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• A Comprehensive Study of the Immunophenotype and its Clinicopathological Significance in Adult T-cell Leukemia/Lymphoma

  Tomoko Tamaki, Kennosuke Karube, Shugo Sakihama, Yuma Tsuruta, Ryoko Awazawa, Masaki Hayashi, Norihiro Nakada, Hirofumi Matsumoto, Nobutake Yagi, Kazuiku Ohshiro, Iwao Nakazato, Sakiko Kitamura, Yukiko Nishi, Takuya Miyagi, Sayaka Yamaguchi, Sawako Nakachi, Satoko Morishima, Hiroaki Masuzaki, Kenzo Takahashi, Takuya Fukushima, Naoki Wada

  Modern Pathology ( Modern Pathology )  36 ( 8 ) 100169 - 100169   2023.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). The typical ATLL immunophenotypes are described in the 2017 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues (positive: CD2, CD3, CD5, CD4, and CD25; negative: CD7, CD8, and cytotoxic markers; and partially positive: CD30, CCR4, and FOXP3). However, limited studies are available on the expression of these markers, and their mutual relationship remains unknown. Furthermore, the expression status of novel markers associated with T-cell lymphomas, including Th1 markers (T-bet and CXCR3), Th2 markers (GATA3 and CCR4), T follicular helper markers (BCL6, PD1, and ICOS), and T-cell receptor (TCR) markers, and their clinicopathologic significance is unclear. In this study, we performed >20 immunohistochemical stains in 117 ATLL cases to determine the comprehensive immunophenotypic profile of ATLL, which were compared on the basis of clinicopathologic factors, including morphologic variants (pleomorphic vs anaplastic), biopsy locations, treatments, Shimoyama classification-based clinical subtype, and overall survival. CD3+/CD4+/CD25+/CCR4+ was considered a typical immunophenotype of ATLL, but approximately 20% of cases did not conform to this pattern. Simultaneously, the following new findings were obtained: (1) most cases were negative for TCR-β and TCR-δ (104 cases, 88.9%), indicating the usefulness of negative conversion of TCR expression to provide differentiation from other T-cell tumors; (2) the positivity of CD30 and CD15 and the negativity of FOXP3 and CD3 were significantly associated with anaplastic morphology; and (3) atypical cases, such as T follicular helper marker-positive (12 cases, 10.3%) and cytotoxic molecule-positive cases (3 cases, 2.6%), were identified. No single markers could predict the overall survival among patients with acute/lymphoma subtypes of ATLL. The results of this study illustrate the diversity of ATLL phenotypes. In T-cell tumors occurring in HTLV-1 carriers, the possibility of ATLL should not be eliminated even when the tumor exhibits an atypical phenotype, and the confirmation of HTLV-1 in the tissue is recommended.

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• Anaplastic thyroid carcinoma with squamous differentiation and diverse cytology

  SHIMABUKURO Takako, HIGUCHI Kayoko, TATETSU Chie, WADA Naoki, TAMAKI Tomoko

  The Journal of the Japanese Society of Clinical Cytology ( The Japanese Society of Clinical Cytology )  64 ( 2 ) 94 - 101   2025.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  <p><i><b>Background</b></i> : Anaplastic thyroid carcinoma is a rare, but highly malignant disease. Herein, we report a case of anaplastic thyroid carcinoma that showed a variety of cytological findings on fine-needle aspiration cytology.</p><p><i><b>Case</b></i> : A female patient in her 60s presented to our hospital with a rapidly enlarging neck mass. Cervical computed tomography and cervical ultrasonography revealed a mass in the right lobe of the thyroid gland and an enlarged right cervical lymph node, both of which were suspected as being malignant. Fine-needle aspiration cytology (FNAC) of the mass in the thyroid gland revealed keratinized atypical cells, which led to the suspicion of squamous cell carcinoma. Postoperative histopathological examination of the excised thyroid gland exhibited features of both papillary and anaplastic thyroid carcinomas, and the final diagnosis was anaplastic thyroid carcinoma with squamous differentiation. A review of the cytology findings revealed papillary carcinoma components, diverse multinucleated giant cells, and neutrophilic infiltration within highly atypical cell clusters.</p><p><i><b>Conclusion</b></i> : When keratinizing atypical cells are found on FNAC, conditions that should be considered in the differential diagnosis include anaplastic carcinoma with squamous differentiation, squamous metaplasia of papillary carcinoma, intrathyroidal thymic carcinoma, sclerosing mucoepidermoid carcinoma with eosinophilia, and diffuse sclerosing papillary carcinoma. Anaplastic carcinoma with squamous differentiation is presumed when necrotic and inflammatory cells are seen in the background, and large atypical cells with various morphologies and mitoses are seen.</p>

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• Recent progress in pathological understanding of adult T-cell leukemia/ lymphoma in the new classification era

  Karube, K; Sakihama, S; Takatori, M; Morichika, K; Tamaki, T; Wada, N; Fukushima, T

  LEUKEMIA RESEARCH ( Leukemia Research )  148   107634   2025.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Tracheal Mucoepidermoid Carcinoma Complicated with Papillary Thyroid Carcinoma

  Igei Masaki, Kise Norimoto, Miyahira Hirohumi, Tamaki Tomoko, Hirakawa Hitoshi, Maeda Hiroyuki, Suzuki Mikio

  Koutou (THE LARYNX JAPAN) ( THE JAPAN LARYNGOLOGICAL ASSOCIATION )  36 ( 1 ) 43 - 47   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  <p>Primary tracheal carcinoma is a rare malignant tumor; among all malignant tumors, it is reported to occur account for 0.04% of malignancies in Japan and 0.1% in Europe and the United States, with squamous cell carcinoma, accounting for 45%, and adenoid cystic carcinoma, accounting for 41%. We report the case of a 79-year-old woman with papillary thyroid carcinoma, cT4aN0M0 (right recurrent), with laryngeal nerve and tracheal wall invasion, The patient underwent total thyroidectomy, right recurrent laryngeal nerve resection, and tracheal fenestration. On the 16th postoperative day, when attempting to remove the cannula, dyspnea developed, and the bilateral vocal cords were observed. The patient was diagnosed with paralysis. This did not improve despite follow-up. The patient was referred to our hospital for glottis surgery. Preoperative computed tomography (CT) images showed a mass protruding from the left wall of the trachea into the lumen, and pretracheal lymphadenopathy, suggesting intratracheal recurrence of papillary thyroid carcinoma and cervical lymph node metastasis. Therefore, glottis surgery was temporarily suspended and tumor resection (tumor resection including combined resection of the trachea and reconstruction of the tracheal wall using a DP flap) was planned and the operation was performed. A pathological examination revealed papillary carcinoma lymph node metastasis in the pretracheal lymph nodes, but the tumor tissue in the trachea was found to be low-grade mucoepidermoid. carcinoma, not papillary carcinoma. In the present case an intratracheal lesion after surgery for papillary thyroid carcinoma was identified as primary mucoepidermoid carcinoma of the trachea.</p>

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• A Case of SMARCB1-Deficient Sinonasal Carcinoma With Clear Cell Morphology

  Tomoko Tamaki, Kyonosuke Teruya, Hitoshi Hirakawa, Mariko Tomita, Naoki Wada

  Cureus   16 ( 5 ) e59684   2024.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  SMARCB1 is a gene known to cause carcinogenesis in many soft tissue tumors, including malignant rhabdoid tumors and epithelioid sarcoma. Since the first report of a subtype of sinonasal carcinoma characterized by a deficiency of the SMARCB1 gene in 2014 to date, fewer than 200 cases have been reported. We report a case of SMARCB1-deficient sinonasal carcinoma with clear cell morphology. In our case, there are no evident basaloid or plasmacytoid/rhabdoid tumor cells, which are typical histopathological features of SMARCB1- deficient sinonasal carcinoma. SMARCB1-deficient sinonasal carcinoma is prone to recurrence and has a very poor prognosis. As the development of molecularly targeted agents progresses, therapeutic efficacy is expected to improve. Simultaneously, the importance of early and accurate diagnosis of SMARCB1-deficient sinonasal carcinoma will increase. With the limited information provided by biopsy specimens, it is necessary to confirm the loss of SMARCB1 expression by immunohistochemistry and investigate the presence of SMARCB1 gene deletion by molecular genetics, considering the possibility of SMARCB1- deficient sinonasal carcinoma even in atypical cases without basaloid or plasmacytoid/rhabdoid cell morphology, as in our case.

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• 免疫チェックポイント阻害薬を放射線化学療法に追加して加療した上部尿路上皮癌の治療経験(Clinical experience of Pembrolizumab for renal pelvic and ureteral cancer after chemo-radiation therapy)

  足立 秀幸, 田中 一輝, 佐々木 翔平, 川越 淳平, 島袋 浩勝, 向山 秀樹, 橋本 成司, 真鍋 良彦, 平安名 常一, 玉城 智子

  日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  110回   PP32 - 06   2023.04

   

• 成人T細胞白血病・リンパ腫(ATLL)の病理組織学的形態および免疫表現型に関する検討(A study on histopathological morphology and immunophenotype of adult T-cell leukemia/lymphoma (ATLL))

  玉城 智子, 加留部 謙之輔, 仲田 典宏, 松本 裕文, 仲里 巌, 和田 直樹

  日本病理学会会誌 ( (一社)日本病理学会 )  112 ( 1 ) 274 - 274   2023.03

   

Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• Young Investigator Award

  2024.11    

• Young Researcher Academic Encouragement Award, Regional Contribution Category

  2023.06    

• Special Research Promotion Project, Ryukyu Medical Association Award

  2023.03   Ryukyu Medical Association  

  Winner: Tomoko Tamaki

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Young Scientists(S)

  Project Year: 2025.04  -  2027.03 

  Direct: 2,900,000 (YEN)  Overheads: 870,000 (YEN)  Total: 3,770,000 (YEN)