和田 直樹 (ワダ ナオキ)

WADA Naoki

写真a

職名

教授

科研費研究者番号

80521731

生年

1978年

研究室住所

〒903-0215 沖縄県中頭郡西原町字上原207番地 琉球大学大学院医学研究科 腫瘍病理学講座

メールアドレス

メールアドレス

研究室電話

098-895-1118/1120

研究室FAX

098-895-1406

現在の所属組織 【 表示 / 非表示

  • 専任   琉球大学   医学研究科   教授  

取得学位 【 表示 / 非表示

  • 大阪大学 -  博士(医学)  医学

研究キーワード 【 表示 / 非表示

  • 悪性リンパ腫

  • 腫瘍幹細胞

論文 【 表示 / 非表示

  • Wide excision alone for elderly patients aged > 70 years old with soft tissue sarcomas.

    Aoki Y, Tome Y, Oshiro H, Katsuki R, Tamaki T, Wada N, Karube K, Nishida K

    Medicine ( Medicine (United States) )  101 ( 36 ) e30127   2022年09月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    The purpose of the present study was to clarify clinical outcomes of elderly patients with soft tissue sarcoma who underwent surgery neither with neoadjuvant nor adjuvant chemotherapy. The median follow-up period was 46.3 (range 6.7-99.0) months. All patients underwent surgical resections. R0 margins were achieved in 24 cases (92.3%) and R1 margins in 2 cases (7.7%). The 1-, 2-, and 5-year sarcoma-specific survival (SSS) rates were 92.3%, 88.5%, and 83.8%, respectively. Multivariate analysis showed no significant risk factors for SSS. No significant relationship of histological grades and local recurrences (P = .56) or distant metastases (P = .54) was shown. In the current study, we observed a comparable survival ratio, despite no neoadjuvant or adjuvant chemotherapies performed. Tumor resections with adequate margins might, at least in part, have contributed to the decent survival ratio regardless of histological grade. Twenty-six consecutive patients aged ≥ 70 years, who underwent surgical resections of soft tissue sarcoma between January 2013 and December 2019, were included. SSS were analyzed by the Kaplan-Meier method, and the relationships between SSS and clinical parameters were evaluated by Cox proportional hazards analysis.

  • Peripheral dentinogenic ghost cell tumor in the mandibular anterior region

    Sho Miyamoto, Hiromasa Hasegawa, Tomoko Tamaki, Akira Matayoshi, Takahiro Goto, Jumpei Shirakawa, Shimpei Goto, Toshiyuki Nakasone, Naoki Wada, Hiroyuki Nakamura

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( ELSEVIER SCIENCE INC )  34 ( 4 ) 436 - 439   2022年07月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    A dentinogenic ghost cell tumor (DGCT), the rarest locally invasive odontogenic tumor, is considered a solid variant of the calcifying odontogenic cyst. Histopathologically, DGCT is characterized by ameloblastoma-like islands of epithelial cells in a mature connective tissue stroma and aberrant keratinization in the form of ghost cells associated with varying amounts of dysplastic dentin. DGCT is classified into the intraosseous type (central) and the extraosseous type (peripheral). The peripheral type is even rarer than the central type. We describe a case of peripheral DGCT measuring a size of 33 x 28 x 19 mmin the mandibular anterior region in a 61-year old woman. The tumor was diagnosed as a peripheral DGCT based on biopsy findings and radiographic images. Under general anesthesia, the lesion was excised by detaching it from the bone on the periosteum with a safety margin, and the bone in contact with the tumor was curetted and shaped. The wound was covered with poly glycolic acid-absorbable reinforcement material and fibrin glue spray. At approximately one year postoperatively, the patient remains recurrence-free.

  • Jejunal Arteriovenous Malformation Detected by Video Capsule Endoscopy.

    Iraha A, Irei Y, Kinjo T, Oishi Y, Ohira T, Kinjo T, Hokama A, Kosuge N, Wada N, Takatsuki M, Fujita J

    Chonnam medical journal   58 ( 2 ) 75 - 76   2022年05月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

  • Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

    Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N

    Science translational medicine   14 ( 632 ) eaax7706   2022年02月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    Cancer-specific cell surface antigens are ideal therapeutic targets for monoclonal antibody (mAb)-based therapy. Here, we report that multiple myeloma (MM), an incurable hematological malignancy, can be specifically targeted by an mAb that recognizes a ubiquitously present protein, CD98 heavy chain (hc) (also known as SLC3A2). We screened more than 10,000 mAb clones raised against MM cells and identified R8H283, an mAb that bound MM cells but not normal hematopoietic or nonhematopoietic cells. R8H283 specifically recognized CD98hc. R8H283 did not react with monomers of CD98hc; instead, it bound CD98hc in heterodimers with a CD98 light chain (CD98lc), a complex that functions as an amino acid transporter. CD98 heterodimers were abundant on MM cells and took up amino acids for constitutive production of immunoglobulin. Although CD98 heterodimers were also present on normal leukocytes, R8H283 did not react with them. The glycoforms of CD98hc present on normal leukocytes were distinct from those present on MM cells, which may explain the lack of R8H283 reactivity to normal leukocytes. R8H283 exerted anti-MM effects without damaging normal hematopoietic cells. These findings suggested that R8H283 is a candidate for mAb-based therapies for MM. In addition, our findings showed that a cancer-specific conformational epitope in a ubiquitous protein, which cannot be identified by transcriptome or proteome analyses, can be found by extensive screening of primary human tumor samples.

  • Mycobacterial lymphadenitis without granuloma formation in a patient with anti-interferon-gamma antibodies.

    Asako M, Matsunaga H, Nakahara W, Ikeda M, Mima F, Minami R, Sekiguchi M, Oka K, Wada N, Suzuki K, Yoshizawa K, Sakagami T, Ueda S

    International journal of hematology ( Japanese society of hematology )  114 ( 5 ) 630 - 635   2021年11月 [ 査読有り ]

    掲載種別: 研究論文(学術雑誌)

     概要を見る

    A previously healthy 49-year-old Japanese woman presented with cervical lymph node swelling and tenderness. Lymph node biopsy revealed reactive lymphadenitis without granulomas. No malignant cells were found, and no acid-fast positive bacilli were identified by Ziehl-Neelsen staining. She was treated unsuccessfully with various antibiotics, and it was very challenging to reach a diagnosis. 18F-Fluorodeoxyglucose (18F-FDG) uptake in bones was evaluated using positron emission tomography-computed tomography (PET-CT), and disseminated mycobacterial infection was suspected. The interferon-gamma (IFN-γ) release assays QuantiFERON (QFT) and T-SPOT were used to diagnose tuberculosis infection. On testing, a difference in mitogen response was found between these assays. The response was low for QFT but adequate for T-SPOT, suggesting the presence of anti-IFN-γ antibodies. This difference depended on whether the patient's plasma (including anti-IFN-γ antibodies) was used within the assay system. Mycobacterium abscessus was isolated from lymph node cultures, and plasma anti-IFN-γ antibodies were confirmed. The patient was diagnosed with disseminated M. abscessus infection with underlying adult-onset immunodeficiency caused by anti-IFN-γ antibodies. Granulomas are a pathological hallmark of mycobacterial infection, but may not fully form in immunodeficient patients. Clinicians should be aware of the possibility of mycobacterial infection without granuloma formation due to anti-IFN-γ antibodies.

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著書 【 表示 / 非表示

  • 臨床病理検討会の進め方・活かし方 CPCの作法 初版

    本間圭一郎, 和田直樹, 森井英一 ( 担当: 分担執筆 , 担当範囲: 第2章 症例から学ぶ-CPCの進め方・活かし方 症例21 生体腎移植後に腹部腫瘤,下血をきたし難治性の経過で死亡した30歳代後半男性 p.191-196 )

    中山書店  2016年 ( 担当ページ: p.p.191-196 )

  • 超・入門 臨床血液内科アトラス ~病理組織診断の苦手意識を克服する!~

    和田直樹,織谷健司,柴山浩彦,濱中有理,石橋知彦,土居由貴子,長手泰宏,森川陽一郎 ( 担当: 分担執筆 , 担当範囲: Ⅴ章11.慢性リンパ性白血病/Ⅴ章12.1)濾胞性リンパ腫/Ⅴ章12.6)前縦隔(胸腺)原発大細胞型B細胞リンパ腫/Ⅴ章12.15)Hodgkinリンパ腫/Ⅵ章6.Castleman病のうち病理組織診断に関する内容を責任執筆 )

    南江堂  2015年 ( 担当ページ: p.p.88-89/p.94-97/p.106-107/p.124-127/p.157-158 )

  • 癌診療指針のための病理診断プラクティス 大腸癌 初版

    和田直樹, 青笹克之 ( 担当: 分担執筆 , 担当範囲: 3章 病理診断の実際 癌と鑑別が必要な疾患 大腸悪性リンパ腫 p.192-207 )

    中山書店  2012年 ( 担当ページ: p.p.192-207 )

  • 癌診療指針のための病理診断プラクティス 肺癌 初版

    和田直樹, 青笹克之 ( 担当: 分担執筆 , 担当範囲: 3章 肺疾患の概要と鑑別診断 リンパ球増殖疾患 p.180-196 )

    中山書店  2011年 ( 担当ページ: p.p.180-196 )

  • みんなに役立つ 悪性リンパ腫の基礎と臨床 改訂版

    青笹克之, 和田直樹 ( 担当: 分担執筆 , 担当範囲: 総論-Ⅰ.基礎-3.リンパ腫の発症機序-5)ウイルス p.75-83 )

    医薬ジャーナル社  2011年 ( 担当ページ: p.p.75-83 )

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