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• Calyculin生合成経路における活性化機構に関する研究

  2021.03

  DOI

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• Onnamides and a Novel Analogue, Onnamide G, as Potent Leishmanicidal Agents.

  Jomori T, Higa N, Tyas TA, Matsuura N, Ueda Y, Suetake A, Miyazaki S, Watanabe S, Arizono S, Hayashi Y, Yasumoto K, Ise Y, Wakimoto T, Yasumoto-Hirose M, Tanaka J, Mori-Yasumoto K

  Marine biotechnology (New York, N.Y.)   27 ( 5 ) 132   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates

  Jomori, T; Higa, N; Hokama, S; Tyas, TA; Matsuura, N; Ueda, Y; Kimura, R; Arizono, S; de Voogd, NJ; Hayashi, Y; Yasumoto-Hirose, M; Tanaka, J; Mori-Yasumoto, K

  MARINE DRUGS ( Marine Drugs )  23 ( 1 ) 16 - 16   2025.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Leishmaniasis is a major public health problem, especially affecting vulnerable populations in tropical and subtropical regions. The disease is endemic in 90 countries, and with millions of people at risk, it is seen as one of the ten most neglected tropical diseases. Current treatments face challenges such as high toxicity, side effects, cost, and growing drug resistance. There is an urgent need for safer, affordable treatments, especially for cutaneous leishmaniasis (CL), the most common form. Marine invertebrates have long been resources for discovering bioactive compounds such as sesterterpenoids. Using bioassay-guided fractionations against cutaneous-type leishmaniasis promastigotes, we identified a novel furanosesterterpenoid, petrosaspongin from Okinawan marine sponges and a nudibranch, along with eight known sesterterpenoids, hippospongins and manoalides. The elucidated structure of petrosaspongin features a β-substituted furane ring, a tetronic acid, and a conjugated triene. The sesterterpenoids with a γ-butenolide group exhibited leishmanicidal activity against Leishmania major promastigotes, with IC50 values ranging from 0.69 to 53 μM. The structure–activity relationship and molecular docking simulation suggest that γ-lactone is a key functional group for leishmanicidal activity. These findings contribute to the ongoing search for more effective treatments against CL.

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• Two isoledene-type sesquiterpenoids from a soft coral<i> Heteroxenia</i> sp.

  Kurnianda, V; Hu, HC; Sung, PJ; Hayashi, Y; Mori-Yasumoto, K; Suetake, A; Nakayama, H; Yasumoto-Hirose, M; Tsutsumi, Y; Koja, G; Tsai, YC; Jomori, T; Tanaka, J

  TETRAHEDRON LETTERS ( Tetrahedron Letters )  151   155323 - 155323   2024.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Parallel loss of sex in field populations of a brown alga sheds light on the mechanisms underlying the emergence of asexuality

  Masakazu Hoshino, Guillaume Cossard, Fabian B. Haas, Emma I. Kane, Kazuhiro Kogame, Takahiro Jomori, Toshiyuki Wakimoto, Susana M. Coelho

  Nature Ecology & Evolution ( Cold Spring Harbor Laboratory )  8   1916 - 1932   2024.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Abstract Sexual reproduction is widespread among eukaryotes, but asexual lineages have repeatedly arisen from sexual ancestors across a wide range of taxa. Despite extensive research on the evolution of asexuality from sexual ancestors, the molecular changes underpinning the switch to asexual reproduction remain elusive, particularly in organisms with haploid sexual systems such as bryophytes, and red and brown algae in which males and females are haploid and multicellular. Here, we investigate independent events in which asexuality has emerged from sexual ancestor lineages in species of the brown algalScytosiphon, we examine the proximate and evolutionary mechanisms involved, and test the importance of sexual conflict on gene expression changes following loss of sex. We find that individuals from asexual, female-only (‘Amazon’) populations lose their ability to produce and sex pheromone and, consequently, are unable to attract and fuse with male gametes, whereas they gain the ability to trigger parthenogenic (asexual) development from large, unfertilized eggs. This independent and convergent decline in pheromone production and optimization of asexual traits is accompanied by convergent changes in gene expression, including de-feminization and masculinization of the Amazon gamete transcriptomes. These data are consistent with the idea that decay of female functions, rather than relaxation of sexual antagonism, is the dominant force at play during the emergence of asexuality in haploid sexual systems. Moreover, we identify a locus on an autosomal protein-coding gene that is associated with the switch to asexuality. We propose that the sex chromosome, together with this autosomal locus, may underlie the switch to obligate asexuality in the Amazon populations.

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• Onnamide A suppresses the severe acute respiratory syndrome-coronavirus 2 infection without inhibiting 3-chymotrypsin-like cysteine protease

  Hayashi, Y; Higa, N; Yoshida, T; Tyas, TA; Mori-Yasumoto, K; Yasumoto-Hirose, M; Tani, H; Tanaka, J; Jomori, T

  JOURNAL OF BIOCHEMISTRY ( Journal of Biochemistry )  176 ( 3 ) 197 - 203   2024.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Abstract Given the continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the development of new inhibitors is necessary to enhance clinical efficacy and increase the options for combination therapy for the coronavirus disease 2019. Because marine organisms have been a resource for the discovery of numerous bioactive molecules, we constructed an extract library of marine invertebrates collected from the Okinawa Islands. In this study, the extracts were used to identify antiviral molecules against SARS-CoV-2. Using a cytopathic effect (CPE) assay in VeroE6/TMPRSS2 cells, an extract from the marine sponge Theonella swinhoei was found to reduce virus-induced CPE. Eventually, onnamide A was identified as an antiviral compound in the extract using column chromatography and NMR analysis. Onnamide A inhibited several SARS-CoV-2 variant-induced CPEs in VeroE6/TMPRSS2 cells as well as virus production in the supernatant of infected cells. Moreover, this compound blocked the entry of SARS-CoV-2 pseudo-virions. Taken together, these results demonstrate that onnamide A suppresses SARS-CoV-2 infection, which may be partially related to entry inhibition, and is expected to be a candidate lead compound for the development of anti-SARS-CoV-2 drugs.

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Research Activity start-up

  Project Year: 2022.09  -  2024.03 

  Direct: 2,200,000 (YEN)  Overheads: 660,000 (YEN)  Total: 2,860,000 (YEN)