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• Utility of Ultrahigh-Resolution Computed Tomography for Laryngeal Reconstructive Surgery

  Kise, N; Hirakawa, H; Aniya, S; Ooshiro, T; Kondo, S; Tomoda, A; Oyakawa, Y; Kiyuna, A; Suzuki, M

  LARYNGOSCOPE ( Wiley )  134 ( 11 ) 4667 - 4673   2024.11

  Type of publication: Research paper (scientific journal)

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  Objective: Unilateral vocal fold paralysis (UVFP) presents as incomplete glottal closure and leads to breathy hoarseness.Various treatments, including laryngeal framework surgery (type 1 thyroplasty [TP1] and arytenoid adduction [AA]), have beendevised to correct this condition. Ultrahigh-resolution computed tomography (U-HRCT) allows detailed three-dimensionalimaging of the larynx, which aids our understanding of vocal fold motion disorders. This study assessed whether U-HRCT isbeneficial for correct diagnosis and surgical planning. Methods: The participants were 26 UVFP patients who underwent laryngeal framework surgery (TP1 and/or AA).U-HRCT was used to measure the vocal fold volume (VFV) and level difference (LD). The need to combine AA with TP1 toobtain satisfactory surgical outcomes was evaluated by U-HRCT and various voice function tests. Results: VFV was smaller in paralyzed folds than in unaffected folds. LD correlated strongly with voice parameters andshowed high intra-rater and inter-rater reliability. The surgical outcome of the laryngeal framework surgery performed wasjudged to be excellent for improving voice function. Comparison of LD between the TP1 group and TP1 + AA group indicatedthat LD is an excellent parameter to determine the need to combine AA with TP1. Conclusion: These findings underscore the value of preoperative U-HRCT, especially LD, in surgical decision-making andafford insights for optimal phonosurgery and individualized intervention. Patients with LD >1.0 mm may benefit fromthyroplasty with AA.

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• p16 Overexpression in Sinonasal Squamous Cell Carcinoma: Association with Human Papillomavirus and Prediction of Survival Outcomes

  Hirakawa, H; Ikegami, T; Touyama, M; Ooshiro, Y; Higa, T; Higa, T; Agena, S; Kinjyo, H; Kondo, S; Kise, N; Tanaka, K; Maeda, H; Tamaki, T; Wada, N; Suzuki, M

  JOURNAL OF CLINICAL MEDICINE ( Journal of Clinical Medicine )  12 ( 21 ) 6861   2023.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Biomarkers for Predicting Anti-Programmed Cell Death-1 Antibody Treatment Effects in Head and Neck Cancer.

  Tanaka K, Hirakawa H, Suzuki M, Higa T, Agena S, Hasegawa N, Kawakami J, Toyama M, Higa T, Kinjyo H, Kise N, Kondo S, Maeda H, Ikegami T

  Current oncology (Toronto, Ont.) ( Current Oncology )  30 ( 6 ) 5409 - 5424   2023.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  In recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC), survival outcomes are significantly better in patients who receive anti-programmed cell death-1 (PD-1) monoclonal antibody therapy than in those who receive standard therapy. However, there is no established biomarker that can predict the anti-PD-1 antibody treatment effect and immune-related adverse events (irAEs) in these patients. This study investigated the inflammatory and nutritional status in 42 patients with R/M-HNSCC and programmed cell death ligand-1 (PD-L1) polymorphisms (rs4143815 and rs2282055) in 35 of the 42 patients. The 1- and 2-year overall survival was 59.5% and 28.6%, respectively; the 1- and 2-year first progression-free survival was 19.0% and 9.5%, respectively, and the respective second progression-free survival was 50% and 27.8%. Performance status and inflammatory and nutritional status (assessed by the geriatric nutritional risk index, modified Glasgow prognostic score, and prognostic nutritional index) were identified as significant indicators of survival outcomes in multivariate analysis. Patients with ancestral alleles in PD-L1 polymorphisms had less frequent irAEs. Performance status and inflammatory and nutritional status before treatment were closely related to survival outcomes after PD-1 therapy. These indicators can be calculated using routine laboratory data. PD-L1 polymorphisms may be biomarkers for predicting irAEs in patients receiving anti-PD-1 therapy.

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• Human Papillomavirus Infection and EGFR Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.

  Hirakawa H, Ikegami T, Kise N, Kinjyo H, Kondo S, Agena S, Hasegawa N, Kawakami J, Maeda H, Suzuki M

  Journal of personalized medicine ( Journal of Personalized Medicine )  13 ( 4 ) 657   2023.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• One-Stage Cochlear Implantation for Adhesive Otitis Media

  Higa Teruyuki, Ganaha Akira, Kondo Shunsuke, Oyakawa Yoshiki, Agena Shinya, Hirakawa Hitoshi, Suzuki Mikio

  Practica Oto-Rhino-Laryngologica ( The Society of Practical Otolaryngology )  114 ( 12 ) 909 - 916   2021

  Type of publication: Research paper (scientific journal)

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  <p>Cochlear implant surgery has been introduced successfully and is now one of the commonly performed surgeries. However, the surgical strategy of cochlear implantation in patients with chronic middle ear diseases, such as chronic otitis media and cholesteatoma, has not yet been fully established. In the present report, we describe the surgical technique adopted and prognosis of two patients with severe adhesive otitis media who underwent cochlear implant surgeries. Both underwent one-stage cochlear implantation combined with external auditory canal closure (blind-sac closure). Mastoidectomy with removal of the whole canal wall was performed to remove the otitis lesion thoroughly, and external auditory canal wall closure was performed to prevent recurrence of the lesion. A pneumatized tympanic cavity was observed and canal wall closure was maintained in both cases. Both patients acquired fair hearing ability with the cochlear implants. No severe complications have occurred until now, four years since the cochlear implantation. Although external ear canal closure destroys the natural structure of the external ear, one-stage cochlear implant surgery combined with canal closure is useful for elderly patients with systemic complications who desire shortening of hearing-deprived period.</p>

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• 中耳腔進展を伴う髄膜腫の2例

  近藤 俊輔, 比嘉 輝之, 赤澤 幸則, 鈴木 幹男

  耳鼻咽喉科臨床 補冊 ( 耳鼻咽喉科臨床学会 )  ( 補冊154 ) 122 - 122   2019.06

   

• 超高精細CTを用いたアブミ骨手術症例の検討

  比嘉 輝之, 近藤 俊輔, 赤澤 幸則, 鈴木 幹男

  日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科学会 )  122 ( 4 ) 593 - 593   2019.04

   

• OTOG遺伝子変異による軽中等度難聴

  我那覇 章, 山田 悠祐, 東野 哲也, 比嘉 輝之, 赤澤 幸則, 近藤 俊輔, 鈴木 幹男

  日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科学会 )  122 ( 4 ) 623 - 623   2019.04

   

• ブーメラン軟骨を用いたscutum plastyを行った弛緩部型真珠腫の術後成績

  我那覇 章, 比嘉 輝之, 近藤 俊輔, 鈴木 幹男, 東野 哲也

  Otology Japan ( (一社)日本耳科学会 )  28 ( 4 ) 335 - 335   2018.09

   

• 真珠腫摘出と人工内耳植え込みを同時に行った2例

  比嘉 輝之, 我那覇 章, 赤澤 幸則, 近藤 俊輔, 鈴木 幹男

  Otology Japan ( (一社)日本耳科学会 )  28 ( 4 ) 583 - 583   2018.09

   

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2029.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Identification of cancer stem cell markers in head and neck cancer

  Grant-in-Aid for Early-Career Scientists

  Project Year: 2019.04  -  2022.03 

  Investigator(s): Kondo Shunsuke 

  Direct: 2,900,000 (YEN)  Overheads: 3,770,000 (YEN)  Total: 870,000 (YEN)

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  Sufficient progress in cancer stem cell research has not yet been made in the field of head and neck cancer, and no specific molecule targeting cancer stem cells that leads to treatment has been identified. For patients with hypopharyngeal cancer, immunostaining of CD44, ALDH1 and PDL1 was performed using cancer tissue sections, and the number of positive cells was measured and quantified to evaluate the relationship with prognosis. CD44 was associated with prognosis, but ALDH1 and PDL1 were not clearly associated with prognosis. In the future, it will be necessary to search for specific markers for hypopharyngeal cancer by narrowing down to CD44-positive cells and identifying populations with cancer stem cell organs.

• Efficacy of novel dendritic cell vaccine treatment for HPV-related cancer

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): Uehara Takayuki 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

  　View Summary

  We researched to develop a cancer immunotherapy using dendritic cells (DC) as a therapeutic strategy for human papillomavirus (HPV) -related head and neck cancer. In vitro culture of CD14 and CD8 cells extracted from human blood with necessary cytokines induces differentiation of DC and cytotoxic T cells (CTL). Furthermore, we stimulated with peptides derived from HPV to create antigen-specific DC. Then, the cells were co-cultured with HPV-positive head and neck cancer-derived HSC4 cell line, and the antitumor effect was examined. As a result, antitumor effect was suggested in DC and CTL prepared under the stimulations of two HPV E6 peptide sequences, which is a certain HPV-derived antigen.

• Efficacy of novel dendritic cell vaccine treatment for HPV-related cancer

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): Uehara Takayuki 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

  　View Summary

  We researched to develop a cancer immunotherapy using dendritic cells (DC) as a therapeutic strategy for human papillomavirus (HPV) -related head and neck cancer. In vitro culture of CD14 and CD8 cells extracted from human blood with necessary cytokines induces differentiation of DC and cytotoxic T cells (CTL). Furthermore, we stimulated with peptides derived from HPV to create antigen-specific DC. Then, the cells were co-cultured with HPV-positive head and neck cancer-derived HSC4 cell line, and the antitumor effect was examined. As a result, antitumor effect was suggested in DC and CTL prepared under the stimulations of two HPV E6 peptide sequences, which is a certain HPV-derived antigen.

• Molecular target for HPV positive HNCs

  Grant-in-Aid for Young Scientists(B)

  Project Year: 2016.04  -  2019.03 

  Investigator(s): Kondo Shunsuke 

  Direct: 3,000,000 (YEN)  Overheads: 3,900,000 (YEN)  Total: 900,000 (YEN)

  　View Summary

  It is still uncertain about molecular targets toward HPV positive HNCs. So we planned this study to detect a specific molecular target towards HPV positive head neck cancers (HNCs) using human cancer cell lines and also using cancer tissues. There was a difference of gene and protein expression between HPV positive cancer cells and negative cancer cells with the component of mTOR complex 1 and 2. And we used mTOR inhibitor temsirolimus toward cancer cells. HPV positive cancer cells were more efective with temsirolimus. Also we extract cDNA from Oropharyngeal cancer tissues and investigate the gene expression of the component of mTOR complex 1 and 2. The result of tissue was similar with the result of cancer cells. With the result of this study mTOR seemed to be an important target toward HPV positive HNCs.

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