Researcher Number(JSPS Kakenhi)


Current Affiliation Organization 【 display / non-display

  • Duty   University of the Ryukyus   Graduate School of Medicine   Professor  

University 【 display / non-display

  • 1990.04

    Jichi Medical University   Faculty of Medicine   Graduated

External Career 【 display / non-display

  • 2005.09


  • 2006.10


  • 2008.04


  • 2010.04


  • 2015.02


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Research Interests 【 display / non-display

  • 疫学

  • 生活習慣病

  • 循環器疾患

  • 心疾患

  • 脳卒中

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Research Areas 【 display / non-display

  • Life Science / Hygiene and public health (non-laboratory)

Acquisition of a qualification 【 display / non-display

  • Doctor

Published Papers 【 display / non-display

  • Obesity and hypertension from a public health perspective in a small remote island of Okinawa, Japan.

    Yumeno Fukumine, Koshi Nakamura

    Hypertension research : official journal of the Japanese Society of Hypertension     2023.05 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

     View Summary

    This study investigated the relationship between obesity and hypertension from a public health perspective in a small remote island of Okinawa where obesity is prevalent. A cross-sectional study was conducted in 456 residents aged ≥18 years in Yonaguni island who underwent an annual health check-up and the Yonaguni dietary survey in 2022. Each participant responded to our original questionnaire and provided further dietary survey data via the Yonaguni municipal government. The odds ratio for hypertension was calculated in the obese group, using a logistic regression model with the non-obese group serving as the reference. Hypertension was defined as a systolic blood pressure ≥140 mmHg, a diastolic blood pressure ≥90 mmHg measured on an automated sphygmomanometer, and/or taking anti-hypertensive agents, while obesity was defined as a body mass index ≥25 kg/m2. The proportion of hypertension associated with obesity among all hypertensive subjects was calculated. The prevalence of obesity and hypertension was 54.3% and 49.0% in the 208 male subjects and 32.3% and 43.6% in the 248 female subjects, respectively. The odds ratio for hypertension in the obese group was 3.73 (95% confidence interval, 1.93-7.20) for men and 4.13 (2.06-8.29) for women after adjusting for age, alcohol drinking habit, behavior for lowering salt intake, and smoking habit. Hypertension in 49.5% (95% confidence interval, 29.4%-63.9%) of males and 37.9% (22.6%-50.2%) of females was associated with obesity in this island. Some areas of Japan could be urgently required to address obesity for preventing cardiovascular disease. A community-based, cross-sectional study in 456 residents aged ≥18 years in Yonaguni island, Okinawa prefecture, Japan.

  • Association of blood pressure and hyperuricemia with proteinuria and reduced renal function in the general population.

    Masako Kochi, Kentaro Kohagura, Nanako Oshiro, Ryo Zamami, Kazufumi Nagahama, Koshi Nakamura, Yusuke Ohya

    Hypertension research : official journal of the Japanese Society of Hypertension     2023.03 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    This study aimed to investigate the effect of hyperuricemia (HU) on the association of systolic blood pressure (SBP) with the prevalence of proteinuria and low estimated glomerular filtration rate (eGFR) in the general population. This cross-sectional study enrolled 24,728 Japanese individuals (11,137 men and 13,591 women) who underwent health checkups in 2010. The prevalence of proteinuria and low eGFR (< 60 mL/min/1.73 m2) among participants classified according to serum uric acid levels and SBP was compared. HU was defined as serum uric acid levels higher than the 75th percentile in male and female participants (> 7.2 and > 5.4 mg/dL, respectively). The odds ratio (OR) for proteinuria increased with elevated SBP. This trend was significantly evident in participants with HU. Moreover, there was an interactive effect of SBP and HU on the prevalence of proteinuria in the male (Pfor interaction = 0.04) and female (Pfor interaction = 0.04) participants. Next, we evaluated the OR for low eGFR (< 60 mL/min/1.73 m2) with and without proteinuria based on the presence of HU. The multivariate analysis revealed that the OR for low eGFR with proteinuria increased with elevated SBP, but that for low eGFR without proteinuria decreased. These trends of OR tended to be prevalent among those with HU. The association between SBP and the prevalence of proteinuria was more pronounced in participants with HU. However, the association between SBP and decreased renal function with and without proteinuria might be different regardless of HU.

  • Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production

    Yu Shimizu, Ryodai Yamamura, Yuki Yokoi, Tokiyoshi Ayabe, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Akiko Tamakoshi, Kiminori Nakamura

    Gut Microbes ( Informa UK Limited )  15 ( 1 )   2023.03 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Study Protocol of Cardiac Rehabilitation for Acute Myocardial Infarction From the JROAD/JROAD-DPC Database - JROAD-CR.

    Yasunori Suematsu, Shin-Ichiro Miura, Akira Minei, Yoko Sumita, Koshiro Kanaoka, Michikazu Nakai, Hisatomi Arima, Koshi Nakamura, Tomoyuki Takura, Kazunori Shimada, Hirokazu Shiraishi, Nagaharu Fukuma, Yusuke Ohya, Shigeru Makita

    Circulation reports   5 ( 2 ) 62 - 65   2023.02 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    Background: Although cardiac rehabilitation (CR) has been reported to be effective for improving the prognosis of acute myocardial infarction (AMI), more patients must participate in CR during admission and as outpatients. Factors contributing to, and countermeasures against, the low CR participation rate need to be identified. Here we describe the protocol for a study designed to evaluate the effectiveness and problems of CR for AMI from the Japanese Registry of All Cardiac and Vascular Diseases (JROAD) and the JROAD-Japanese Diagnosis Procedure Combination system (JROAD-DPC) database. Methods and Results: This is a multicenter retrospective cohort study that will use the JROAD/JROAD-DPC database to evaluate the effectiveness of CR for AMI (JROAD-CR). Five thousand patients with AMI who were admitted to hospitals registered in the JROAD database in 2014 will be investigated with regard to their baseline characteristics, AMI severity and treatment, examination results, history of CR, and prognosis up to 5 years. We will also investigate the presence, quantity, and quality of CR, and evaluate the effectiveness of CR with respect to cost, exercise tolerance, and prognosis during admission and follow-up. Conclusions: The JROAD-CR study will seek to reveal the effectiveness of CR for AMI in the era of early reperfusion therapy and shortened hospitalization.

  • Associations between Maternal Diet, Human Milk Macronutrients, and Breast-Fed Infant Growth during the First Month of Life in the SMILE Iwamizawa in Japan.

    Yosuke Komatsu, Yasuaki Wada, Fuka Tabata, Satomi Kawakami, Yasuhiro Takeda, Kiminori Nakamura, Tokiyoshi Ayabe, Koshi Nakamura, Takashi Kimura, Akiko Tamakoshi

    Nutrients   15 ( 3 )   2023.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    Maternal diet may affect human milk macronutrients, but it remains to be elucidated whether this is also influential in infant growth. This study aimed to examine (1) how maternal diet influences human milk macronutrients, and (2) to what extent the variation in milk macronutrients affects infant growth during the first month of life. In 71 Japanese lactating women, maternal dietary information was collected from the brief-type self-administered diet history questionnaire, and anthropometry of mother-infant dyads was collected from medical records. Macronutrients in milk were analyzed by a Human Milk Analyzer. Maternal retinol intake was associated with the carbohydrate content in human milk at 1-month postpartum (standardized β coefficient: 0.287; p = 0.038). Moreover, the energy content in human milk was associated with an increase in the weight standard deviation score based on the WHO growth standard at 1 month of age (standardized β coefficient: 0.399; p = 0.046). Nevertheless, the milk macronutrient was not associated with the risk of infant growth abnormalities. In conclusion, a part of the maternal diet impacts macronutrient contents in human milk, but milk macronutrients have a limited effect on infant growth only within the normal growth curve during the first month of life.

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Other Papers 【 display / non-display

  • Japanese Medical Facilities Maintained the Quality of Medical Care for Acute Coronary Syndrome during the First Wave of the Coronavirus Disease 2019 Pandemic in Japan.

    Koshi Nakamura

    Journal of atherosclerosis and thrombosis     2021.06


    DOI PubMed

  • 生活習慣病の予防と医療費:10年間の追跡調査による健診所見と医療費の関連:滋賀国保コホート研究の知見から

    岡村 智教, 中村幸志, 早川岳人, 神田秀幸, 三浦克之, 岡山 明, 上島弘嗣

    日本衛生学雑誌   67 ( 1 ) 38 - 43   2012.01


  • Smoking cessation rate and its related factors on a smoking cessation support program in a workplace

    C.Aoki, M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura, Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse

      35 ( 1 ) 36 - 38   2008.10  [Refereed]


  • Effects of educational program under a tutorial or a small-group system on body weight loss for obese participants in a workplace

    C.Okamoto, M.Higashiyama, E.Nagayama, C.Aoki, H.Takayoshi, Y.Nakashima, C.Kobayashi, K.Miura, M.Sakurai, K.Nakamura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa

      35 ( 1 ) 39 - 41   2008.10  [Refereed]