Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

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Research Interests 【 display / non-display 】

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Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Biomarkers for Predicting Anti-Programmed Cell Death-1 Antibody Treatment Effects in Head and Neck Cancer.

  Tanaka K, Hirakawa H, Suzuki M, Higa T, Agena S, Hasegawa N, Kawakami J, Toyama M, Higa T, Kinjyo H, Kise N, Kondo S, Maeda H, Ikegami T

  Current oncology (Toronto, Ont.) ( Current Oncology )  30 ( 6 ) 5409 - 5424   2023.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Human Papillomavirus Infection and EGFR Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.

  Hirakawa H, Ikegami T, Kise N, Kinjyo H, Kondo S, Agena S, Hasegawa N, Kawakami J, Maeda H, Suzuki M

  Journal of personalized medicine ( Journal of Personalized Medicine )  13 ( 4 ) 657   2023.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• One-Stage Cochlear Implantation for Adhesive Otitis Media

  Higa Teruyuki, Ganaha Akira, Kondo Shunsuke, Oyakawa Yoshiki, Agena Shinya, Hirakawa Hitoshi, Suzuki Mikio

  Practica Oto-Rhino-Laryngologica ( The Society of Practical Otolaryngology )  114 ( 12 ) 909 - 916   2021

  Type of publication: Research paper (scientific journal)

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  <p>Cochlear implant surgery has been introduced successfully and is now one of the commonly performed surgeries. However, the surgical strategy of cochlear implantation in patients with chronic middle ear diseases, such as chronic otitis media and cholesteatoma, has not yet been fully established. In the present report, we describe the surgical technique adopted and prognosis of two patients with severe adhesive otitis media who underwent cochlear implant surgeries. Both underwent one-stage cochlear implantation combined with external auditory canal closure (blind-sac closure). Mastoidectomy with removal of the whole canal wall was performed to remove the otitis lesion thoroughly, and external auditory canal wall closure was performed to prevent recurrence of the lesion. A pneumatized tympanic cavity was observed and canal wall closure was maintained in both cases. Both patients acquired fair hearing ability with the cochlear implants. No severe complications have occurred until now, four years since the cochlear implantation. Although external ear canal closure destroys the natural structure of the external ear, one-stage cochlear implant surgery combined with canal closure is useful for elderly patients with systemic complications who desire shortening of hearing-deprived period.</p>

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• Measurement of stapes footplate thickness in otosclerosis by ultra-high-resolution computed tomography.

  Akazawa Y, Ganaha A, Higa T, Kondo S, Oyakawa Y, Hirakawa H, Suzuki M, Yamashiro T

  Acta oto-laryngologica ( Acta Oto-Laryngologica )  140 ( 11 ) 899 - 903   2020.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: Ultra-high-resolution computed tomography (U-HRCT) utilizes a 1024 × 1024 matrix with 0.25-mm section thickness, offering better spatial resolution than conventional multi-detector row CT to detect anatomic data for otologic surgery. AIMS: We examined stapes footplate thickness using U-HRCT in relation to stapedotomy to predict the difficulty of the surgical procedure. MATERIALS AND METHODS: Subjects were 12 otosclerosis patients and 25 controls who underwent diagnostic U-HRCT. A profile curve (Hounsfield units) was used to measure stapes footplate thickness along a perpendicular line across the stapes footplate in a plane parallel to the lateral semicircular canal. RESULTS: Footplate thickness was smaller at the midpoint than just before the anterior crus and just after the posterior crus. Interobserver variability was lowest at the midpoint, where foot plate thickness was significantly greater in the affected ear in otosclerosis patients compared with controls (0.60 ± 0.09 mm vs 0.46 ± 0.04 mm; p < .001). Otosclerosis patients were detected using U-HRCT with a high area under the curve. Difficulty in the stapes opening procedure correlated with stapes footplate thickness. CONCLUSIONS: Footplate thickness on U-HRCT correlated with temporal bone anatomy and corresponded to surgical difficulty. Significance: U-HRCT-derived anatomic data is useful for evaluating the stapes.

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• Induction chemotherapy in hypopharyngeal cancers: influences of DNA repair gene polymorphisms

  Hirakawa H, Ikegami T, Azechi S, Agena S, Uezato J, Kinjyo H, Yamashita Y, Kiyuna A, Tanaka K, Kondo S, Maeda H, Suzuki M, Ganaha A

  Anticancer Research   40 ( in press )   2020.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• 中耳腔進展を伴う髄膜腫の2例

  近藤 俊輔, 比嘉 輝之, 赤澤 幸則, 鈴木 幹男

  耳鼻咽喉科臨床 補冊 ( 耳鼻咽喉科臨床学会 )  ( 補冊154 ) 122 - 122   2019.06

   

• 超高精細CTを用いたアブミ骨手術症例の検討

  比嘉 輝之, 近藤 俊輔, 赤澤 幸則, 鈴木 幹男

  日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科学会 )  122 ( 4 ) 593 - 593   2019.04

   

• OTOG遺伝子変異による軽中等度難聴

  我那覇 章, 山田 悠祐, 東野 哲也, 比嘉 輝之, 赤澤 幸則, 近藤 俊輔, 鈴木 幹男

  日本耳鼻咽喉科学会会報 ( (一社)日本耳鼻咽喉科学会 )  122 ( 4 ) 623 - 623   2019.04

   

• ブーメラン軟骨を用いたscutum plastyを行った弛緩部型真珠腫の術後成績

  我那覇 章, 比嘉 輝之, 近藤 俊輔, 鈴木 幹男, 東野 哲也

  Otology Japan ( (一社)日本耳科学会 )  28 ( 4 ) 335 - 335   2018.09

   

• 真珠腫摘出と人工内耳植え込みを同時に行った2例

  比嘉 輝之, 我那覇 章, 赤澤 幸則, 近藤 俊輔, 鈴木 幹男

  Otology Japan ( (一社)日本耳科学会 )  28 ( 4 ) 583 - 583   2018.09

   

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Efficacy of novel dendritic cell vaccine treatment for HPV-related cancer

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): Uehara Takayuki 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

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  We researched to develop a cancer immunotherapy using dendritic cells (DC) as a therapeutic strategy for human papillomavirus (HPV) -related head and neck cancer. In vitro culture of CD14 and CD8 cells extracted from human blood with necessary cytokines induces differentiation of DC and cytotoxic T cells (CTL). Furthermore, we stimulated with peptides derived from HPV to create antigen-specific DC. Then, the cells were co-cultured with HPV-positive head and neck cancer-derived HSC4 cell line, and the antitumor effect was examined. As a result, antitumor effect was suggested in DC and CTL prepared under the stimulations of two HPV E6 peptide sequences, which is a certain HPV-derived antigen.

• Molecular target for HPV positive HNCs

  Grant-in-Aid for Young Scientists(B)

  Project Year: 2016.04  -  2019.03 

  Investigator(s): Kondo Shunsuke 

  Direct: 3,000,000 (YEN)  Overheads: 3,900,000 (YEN)  Total: 900,000 (YEN)

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  It is still uncertain about molecular targets toward HPV positive HNCs. So we planned this study to detect a specific molecular target towards HPV positive head neck cancers (HNCs) using human cancer cell lines and also using cancer tissues. There was a difference of gene and protein expression between HPV positive cancer cells and negative cancer cells with the component of mTOR complex 1 and 2. And we used mTOR inhibitor temsirolimus toward cancer cells. HPV positive cancer cells were more efective with temsirolimus. Also we extract cDNA from Oropharyngeal cancer tissues and investigate the gene expression of the component of mTOR complex 1 and 2. The result of tissue was similar with the result of cancer cells. With the result of this study mTOR seemed to be an important target toward HPV positive HNCs.