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• Association between KSHV genotype and immune response to Kaposi sarcoma

  Yogi Shohei, Ishikawa Haruna, Yamakawa Natsuko, Yara Maika, Kuninaka Nobuo, Uehara Karina, Tanabe Yasuka, Kurima Kiyoto, Kina Shinichiro, Kina Mika, Takahashi Kenzo, Arakawa Hirofumi, Kinjo Takao

  Human Pathology ( Elsevier )  172   1 - 8   2026.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Kaposi sarcoma (KS) is a locally aggressive endothelial tumor that can be classified into four clinical types: classic, AIDS-related, iatrogenic, and endemic. KS usually affects the skin and soft tissues, but it can develop into mucosal, lymph node, and multiple-organ lesions. KS is caused by Kaposi sarcoma-associated herpes virus (KSHV), which has six genotypes (A, B, C, D, E, and F). However, it remains unclear whether the KSHV genotype affects clinical presentation. In this study, we investigated clinical stage, cellular proliferation, NF-κB activity, and lymphocyte infiltration around the tumor of KS lesions. Additionally, we evaluated the association between the parameters described above and the viral genotypes. Classic KS with genotype C exhibited elevated proliferative activity and most cases progressed to an advanced stage. Lesions in classic KS with genotype C were limited to the skin with high CD4 and CD8 cell infiltration. In contrast, some AIDS-related KS patients with genotype A showed lymph node and visceral involvement and a lower number of immune cells around the tumor, which suggests that host immunity against KSHV affects the clinical presentation. Among patients with AIDS-related KS, the numbers of CD3 and CD8 cells in genotype C were higher than those in genotype A. These results imply that genotype C induces more potent host tumor immunity than genotype A. Thus, the present study suggests that the clinical presentation of KS is associated with both host immunity and KSHV genotypes.

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• Association between Kaposi's sarcoma-associated herpesvirus genotype and clinical types

  Yogi, S; Ishikawa, H; Oshiro, A; Yamazato, R; Sakamoto, C; Tanabe, Y; Uehara, K; Kurima, K; Kina, S; Takahashi, K; Arakawa, H; Kinjo, T

  PATHOLOGY & ONCOLOGY RESEARCH ( Pathology and Oncology Research )  31   1612009   2025.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  Kaposi’s sarcoma (KS) is a vascular intermediate malignant tumor classified into four clinical types: classic, AIDS-related, iatrogenic, and endemic. Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of KS. Six KSHV genotypes (A, B, C, D, E, and F) classified by K1 or two genotypes (P and M) by K15 have been reported. However, whether the KSHV genotype affects clinical presentation remains elusive. Herein, we investigated the association between viral genotypes and clinical presentations in patients with KS in Okinawa, an endemic area in Japan. Classic KS caused by KSHV genotype C was identified as the most common clinical type of KS in Okinawa. Conversely, 80% of the patients with AIDS-related KS were associated with genotype A. According to K15 genotyping, the population of genotype M was higher than that of genotype P. Although genotype M accounted for most cases of both classic and iatrogenic KS in Okinawa, genotype P constituted the majority of AIDS-related KS. Regarding the association between the K1 and K15 genotypes, single genotype A was associated with genotype P, whereas single genotype C was associated with genotype M. These K1 and K15 associations in Okinawa differed from those in Europe and Africa. In terms of the association between viral genotype and clinical types, A/P tended to be associated with AIDS-related KS and genotype C/M tended to be associated with classic KS. The findings of the current study suggest that the KSHV genotype in Okinawa differs from that in other countries, which is related to the KSHV geographic distribution and population migration. Our data also suggest that the viral genotype in Okinawa is associated with clinical presentations.

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• Detection of community-acquired respiratory viruses during COVID-19 pandemic in subtropical region in Japan

  Kami, W; Kinjo, T; Hashioka, H; Arakaki, W; Takahashi, A; Yogi, S; Uechi, K; Maeda, S; Yamamoto, K; Fujita, J

  EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES ( European Journal of Clinical Microbiology and Infectious Diseases )  43 ( 12 ) 2269 - 2276   2024.12 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Evaluation of antimicrobial susceptibility testing method for colistin in Enterobacterales.

  The Japanese Society For Clinical Microbiology   34 ( 3 )   2024.06 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

• Evaluation of an antimicrobial susceptibility testing system for <i>Aerococcus urinae</i> using DPS192iX

  SHIMOJI Maria, UECHI Kohei, NAKANO Ami, YOGI Shohei, UECHI Ayumi, MAEDA Shiro

  Japanese Journal of Medical Technology ( Japanese Association of Medical Technologists )  72 ( 4 ) 557 - 561   2023.10 [ Peer Review Accepted ]

  Type of publication: Research paper (other science council materials etc.)

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  <p>In this study, we evaluated the clinical usefulness of an automated antimicrobial susceptibility testing system (DPS192iX, Eiken Chemical Co. Ltd.) for <i>Aerococcus urinae</i>. MICs for nine antimicrobial agents, whose breakpoints were defined in CLSI M45 3rd Edition, were measured using DPS192iX for 38 <i>A. urinae</i> strains isolated and stored in the University of the Ryukyus Hospital between 2014 and 2020 and two ATCC strains, <i>Streptococcus pneumoniae</i> ATCC49619 and <i>A. urinae</i> ATCC51268. Results were compared with MICs determined by a reference method using frozen plates (Eiken Chemical Co., Ltd.). Overall, the ±1 essential agreement (±1 EA) and category agreement (CA) were 94.3% and 97.1%, respectively, whereas the ±1 EA or CA for several agents was less than 90% (±1 EA for ceftriaxone was 85.7%, that for linezolid was 88.6%, and CA for levofloxacin was 85.7%). The minor errors for ciprofloxacin and levofloxacin were 8.6% and 14.3%, respectively, but we did not observe a major error or a very major error. From these observations, the antimicrobial susceptibility testing system DPS192iX is considered useful for <i>A. urinae</i>, although further evaluation is required for several antimicrobial agents such as fluoroquinolones, ceftriaxone, and linezolid.</p>

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