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Published Papers 【 display / non-display 】

• Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

  Sempach L, Ulrich S, Bauduin SEEC, Bauer J, Benedetti F, Berger K, Besteher B, Bülow R, Connolly CG, Corruble E, Couvy-Duchesne B, Cullen KR, Dannlowski U, Davey CG, Dima D, Dols A, Evans JW, Fu C, Fuentes-Claramonte P, Gonul AS, Gotlib IH, Goya-Maldonado R, Grabe HJ, Groenewold NA, Grotegerd D, Gruber O, Hahn T, Hamilton JP, Han LKM, Harrison BJ, Hatton SN, Hermesdorf M, Hickie IB, Ho TC, Hubbert JM, Jahanshad N, Jamalabadi H, Jamieson AJ, Jurischka C, Jüllig A, Kamishikiryo T, Kircher T, Koopowitz SM, Krämer B, Kraus A, Krieger J, Krug A, Lagopoulos J, Li M, McIntosh A, Meinert S, Melloni EMT, Mwangi B, Nenadic I, Ojha A, Okada G, Oudega ML, Penninx BWJH, Poletti S, Pomarol-Clotet E, Portella MJ, Reneman L, Rodriguez-Cano E, Sacchet M, Salvador R, Schrantee A, Shinzato H, Sim K, Slump TM, Soares JC, Stein DJ, Stein F, Teutenberg L, Thomas-Odenthal F, Thomopoulos SI, van der Wee NJA, van der Werff SJA, Völzke H, Walter M, Whalley HC, Whittle S, Wittfeld K, Wu MJ, Yang TT, Zarate C, Zunta-Soares GB, Thompson PM, Veltman DJ, Pozzi E, Schmaal L, Schmidt A

  Translational psychiatry     2026.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group

  Serrarens, C; Toenders, YJ; Pozzi, E; Aleman, A; Alexander, N; Basgöze, Z; Belov, V; Berger, K; Brosch, K; Bülow, R; Busatto, GF; Capitao, LP; Connolly, CG; Couvy-Duchesne, B; Cullen, KR; Dannlowski, U; Davey, CG; De Zubicaray, GI; Dima, D; Dohm, K; Enneking, V; Erwin-Grabner, T; Evermann, U; Fu, CHY; Fuentes-Claramonte, P; Godlewska, BR; Gonul, AS; Gotlib, IH; Goya-Maldonado, R; Grabe, HJ; Groenewold, NA; Grotegerd, D; Gruber, O; Hahn, T; Hall, G; Harrison, B; Heindel, W; Hermesdorf, M; Ho, TC; Ichikawa, N; Itai, E; Jahanshad, N; Jamalabadi, H; Jamieson, AJ; Jansen, A; Kircher, T; Klimes-Dougan, B; Krämer, B; Krug, A; Lancaster, TM; Leehr, EJ; Li, M; Linden, DEJ; MacMaster, F; McMahon, KL; Medland, SE; Mehler, DMA; Meinert, S; Mwangi, B; Nenadic, I; Okada, G; Okamoto, Y; Opel, N; Pfarr, JK; Pomarol-Clotet, E; Portella, MJ; Redlich, R; Reneman, L; Repple, J; Ringwald, K; Rodriguez-Cano, E; Rosa, PGP; Sacchet, MD; Sämann, PG; Salvador, R; Schrantee, A; Shinzato, H; Sim, K; Simulionyte, E; Soares, JC; Stein, DJ; Stein, F; Straube, B; Strike, LT; Thomas-Odenthal, F; Thomopoulos, SI; Thompson, PM; Van Tol, MJ; Usemann, P; Uyar, A; van der Wee, N; van der Werff, S; Vives-Gilabert, Y; Völzke, H; Walter, M; Whittle, S; Wittfeld, K; Wroblewski, A; Wu, MJ; Yang, TT; Zunta-Soares, GB; Veltman, DJ; Schmaal, L; van Velzen, LS

  MOLECULAR PSYCHIATRY ( Molecular Psychiatry )  30 ( 12 ) 5625 - 5636   2025.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Depressive mixed state and anxious distress as risk factors for suicidal behavior during major depressive episodes

  Ota, K; Shinzato, H; Otsuka, N; Zamami, Y; Kurihara, K; Futenma, K; Kondo, T; Takaesu, Y

  SCIENTIFIC REPORTS ( Scientific Reports )  15 ( 1 ) 11918 - 11918   2025.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Accurately assessing and predicting suicidal behavior in patients with depression are challenging for researchers and clinicians. We examined various risk factors for suicidal behavior during major depressive episodes (MDE), especially focusing on depressive mixed state (DMX) and anxious distress (AD). We recruited 187 patients with MDE and divided them into two groups-with and without suicidal behavior-defined as the cut-off score of 1 or more on the suicidal behavior sub-item in the quick inventory of depressive symptomatology-self report. The presence of DMX was defined as a total score of 13 or more on the self-administered 8-item questionnaire for DMX. We used multivariate logistic regression analysis with the presence or absence of suicidal behavior as a dependent variable for investigating factors associated with suicidal behavior. The with suicidal behavior group was younger and indicated a greater proportion of past suicide attempts, AD, and DMX than the without suicidal behavior group. Logistic regression analysis revealed that AD (P = 0.020) and DMX (P = 0.018) were significantly associated with suicidal behavior. AD and DMX may promote suicidal behavior during MDE. These two psychopathological features should be carefully monitored and intensively treated for the prevention of suicide-related events.

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• Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study.

  Bayer JMM, van Velzen LS, Pozzi E, Davey C, Han LKM, Bauduin SEEC, Bauer J, Benedetti F, Berger K, Bonnekoh LM, Brosch K, Bülow R, Couvy-Duchesne B, Cullen KR, Dannlowski U, Dima D, Dohm K, Evans JW, Fu CHY, Fuentes-Claramonte P, Godlewska BR, Goltermann J, Gonul A, Goya-Maldonado R, Grabe HJ, Groenewold NA, Grotegerd D, Gruber O, Hahn T, Hall GB, Hamilton J, Harrison BJ, Hatton SN, Hermesdorf M, Hickie IB, Ho TC, Jahanshad N, Jansen A, Jamieson AJ, Kamishikiryo T, Kircher T, Klimes-Dougan B, Krämer B, Kraus A, Krug A, Leehr EJ, Leenings R, Li M, McIntosh A, Medland SE, Meinert S, Melloni E, Mwangi B, Nenadić I, Okada G, Oudega M, Portella MJ, Rodríguez E, Romaniuk L, Rosa PG, Sacchet MD, Salvador R, Sämann PG, Shinzato H, Sim K, Simulionyte E, Soares JC, Stein DJ, Stein F, Stolicyn A, Straube B, Strike LT, Teutenberg L, Thomas-Odenthal F, Thomopoulos SI, Usemann P, van der Wee NJA, Völzke H, Wagenmakers M, Walter M, Whalley HC, Whittle S, Winter NR, Wittfeld K, Wu M, Yang TT, Zarate CA, Zunta-Soares GB, Thompson PM, Veltman DJ, Marquand AF, Schmaal L

  bioRxiv : the preprint server for biology     2025.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• The 12-item self-report Questionnaire for Difficulty in Social Communication as a simultaneous prescreening of autism spectrum and social anxiety

  Teruya, M; Kurihara, K; Ishibashi, T; Ota, K; Shinzato, H; Takaesu, Y; Kondo, T

  PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS ( Psychiatry and Clinical Neurosciences Reports )  4 ( 1 ) e70084   2025.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIM: Young patients with social communication difficulties are often diagnosed with autism spectrum disorder (ASD), social communication disorder (SCD), or social anxiety disorder (SAD). This study aimed to develop a questionnaire, especially focusing on the prescreening of SAD complicated by ASD/SCD. METHODS: The 12-item self-report Questionnaire for Difficulty in Social Communication (DISC-12) was developed and analyzed using exploratory factor analysis in 94 patients with ASD/SCD (35 with SAD, 59 without). An additional 17 patients with only SAD were included. Convergent validity was assessed via correlations with the Autism Spectrum Quotient (AQ) and Liebowitz Social Anxiety Scale (LSAS). DISC-12 scores and demographics were compared across ASD/SCD, ASD/SCD + SAD, and SAD groups. Receiver operating characteristic (ROC) analysis of DISC-12 subscales distinguished autistic traits from social anxiety. RESULTS: Factor analysis revealed a three-factor model for the DISC-12, comprising nonassertiveness, poor empathy, and interpersonal hypersensitivity. DISC-12 showed significant correlations with the AQ (r = 0.412, p < 0.001) and LSAS (r = 0.429, p < 0.001). Patients with ASD/SCD had higher Poor Empathy scores, while SAD patients had higher Interpersonal Hypersensitivity scores than the other groups. ROC analysis indicated that Poor Empathy and Interpersonal Hypersensitivity subscale scores effectively differentiated ASD/SCD from patients with SAD and vice versa. CONCLUSION: DISC-12 is a rapid and effective prescreening tool for identifying both ASD and social anxiety, particularly in young patients with self-reported difficulties in social communication.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Depression treatment focusing on the anxious distress specifier.

  新里輔鷹, 高江洲義和

  臨床精神薬理   28 ( 6 )   2025

   

  J-GLOBAL

• Assessment and risk factors for depressive mixed states

  新里輔鷹, 新里輔鷹

  日本臨床精神神経薬理学会プログラム・抄録集   33rd   2023

   

  J-GLOBAL

• Longitudinal reliability of Brain Network Marker for Major Depressive Disorder and its association with clinical status

  新里輔鷹, 新里輔鷹, 岡田剛, 吉岡利福, 吉岡利福, 山下歩, 板井江梨, 上敷領俊晴, 横山仁史, 光山祐生, 増田慶一, 川人光男, 川人光男, 山下宙人, 酒井雄希, 酒井雄希, 岡本泰昌

  日本生物学的精神医学会(Web)   45th   2023

   

  J-GLOBAL

• Can functional brain imaging techniques be used to diagnose psychiatric disorders?

  新里輔鷹, 岡田剛, 岡本泰昌

  日本生物学的精神医学会(Web)   44th   2022

   

  J-GLOBAL

• 統合失調症認知機能簡易評価尺度日本語版(BACS-J)を用いた,アルコール依存症患者の認知機能の評価

  栗原 雄大, 前上里 泰史, 新城 架乃, 石橋 孝勇, 新里 輔鷹, 甲田 宗良, 中井 美紀, 大鶴 卓, 近藤 毅

  精神神経学雑誌 ( (公社)日本精神神経学会 )  ( 2019特別号 ) S750 - S750   2019.06

   

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Assessment of mixed depression and bipolar disorder by longitudinal MRI and establishment of rational treatment strategies.

  Grant-in-Aid for Young Scientists

  Project Year: 2022.04  -  2025.03 

  Direct: 2,300,000 (YEN)  Overheads: 2,990,000 (YEN)  Total: 690,000 (YEN)

• Quantification and biological backgrounds of depressive mixed state

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2021.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Quantification and biological backgrounds of depressive mixed state

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2021.03 

  Investigator(s): Kondo Tsuyoshi 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

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  Depressive mixed state (DMX) in patients with major depressive episode was examined using the 12-item quantification scale for DMX (DMX-12) developed by us. Main DMX symptoms were hypersensitivity, racing/crowded thought, distractibility, overreaction, and inner tension. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX, especially with disruptive emotion/behavior symptoms. Selected 8 symptoms from the DMX-12 may be helpful in screening of DMX with considerable severity since it well differentiates individuals with mixed depression or mixed features during major depressive episode from non-mixed patients, with the same cut-off and excellent sensitivity/negative predictive value.