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Published Papers 【 display / non-display 】

• Machine Learning-Enabled Quantification of Fucosylated Human Milk Oligosaccharides in Human Breast Milk by Benchtop 1H NMR Spectroscopy.

  Zhiyan Hu, Jiaxi Jiang, Jun Abe, Thanawat Thumrongtaradol, Miho Akasaka, Yuki Ohnishi, Seiji Osada, Tatsuya Arai, Hiroyuki Kumeta, Yasuhiro Kumaki, Kazuo Yamauchi, Yu Shimizu, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Koshi Nakamura, Takashi Kimura, Akiko Tamakoshi, Tomoyasu Aizawa

  Journal of agricultural and food chemistry   74 ( 30 ) 23924 - 23934   2026.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Human milk oligosaccharides (HMOs) are bioactive components of human breast milk (HBM), but their concentrations vary with maternal secretor phenotype and lactation stage, making individual HMO quantification analytically demanding. Here, we present a reference-guided benchtop 60 MHz NMR workflow integrating chemometrics and machine learning to quantify major fucosylated HMOs in HBM. A total of 111 HBM samples from 37 donors across lactation stages were analyzed. Using 800 MHz NMR-derived concentrations as references, predictive models were developed from benchtop NMR spectra for 2'-fucosyllactose (2'-FL), 3-fucosyllactose (3-FL), and lacto-N-fucopentaose I (LNFP-I). Unlike conventional peak-fitting-based NMR quantification, this workflow recovered HMO-specific quantitative information from highly overlapped 60 MHz carbohydrate signals that were not directly resolvable in authentic HBM. Elastic Net yielded practical models, particularly for lower-abundance 3-FL and LNFP-I. These results support benchtop NMR combined with machine learning as an accessible platform for HMO screening.

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• Worksite Healthcare Systems and Lifestyle-related Risk Factors among Employees at Small-to-medium Worksites in Okinawa, Japan.

  Shota Kudaka, Kenshu Taira, Atsushi Sakima, Koshi Nakamura

  Journal of atherosclerosis and thrombosis     2026.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIM: To investigate whether the presence of common health education (HE) and a healthcare administrator (HA) at a worksite would be associated with a lower prevalence of current smoking, current daily alcohol consumption, and obesity among employees at real-world, small-to-medium worksites. METHODS: The present cross-sectional study included 72,704 employees aged 35-59 years at 5,910 small-to-medium companies in Okinawa, Japan. Odds ratios were calculated by sex for each factor for HE (information provision alone, lecture classes alone, or both services) presence and HA presence, using a multilevel logistic regression model, with HE absence (neither) and HA absence, respectively, serving as the reference. RESULTS: The odds ratios (95% confidence intervals) for current smoking among men and women in the combined HE services group were 0.80 (0.68-0.93) and 0.68 (0.52-0.88), respectively, after adjusting for age, HA status, medication status, and basic worksite characteristics. The adjusted odds ratios for current daily alcohol consumption among men and women in the combined HE services group were 0.81 (0.69-0.95) and 0.84 (0.69-1.02), respectively. However, the four HE groups had similar odds of obesity in both men and women. The HA-present and HA-absent groups had similar odds of all outcomes in both men and women, except that men in the HA-present group had lower odds of current daily alcohol consumption: 0.92 (0.86-0.98). CONCLUSIONS: The combined HE services presence was associated with lower odds of current smoking and daily alcohol consumption among employees, whereas HA presence was associated with lower odds of daily alcohol consumption among men.

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• Association between low-carbohydrate diet scores and glucose metabolism markers among Japanese adults: results from the DOSANCO health study: a cross-sectional study.

  Akinori Yaegashi, Takashi Kimura, Emiko Okada, Koshi Nakamura, Shigekazu Ukawa, Takafumi Nakagawa, Akihiro Imae, Akinobu Nakamura, Akiko Tamakoshi

  Diabetology international   17 ( 3 ) 43 - 43   2026.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: Low-carbohydrate diet (LCD) scores show inconsistent associations with diabetes across regions. As Japanese diets have shifted toward higher meat and lower fish intake in recent decades, the metabolic implications of higher LCD scores in contemporary Japanese populations may differ from earlier findings. We aimed to examine the association between LCD scores and glucose metabolism markers in adults in Hokkaido, Japan, in 2015. METHODS: We conducted a study involving 348 adults aged 35-79 years. Dietary intake was assessed using a validated food frequency questionnaire. Participants with diagnosed diabetes, those receiving diabetes treatment, and those with HbA1c ≥ 6.5% or fasting glucose ≥ 126 mg/dL were excluded. Three LCD scores (normal, animal, and vegetable) were calculated based on the percentage of energy derived from carbohydrate, protein, and fat. Multivariate linear regression was used to estimate the geometric means and 95% confidence intervals of glucose metabolism markers across the quartiles for each LCD score, and linear trends were assessed using the median value in each quartile. RESULTS: Higher normal LCD scores were associated with higher glycated hemoglobin (HbA1c); the geometric mean HbA1c values across quartiles were 5.35, 5.44, 5.40, and 5.52 (p-trend < 0.001). Similar positive trends were observed for the animal and vegetable LCD scores. CONCLUSIONS: Higher LCD scores are associated with higher HbA1c levels in Japanese adults. As cross-sectional data cannot establish temporality or causality, findings should be interpreted cautiously; however, LCD patterns may have different metabolic implications across dietary contexts, including modern Japanese diets with more meat. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-026-00896-4.

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• Association of dietary diversity measured by the number of dishes with cardiovascular risk factors among Japanese adults: findings from the National Health and Nutrition Survey, 2018-19.

  Saeka Takabayashi, Emiko Okada, Hidemi Takimoto, Mieko Nakamura, Satoshi Sasaki, Kunihiko Takahashi, Koshi Nakamura, Shigekazu Ukawa, Akiko Tamakoshi

  Nutrition journal   25 ( 1 )   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: The Japanese-style diet has attracted attention as a factor contributing to the Japanese population's longevity by reducing cardiovascular disease (CVD) mortality. The Japanese-style diet is said to be "ichijusansai" (rice with one soup and three dishes) and is characterized by a high number of dishes. However, the relationship between the number of dishes in all meals (NDAM) and CVD risk factors remains unclear. METHODS: In this cross-sectional study, we analyzed data from 2,900 participants aged ≥20 years from the 2018-19 National Health and Nutrition Survey. Participants were divided into four groups according to sex and NDAM. NDAM was calculated based on a one-day weighed dietary record, excluding beverages, and including all other dishes and foods. Multivariable relative risks (RRs) were estimated using a modified Poisson regression model adjusted for age, living alone, area, occupation, exercise habits, smoking habits, drinking habits, and total energy intake. RESULTS: Participants with higher NDAM were more likely to be older, non-smokers, and physically active. In men, higher NDAM (Groups 2-4) was associated with a lower risk of dyslipidemia compared to Group 1 (the lowest NDAM). In women, an inverse association was observed for overweight/obesity, with Group 4 (the highest NDAM) showing a lower risk than Group 1. Furthermore, a lower risk of hypertension was found in Groups 2-3 compared to Group 1. However, these associations did not remain statistically significant after Bonferroni correction. CONCLUSION: A diet with a high NDAM may be inversely associated with several CVD risk factors among Japanese adults.

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• Benchtop NMR-based lactose quantification in human milk: correction of oligosaccharide interference and comparison with high-field NMR

  Jiaxi Jiang, Zhiyan Hu, Jun Abe, Thanawat Thumrongtaradol, Miho Akasaka, Yuki Ohnishi, Seiji Osada, Tatsuya Arai, Hiroyuki Kumeta, Yasuhiro Kumaki, Kazuo Yamauchi, Yu Shimizu, Yuki Yokoi, Kiminori Nakamura, Tokiyoshi Ayabe, Koshi Nakamura, Takashi Kimura, Akiko Tamakoshi, Tomoyasu Aizawa

  Microchemical Journal ( Elsevier BV )    118371 - 118371   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• The Japanese Society of Hypertension Guidelines for blood pressure control using digital technologies.

  Hisatomi Arima, Hiroshi Itoh, Takayoshi Ohkubo, Yusuke Ohya, Mai Kabayama, Takuya Kishi, Nobuhito Hirawa, Katsuyuki Miura, Shin-Ichiro Miura, Koichi Yamamoto, Chikara Yoshimura, Hiromi Rakugi, Kei Asayama, Taku Inoue, Mitsuru Ohishi, Miho Kusaka, Kenichi Goto, Tatsuo Shimosawa, Akira Nishiyama, Satoshi Hoshide, Yuichiro Yano, Keiko Kaneko, Fujiko Uesugi, Mutsumi Shigyo, Erika Suenaga, Takeshi Masujima, Souichiro Kawachi, Akira Okayama, Masaaki Miyakawa, Naomi Miyamatsu, Koshi Nakamura, Isao Saito, Yoshitaka Murakami, Mari Ishida, Kazuo Kitagawa, Hirofumi Ohnishi, Hirokazu Okada, Yoshio Fujioka, Yoshihiro Ogawa, Kenichiro Shide, Shigeru Inoue

  Hypertension research : official journal of the Japanese Society of Hypertension     2026.02  [Refereed]

   

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• Can Japan contribute to developing research on the relation between blood pressure variability and suicide risk?

  Koshi Nakamura

  Hypertension research : official journal of the Japanese Society of Hypertension   48 ( 10 ) 2730 - 2731   2025.10

   

  DOI PubMed

• Japanese Medical Facilities Maintained the Quality of Medical Care for Acute Coronary Syndrome during the First Wave of the Coronavirus Disease 2019 Pandemic in Japan.

  Koshi Nakamura

  Journal of atherosclerosis and thrombosis     2021.06

   

  DOI PubMed

• 生活習慣病の予防と医療費:10年間の追跡調査による健診所見と医療費の関連:滋賀国保コホート研究の知見から

  岡村 智教, 中村幸志, 早川岳人, 神田秀幸, 三浦克之, 岡山 明, 上島弘嗣

  日本衛生学雑誌   67 ( 1 ) 38 - 43   2012.01

   

• Smoking cessation rate and its related factors on a smoking cessation support program in a workplace

  C.Aoki, M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura, Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse

    35 ( 1 ) 36 - 38   2008.10  [Refereed]

   

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Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2025.04  -  2029.03 

  Direct: 14,500,000 (YEN)  Overheads: 18,850,000 (YEN)  Total: 4,350,000 (YEN)