月の話題 黄斑部毛細血管拡張症の病態と治療

古泉 英貴

臨床眼科 ( (株)医学書院 )  66 ( 3 ) 233 - 238   2012.03

Type of publication: Research paper (other science council materials etc.)

Predictive factors of resolved retinal fluid after intravitreal ranibizumab for polypoidal choroidal vasculopathy

Hideki Koizumi, Tetsuya Yamagishi, Taizo Yamazaki, Shigeru Kinoshita

BRITISH JOURNAL OF OPHTHALMOLOGY   95 ( 11 ) 1555 - 1559   2011.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy

Hideki Koizumi, Tetsuya Yamagishi, Taizo Yamazaki, Ryo Kawasaki, Shigeru Kinoshita

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY   249 ( 8 ) 1123 - 1128   2011.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Enhanced depth imaging optical coherence tomography.

Wong IY, Koizumi H, Lai WW

Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye   42 Suppl   S75 - 84   2011.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

　View Summary

Imaging the choroid with conventional commercial spectral-domain optical coherence tomography (SD-OCT) has been difficult, mainly because of difficulty in signal transmission beyond the retinal pigment epithelium. A recent modification to the standard technique, termed enhanced depth imaging optical coherence tomography (EDI-OCT), was able to image the choroid with reasonable clarity using commercial SD-OCTs. The aim of this article was to review the technique, principle, recent findings, and possible future developments regarding EDI-OCT. A MEDLINE search on all published articles on EDI-OCT was performed up to December 2010. The principle behind EDI-OCT was discussed. Modification to the conventional technique in image acquisition was described and illustrated with figures. EDI-OCT findings in various retinal and choroidal diseases were discussed. Advantages and disadvantages were also discussed. EDI-OCT has proved to be a promising novel technique in imaging the choroid.

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High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy

Sotaro Ooto, Masanori Hangai, Kohei Takayama, Naoko Arakawa, Akitaka Tsujikawa, Hideki Koizumi, Susumu Oshima, Nagahisa Yoshimura

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE   52 ( 8 ) 5541 - 5550   2011.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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眼科医の手引 Enhanced Depth Imaging Optical Coherence Tomography(EDI OCT)による脈絡膜の評価

古泉 英貴

日本の眼科 ( (公社)日本眼科医会 )  82 ( 6 ) 765 - 766   2011.06

Type of publication: Research paper (other science council materials etc.)

眼画像診断の進歩 黄斑疾患の病態 画像診断による形態と機能解析

飯田 知弘, 石龍 鉄樹, 丸子 一朗, 小島 彰, 菅野 幸紀, 小山田 紘, 大口 泰治, 古田 実, 齋藤 昌晃, 今 陽子, 齋藤 国治, 近藤 剛史, 小笠原 雅, 古泉 英貴, 堀口 正之, 藤原 貴光, Spaide Richard F, 今村 裕

日本眼科学会雑誌 ( (公財)日本眼科学会 )  115 ( 3 ) 238 - 275   2011.03

Type of publication: Research paper (other science council materials etc.)

【黄斑疾患アップデート】黄斑部毛細血管拡張症

古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  28 ( 2 ) 205 - 212   2011.02

Type of publication: Research paper (other science council materials etc.)

Blue light and near-infrared fundus autofluorescence in acute Vogt-Koyanagi-Harada disease

Hideki Koizumi, Kazuichi Maruyama, Shigeru Kinoshita

BRITISH JOURNAL OF OPHTHALMOLOGY   94 ( 11 ) 1499 - 1505   2010.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Enhanced Depth Imaging Optical Coherence Tomography(EDI-OCT)

古泉 英貴

眼科手術 ( (公社)日本眼科手術学会 )  23 ( 3 ) 395 - 397   2010.07

Type of publication: Research paper (other science council materials etc.)

Unusual Loop-Like Vessel Formation After Intravitreal Ranibizumab Injections in AMD.

Koizumi H, Ferrara DC, Slakter JS

Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye     1 - 2   2010.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

　View Summary

The authors observed an unusual closed loop-like vessel formation in the macula and describe its regression caused by the heterogenous treatment effects of intravitreal ranibizumab injections in an eye with exudative age-related macular degeneration associated with multiple retinochoroidal anastomoses.

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Severe Retinal Vascular Infarction After Photodynamic Therapy With Verteporfin Using the Standard Protocol

Hideki Koizumi, Hiroki Hatanaka

ARCHIVES OF OPHTHALMOLOGY   128 ( 2 ) 259 - 262   2010.02 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

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Retinal Arteriolar Macroaneurysm and Congenital Retinal Macrovessel

Hideki Koizumi, Tomohiro Iida, Takafumi Mori, Minoru Furuta, Lawrence A. Yannuzzi

OPHTHALMIC SURGERY LASERS & IMAGING   40 ( 5 ) 513 - 515   2009.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Spectral Domain Optical Coherence Tomographic Findings of Occult Macular Dystrophy

Hideki Koizumi, Joseph I. Maguire, Richard F. Spaide

OPHTHALMIC SURGERY LASERS & IMAGING   40 ( 2 ) 174 - 176   2009.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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【病変がわかる!医師の求める写真が撮れる!眼底・前眼部写真のすべて】眼底検査 検査員なら知っておきたい!眼底病変 加齢黄斑変性

古泉 英貴

眼科ケア ( (株)メディカ出版 )  ( 2008冬季増刊 ) 154,20 - 164,20   2008.12

Type of publication: Research paper (other science council materials etc.)

Enhanced depth imaging spectral-domain optical coherence tomography

Richard F. Spaide, Hideki Koizumi, Maria C. Pozonni

AMERICAN JOURNAL OF OPHTHALMOLOGY   146 ( 4 ) 496 - 500   2008.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes

Louis K. Chang, Hideki Koizumi, Richard F. Spaide

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   28 ( 7 ) 969 - 975   2008.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Ultrastructural correlation of spectral-domain optical coherence tomographic findings in Vitreomacular Traction syndrome

Louis K. Chang, Howard F. Fine, Richard F. Spaide, Hideki Koizumi, Hans E. Grossniklaus

AMERICAN JOURNAL OF OPHTHALMOLOGY   146 ( 1 ) 121 - 127   2008.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Spectral domain optical coherence tomographic findings of occult macular dystrophy

Hideki Koizumi, Joseph I. Maguire, Richard F. Spaide

OPHTHALMIC SURGERY LASERS & IMAGING   39 ( 4 ) S114 - S116   2008.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Photoreceptor outer segment abnormalities as a cause of blind spot enlargement in acute zonal occult outer retinopathy-complex diseases

Richard F. Spaide, Hideki Koizumi, K. Bailey Freund

AMERICAN JOURNAL OF OPHTHALMOLOGY   146 ( 1 ) 111 - 120   2008.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Fundus autofluorescence in birdshot chorioretinopathy.

Koizumi H, Pozzoni MC, Spaide RF

Ophthalmology   115 ( 5 ) e15 - 20   2008.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To investigate the characteristics of fundus autofluorescence in birdshot chorioretinopathy (BSCR). DESIGN: Retrospective, observational case series. PARTICIPANTS: Sixteen eyes of 8 consecutive patients with BSCR (3 men, 5 women). METHODS: Color and autofluorescence photography and optical coherence tomograms of patients with BSCR seen in a referral practice were evaluated. MAIN OUTCOME MEASURES: Autofluorescent characteristics in BSCR. RESULTS: The 8 patients ranged in age from 35 to 73 years (mean, 56.9 years). Of the 16 eyes, 11 eyes (69%) of 6 patients had retinal pigment epithelium (RPE) atrophy as evidenced by hypoautofluorescent regions. Some of the hypoautofluorescent areas corresponded to the hypopigmented birdshot lesions, but the others did not necessarily show a correspondence. Eight eyes (50%) of 4 patients showed linear hypoautofluorescent streaks along the retinal vessels, most of which corresponded to visible changes at the level of the RPE. Placoid hypoautofluorescence in the macula was seen in 6 eyes (38%) of 3 patients and was correlated significantly with best-corrected visual acuity of 20/50 or less (P<0.05). CONCLUSIONS: Autofluorescence photography demonstrated the RPE atrophy, which was hard to see by other means of investigation. The areas of RPE atrophy did not necessarily correspond to the hypopigmented lesions, which suggested that both the choroid and the RPE can be affected independently. Retinal pigment epithelium atrophy in the macula may be an important cause of poor central visual acuity in eyes with BSCR.

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Choroidal circulatory disturbances associated with retinal angiomatous proliferation on indocyanine green angiography

Hideki Koizumi, Tomohiro Iida, Masaaki Saito, Dai Nagayama, Ichiro Maruko

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY   246 ( 4 ) 515 - 520   2008.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography

Hideki Koizumi, Richard F. Spaide, Yale L. Fisher, K. Bailey Freund, James M. Klancnik, Lawrence A. Yannuzzi

AMERICAN JOURNAL OF OPHTHALMOLOGY   145 ( 3 ) 509 - 517   2008.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Type 3 neovascularization - The expanded spectrum of retinal angiomatous proliferation

K. Bailey Freund, I. -Van Ho, Irene A. Barbazetto, Hideki Koizumi, Ketan Laud, Daniela Ferrara, Yoko Matsumoto, John A. Sorenson, Lawrence Yannuzzi

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   28 ( 2 ) 201 - 211   2008.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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3d spectral optical coherence tomography documentation of a retinal vein occlusion associated with a pigment epithelial detachment.

Reddy S, Koizumi H, Peralta R, Freund KB

Retinal cases & brief reports   2 ( 2 ) 99 - 100   2008 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To describe a case of a pigment epithelial detachment (PED) that likely led to a branch retinal vein occlusion (BRVO). METHODS: Color photography, fluorescein angiography, and three-dimensional spectral optical coherence tomography (3D-spectral OCT) were performed. RESULTS: Fluorescein angiography identified a PED at the site of a BRVO, and 3D-spectral OCT illustrated compression and distortion of the overlying retina at the location of the venous obstruction. CONCLUSION: It is well known that retinal arterial disease can compress an underlying vein and lead to a BRVO. A theoretically possible, but previously unrecognized cause of a BRVO is compression of an overlying vein by an underlying PED. Our case reminds us to continue to explore local anatomical factors in addition to systemic factors in patients with venous occlusive disease.

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Sodium hyaluronate eye drops prevent late-onset bleb leakage after trabeculectomy with mitomycin C

H. Sagara, T. Iida, K. Suzuki, T. Fujiwara, H. Koizumi, K. Yago

Eye ( Nature Publishing Group )  22 ( 4 ) 507 - 514   2008 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Indocyanine green angiography in eyes with substantially increased subretinal fluid 1 week after photodynamic therapy.

Koizumi H, Iida T, Nagayama D, Saito M, Sekiryu T

Retinal cases & brief reports   2 ( 1 ) 12 - 14   2008 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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PURPOSE: To investigate the characteristics of eyes in which a serous retinal detachment became substantially more extensive and persisted 1 week after photodynamic therapy (PDT) using indocyanine green (ICG) angiography. DESIGN: Retrospective, interventional case series. PATIENTS AND METHODS: The authors reviewed the ICG angiograms of five eyes of five patients with neovascular age-related macular degeneration. RESULTS: In all eyes, the ICG angiograms obtained 1 week after PDT showed a well-demarcated hypofluorescent area corresponding to the treatment spot. Vascular hyperpermeability emanating from the middle and large choroidal vessels was seen within the hypofluorescent area whether the targeted choroidal neovascularization was perfused or not. CONCLUSIONS: Choroidal vascular hyperpermeability on ICG angiography is a common finding in eyes with substantially increased subretinal fluid 1 week after PDT. PDT might even affect the middle and large choroidal vessels within the treatment spots under some conditions, leading to a supply of subretinal fluid and causing a persistent serous retinal detachment.

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Familial bilateral macular aneurysmal telangiectasia.

Koizumi H, Rutledge BK, Yannuzzi LA

Retinal cases & brief reports   2 ( 2 ) 87 - 90   2008 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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BACKGROUND: Idiopathic macular aneurysmal telangiectasia or so-called Coats' disease is usually a unilateral retinal vascular abnormality in males. It has been rarely reported to occur bilaterally with and without associated abnormalities, and its occurrence in a familial setting is even rarer. PURPOSE: This is a report of a familial occurrence of bilateral macular aneurysmal telangiectasia or Coats' disease in a father and daughter. RESULTS: A 44-year-old woman and her father had bilateral macular angiopathy with macular telangiectasia, aneurysms, ischemia, and leakage, including lipid deposition. The clinical findings were confirmed with fluorescein angiography and optical coherence tomography. There was no history of systemic disease associated with a retinal vascular abnormality. CONCLUSION: To our knowledge, this is the first report of a familial occurrence of bilateral macular aneurysmal telangiectasia or Coats' disease in a daughter and father without associated systemic disease.

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Central retinal vein occlusion case-control study

Hideki Koizumi, Daniela C. Ferrara, Claudia Brue, Richard F. Spaide

AMERICAN JOURNAL OF OPHTHALMOLOGY   144 ( 6 ) 858 - 863   2007.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Early bevacizumab treatment of central retinal vein occlusion

Daniela C. Ferrara, Hideki Koizumi, Richard F. Spaide

AMERICAN JOURNAL OF OPHTHALMOLOGY   144 ( 6 ) 864 - 871   2007.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Centripetal retinal capillary proliferation in idiopathic parafoveolar telangiectasis

Hideki Koizumi, Michael J. Cooney, Anita Leys, Richard F. Spaide

BRITISH JOURNAL OF OPHTHALMOLOGY   91 ( 12 ) 1719 - 1720   2007.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Detection of a microrip using spectral-domain optical coherence tomography with three-dimensional image reconstruction

Hideki Koizumi, Richard F. Spaide

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   27 ( 8 ) 1152 - 1153   2007.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Full-thickness macular hole formation in idiopathic parafoveal telangiectasis

Hideki Koizumi, Jason S. Slakter, Richard F. Spaide

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES   27 ( 4 ) 473 - 476   2007.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Morphologic features of group 2A idiopathic juxtafoveolar retinal telangiectasis in three-dimensional optical coherence tomography

Hideki Koizumi, Tomohiro Iida, Ichiro Maruko

AMERICAN JOURNAL OF OPHTHALMOLOGY   142 ( 2 ) 340 - 343   2006.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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光線力学的療法不適応例を含めた経瞳孔温熱療法の治療成績

古泉 英貴, 瓶井 資弘, 安原 徹, 鄭 守, 大内 雅之, 小森 秀樹, 山本 恭三, 木下 茂

眼科臨床医報 ( 眼科臨床医報会 )  99 ( 9 ) 729 - 732   2005.09

Type of publication: Research paper (other science council materials etc.)

【黄斑部疾患を見直そう】中心性漿液性網脈絡膜症の病態と治療

古泉 英貴, 飯田 知弘

あたらしい眼科 ( (株)メディカル葵出版 )  22 ( 5 ) 567 - 572   2005.05

Type of publication: Research paper (other science council materials etc.)