Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

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Acquisition of a qualification 【 display / non-display 】

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Dual orexin receptor antagonist-assisted dose reduction of benzodiazepines and benzodiazepine receptor agonists: a mirror-image analysis of insurance claims data.

  Matsui K, Sugiura K, Shimura A, Takagi S, Kurihara K, Takaesu Y, Inoue Y

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine   22 ( 1 )   2026.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Comparison of depressive symptoms and anxious distress between major depressive disorder and bipolar disorder using the CUDOS-A

  Oishi, K; Matsumoto, Y; Aoki, Y; Takaesu, Y; Murao, M; Maruki, T; Tsuboi, T; Nakano, M; Watanabe, K; Sakurai, H

  PSYCHIATRY AND CLINICAL NEUROSCIENCES REPORTS ( Psychiatry and Clinical Neurosciences Reports )  5 ( 3 ) e70403   2026.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Response to 'Hypnotic discontinuation is not synonymous with successful deprescribing: A Taiwan perspective'

  Kurihara, K; Sugiura, K; Shimura, A; Matsui, K; Takagi, S; Inoue, Y; Takaesu, Y

  PSYCHIATRY AND CLINICAL NEUROSCIENCES ( Psychiatry and Clinical Neurosciences )    2026.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Occupational performance characteristics in patients with bipolar disorders: discriminant analysis with major depressive disorders

  Hayasaka, T; Nagashima, I; Hoshino, M; Teruya, K; Matumoto, Y; Murao, M; Maruki, T; Watanabe, M; Katagiri, T; Kurihara, M; Oe, Y; Takaesu, Y; Tsuboi, T; Watanabe, K; Sakurai, H

  FRONTIERS IN PSYCHIATRY ( Frontiers in Psychiatry )  17   1844682   2026.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Machine-learning classification of bipolar disorder incorporating wearable-derived core body temperature and actigraphy-derived sleep indices.

  Kurihara K, Shiroma A, Kamata M, Yoshimoto N, Saso A, Shimura A, Imai Y, Miyahara T, Takaesu Y

  PCN reports : psychiatry and clinical neurosciences ( Psychiatry and Clinical Neurosciences Reports )  5 ( 2 ) e70359   2026.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  AIM: This study aimed to classify patients with bipolar disorder (BD) and normal controls (NCs) using machine-learning models that incorporate wearable-derived core body temperature (CBT) and actigraphy-derived sleep indices. METHODS: We enrolled 23 euthymic patients with BD and 43 NCs. Sleep parameters were collected via wrist actigraphy for 14 days, and CBT was measured with a wearable device for 3 days to estimate the CBT nadir and its phase differences with sleep indices. Models were constructed with a base model using CBT- and sleep-derived features, and an extended model that included sociodemographic variables. Features were standardized (StandardScaler), and classifiers (random forest, LightGBM, and XGBoost) were evaluated. Hyperparameters were optimized using cross-validation within the training data. Performance was evaluated using repeated nested cross-validation. SHapley Additive exPlanations (SHAP) values were computed in the extended model to quantify relative feature contributions to the model output. RESULTS: In nested cross-validation at the MaxF1 operating point, the mean area under the receiver operating characteristic curve (ROC-AUC) was 0.771 ± 0.162 for the base model and 0.930 ± 0.050 for the extended model. In the extended model, SHAP suggested that total sleep time, wake time, and the wake time-CBT nadir phase difference were features potentially associated with the model output. CONCLUSION: In this small-sample study, a classification approach combining wearable-derived CBT indices and actigraphy-based sleep parameters suggested preliminary discrimination between BD and NC. Further validation is warranted in larger cohorts with balanced background characteristics, including disorders requiring differential diagnosis.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• Depression treatment focusing on the anxious distress specifier.

  新里輔鷹, 高江洲義和

  臨床精神薬理   28 ( 6 )   2025

   

  J-GLOBAL

• Differentiating "sleepiness": daytime sleepiness, difficulty in getting up: Mood disorders and circadian rhythm dysfunctions

  大塚直亮, 高江洲義和

  臨床精神医学   53 ( 1 )   2024

   

  J-GLOBAL

• A retrospective multicenter analysis of factors related to the achievement of discontinuation of anticholinergic medication in patients with schizophrenia

  村田篤信, 古郡規雄, 堀輝, 長谷川尚美, 姜善貴, 高江洲義和, 伊賀淳一, 越智紳一郎, 降籏隆二, 鬼塚俊明, 竹島正浩, 三浦健一郎, 松本純弥, 稲田健, 渡邊衡一郎, 橋本亮太

  日本臨床精神神経薬理学会プログラム・抄録集   30th   2021

   

  J-GLOBAL

• 睡眠-覚醒リズム障害を訴える患者

    108 ( 12 ) 1579 - 1582   2020.12

   

  DOI

• 共同意思決定(SDM)の普及可能性

    62 ( 10 ) 1387 - 1392   2020.10

   

  DOI

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Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Clinical Research Award

  2016   American Academy of Dental Sleep Medicine  

  Winner: Yoshikazu Takaesu

• Excellent Presentation Award

  2016    

  Winner: Yoshikazu Takaesu

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Development of software as Medical Device for patients with bipolar disorder focusing on circadian rhythm dysfunction

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2027.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Development of nighttime lighting to promote patient sleep under metameric conditions

  Challenging research (sprout)

  Project Year: 2023.06  -  2025.03 

  Direct: 4,900,000 (YEN)  Overheads: 6,370,000 (YEN)  Total: 1,470,000 (YEN)

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2023.04  -  2027.03 

  Direct: 12,300,000 (YEN)  Overheads: 15,990,000 (YEN)  Total: 3,690,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2027.03 

  Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2023.04  -  2027.03 

  Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

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