中村 幸志 (ナカムラ コウシ)

NAKAMURA Koshi

写真a

職名

教授

科研費研究者番号

80422898

現在の所属組織 【 表示 / 非表示

  • 専任   琉球大学   医学研究科   教授  

出身大学 【 表示 / 非表示

  • 1990年04月
    -
    1996年03月

    自治医科大学   医学部   卒業

取得学位 【 表示 / 非表示

  •  -  博士(医学)  医学

職歴 【 表示 / 非表示

  • 2005年09月
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    2006年09月

      滋賀医科大学 医学部 社会医学講座 福祉保健医学分野 特任助手  

  • 2006年10月
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    2008年02月

      The George Institute for International Health Visiting Research Fellow  

  • 2008年04月
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    2010年03月

      金沢医科大学 医学部 健康増進予防医学部門 講師  

  • 2010年04月
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    2015年01月

      金沢医科大学 医学部 公衆衛生学講座 准教授  

  • 2015年02月
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    2019年06月

      北海道大学 大学院医学研究科 社会医学分野 公衆衛生学教室 准教授  

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所属学会・委員会 【 表示 / 非表示

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    日本公衆衛生学会

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    日本疫学会

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    日本循環器病予防学会

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    日本動脈硬化学会

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    日本高血圧学会

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研究分野 【 表示 / 非表示

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

取得資格 【 表示 / 非表示

  • 医師

論文 【 表示 / 非表示

  • Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study.

    Koshi Nakamura, Shu-Ping Hui, Shigekazu Ukawa, Emiko Okada, Takafumi Nakagawa, Akihiro Imae, Hiroaki Okabe, Zhen Chen, Yusuke Miura, Hitoshi Chiba, Akiko Tamakoshi

    Journal of epidemiology     2021年09月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    BACKGROUND: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D3 (25[OH]D3) insufficiency. METHODS: The present cross-sectional study compared the prevalence of diabetes, defined as a fasting plasma glucose level ≥126 mg/dL and/or a HbA1c level ≥6.5%, among 480 participants aged 35-79 years not taking anti-diabetes medications, based on serum 25(OH)D3 levels. A logistic regression model was used to calculate the odds ratios for diabetes in each serum 25(OH)D3 group. Furthermore, this study examined the association between serum 25(OH)D3 levels and the index of homeostasis model assessment of insulin resistance (HOMA-IR) using a linear regression model. RESULTS: The prevalence of diabetes was 7.29% in the study population, and was higher in lower serum 25(OH)D3 quartile groups. The odds ratios for diabetes in the first, second, and third serum 25(OH)D3 quartile groups (25[OH]D3: ≤18.10, 18.11-22.90, and 22.91-28.17 ng/mL) were 4.02 (95% confidence interval [CI], 1.25-12.92), 2.50 (95% CI, 0.77-8.10), and 1.91 (95% CI, 0.60-6.09), respectively, with the fourth quartile group (≽28.18 ng/mL) serving as the reference group, after adjusting for sociodemographic, lifestyle, physical and environmental factors. Serum 25(OH)D3 levels showed an inverse association with log-transformed HOMA-IR after adjusting for similar factors (standardized β = -0.08; 95% CI, -0.14 to -0.02). CONCLUSIONS: Serum 25(OH)D3 levels were inversely associated with diabetes prevalence in a general Japanese population, with a slight inverse association between serum 25(OH)D3 levels and HOMA-IR.

  • Comparison of dimension reduction methods on fatty acids food source study.

    Yifan Chen, Yusuke Miura, Toshihiro Sakurai, Zhen Chen, Rojeet Shrestha, Sota Kato, Emiko Okada, Shigekazu Ukawa, Takafumi Nakagawa, Koshi Nakamura, Akiko Tamakoshi, Hitoshi Chiba, Hideyuki Imai, Hiroyuki Minami, Masahiro Mizuta, Shu-Ping Hui

    Scientific reports   11 ( 1 ) 18748 - 18748   2021年09月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Serum fatty acids (FAs) exist in the four lipid fractions of triglycerides (TGs), phospholipids (PLs), cholesteryl esters (CEs) and free fatty acids (FFAs). Total fatty acids (TFAs) indicate the sum of FAs in them. In this study, four statistical analysis methods, which are independent component analysis (ICA), factor analysis, common principal component analysis (CPCA) and principal component analysis (PCA), were conducted to uncover food sources of FAs among the four lipid fractions (CE, FFA, and TG + PL). Among the methods, ICA provided the most suggestive results. To distinguish the animal fat intake from endogenous fatty acids, FFA variables in ICA and factor analysis were studied. ICA provided more distinct suggestions of FA food sources (endogenous, plant oil intake, animal fat intake, and fish oil intake) than factor analysis. Moreover, ICA was discovered as a new approach to distinguish animal FAs from endogenous FAs, which will have an impact on epidemiological studies. In addition, the correlation coefficients between a published dataset of food FA compositions and the loading values obtained in the present ICA study suggested specific foods as serum FA sources. In conclusion, we found that ICA is a useful tool to uncover food sources of serum FAs.

  • Effect of a mobile digital intervention to enhance physical activity in individuals with metabolic disorders on voiding patterns measured by 24-h voided volume monitoring system: Kumejima Digital Health Project (KDHP).

    Minoru Miyazato, Asuka Ashikari, Koshi Nakamura, Takehiro Nakamura, Kiyoto Yamashiro, Tsugumi Uema, Moriyuki Uehara, Hiroaki Masuzaki, Seiichi Saito, Shiro Maeda, Hajime Ishida, Masayuki Matsushita

    International urology and nephrology   53 ( 8 ) 1497 - 1505   2021年08月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    PURPOSE: To evaluate the effect of a mobile digital intervention on voiding patterns, we performed 24-h voided volume monitoring in individuals with metabolic disorders. METHODS: Participants with metabolic disorders were grouped into either the intervention group (n = 17), who had access to a smartphone app (CARADA), or the non-intervention group (n = 11), who did not. Urine monitoring was conducted for 24 h using a novel digital self-health monitoring system for urine excretion (s-HMSU). Body weight, abdominal circumference, blood pressure, and biomarkers were measured. RESULTS: Physical findings and blood test results at baseline and 6 months indicated no significant between-group differences. Night-time frequency did not change between baseline and 6 months in the intervention group but significantly worsened at 6 months in the non-intervention group, as compared to baseline (1.0 ± 0.7 vs. 1.5 ± 0.5, p < 0.05). The change in night-time frequency over 6 months did not differ between the intervention and non-intervention groups. Furthermore, the change in hours of undisturbed sleep over 6 months did not differ between the two groups. However, compared with baseline, nocturnal polyuria index tended to worsen at 6 months in the non-intervention group. CONCLUSION: Our study results suggest that mobile digital intervention might be useful for behavioral therapy to improve night-time frequency and urine production and that s-HMSU might be beneficial for confirming the prevention of progress in individuals with metabolic disorders, which can aid in modifying lifestyle.

  • Fecal short-chain fatty acids and obesity in a community-based Japanese population: The DOSANCO Health Study

    Ryodai Yamamura, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Takafumi Nakagawa, Akihiro Imae, Tadao Kunihiro, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

    Obesity research & clinical practice ( ELSEVIER SCI LTD )  15 ( 4 ) 345 - 350   2021年07月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    In Western populations, fecal concentrations of short-chain fatty acids (SCFAs) are positively correlated with the prevalence of obesity. However, gut microbiota involved in the production of SCFA varies between races. Our purpose was to investigate the associations between fecal SCFAs and the prevalence of obesity in a community-based Japanese population. We classified a total of 568 participants aged >= 18 into four quartiles of fecal concentrations of SCFA subtypes (acetate, butyrate, and propionate) and total SCFAs to compare the prevalence of obesity, defined as a body mass index >= 25.0 kg/m(2). Using the first quartile SCFA group as a reference, the prevalence ratios of obesity were calculated for each SCFA group through a log-binomial regression model adjusted for major potentially confounding factors including age, sex, exercise habits, total energy intake, and total dietary fiber intake. In the study population, the prevalence of obesity was 35.8%. The prevalence ratios (95% confidence intervals) of obesity in the second, third, and fourth quartile groups of fecal total SCFAs were 1.30 (0.89-1.89), 1.74 (1.23-2.47) and 1.70 (1.19-2.41), respectively, after adjusting for the confounders. Similar positive associations were observed for every subtype. The prevalence ratios (95% confidence intervals) in the fourth quartile groups of fecal acetate, butyrate, and propionate were 1.41 (1.02-1.97), 2.16 (1.49-3.14), and 1.97 (1.35-2.89), respectively, after adjusting for the confounders. In conclusion, our results demonstrated that fecal SCFA concentrations of every subtype were positively associated with the prevalence of obesity in a community-based Japanese population.

  • Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study.

    Yu Shimizu, Kiminori Nakamura, Mani Kikuchi, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Ryodai Yamamura, Akiko Tamakoshi, Tokiyoshi Ayabe

    GeroScience     2021年06月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Recently, aging is considered a risk factor for various diseases. Although changes in the intestinal microbiota along with aging are thought to associate with the increased disease risk, mechanisms that cause age-related transition of the intestinal microbiota remain unknown. This study aims to clarify relationships between the amount of human defensin 5 (HD5), a Paneth cell α-defensin, which is known to regulate the intestinal microbiota, and age-related differences of the intestinal microbiota composition. Fecal samples from 196 healthy Japanese (35 to 81 years old) were collected and measured HD5 concentration. HD5 concentration in the elderly group (age > 70 years old) was significantly lower than the middle-aged group (age ≤ 70 years old). Furthermore, individual age was negatively correlated with HD5 concentration (r =  - 0.307, p < 0.001). In β-diversity, the intestinal microbiota of the elderly showed a significantly different composition compared to the middle-aged. At the genus level, relative abundance of Collinsella, Alistipes, Peptococcaceae; unassigned, Lactobacillus, Lactococcus, Weissella, Christensenellaceae R-7 group, Megasphaera, and [Eubacterium] eligens group was significantly higher, and Lachnospiraceae; unassigned, Blautia, Anaerostipes, Fusicatenibacter, Dorea, and Faecalibacterium was significantly lower in the elderly compared to the middle-aged. In addition, HD5 concentration was negatively correlated with Alistipes, Peptococcaceae; unassigned, and Christensenellaceae R-7 group and positively correlated with Lachnospiraceae; unassigned and Dorea. These results provide novel insights into the immunosenescence of enteric innate immunity, indicating low HD5 is suggested to contribute to the age-related differences in the intestinal microbiota and may relate to increased risk of diseases in elderly people.

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MISC(その他業績・査読無し論文等) 【 表示 / 非表示

  • Japanese Medical Facilities Maintained the Quality of Medical Care for Acute Coronary Syndrome during the First Wave of the Coronavirus Disease 2019 Pandemic in Japan.

    Koshi Nakamura

    Journal of atherosclerosis and thrombosis     2021年06月

     

    DOI PubMed

  • 循環器病予防総説(シリーズ16) 要因編 喫煙と循環器疾患

    中村 幸志

    日本循環器病予防学会誌 ( (一社)日本循環器病予防学会 )  54 ( 3 ) 145 - 154   2019年12月

     

  • 【循環器疾患を予防する】循環器疾患と医療費 危険因子からの考察

    中村 幸志

    公衆衛生 ( (株)医学書院 )  83 ( 5 ) 362 - 366   2019年05月

     

  • 【患者さんからよく尋ねられる内科診療のFAQ】(第4章)循環器 いまさらたばこをやめても意味がないですよね? [71歳 男性,喫煙]

    中村 幸志

    内科 ( (株)南江堂 )  120 ( 3 ) 545 - 546   2017年09月

     

  • Diagnosis Procedure Combination Database Would Develop Nationwide Clinical Research in Japan.

    Koshi Nakamura

    Circulation journal : official journal of the Japanese Circulation Society ( JAPANESE CIRCULATION SOC )  80 ( 11 ) 2289 - 2290   2016年10月  [査読有り]

     

    DOI PubMed

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学術関係受賞 【 表示 / 非表示

  • 日本アルコール・アディクション医学会 柳田知司賞

    2016年   日本アルコール・アディクション医学会  

    受賞者: 中村 幸志

  • 日本疫学会 奨励賞

    2014年   日本疫学会  

    受賞者: 中村 幸志