Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Published Papers 【 display / non-display 】

• Syphilitic descending aortic aneurysm presenting with characteristic double-ring sign on CT: Radiologic-pathologic correlation.

  Tsubasa Sugie, Syohei Miyaguni, Nanae Tsuchiya, Yuma Chinen, Hitoshi Inafuku, Tatsuya Maeda, Kojiro Furukawa, Naoki Wada, Akihiro Nishie

  Radiology case reports   21 ( 10 ) 4378 - 4382   2026.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  A man in his 50s presented with worsening anterior chest pain. Serologic testing revealed active syphilis infection, and polymerase chain reaction testing was positive for COVID-19. Contrast-enhanced computed tomography demonstrated a descending thoracic aortic aneurysm with circumferential wall thickening and a characteristic double-ring sign suggestive of inflammatory aortitis. After blood pressure control and antibiotic therapy, elective descending aortic replacement was performed. Surgical inspection showed diffuse intimal thickening with a tree-bark appearance. Histopathology demonstrated lymphoplasmacytic infiltration in the media, adventitia, and around the vasa vasorum, consistent with syphilitic aortitis. This case highlights the diagnostic value of CT, particularly the double-ring sign, in identifying syphilitic aortitis and demonstrates a rare presentation of syphilitic aneurysm in the descending thoracic aorta.

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• Carcinoma of unknown primary with a lung cancer profile in mediastinal and/or hilar lymph nodes: EGFR-mutant cases and a literature review of actionable drivers.

  Reo Tome, Makoto Furugen, Shigeki Chinen, Wakako Arakaki, Kazuya Miyagi, Yuten Shuri, Fumi Kawakami, Naoki Wada, Kazuko Yamamoto

  Respiratory investigation   64 ( 3 ) 101399 - 101399   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  We report two cases of carcinoma of unknown primary (CUP) with a lung cancer profile harboring epidermal growth factor receptor (EGFR) mutations. Case 1 was node-limited and achieved a durable partial response for at least 15 months with osimertinib. Case 2 harbored an EGFR exon 20 insertion and showed disease progression despite therapy. While responses to first- and second-generation EGFR tyrosine kinase inhibitors have been reported in EGFR-mutant CUP, evidence for the third-generation EGFR-TKI osimertinib remains limited. These cases highlight that early molecular profiling can identify actionable targets and enable lung cancer-standard therapies even when the primary lesion remains undetected.

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• Management of a Complex Orbital Post-transplantation Lymphoproliferative Disorder: A Case Report and Literature Review.

  Tessho Maruyama, Yohei Hokama, Kazutaka Kishaba, Tomomi Kuninaka, Shigetaka Kobayashi, Hideki Nagamine, Hirofumi Miyahira, Kei Tanaka, Kazuho Morichika, Fumi Kawakami, Mariko Tomita, Naoki Wada, Akira Yogi, Hiroaki Masuzaki, Tadashi Hamasaki

  In vivo (Athens, Greece)   40 ( 3 ) 1824 - 1831   2026 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND/AIM: Post-transplantation lymphoproliferative disorder (PTLD) is an uncommon but serious complication of organ transplantation. Management often requires multiple treatment modalities and reduction in immunosuppressant treatment (RIT). Orbital involvement is rare, and optimal diagnostic and therapeutic approaches remain uncertain. CASE REPORT: Here, we report a case of localized orbital PTLD that was successfully treated with RIT alone. A 62-year-old man, who had undergone kidney transplantation 18 years prior, presented with left eye pain and proptosis. Imaging revealed an enhancing intraorbital mass extending to the optic nerve and adjacent intracranial structures. Transcranial biopsy confirmed B-cell-type PTLD. The lesion regressed with stepwise RIT alone without additional therapy. The patient showed clear clinical improvement and remained in remission for more than 13 months. CONCLUSION: This case suggests the potential role of a conservative, individualized, stepwise approach in selected patients with localized orbital PTLD, and may inform management strategies for other localized forms of PTLD.

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• A Case of Spermatocytic Tumor of Testis.

  Satsuki Nagamine, Yosuke Nakanishi, Kei Tanaka, Asuka Ashikari, Ryu Kimura, Shotaro Nakanishi, Rin Kawamitsu, Naoki Wada, Akihiro Nishie, Junichi Inokuchi

  IJU case reports   8 ( 6 ) 563 - 566   2025.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: Spermatocytic tumor is a rare type of testicular germ cell tumor, accounting for approximately 1% of all testicular neoplasms. CASE PRESENTATION: A 51-year-old male presented to the hospital with a painless mass in the left testis. Ultrasonography revealed a heterogeneous intratesticular mass with cystic components. Testicular tumor markers were within normal ranges. The patient underwent a left orchiectomy. Pathologically, the tumor was characterized by the presence of medium to large neoplastic cells and small neoplastic cells without sarcomatoid or anaplastic features. Immunohistochemically, the tumor was positive for SALL4 and negative for CD30, AFP, OCT3/4, PLAP, D2-40, and hCG. Based on these findings, we diagnosed spermatocytic tumor of testis. CONCLUSION: We present a case of spermatocytic tumor, which is a distinct entity among testicular germ cell tumors, with a generally favorable prognosis following orchiectomy. However, long-term follow-up is recommended due to the potential for late metastasis.

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• Extranodal natural killer/T-cell lymphoma with lung involvement in a young adult with suspected mosquito bite hypersensitivity: A case report.

  Mariko Higa, Eriko Atsumi, Hironobu Hoshino, Mahito Yamashiro, Tomo Nakajima, Mariko Tomita, Hiroaki Masuzaki, Naoki Wada, Isoko Owan

  Respiratory investigation   63 ( 5 ) 872 - 876   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  A young adult with suspected pulmonary lymphoma was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL). The patient had a history of possible mosquito bite hypersensitivity (MBH), suggesting a potential association between MBH and ENKTL. Although ENKTL typically affects middle-aged adults, it has rarely been reported in children with MBH or chronic active Epstein-Barr virus (EBV) disease. This case highlights the challenges of obtaining pathological confirmation from small biopsy samples of pulmonary ENKTL. Detailed history taking and EBV DNA testing may aid in diagnosis, particularly in younger patients.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• 耳下腺に発生したmucoacinar carcinomaの一例(A case report of mucoacinar carcinoma of the parotid gland)

  樋口 佳代子, 浦野 誠, 和田 直樹

  日本病理学会会誌 ( (一社)日本病理学会 )  115 ( 1 ) 386 - 387   2026.03

   

• Groove膵癌の一例(A case report of groove pancreatic carcinoma)

  小橋川 早紀, 川上 史, 和田 直樹, 樋口 佳代子

  日本病理学会会誌 ( (一社)日本病理学会 )  114 ( 1 ) 346 - 346   2025.03

   

• 成人T細胞白血病・リンパ腫(ATLL)の病理組織学的形態および免疫表現型に関する検討(A study on histopathological morphology and immunophenotype of adult T-cell leukemia/lymphoma (ATLL))

  玉城 智子, 加留部 謙之輔, 仲田 典宏, 松本 裕文, 仲里 巌, 和田 直樹

  日本病理学会会誌 ( (一社)日本病理学会 )  112 ( 1 ) 274 - 274   2023.03

   

• Standardization of CD30 immunohistochemical staining on different staining platforms

  関雅文, 佐藤啓, 舩戸連嗣, 玉城智子, 和田直樹, 加留部謙之輔

  日本病理学会会誌   112 ( 1 )   2023

   

  J-GLOBAL

• SDPRは子宮体部類内膜癌においてILKを介してALDH1を制御する

  田原 紳一郎, 野島 聡, 大島 健司, 堀 由美子, 倉重 真沙子, 和田 直樹, 本山 雄一, 奥崎 大介, 池田 純一郎, 森井 英一

  日本癌学会総会記事 ( (一社)日本癌学会 )  79回   YSA - 2   2020.10

   

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• A case report of mucoacinar carcinoma of the parotid gland

  The 115th Annual Meeting of the Japanese Society of Pathology  2026.04  -  2026.04 

• Groove膵癌の一例

  小橋川 早紀, 川上 史, 和田 直樹, 樋口 佳代子

  第114回日本病理学会総会  (仙台国際センター)  2025.04  -  2025.04 

• Medical DX in the Pathology Department: A Start from Glass Slide Logistics Management

  The 114th Annual Meeting of the Japanese Society of Pathology  2025.04  -  2025.04 

• A study on histopathological morphology and immunophenotype of adult T-cell leukemia/lymphoma (ATLL)

  Tomoko Tamaki, Kennosuke Karube, Norihiro Nakada, Hirofumi Matsumoto, Iwao Nakazato, Naoki Wada

  2023.04  -  2023.04 

• Cytologic Characteristics and Differential Diagnosis of Secretory Carcinoma: An Analysis of 16 Cases

  Kayoko Higuchi, Akihiko Kawahara, Katsuyuki Tsuha, Yuri Kato, Tomoya Minami, Yuko Chibana, Hirofumi Koyama, Naoki Wada, Makoto Urano, Toshitaka Nagao

  第20回日韓細胞診合同会議  (韓国Gunsan city（群山）のGunsan Saemangeum Convention Center(GSCO))  1900.01  -  1900.01 

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2018.04  -  2021.03 

  Direct: 3,500,000 (YEN)  Overheads: 1,050,000 (YEN)  Total: 4,550,000 (YEN)

• Elucidation of the factor involved in the dynamic differentiation of lymphoplasmacytic lymphoma

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2018.04  -  2021.03 

  Investigator(s): WADA Naoki 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

  　View Summary

  Glutamine (Gln) is important not only for cell proliferation but also for differentiation. Although Gln is essential for plasmacytic differentiation of lymphocytes, no study has been done on the effect of Gln on differentiation of tumor cells, such as lymphoma. Here I examined the effect of Gln on plasmacytic differentiation of lymphoplasmacytic lymphoma (LPL) with its cell line. Gln promoted plasmacytic differentiation of LPL, and p38 MAPK signaling pathway mediated such differentiation. I previously reported that the subpopulation with plasmacytic differentiation was vulnerable to apoptosis in LPL. Although it is difficult to lead these findings to the radical therapy, they might help the treatment of LPL.

• The positive marker identification of tumor-initiating cells and the dynamic analyses of them in lymphoplasmacytic lymphoma (LPL)

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2015.04  -  2018.03 

  Investigator(s): WADA Naoki 

  Direct: 3,800,000 (YEN)  Overheads: 1,140,000 (YEN)  Total: 4,940,000 (YEN)

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  MWCL-1 was established as LPL cell line. MWCL-1 cells were classified into three subpopulations by flow cytometric analyses using anti-CD20 and anti-CD138 antibodies: CD20-CD138-, CD20+CD138-, and CD20+CD138+ cells. We searched for markers preferentially expressed in CD20-CD138- cells of MWCL-1 (the candidates for tumor-initiating cells of LPL), and the chemokine receptor CXCR7 was isolated. We also searched for favorable microenvironments for their proliferation, and we found that hypoxia and CXCL12-CXCR7 signaling appeared to be favorable microenvironments. We then examined the effect of plasma-activated medium (PAM) on LPL cell line, and we found that PAM induced plasma cell (CD138 positive) differentiation, which appeared to be mediated by PRDM1α (the transcription factor promoting plasma cell differentiation).

• The positive marker identification of tumor-initiating cells and the dynamic analyses of them in lymphoplasmacytic lymphoma (LPL)

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2015.04  -  2018.03 

  Investigator(s): WADA Naoki 

  Direct: 3,800,000 (YEN)  Overheads: 4,940,000 (YEN)  Total: 1,140,000 (YEN)

  　View Summary

  MWCL-1 was established as LPL cell line. MWCL-1 cells were classified into three subpopulations by flow cytometric analyses using anti-CD20 and anti-CD138 antibodies: CD20-CD138-, CD20+CD138-, and CD20+CD138+ cells. We searched for markers preferentially expressed in CD20-CD138- cells of MWCL-1 (the candidates for tumor-initiating cells of LPL), and the chemokine receptor CXCR7 was isolated. We also searched for favorable microenvironments for their proliferation, and we found that hypoxia and CXCL12-CXCR7 signaling appeared to be favorable microenvironments. We then examined the effect of plasma-activated medium (PAM) on LPL cell line, and we found that PAM induced plasma cell (CD138 positive) differentiation, which appeared to be mediated by PRDM1α (the transcription factor promoting plasma cell differentiation).

• Dynamic analyses of tumor-initiating cells in lymphoplasmacytic lymphoma (LPL)

  Grant-in-Aid for Young Scientists(B)

  Project Year: 2013.04  -  2015.03 

  Investigator(s): WADA NAOKI 

  Direct: 3,200,000 (YEN)  Overheads: 960,000 (YEN)  Total: 4,160,000 (YEN)

  　View Summary

  MWCL-1 was established as LPL cell line. MWCL-1 cells were classified into three subpopulations using a flow cytometer with anti-CD20 and anti-CD138 antibodies: CD20-CD138-, CD20+CD138-, and CD20+CD138+. When cultured, CD20-CD138- cells yielded all three subpopulations. Compared to the other subpopulations, CD20-CD138- cells possessed the efficient ROS expelling and in vitro colony formation activities, and were resistant to apoptosis. These results suggested that CD20-CD138- cells might be a candidate for tumor-initiating cells in LPL. Low oxygen culture of MWCL-1 induced the production of CD20-CD138- cells, and this result suggested that hypoxia was an advantageous microenvironment for CD20-CD138- cells. CXCR7 mRNA/protein expression was the highest in CD20-CD138- cells. When CXCL12, a ligand of CXCR7, was added, the proportion of CD20-CD138- cells significantly increased. CXCL12-CXCR7 signaling might exert a great influence on CD20-CD138- cells.

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Social Activity 【 display / non-display 】

Social Activity 【 display / non-display 】

• 2024.01