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• Calyculin生合成経路における活性化機構に関する研究

  2021.03

  DOI

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• Nitrogen-Functionalized Amphilectane-Type Diterpenoids with Anti-HBV Activity from the Okinawan Marine Sponge Stylissa sp.

  Trianda A. Tyas, Yasuhiro Hayashi , Keiyo Nakai, Kuniyoshi Miki, Kanami Mori-Yasumoto, Mina Yasumoto-Hirose, Nicole J. de Voogd, Toshiaki Teruya, Junichi Tanaka, Takahiro Jomori

  Journal of Natural Products ( American Chemical Society )    2026.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Onnamides A and B Suppress Hepatitis B Virus Transcription by Inhibiting Viral Promoter Activity

  林 康広

  Marine drugs ( MDPI AG )  24 ( 1 ) 21   2026.01 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  We recently reported that onnamide A, a marine-derived natural compound isolated from the sponge Theonella sp., inhibits the entry process of SARS-CoV-2 infection. However, its antiviral activity against other viruses remains largely unexplored. Here, we investigated the effects of onnamide A and its structurally related analog, onnamide B, on hepatitis B virus (HBV) infection. Using iNTCP cells, a hepatoblastoma-derived cell line permissive to HBV infection, we found that onnamides A and B exhibited cytotoxicity, with CC50 values of 0.53 ± 0.10 μM and 2.37 ± 0.25 μM, respectively. Following HBV infection, the levels of total HBV RNA were significantly reduced by onnamide A (IC50 = 0.06 ± 0.01 μM) and onnamide B (IC50 = 0.23 ± 0.06 μM). Notably, both compounds markedly decreased the levels of HBV pregenomic RNA. Furthermore, significant inhibition was particularly evident when onnamide treatment was initiated after HBV infection. Consistent with these observations, onnamides did not affect HBV binding, entry, or covalently closed circular DNA formation, but they significantly suppressed HBV RNA transcription. In particular, the transcriptional activities driven by the core and X promoters were markedly inhibited by onnamide treatment. Taken together, our findings demonstrate that onnamides possess potent anti-HBV activity and highlight their potential as candidate compounds targeting HBV RNA transcription.

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• Demethylmycemycin A, a dibenzoxazepinone from the marine-derived <i>Dactylosporangium</i> sp. OK1079, with prostate cancer suppressive effects via targeting BRK-FAK-STAT3 axis

  Elsbaey, M; Tarun, MTI; Alnajjar, R; Jomori, T; Tanaka, J; Oku, N; El Sayed, K; Igarashi, Y

  JOURNAL OF ANTIBIOTICS ( Journal of Antibiotics )  79 ( 1 ) 1 - 14   2025.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products

  Hanif, N; Pakan, JS; Lisias, SC; Sael, WB; Santosa, NF; Tyas, TA; Lemuel, MM; Mohamad, K; Sa'diah, S; Dewi, FNA; Oluwabusola, ET; Tsunematsu, Y; Tan, LT; Chasanah, E; Murni, A; de Voogd, NJ; Jomori, T; Kita, M; Jaspars, M; Tanaka, J

  NATURAL PRODUCT RESEARCH ( Natural Product Research )    1 - 6   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Onnamides and a Novel Analogue, Onnamide G, as Potent Leishmanicidal Agents.

  Jomori T, Higa N, Tyas TA, Matsuura N, Ueda Y, Suetake A, Miyazaki S, Watanabe S, Arizono S, Hayashi Y, Yasumoto K, Ise Y, Wakimoto T, Yasumoto-Hirose M, Tanaka J, Mori-Yasumoto K

  Marine biotechnology (New York, N.Y.)   27 ( 5 ) 132   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Research for the discovery of anti-proliferation compounds selectively under low-pH conditions

  石田良典, 影近弘之, 城森啓宏

  生体医歯工学共同研究拠点成果報告書(Web)   2024   2025

   

  J-GLOBAL

• Studies on the antileishmanial constituents of medicinal plants (Part 47): Chemical constituents from Toddalia asiatica (L.) Lam.

  渡邊周一, 飯田基雄, 荻貴之, 廣瀬美奈, 林康広, 城森啓宏, 田中淳一, 安元加奈未

  日本薬学会年会要旨集(Web)   145th   2025

   

  J-GLOBAL

• Studies on the antileishmanial constituents of medicinal plants (part 46): Chemical constituents from Diospyros ebenum

  宮崎深, 飯田基雄, 川崎萌由, 中山日花梨, 荻貴之, 安元剛, 廣瀬美奈, 林康広, 城森啓宏, 田中淳一, 安元加奈未

  日本薬学会年会要旨集(Web)   145th   2025

   

  J-GLOBAL

• Research for the discovery of anti-proliferation compounds selectively under low-pH conditions

  石田良典, 影近弘之, 城森啓宏

  生体医歯工学共同研究拠点成果報告書   2022   2023

   

  J-GLOBAL

• Research for the discovery of anti-proliferation compounds selectively under low-pH conditions

  石田良典, 影近弘之, 城森啓宏

  生体医歯工学共同研究拠点成果報告会   2022 (CD-ROM)   2023

   

  J-GLOBAL

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• Journal of Natural Medicines

  Editing academic journals etc. 

  2025.04

  　

  　

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• Grant-in-Aid for Research Activity start-up

  Project Year: 2022.09  -  2024.03 

  Direct: 2,200,000 (YEN)  Overheads: 660,000 (YEN)  Total: 2,860,000 (YEN)

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• 沖縄産の海綿で寄生虫駆除　琉大の城森助教ら化合物分離　熱帯病「皮膚リーシュマニア症」新薬に期待  Newspaper, magazine

  琉球新報  23頁  2025.10

  Author： Other 

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  本報告は、SDGs Goal 3に該当する成果である。 下記、掲載文の冒頭より抜粋。 東南アジアや南米でまん延する寄生虫性疾患「皮膚型リーシュマニア症」は高価で効目が乏しい治療薬しかないが、琉球大学理学部の城森啓宏助教らが沖縄産の海綿動物から、原虫の駆除に強い効果をもたらし、安全性も高い新規の天然化合物を分離することに成功した。

• 沖縄県の海綿から強力な抗リーシュマニア活性化合物の単離に成功 ～世界の熱帯・亜熱帯地域に蔓延するリーシュマニア症への新規治療薬開発につながる知見～  Internet

  東京理科大学・琉球大学・宮崎大学　共同プレスリリース  PR TIMES,　東京新聞, 日経バイオテク、日本経済新聞、MONOist、Mapion,   2025.9

  Author： Myself 

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  本報告は、SDGs Goal 3に該当する成果である。 下記、掲載文の冒頭より抜粋。 　安元加奈未（東京理科大学薬学部）、城森啓宏（琉球大学理学部）、林康広（宮崎大学農学部）、廣瀬美奈（一般社団法人トロピカルテクノプラス）、田中淳一（琉球大学名誉教授）らの研究グループは、沖縄産の海綿動物Theonella sp.から、新規化合物「オンナミドG（onnamide G）」を含む10種の天然化合物を単離し、それらが寄生虫リーシュマニア原虫に対して極めて高い駆除活性を示すことを明らかにしました。