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• Bacterial pneumonia co-infection in adult inpatients with coronavirus disease 2019 during the Omicron variants epidemic in Okinawa, Japan: risk factors and clinical outcomes.

  Kami W, Ideguchi S, Miyagi K, Tasato D, Higa F, Nakamura H, Kinjo T, Nakamatsu M, Haranaga S, Tokushige A, Fujita J, Yamamoto K

  Respiratory investigation ( Respiratory Investigation )  63 ( 6 ) 1087 - 1092   2025.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Factors associated with diagnostic delay and prognosis in hospitalized patients with strongyloidiasis in Okinawa, Japan.

  Arima S, Nishiyama N, Higure Y, Naha Y, Uchihara T, Ideguchi S, Nakamura H, Miyagi K, Nakamatsu M, Haranaga S, Kinjo T, Tokushige A, Akamine M, Yamamoto K

  PLoS neglected tropical diseases ( Plos Neglected Tropical Diseases )  19 ( 8 ) e0013380   2025.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  BACKGROUND: Prognosis and factors correlated to diagnostic delays in patients with strongyloidiasis, a parasitic disease, remain poorly understood. This study investigated the relationship among diagnostic delay, prognosis, and eosinophilia in patients with strongyloidiasis. METHODOLOGY/PRINCIPAL FINDINGS: Hospitalized patients with a confirmed diagnosis of strongyloidiasis at a single hospital over 10 years (2013-2023) were retrospectively screened. Fifty-five inpatients were included (median age, 81 years); 34 patients (61.8%) were male, and all but one patient was born in Okinawa before 1960. Duration from onset of symptoms to diagnosis was 10 days (median), hospitalization length was 37 days (median), and eight patients (14.5%) died. We classified diagnoses made after ≥30 days as delayed diagnosis and compared the patients with and without delayed diagnosis. Patients with delayed diagnosis had more in-hospital deaths than their counterparts (55.6% versus [vs.] 7.1%, P < 0.005). Compared with patients diagnosed earlier, those with delayed diagnosis were also characterized by older age (90 vs. 78.5 years, P < 0.005), more frequent fever (55.6% vs. 19.6%, P = 0.037), lower hemoglobin levels (10.1 vs. 11.8 g/dL, P = 0.0363), absence of eosinophilia (0% vs. 22%, P = 0.015), higher rates of sepsis (50% vs. 10.7%, P = 0.03), and prolonged hospitalization (77 vs. 23.5 days, P < 0.005). Diagnostic delay even after adjusting for age and sex using multivariate logistic regression analyses was a significant risk factor for mortality (odds ratio = 11.3, P = 0.022). Patients without eosinophilia were older than those with eosinophilia (84.5 vs. 76 years, P = 0.005) and not associated with in-hospital death (23.3% vs. 4.8%, P = 0.118). CONCLUSIONS/SIGNIFICANCE: Diagnostic delays are associated with a poor prognosis of strongyloidiasis. The absence of eosinophilia led to overlooked diagnoses. Screening should be considered before starting immunosuppressive therapy; relying on eosinophil counts could delay diagnosis.

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• Two Cases of Mpox with Proctitis: One with and One Without Skin Rash

  YAMANIHA Kazutaka, IDEGUCHI Shuhei, NAKAMURA Hideta, ZUKEYAMA Haruka, NISHIYAMA Naoya, NAKAMATSU Masashi, KINJO Takeshi, FURUGEN Makoto, MIYAGI Kazuya, YAMAMOTO Kazuko

  Kansenshogaku Zasshi ( The Japanese Association for Infectious Diseases )  99 ( 2 ) 177 - 182   2025.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  <p>Mpox (formerly known as monkeypox) is caused by monkeypox virus (MPXV), a member of the orthopoxvirus genus of viruses. Historically, it is endemic to Central and West Africa. Since 2022, however, a sharp rise in the number of mpox cases has been reported from non-endemic regions such as Europe and the United States. As compared with the traditional cases of mpox reported from the endemic regions, the majority of the patients in the new cases of mpox from non-endemic regions are gay, bisexual, and/or people living with HIV (PLWH), and anogenital skin lesions are a predominant clinical feature. Herein, we report two cases of mpox in PLWH. While case 1 had typical anogenital skin rashes with hemorrhagic proctitis, case 2 manifested proctitis without a skin rash. MPXV was detected by polymerase-chain reaction of scrapings from the skin rash in case 1, and from an anal swab in case 2. Our cases highlight the fact that in the recent outbreak of mpox, proctitis could be the sole presenting feature. Clinicians should consider the possibility of mpox in patients presenting with proctitis, irrespective of the presence/absence of skin lesions.</p>

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• Unseasonal respiratory syncytial virus epidemics during the COVID-19 pandemic: Relationship between climatic factors and epidemic strain switching.

  Shinzato A, Hibiya K, Nishiyama N, Ikemiyagi N, Arakaki W, Kami W, Nabeya D, Ideguchi S, Nakamura H, Furugen M, Miyagi K, Nakamatsu M, Haranaga S, Kinjo T, Fujita J, Nakamura K, Yamamoto K

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases ( International Journal of Infectious Diseases )  154   107833 - 107833   2025.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  OBJECTIVES: The COVID-19 pandemic has altered respiratory syncytial virus (RSV) epidemic patterns. However, the influence of climatic and virological factors on RSV outbreaks remains unclear. We examined RSV incidence in Okinawa, Japan; Taiwan, China; and Florida, USA before and after the COVID-19 pandemic, focusing on the effects of population mobility and climate. METHODS: We analysed correlations among RSV incidence, human mobility, and climate before and after the pandemic. Additionally, we conducted a phylogenetic analysis of the second variable region of RSV G proteins using viral genomes isolated from patients with acute respiratory tract infections in Okinawa. RESULTS: Annual RSV epidemics in Okinawa were not correlated with post-pandemic human mobility. The temperature and humidity ranges at the onset of RSV epidemics differed between the pre- and post-pandemic periods, with decreased standard deviations. Genetic analysis of RSV strains from 2020 to 2022 revealed a cluster with low genetic diversity, which differed markedly from pre-2019 and 2023 prevalent strains. CONCLUSION: Reduced human migration led to an RSV epidemic caused by an indigenous endemic strain, highlighting the natural relationship between epidemics and climatic factors. These findings could aid in developing effective prediction and control programs for RSV epidemics and optimising vaccine programs.

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• Varicella-zoster virus reactivation with severe pneumonia following convalescence from coronavirus disease: A case report and literature review

  Tome, R; Arima, S; Akamine, M; Hashioka, H; Arakaki, W; Kami, W; Nabeya, D; Ideguchi, S; Nakamura, H; Kinjo, T; Nakamatsu, M; Furugen, M; Miyagi, K; Haranaga, S; Yamamoto, K

  INTERNAL MEDICINE ( 一般社団法人 日本内科学会 )  advpub ( 0 ) 3051 - 3056   2025 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  <p>An association between coronavirus disease 2019 (COVID-19) and concomitant varicella-zoster virus (VZV) reactivation has been proposed. We herein report a case of severe VZV pneumonia in a 73-year-old man who underwent corticosteroid tapering after recovering from COVID-19 and presented with fever, vesicular rashes, and hypoxemia. Chest computed tomography (CT) revealed ground-glass opacities and multiple granular shadows. Varicella-zoster virus was detected in the skin and bronchoalveolar lavage fluid. The patient was diagnosed with disseminated VZV reactivation and thereafter successfully recovered with acyclovir treatment. Physicians should consider the possibility of VZV reactivation when ground-glass opacities or patchy nodular shadows appear during the course of patients with COVID-19. </p>

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Other Papers 【 display / non-display 】

Other Papers 【 display / non-display 】

• 肺炎球菌株のマクロファージNF-κB活性誘導能がもつ臨床的な意義

  井手口 周平, 山本 和子, 高園 貴弘, 西條 知見, 今村 圭文, 宮崎 泰可, 柳原 克紀, 福田 雄一, 一門 和哉, 矢寺 和博, 常 彬, 迎 寛

  日本呼吸器学会誌 ( (一社)日本呼吸器学会 )  8 ( 増刊 ) 140 - 140   2019.03

   

• 非結核性抗酸菌種別のマクロファージNF-κB活性誘導能の検討

  巌水 慧, 山本 和子, 井手口 周平, 井手 昇太郎, 武田 和明, 高園 貴弘, 宮崎 泰可, 泉川 公一, 柳原 克紀, 迎 寛

  結核 ( (一社)日本結核病学会 )  94 ( 3 ) 297 - 297   2019.03

   

• 下気道微生物と関節リウマチの疾患活動性との関連性の検討

  井手口 周平, 山本 和子, 高園 貴弘, 西條 知見, 今村 圭文, 宮崎 泰可, 遠藤 友志郎, 古賀 智裕, 川上 純, 迎 寛

  日本内科学会雑誌 ( (一社)日本内科学会 )  108 ( Suppl. ) 201 - 201   2019.02

   

• 緑膿菌の気道定着と関節リウマチ患者の予後との関連性についての検討

  井手口 周平, 山本 和子, 高園 貴弘, 西條 知見, 今村 圭文, 宮崎 泰可, 迎 寛

  日本化学療法学会雑誌 ( (公社)日本化学療法学会 )  66 ( Suppl.A ) 382 - 382   2018.04

   

• 飛蚊症が契機で診断に至った結核性ぶどう膜炎合併肺結核の2例

  石岡 泰知, 井手口 周平, 梅村 明日香, 山本 和子, 高園 貴弘, 今村 圭文, 宮崎 泰可, 福島 喜代康, 迎 寛, 井上 大輔

  結核 ( (一社)日本結核病学会 )  93 ( 4 ) 307 - 307   2018.04

   

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Neutrophils in mediastinal lymph node mediates innate immune response during pneumococcal pneumonia.

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): YAMAMOTO Kazuko 

  Direct: 3,700,000 (YEN)  Overheads: 4,810,000 (YEN)  Total: 1,110,000 (YEN)

  　View Summary

  Mediastinal lymph nodes (MLN) are secondary lymphoid organs of the lung. Lymphatic vessels link lung to MLN and MLN to blood. We postulate that innate immune activities in the MLN interrupt bacterial passage, preventing disseminated infection during pneumonia. Our objective was to determine whether neutrophils migrate into MLNs during pneumonia, and to evaluate whether neutrophils in MLN affect bacteremia during pneumonia. Our data showed that neutrophils migrate to MLN during pneumococcal pneumonia, mediated by CXCL1 and CXCL5 in lymphatic endothelial cells, and to prevent bacterial dissemination from the lung via lymphatics. Neutrophils in MLN present MHC class II to stimulate acquired immune response. MLN neutrophils prevent bacteremia during pneumonia.

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• 2023.06