Current Affiliation Organization 【 display / non-display 】

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Published Papers 【 display / non-display 】

• Two Cases of Mpox with Proctitis: One with and One Without Skin Rash

  YAMANIHA Kazutaka, IDEGUCHI Shuhei, NAKAMURA Hideta, ZUKEYAMA Haruka, NISHIYAMA Naoya, NAKAMATSU Masashi, KINJO Takeshi, FURUGEN Makoto, MIYAGI Kazuya, YAMAMOTO Kazuko

  Kansenshogaku Zasshi ( The Japanese Association for Infectious Diseases )  99 ( 2 ) 177 - 182   2025.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  <p>Mpox (formerly known as monkeypox) is caused by monkeypox virus (MPXV), a member of the orthopoxvirus genus of viruses. Historically, it is endemic to Central and West Africa. Since 2022, however, a sharp rise in the number of mpox cases has been reported from non-endemic regions such as Europe and the United States. As compared with the traditional cases of mpox reported from the endemic regions, the majority of the patients in the new cases of mpox from non-endemic regions are gay, bisexual, and/or people living with HIV (PLWH), and anogenital skin lesions are a predominant clinical feature. Herein, we report two cases of mpox in PLWH. While case 1 had typical anogenital skin rashes with hemorrhagic proctitis, case 2 manifested proctitis without a skin rash. MPXV was detected by polymerase-chain reaction of scrapings from the skin rash in case 1, and from an anal swab in case 2. Our cases highlight the fact that in the recent outbreak of mpox, proctitis could be the sole presenting feature. Clinicians should consider the possibility of mpox in patients presenting with proctitis, irrespective of the presence/absence of skin lesions.</p>

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• Unseasonal respiratory syncytial virus epidemics during the COVID-19 pandemic: Relationship between climatic factors and epidemic strain switching.

  Shinzato A, Hibiya K, Nishiyama N, Ikemiyagi N, Arakaki W, Kami W, Nabeya D, Ideguchi S, Nakamura H, Furugen M, Miyagi K, Nakamatsu M, Haranaga S, Kinjo T, Fujita J, Nakamura K, Yamamoto K

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases ( International Journal of Infectious Diseases )  154   107833   2025.02 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Blood digital PCR for diagnosis and evaluation of treatment efficacies in patients with pneumocystis pneumonia

  Ideguchi, S; Kawamoto, N; Ikemiyagi, N; Nishiyama, N; Arakaki, W; Nabeya, D; Nakamura, H; Kinjo, T; Furugen, M; Miyagi, K; Yamamoto, K

  RESPIROLOGY   29   243 - 243   2024.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Clinical features of and severity risk factors for COVID-19 in adults during the predominance of SARS-CoV-2 XBB variants in Okinawa, Japan

  Ideguchi, S; Miyagi, K; Kami, W; Tasato, D; Higa, F; Maeshiro, N; Nagamine, S; Nakamura, H; Kinjo, T; Nakamatsu, M; Haranaga, S; Tokushige, A; Ueda, S; Fujita, J; Yamamoto, K

  PLOS ONE ( PLoS ONE )  19 ( 10 ) e0309808   2024.10 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Impact of Non-Influenza Respiratory Viruses on Emergency Department Utilization and Hospitalization

  Nabeya, D; Kinjo, T; Arakaki, W; Ikemiyagi, N; Nishiyama, N; Ideguchi, S; Nakamura, H; Furugen, M; Miyagi, K; Kishaba, T; Yamamoto, K

  EUROPEAN RESPIRATORY JOURNAL   64   2024.09 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• 肺炎球菌株のマクロファージNF-κB活性誘導能がもつ臨床的な意義

  井手口 周平, 山本 和子, 高園 貴弘, 西條 知見, 今村 圭文, 宮崎 泰可, 柳原 克紀, 福田 雄一, 一門 和哉, 矢寺 和博, 常 彬, 迎 寛

  日本呼吸器学会誌 ( (一社)日本呼吸器学会 )  8 ( 増刊 ) 140 - 140   2019.03

   

• 非結核性抗酸菌種別のマクロファージNF-κB活性誘導能の検討

  巌水 慧, 山本 和子, 井手口 周平, 井手 昇太郎, 武田 和明, 高園 貴弘, 宮崎 泰可, 泉川 公一, 柳原 克紀, 迎 寛

  結核 ( (一社)日本結核病学会 )  94 ( 3 ) 297 - 297   2019.03

   

• 下気道微生物と関節リウマチの疾患活動性との関連性の検討

  井手口 周平, 山本 和子, 高園 貴弘, 西條 知見, 今村 圭文, 宮崎 泰可, 遠藤 友志郎, 古賀 智裕, 川上 純, 迎 寛

  日本内科学会雑誌 ( (一社)日本内科学会 )  108 ( Suppl. ) 201 - 201   2019.02

   

• 緑膿菌の気道定着と関節リウマチ患者の予後との関連性についての検討

  井手口 周平, 山本 和子, 高園 貴弘, 西條 知見, 今村 圭文, 宮崎 泰可, 迎 寛

  日本化学療法学会雑誌 ( (公社)日本化学療法学会 )  66 ( Suppl.A ) 382 - 382   2018.04

   

• 飛蚊症が契機で診断に至った結核性ぶどう膜炎合併肺結核の2例

  石岡 泰知, 井手口 周平, 梅村 明日香, 山本 和子, 高園 貴弘, 今村 圭文, 宮崎 泰可, 福島 喜代康, 迎 寛, 井上 大輔

  結核 ( (一社)日本結核病学会 )  93 ( 4 ) 307 - 307   2018.04

   

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Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2021.04  -  2024.03 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

• Neutrophils in mediastinal lymph node mediates innate immune response during pneumococcal pneumonia.

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2017.04  -  2020.03 

  Investigator(s): YAMAMOTO Kazuko 

  Direct: 3,700,000 (YEN)  Overheads: 4,810,000 (YEN)  Total: 1,110,000 (YEN)

  　View Summary

  Mediastinal lymph nodes (MLN) are secondary lymphoid organs of the lung. Lymphatic vessels link lung to MLN and MLN to blood. We postulate that innate immune activities in the MLN interrupt bacterial passage, preventing disseminated infection during pneumonia. Our objective was to determine whether neutrophils migrate into MLNs during pneumonia, and to evaluate whether neutrophils in MLN affect bacteremia during pneumonia. Our data showed that neutrophils migrate to MLN during pneumococcal pneumonia, mediated by CXCL1 and CXCL5 in lymphatic endothelial cells, and to prevent bacterial dissemination from the lung via lymphatics. Neutrophils in MLN present MHC class II to stimulate acquired immune response. MLN neutrophils prevent bacteremia during pneumonia.