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• Odontogenic keratocyst in the mandibular condyle base region: A case report.

  Sho Miyamoto, Takahiro Goto, Jumpei Shirakawa, Toshihiro Kawano, Makoto Murahashi, Kentaro Ide, Nobuyuki Maruyama, Akira Matayoshi, Kazuhide Nishihara, Hiroyuki Nakamura

  Experimental and therapeutic medicine   25 ( 3 ) 141 - 141   2023.03 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

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  Odontogenic keratocysts (OKCs) often occur in the molars in the mandibular ramus; they often progress asymptomatically and are discovered only after widespread development. Some cases of OKC progress to the mandibular condyle; however, very few cases exist only in the condyle. To the best of our knowledge, in all of the previously reported cases, OKCs occurred in the mandibular ramus, which underwent resection. The present study reports the case of a 31-year-old man in whom an OKC (13x12x6 mm) occurred discretely in the base of the condyle, in which the condylar head was successfully preserved. The tumor was removed under general anesthesia using the approach of shaving the anterior surface of the mandible. The extraction cavity was managed using the packed open technique and with an obturator. Approximately 20 months post-operation, the patient remained recurrence-free. This report presents a rare case of an OKC in the mandibular condyle base region. Resection was performed under general anesthesia and the condylar process was successfully preserved.

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• An unusual case of oral surgical management in a patient with chronic mucocutaneous candidiasis and pure red cell aplasia: A case report

  Jumpei Shirakawa, Sho Miyamoto, Nobuyuki Maruyama, Kentaro Ide, Toshihiro Kawano, Hiroyuki Nakamura

  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology     2023 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Hereditary diseases such as chronic mucocutaneous candidiasis (CMC), autoimmune diseases such as systemic lupus erythematosus (SLE), and chronic secondary diseases such as pure red cell aplasia (PRCA) can make oral/dental surgery for some patients complicated and difficult. Because various comorbidities can increase the risk of complications and reaggravation associated with surgery, there are complexity concerns, challenges, and technical constraints. The comorbid conditions of these intractable diseases can be considered significant risk factors for postoperative complications. Dental disease in a patient with a rare genetic disease with an autoimmune disease and a subsequent refractory disease is an extremely rare case in oral and dental surgery. To our knowledge, few reports have investigated appropriate peri- and preoperative management strategies to minimize risk for postoperative complications. Therefore, informed contemplation is required to perform safe and effective surgical therapy for such patients. This case report aimed to present the experience of managing a 24-year-old woman having multiple dental caries comorbid with rare diseases, including CMC, PRCA, and SLE, and a brief overview of the symptoms and possible complications of the patient's comorbidities. In this case, local antifungal drugs, blood transfusion, and antibiotic treatment were administered before surgery to improve the oral environment and reduce the risk of infection and delayed wound healing. Furthermore, general anesthesia was applied to surgically remove caries. The patient was treated with intensive medication and wound management and recovered without postoperative complications after 1 year of follow-up. (237words)

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• Management of temporomandibular joint diseases: a rare case report of coexisting calcium pyrophosphate crystal deposition and synovial chondromatosis.

  Makoto Murahashi, Edward Hosea Ntege, Masaru Higa, Nobuyuki Maruyama, Toshihiro Kawano, Yusuke Shimizu, Hiroyuki Nakamura

  BMC oral health   22 ( 1 ) 662 - 662   2022.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: The coexistence of calcium pyrophosphate dihydrate crystal deposition (CPP) and synovial chondromatosis (SC) in the temporomandibular joint (TMJ) is rarely reported. CPP disease (CPPD) is complex arthritis synonymous with excessive pyrophosphate production and variable aberrations in mineral and organic phase metabolism of the joint cartilage, leading to local inundated CPP and crystal deposition of partially deciphered predispositions. Meanwhile, SC is a rare benign synovial joint proliferative disease of unclear etiology and has a low risk of malignant transformation. However, SC manifests severe joint disability and dysfunction because of connective tissue metaplasia of the synovial membrane, which forms cartilaginous nodules with or without calcifications or ossifications. These nodules often detach and form intra-articular loose bodies and very rarely within extraarticular spaces. CASE PRESENTATION: We report the case of a 61-year-old man to expand the body of literature on these unusual coexisting arthropathies of the TMJ. The patient presented to our hospital in 2020 with complaints of pain in the right TMJ and trismus for over 6 months. Radiographic assessments of the TMJ provided a preoperative provisional diagnosis of SC. However, the histopathology of the open biopsy revealed tumor-like lesions comprising several deposits of rhomboid and rod-shaped crystals that displayed positive birefringence in polarized light, confirming a coexistence of CPPD. A second-stage operation was performed for the complete removal of the loose bodies and chalk-like lesions including synovectomy. No evidence of recurrence was recorded after a follow-up of nearly 1.5 years. CONCLUSIONS: Isolated CPPD and SC of the TMJ are prevalent in the literature however, monoarticular coexistence of these diseases is rare, due to the lack of consistency in the diagnostic criteria in clinical practice. Moreover, optimal treatment depends on several considerations. This report delineated the molecular etiopathology and underscored the need for continued deciphering of the causal mechanisms of coexisting CPPD and SC of the TMJ. In addition, the importance of confirmatory testing for accurate diagnosis, and appropriate management of these diseases were discussed.

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• An unusual case of oral surgical management in a patient with isovaleric acidemia and schizophrenia: A case report.

  Sho Miyamoto, Edward Hose Ntege, Yasutsugu Chinen, Takahiro Goto, Jumpei Shirakawa, Shimpei Goto, Toshihiro Kawano, Yusuke Shimizu, Koichi Nakanishi, Hiroyuki Nakamura

  Biomedical reports   17 ( 2 ) 64 - 64   2022.08 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

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  Oral/dental surgical care in patients with chronic medical comorbidities, such as isovaleric acidemia (IVA), can be challenging. In addition to technical complications, different comorbidities also present a complex range of concerning factors/challenges, which can increase the incidence of morbidity and mortality associated with surgery. IVA, a congenital error of metabolism, is a rare organic acidemia with a predisposition towards acute acidosis and life-threatening metabolic decompensation during stressful conditions, such as prolonged fasting and surgery. In addition, schizophrenia, a major neurological disorder, can result in manifestation of severe dental or periodontal conditions, including pericoronitis. The condition is associated with significant risk factors of postoperative complications, such as dangerous behaviors and adverse interactions between antipsychotic drugs and anesthetic agents. A case of comorbid dental disease with two coexisting chronic and life-threatening medical conditions, one of which is rare, is an unusual encounter in oral/dental surgery that is seldomly published. Moreover, implementing a safe and effective surgical intervention in such patients requires several informed considerations. However, only a few reported experiences or guidelines exist, reporting appropriate perioperative management strategies to minimize risks. Hence, in this case report, our experience of managing one of these rare encounters of a 20-year-old man who suffered from bilaterally partially erupted third molars, associated with chronic pericoronitis and dental caries of both the maxilla wisdom teeth with coexisting IVA and schizophrenia comorbidities is described. Additionally, the presentation and anticipated complications of the comorbid disorders of the patient are briefly reviewed. In this case, the pericoronitis and dental caries were treated by surgically removing the impacted third molars and the antagonist maxilla wisdom teeth under regional anesthesia and application of antibiotics for 3 days. The patient recovered without any postoperative complications after 1 year of follow-up.

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• Peripheral dentinogenic ghost cell tumor in the mandibular anterior region

  Sho Miyamoto, Hiromasa Hasegawa, Tomoko Tamaki, Akira Matayoshi, Takahiro Goto, Jumpei Shirakawa, Shimpei Goto, Toshiyuki Nakasone, Naoki Wada, Hiroyuki Nakamura

  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology ( Elsevier BV )  34 ( 4 ) 436 - 439   2022.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• ApoE E4有無別にみた主観的認知障害と将来の認知機能低下との関連 中島町研究

  柚木 颯偲, 篠原 もえ子, 堀本 真以, 森 彩香, 阿部 智絵美, 岩佐 和夫, 横川 正美, 中村 博幸, 駒井 清暢, 山田 正仁

  Dementia Japan ( (一社)日本認知症学会 )  33 ( 4 ) 562 - 562   2019.10  [Refereed]

   

• がんの多様性と新規治療法への展望 再発又は転移性頭頸部扁平上皮癌の病態解明と分子標的薬

  中村 博幸

  Journal of Oral Biosciences Supplement ( (一社)歯科基礎医学会 )  2019   78 - 78   2019.10  [Refereed]

   

• 高齢者の睡眠習慣と認知機能に関する縦断的検討 中島町研究

  阿部 智絵美, 篠原 もえ子, 堀本 真以, 森 彩香, 柚木 颯偲, 岩佐 和夫, 中村 博幸, 駒井 清暢, 山田 正仁

  Dementia Japan ( (一社)日本認知症学会 )  33 ( 4 ) 561 - 561   2019.10  [Refereed]

   

• 同時性三重複癌(口腔癌・食道がん・大腸癌)の1例

  本保 敦志, 加藤 広禄, 宮澤 広樹, 野口 夏代, 大井 一浩, 中村 博幸, 小山 岳海, 長谷 剛志, 川尻 秀一

  日本口腔科学会雑誌 ( (NPO)日本口腔科学会 )  68 ( 3 ) 246 - 246   2019.09  [Refereed]

   

• Differences in Dementia Beliefs and Intention to Attend a Future Dementia Screening between Public Screeners and in-Home Screeners

  Sohshi Yuki-Nozaki, Moeko Shinohara, Chiaki Domoto, Yoshihisa Ikeda, Miharu Samuraki, Kazuo Iwasa, Masami Yokogawa, Kimiko Asai, Kiyonobu Komai, Hiroyuki Nakamura, Masahito Yamada

    Supplement 15 ( 7 )   2019.07  [Refereed]

   

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• 再発又は転移性頭頸部扁平上皮癌の病態解明と分子標的薬

  中村 博幸

  第61回歯科基礎学会 アップデートシンポジウム1  2019.10  -  2019.10 

• 小児難病の早期発見

  中村 博幸

  第2回日本外傷歯学会認定医更新セミナー  2019.07  -  2019.07 

• 金沢市3歳児歯科検診でのHPP早期発見の取り組み

  中村 博幸

  第13回ALPS研究会  2019.07  -  2019.07 

• 難病（低ホスファターゼ症）を早期発見するためのシステムと小児歯科医の“気づき”

  中村 博幸

  第57回日本小児歯科学会大会 ランチョンセミナー  2019.06  -  2019.06 

• 再発又は転移性頭頸部扁平上皮癌の病態解明と分子標的薬

  中村 博幸

  第73回日本口腔科学会学術集会 指名報告  2019.04  -  2019.04 

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2026.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2018.04  -  2022.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

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Social Activity 【 display / non-display 】

Social Activity 【 display / non-display 】

• 2018.12

  　

  　

• 2018.12

  　

  　

• 2018.11

  　

  　

• 2018.11

  　

  　

• 2018.07

  　

  　

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Media Coverage 【 display / non-display 】

Media Coverage 【 display / non-display 】

• 高齢者の歯と口腔の健康と認知症の進行予防  TV or radio program

  MROﾗｼﾞｵ健康百科  2018.1

• お口のｹｱは生命（いのち）のｹｱ  TV or radio program

  MROﾗｼﾞｵ健康百科  2016.4