論文 - 古泉　英貴

【7年前の常識は現在の非常識!-眼科診療の最新標準】網膜・硝子体疾患 診断・治療 ポリープ状脈絡膜血管症の診断と治療

古泉 英貴

臨床眼科 ( (株)医学書院 )  72 ( 11 ) 234 - 237   2018年10月

掲載種別: 研究論文（その他学術会議資料等）

【TOPICS 2018!】Pachychoroidという疾患スペクトラム

古泉 英貴, 玉城 環, 湧川 空子

Retina Medicine ( (株)先端医学社 )  7 ( 2 ) 118 - 123   2018年10月

掲載種別: 研究論文（その他学術会議資料等）

Comparison of subfoveal choroidal structures in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

Takahashi, Y; Koizumi, H; Hasegawa, T; Izumi, T; Maruko, I; Sonoda, S; Sakamoto, T; Iida, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  62 ( 5 ) 576 - 583   2018年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: To evaluate and compare the intrachoroidal structures of eyes with typical neovascular age-related macular degeneration (AMD) with those of eyes with polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective and comparative case series. METHODS: Eighty-four treatment-naïve eyes of 84 patients (22 women and 62 men) with typical neovascular AMD or PCV located in the subfoveal region were studied. Cross-sectional images of the retina and choroid were obtained by swept-source optical coherence tomography (SS-OCT). The horizontal SS-OCT images were analyzed by a manual delineation technique and by a binarization method. RESULTS: Thirty-nine eyes with typical neovascular AMD and 45 eyes with PCV were studied. Although the subfoveal choroidal thickness (SCT) did not differ significantly between the 2 subtypes (255.1 ± 86.7 µm in typical neovascular AMD and 289.2 ± 116.5 µm in PCV, P = 0.29), the ratio of the large choroidal vessel layer (LCVL) thickness to the SCT was significantly larger in the eyes with PCV than in the eyes with typical neovascular AMD (0.863 ± 0.084 vs 0.803 ± 0.125, P = 0.023). The binarization method did not find significant differences in the choroidal structure between the 2 subtypes. Multivariate logistic regression analyses found the ratio of the LCVL thickness to the SCT to be the only significantly different factor between typical neovascular AMD and PCV (P = 0.035). CONCLUSION: The intrachoroidal structures of typical neovascular AMD and PCV eyes differ significantly. In eyes with PCV, there seemed to be a greater dilation of the large choroidal vessels.

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Prognostic factors after aflibercept therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy

Ogasawara, M; Koizumi, H; Yamamoto, A; Itagaki, K; Saito, M; Maruko, I; Okada, AA; Iida, T; Sekiryu, T

JAPANESE JOURNAL OF OPHTHALMOLOGY ( Japanese Journal of Ophthalmology )  62 ( 5 ) 584 - 591   2018年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: To determine factors predictive of visual outcomes in eyes treated with intravitreal aflibercept injections (IAIs) for typical neovascular age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, multicenter, institutional, consecutive, interventional case series. METHODS: One hundred nine eyes (107 patients) with treatment-naïve neovascular AMD at 3 university hospitals were studied. After a loading phase of 3 monthly 2.0-mg IAIs, injections were administered every 2 months. The baseline clinical characteristics were investigated in relation to the 12-month visual outcomes. Changes in the mean best-corrected visual acuity (BCVA) were measured at 12 months after initiation of aflibercept therapy. RESULTS: Forty-five eyes (41.3%) had typical neovascular AMD, and 64 eyes (58.7%) had PCV. The changes in the mean BCVA at 12 months compared with baseline did not differ significantly (P = .737) between the 2 groups. Stepwise analysis showed that larger gains in the BCVA at 12 months were associated with poor BCVA (P < .001), no pigment epithelial detachment (P = .004), and subretinal fluid (P = .039) at baseline in eyes with typical neovascular AMD; larger gains in the BCVA were associated with poorer BCVA (P < .001), presence of choroidal vascular hyperpermeability (CVH) (P = .013), and subretinal fluid (P = .044) at baseline in eyes with PCV. CONCLUSIONS: Although poorer BCVA and the presence of subretinal fluid predicted larger gains in BCVA in both subtypes treated with aflibercept, eyes with typical neovascular AMD had greater improvement if no pigment epithelial detachment was present, while eyes with PCV had greater improvement if CVH was present.

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【主訴と所見からみた眼科 common disease】所見からみた診断の進め方 網膜硝子体 網膜剥離

今永 直也, 古泉 英貴

眼科 ( 金原出版(株) )  60 ( 10 ) 1251 - 1255   2018年09月

掲載種別: 研究論文（その他学術会議資料等）

Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration

Terao, N; Koizumi, H; Kojima, K; Yamagishi, T; Yamamoto, Y; Yoshii, K; Kitazawa, K; Hiraga, A; Toda, M; Kinoshita, S; Sotozono, C; Hamuro, J

SCIENTIFIC REPORTS ( Scientific Reports )  8 ( 1 ) 10520 - 10520   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibercept were also analysed in the PNV and nAMD groups. In the PNV group, vascular endothelial growth factor (VEGF)-A was significantly lower than in the nAMD group (p = 0.03) but was almost identical to that in the control group (p = 0.86). The nAMD group showed positive correlations between interleukin (IL)-6 and IL-8 (r = 0.78, p < 0.001), IL-6 and monocyte chemoattractant protein (MCP)-1 (r = 0.68, p = 0.002) and IL-8 and MCP-1 (r = 0.68, p = 0.002). In the nAMD group, eyes with dry maculae one month after the first aflibercept injection showed significantly lower VEGF-A and placental growth factor (PlGF) at baseline than those with wet maculae (p = 0.02 for both). However, there was no significant difference between dry and wet maculae in the PNV group. The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD.

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CLINICAL FINDINGS OF EYES WITH MACULAR EDEMA ASSOCIATED WITH BRANCH RETINAL VEIN OCCLUSION REFRACTORY TO RANIBIZUMAB

Hasegawa, T; Kawano, T; Maruko, I; Koizumi, H; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  38 ( 7 ) 1347 - 1353   2018年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

PURPOSE: To determine the relationship between the clinical findings and the response to ranibizumab therapy in eyes with macular edema associated with branch retinal vein occlusion. METHODS: We reviewed the medical records of 68 patients with macular edema associated with a branch retinal vein occlusion. The patients were placed in the refractory group if the central foveal thickness remained more than 250 μm throughout the 6-month study period despite the ranibizumab therapy; otherwise, they were placed in the responsive group. RESULTS: Sixty (88.2%) of 68 eyes were placed in the responsive group and the other 8 eyes (11.8%) were placed in the refractory group. At the pretreatment examination, fluorescein angiography showed extensive leakage from occluded vessels in 52 (86.7%) of the 60 eyes in the responsive group and focal leakages from microaneurysms or dilated capillaries in the other 8 eyes (13.3%). In the refractory group, 7 (87.5%) of 8 eyes had only focal leakage and 1 eye (12.5%) had extensive leakage (P < 0.0001). The mean initial subfoveal choroidal thickness in the eyes with branch retinal vein occlusion in the responsive group was significantly thicker than that in the fellow eyes (278.0 ± 90.5 μm, 249.9 ± 94.4 μm; P < 0.0001). On the other hand, the mean initial subfoveal choroidal thickness in the refractory group was not significantly different from that of the fellow eyes (P = 0.4002). CONCLUSION: The dye leakage pattern in the fluorescein angiography images and choroidal thickness may be associated with response to ranibizumab therapy.

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Unmeasurable small size of foveal avascular zone without visual impairment in optical coherence tomography angiography

Yokoyama, T; Maruko, I; Koizumi, H; Ishikawa, Y; Iida, T

EYE ( Eye Basingstoke )  32 ( 6 ) 1062 - 1066   2018年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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【ガイドラインに準拠 硝子体内注射の臨床手技】適応疾患と使用法および注意すべき患者背景

玉城 環, 古泉 英貴

眼科グラフィック ( (株)メディカ出版 )  7 ( 3 ) 282 - 288   2018年06月

掲載種別: 研究論文（その他学術会議資料等）

臨床報告 En face OCTを用いた神経線維腫症1型の脈絡膜所見

渡辺 一郎, 丸子 一朗, 長谷川 泰司, 古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  60 ( 5 ) 547 - 552   2018年05月

掲載種別: 研究論文（その他学術会議資料等）

Drusenの分類

古泉 英貴, 飯田 知弘

眼科 ( 金原出版(株) )  59 ( 13 ) 1587 - 1594   2017年12月

掲載種別: 研究論文（その他学術会議資料等）

Foveal Retinal Neovascularization in Proliferative Diabetic Retinopathy: Assessment by Optical Coherence Tomography Angiography

Murakawa, S; Hasegawa, T; Koizumi, H; Maruko, I; Iida, T

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES ( Retina )  37 ( 11 ) E135 - E137   2017年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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【眼科救急Q&A】主訴・主要他覚所見ごとの救急疾患の鑑別診断 急に何かが飛んで見えるようになったと訴えて患者が救急外来を受診しました。鑑別すべき疾患と鑑別の方法を教えてください

寺尾 信宏, 古泉 英貴

あたらしい眼科 ( (株)メディカル葵出版 )  34 ( 臨増 ) 26 - 29   2017年11月

掲載種別: 研究論文（その他学術会議資料等）

Pachychoroid spectrum diseaseの前房水サイトカイン網羅的解析

寺尾 信宏, 山岸 哲哉, 平賀 朝子, 戸田 宗豊, 山本 雄士, 北澤 耕司, 永田 健児, 小嶋 健太郎, 古泉 英貴, 羽室 淳爾, 外園 千恵

日本眼科学会雑誌 ( (公財)日本眼科学会 )  121 ( 11 ) 887 - 888   2017年11月

掲載種別: 研究論文（その他学術会議資料等）

網膜静脈分枝閉塞症における黄斑虚血の評価

三上 侑利子, 小暮 朗子, 古泉 英貴, 新田 恵理, 小川 友紀, 飯田 知弘

臨床眼科 ( (株)医学書院 )  71 ( 10 ) 1533 - 1539   2017年10月

掲載種別: 研究論文（その他学術会議資料等）

レーザースペックルフローグラフィを用いた網膜中心静脈閉塞症における虚血性変化の評価

小川 友紀, 小暮 朗子, 古泉 英貴, 三上 侑利子, 飯田 知弘

臨床眼科 ( (株)医学書院 )  71 ( 10 ) 1601 - 1607   2017年10月

掲載種別: 研究論文（その他学術会議資料等）

Evaluation of ischemic change in central retinal vein occlusion using with laser speckle flowgraphy

Ogawa Y.

Japanese Journal of Clinical Ophthalmology ( Japanese Journal of Clinical Ophthalmology )  71 ( 10 ) 1601 - 1607   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Evaluation of macular ischemia in branch retinal vein occlusion

Mikami Y.

Japanese Journal of Clinical Ophthalmology ( Japanese Journal of Clinical Ophthalmology )  71 ( 10 ) 1533 - 1539   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Subthreshold 577 nm micropulse laser treatment for central serous chorioretinopathy

Maruko, I; Koizumi, H; Hasegawa, T; Arakawa, H; Iida, T

PLOS ONE ( Plos One )  12 ( 8 ) e0184112   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration

Yamashiro, K; Mori, K; Honda, S; Kano, M; Yanagi, Y; Obana, A; Sakurada, Y; Sato, T; Nagai, Y; Hikichi, T; Kataoka, Y; Hara, C; Koyama, Y; Koizumi, H; Yoshikawa, M; Miyake, M; Nakata, I; Tsuchihashi, T; Horie-Inoue, K; Matsumiya, W; Ogasawara, M; Obata, R; Yoneyama, S; Matsumoto, H; Ohnaka, M; Kitamei, H; Sayanagi, K; Ooto, S; Tamura, H; Oishi, A; Kabasawa, S; Ueyama, K; Miki, A; Kondo, N; Bessho, H; Saito, M; Takahashi, H; Tan, X; Azuma, K; Kikushima, W; Mukai, R; Ohira, A; Gomi, F; Miyata, K; Takahashi, K; Kishi, S; Iijima, H; Sekiryu, T; Iida, T; Awata, T; Inoue, S; Yamada, R; Matsuda, F; Tsujikawa, A; Negi, A; Yoneya, S; Iwata, T; Yoshimura, N

SCIENTIFIC REPORTS ( Scientific Reports )  7 ( 1 ) 9196 - 9196   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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