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• Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction.

  Yasunori Suematsu, Akira Minei, Yoko Sumita, Koshiro Kanaoka, Michikazu Nakai, Yoshihiro Miyamoto, Hisatomi Arima, Koshi Nakamura, Tomoyuki Takura, Kazunori Shimada, Hirokazu Shiraishi, Nagaharu Fukuma, Masataka Sata, Hideo Izawa, Yoshihiro Fukumoto, Shigeru Makita, Yusuke Ohya, Shin-Ichiro Miura

  European journal of preventive cardiology     2026.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIMS: Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among outpatients. Therefore, we evaluated the effects of CR, stratified into inpatient and outpatient phases, on the prognosis of patients with AMI in Japan. METHODS AND RESULTS: A multi-centre, retrospective, cohort study in which extracted 4411 AMI patients from 72 institutes throughout Japan who were identified from a Japanese Registry Of All cardiac and vascular Diseases (JROAD) in 2014 was performed. JROAD is a database from Diagnosis Procedure Combination, and we additionally investigated the detailed information about severity, complications, treatment of AMI, the results of examinations, and the 5-year prognosis with respect to CR (JROAD-CR). The patients were divided into four groups, depending on their history of CR as inpatients and outpatients. The percentages of inpatients and outpatients who received CR were 66.1% (n = 2917) and 9.91% (n = 437), respectively. The groups in which only inpatients received CR [In(+)Out(-)] and in which both inpatients and outpatients received CR [In(+)Out(+)] showed significant reduction in all-cause mortality [In(+)Out(-) group; hazard ratio (HR): 0.720, 95% confidence interval (CI) (0.546-0.950) and In(+)Out(+) group; HR: 0.575, 95% CI (0.338-0.977)], although composite major adverse cardiovascular events did not show significant reduction. CONCLUSION: This JROAD-CR study newly revealed that even short periods of CR during hospitalization are important, and continuing CR into the outpatient phase may further improve the prognosis of patients with AMI in this early reperfusion and short hospital staying era.

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• Factors Affecting Body Weight/Waist Circumference Changes after Specific Health Guidance for Obese People with CVD Risk Factors in Japan.

  Nagako Okuda, Koshi Nakamura, Makoto Watanabe, Kei Kamide, Katsushi Yoshita, Sayuki Torii, Katsuyuki Miura, Aya Higashiyama, Kozo Tanno, Yuki Yonekura, Tomomi Nagahata, Toru Kuribayashi, Akira Okayama

  Journal of atherosclerosis and thrombosis     2025.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIM: Specific Health Checkups (SHCs) and Specific Health Guidance (SHG) were launched in 2008, but the factors related to their effectiveness have not been clarified. We examined the mean reduction in body weight (BW) and waist circumference (WC) of participants eligible for active support under SHG. Body size was considered, as well as the number of support points given during SHG, which indicates the amount of support they received. METHODS: A dataset of participants (aged 40-64) who were eligible for SHG and had SHC results collected between 2011 and 2012 was analyzed (n = 76,565). The mean changes in BW and WC between 2011 and 2012 were compared among participants based on their participation status (did not participate, dropped out, finished) and the number of support points for those who finished. Participants were also stratified by sex and BMI (kg/m2): normal weight, overweight, and obese. RESULTS: The mean BW change (95% CI) for those who did not participate and finished SHG was -0.45 kg (-0.47, -0.43) and -1.32 kg (-1.39, -1.25) in men, and -0.66 kg (-0.72, -0.60) and -1.68 kg (-1.87, -1.49) in women, respectively. Higher support points and larger body sizes correlated with greater reductions in BW in men (P＜0.001), but the associations were not significant in women. The reduction in WC was greater in women with normal weight than in obese women. CONCLUSION: Sex differences were observed in the association between BW/WC reduction and body size or the amount of support given during SHG.

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• [Association of regularity of dinnertime and elapsed time from dinner to going to bed with subjective sleep quality among locally-living working-age men and women].

  Chie Kato, Takashi Kimura, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Sachiko Sasaki, Akiko Tamakoshi

  [Nihon koshu eisei zasshi] Japanese journal of public health     2025.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Objective This study aimed to clarify the relationship between the regularity of dinnertime, elapsed time between dinner and bedtime (elapsed time after dinner), and subjective sleep quality among locally-living working-age men and women.Methods Data from the DOSANCO Health Study conducted in 2015 in Suttsu-chou, Hokkaido, Japan, were used. Of the 2,638 residents aged ≥3 years, excluding nursing home residents, 773 aged 20-69 years and those who met the inclusion criteria were analyzed. The regularity of dinnertime was divided into two groups; "regular" and "irregular." Furthermore, the regular group was divided into five groups according to the time elapsed between dinner and bedtime; "≤2 h," ">2 h, ≤3 h," ">3 h, ≤4 h," ">4 h, ≤5 h," and ">5 h." Subjective sleep quality was assessed using the Japanese version of the Pittsburgh Sleep Quality Index, with a total score of ≥6 being "subjective poor sleep quality." Prevalence ratios (PR) and 95% confidence intervals (CI) were calculated by sex and age group (20-39, 40-59, and 60-69 years) using log-binomial regression analysis with SAS software (version 9.4; SAS Institute Inc.).Results The PR (95% CI) for subjective poor sleep quality was significantly higher in the irregular group (men; 1.71 [1.28-2.28], women; 1.50 [1.12-2.00]) than the regular group. Among the regular group, the PR (95% CI) for subjective poor sleep quality compared with the ">3 h, ≤4 h" group as the reference was 1.81 (1.17-2.80) in the ">5 h" group of women. The group with a longer elapsed time from dinner had higher subjective poor sleep quality in women, particularly in women aged 40-59 years.Conclusions Irregular dinnertimes or a lifestyle with a long elapsed time between dinner and bedtime, despite regular dinnertimes, may be associated with poor sleep quality.

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• Making time at a worksite increased medical visits by employees with hypertension at small-to-medium worksites in Okinawa, Japan.

  Koshi Nakamura, Shota Kudaka, Atsushi Sakima

  Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 10 ) 2584 - 2594   2025.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  This longitudinal study investigated whether a worksite healthcare policy of making time for medical visits (exposure factor) facilitated attendance (outcome) at these visits for treatment of newly identified hypertension after a health checkup. The study included employees at small-to-medium companies in Okinawa, Japan, who had a systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, no history of hypertension in the last year, and were not taking antihypertensive medication. Pre-existing data on worksite characteristics, employees' health checkups, and health insurance claims were collected. A multilevel logistic regression model was used to calculate the odds ratio for the worksite group providing time to attend the medical visit, with the worksite group not providing this time acting as the reference. In the 2906 participants with newly identified hypertension employed at 1366 worksites, the cumulative incidence of interest increased gradually with longer follow-up in both groups, although the incidence was higher in the group providing time for the visit. After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for visits by the end of the 4th, 5th, and 6th months after the health checkup in the group with time for a medical visit were 1.80 (1.13-2.86), 1.72 (1.10-2.70), and 1.55 (0.99-2.45), respectively. Similar patterns were observed for every stratum of company size, business category, and healthcare administrator status. These results indicate that a worksite making time for a visit to a medical facility was associated with increased visits by employees with newly identified hypertension at a health checkup.

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• Modulation of Bifidobacterium by HD5 during weaning is associated with high abundance in later life.

  Yu Shimizu, Yuki Yokoi, Shuya Ohira, Hirohisa Izumi, Satomi Kawakami, Miu Ihara, Fuka Tabata, Yasuhiro Takeda, Takashi Kimura, Koshi Nakamura, Akiko Tamakoshi, Tokiyoshi Ayabe, Kiminori Nakamura

  Communications medicine   5 ( 1 ) 250 - 250   2025.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: Bifidobacterium colonization of the intestine is believed to have beneficial effects on our health from infancy throughout life. However, how particular members of the genus Bifidobacterium colonize the neonatal intestine and whether early-life bifidobacterial colonization affects establishment of Bifidobacterium-rich microbiota in later life remain unanswered. α-Defensin secreted from small intestinal Paneth cells elicits selective bactericidal activities that efficiently kill pathogens while hardly affecting commensals including Bifidobacterium in vitro, thus contributing to intestinal microbiota regulation. METHODS: One hundred forty-eight fecal samples were serially obtained from 33 children from postnatal 3-5 days to 3 years old, conducting a longitudinal cohort study of mothers and children living in Iwamizawa city, Hokkaido, Japan (SMILE Iwamizawa study). Microbiota composition and secretory level of α-defensin, human defensin 5 (HD5), were assessed to investigate the relationship between HD5 and Bifidobacterium colonization. RESULTS: We show that HD5 is associated with colonization of Bifidobacterium in early life from pre-weaning to weaning periods. Furthermore, high relative abundance of Bifidobacterium in the weaning period, which positively correlates with HD5 secretion, is associated with the establishment of Bifidobacterium-rich microbiota at 3 years old, when the intestinal microbiota matures. CONCLUSIONS: This study suggests the importance of the weaning period in establishing long-lasting homeostasis interwoven with the host innate immunity and Bifidobacterium in the intestinal microbiota.

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• Can Japan contribute to developing research on the relation between blood pressure variability and suicide risk?

  Koshi Nakamura

  Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 10 ) 2730 - 2731   2025.10

   

  DOI PubMed

• Japanese Medical Facilities Maintained the Quality of Medical Care for Acute Coronary Syndrome during the First Wave of the Coronavirus Disease 2019 Pandemic in Japan.

  Koshi Nakamura

  Journal of atherosclerosis and thrombosis     2021.06

   

  DOI PubMed

• 生活習慣病の予防と医療費:10年間の追跡調査による健診所見と医療費の関連:滋賀国保コホート研究の知見から

  岡村 智教, 中村幸志, 早川岳人, 神田秀幸, 三浦克之, 岡山 明, 上島弘嗣

  日本衛生学雑誌   67 ( 1 ) 38 - 43   2012.01

   

• Smoking cessation rate and its related factors on a smoking cessation support program in a workplace

  C.Aoki, M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura, Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse

    35 ( 1 ) 36 - 38   2008.10  [Refereed]

   

• Effects of educational program under a tutorial or a small-group system on body weight loss for obese participants in a workplace

  C.Okamoto, M.Higashiyama, E.Nagayama, C.Aoki, H.Takayoshi, Y.Nakashima, C.Kobayashi, K.Miura, M.Sakurai, K.Nakamura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa

    35 ( 1 ) 39 - 41   2008.10  [Refereed]

   

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2025.04  -  2029.03 

  Direct: 14,500,000 (YEN)  Overheads: 18,850,000 (YEN)  Total: 4,350,000 (YEN)