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• Calyculin生合成経路における活性化機構に関する研究

  2021.03

  DOI

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• Onnamides A and B Suppress Hepatitis B Virus Transcription by Inhibiting Viral Promoter Activity

  林 康広

  Marine drugs ( MDPI AG )  24 ( 1 ) 21   2026.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  We recently reported that onnamide A, a marine-derived natural compound isolated from the sponge Theonella sp., inhibits the entry process of SARS-CoV-2 infection. However, its antiviral activity against other viruses remains largely unexplored. Here, we investigated the effects of onnamide A and its structurally related analog, onnamide B, on hepatitis B virus (HBV) infection. Using iNTCP cells, a hepatoblastoma-derived cell line permissive to HBV infection, we found that onnamides A and B exhibited cytotoxicity, with CC50 values of 0.53 ± 0.10 μM and 2.37 ± 0.25 μM, respectively. Following HBV infection, the levels of total HBV RNA were significantly reduced by onnamide A (IC50 = 0.06 ± 0.01 μM) and onnamide B (IC50 = 0.23 ± 0.06 μM). Notably, both compounds markedly decreased the levels of HBV pregenomic RNA. Furthermore, significant inhibition was particularly evident when onnamide treatment was initiated after HBV infection. Consistent with these observations, onnamides did not affect HBV binding, entry, or covalently closed circular DNA formation, but they significantly suppressed HBV RNA transcription. In particular, the transcriptional activities driven by the core and X promoters were markedly inhibited by onnamide treatment. Taken together, our findings demonstrate that onnamides possess potent anti-HBV activity and highlight their potential as candidate compounds targeting HBV RNA transcription.

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• Demethylmycemycin A, a dibenzoxazepinone from the marine-derived <i>Dactylosporangium</i> sp. OK1079, with prostate cancer suppressive effects via targeting BRK-FAK-STAT3 axis

  Elsbaey, M; Tarun, MTI; Alnajjar, R; Jomori, T; Tanaka, J; Oku, N; El Sayed, K; Igarashi, Y

  JOURNAL OF ANTIBIOTICS ( Journal of Antibiotics )  79 ( 1 ) 1 - 14   2025.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products

  Hanif, N; Pakan, JS; Lisias, SC; Sael, WB; Santosa, NF; Tyas, TA; Lemuel, MM; Mohamad, K; Sa'diah, S; Dewi, FNA; Oluwabusola, ET; Tsunematsu, Y; Tan, LT; Chasanah, E; Murni, A; de Voogd, NJ; Jomori, T; Kita, M; Jaspars, M; Tanaka, J

  NATURAL PRODUCT RESEARCH ( Natural Product Research )    1 - 6   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Onnamides and a Novel Analogue, Onnamide G, as Potent Leishmanicidal Agents.

  Jomori T, Higa N, Tyas TA, Matsuura N, Ueda Y, Suetake A, Miyazaki S, Watanabe S, Arizono S, Hayashi Y, Yasumoto K, Ise Y, Wakimoto T, Yasumoto-Hirose M, Tanaka J, Mori-Yasumoto K

  Marine biotechnology (New York, N.Y.)   27 ( 5 ) 132   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates

  Jomori, T; Higa, N; Hokama, S; Tyas, TA; Matsuura, N; Ueda, Y; Kimura, R; Arizono, S; de Voogd, NJ; Hayashi, Y; Yasumoto-Hirose, M; Tanaka, J; Mori-Yasumoto, K

  MARINE DRUGS ( Marine Drugs )  23 ( 1 ) 16 - 16   2025.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Leishmaniasis is a major public health problem, especially affecting vulnerable populations in tropical and subtropical regions. The disease is endemic in 90 countries, and with millions of people at risk, it is seen as one of the ten most neglected tropical diseases. Current treatments face challenges such as high toxicity, side effects, cost, and growing drug resistance. There is an urgent need for safer, affordable treatments, especially for cutaneous leishmaniasis (CL), the most common form. Marine invertebrates have long been resources for discovering bioactive compounds such as sesterterpenoids. Using bioassay-guided fractionations against cutaneous-type leishmaniasis promastigotes, we identified a novel furanosesterterpenoid, petrosaspongin from Okinawan marine sponges and a nudibranch, along with eight known sesterterpenoids, hippospongins and manoalides. The elucidated structure of petrosaspongin features a β-substituted furane ring, a tetronic acid, and a conjugated triene. The sesterterpenoids with a γ-butenolide group exhibited leishmanicidal activity against Leishmania major promastigotes, with IC50 values ranging from 0.69 to 53 μM. The structure–activity relationship and molecular docking simulation suggest that γ-lactone is a key functional group for leishmanicidal activity. These findings contribute to the ongoing search for more effective treatments against CL.

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Other Research Activities 【 display / non-display 】

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• Journal of Natural Medicines

  Editing academic journals etc. 

  2025.04

  　

  　

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• Grant-in-Aid for Research Activity start-up

  Project Year: 2022.09  -  2024.03 

  Direct: 2,200,000 (YEN)  Overheads: 660,000 (YEN)  Total: 2,860,000 (YEN)

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• 沖縄産の海綿で寄生虫駆除　琉大の城森助教ら化合物分離　熱帯病「皮膚リーシュマニア症」新薬に期待  Newspaper, magazine

  琉球新報  23頁  2025.10

  Author： Other 

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  本報告は、SDGs Goal 3に該当する成果である。 下記、掲載文の冒頭より抜粋。 東南アジアや南米でまん延する寄生虫性疾患「皮膚型リーシュマニア症」は高価で効目が乏しい治療薬しかないが、琉球大学理学部の城森啓宏助教らが沖縄産の海綿動物から、原虫の駆除に強い効果をもたらし、安全性も高い新規の天然化合物を分離することに成功した。

• 沖縄県の海綿から強力な抗リーシュマニア活性化合物の単離に成功 ～世界の熱帯・亜熱帯地域に蔓延するリーシュマニア症への新規治療薬開発につながる知見～  Internet

  東京理科大学・琉球大学・宮崎大学　共同プレスリリース  PR TIMES,　東京新聞, 日経バイオテク、日本経済新聞、MONOist、Mapion,   2025.9

  Author： Myself 

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  本報告は、SDGs Goal 3に該当する成果である。 下記、掲載文の冒頭より抜粋。 　安元加奈未（東京理科大学薬学部）、城森啓宏（琉球大学理学部）、林康広（宮崎大学農学部）、廣瀬美奈（一般社団法人トロピカルテクノプラス）、田中淳一（琉球大学名誉教授）らの研究グループは、沖縄産の海綿動物Theonella sp.から、新規化合物「オンナミドG（onnamide G）」を含む10種の天然化合物を単離し、それらが寄生虫リーシュマニア原虫に対して極めて高い駆除活性を示すことを明らかにしました。