Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

Graduate School 【 display / non-display 】

Graduate School 【 display / non-display 】

Study abroad experiences 【 display / non-display 】

Study abroad experiences 【 display / non-display 】

External Career 【 display / non-display 】

External Career 【 display / non-display 】

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

display all >>

Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• Risk of Type 2 Diabetes According to Body Mass Index, Television Viewing Time, and Their Combination in the Japanese Population: Findings From the Japan Collaborative Cohort Study

  Ukawa S, Zhao W, Ikehara S, Shirai K, Iso H, Tamakoshi A

  Journal of Obesity   2026 ( 1 ) e1830356   2026.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  • Access this article

    DOI

• Association between Total Fruit Consumption and Risk of Gestational Diabetes Mellitus: The Japan Environment and Children's Study

  Kojima, A; Ikehara, S; Miyazaki, J; Kawasaki, R; Iso, H

  ANNALS OF NUTRITION AND METABOLISM ( Annals of Nutrition and Metabolism )  82 ( 2 ) 81 - 89   2026.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  INTRODUCTION: Whether the consumption of fruits, flavonoid-rich fruits, and 100% fruit juice is associated with the risk of gestational diabetes mellitus (GDM) is unclear. We aimed to examine the association of total fruit, flavonoid-rich fruits, and 100% fruit juice consumption with the risk of GDM. METHODS: A total of 93,759 singleton pregnancies who were enrolled in the Japan Environment and Children's Study remained for the analysis. Total fruit consumption including fruits and 100% fruit juice during the past year in the first trimester was assessed using a validated food frequency questionnaire (FFQ). Odds ratios (ORs) and 95% confidence intervals (CIs) for GDM associated with total fruit, flavonoid-rich fruits, non-flavonoid-rich fruits, and 100% fruit juice consumption were estimated using logistic regression analysis. RESULTS: GDM occurred in 2,096 (2.2%) of the 93,759 pregnant women. Total fruit consumption was inversely associated with the risk of GDM; the multivariable ORs (95% CI) for the highest vs lowest quartiles of total fruit consumption were 0.82 (0.71, 0.95) (p for trend = 0.013). An increase in total fruit consumption by each 100 g/d was inversely associated with the risk of GDM [OR = 0.94 (0.91, 0.98), p for trend = 0.001)]. The multivariable ORs (95% CIs) for the highest versus lowest quartiles of flavonoid-rich fruits consumption was 0.80 (0.70, 0.93) (p for trend = 0.003), whereas that for non-flavonoid-rich fruits consumption was 0.96 (0.83, 1.11) (p for trend = 0.504); 100% fruit juice consumption was inversely associated with the risk of GDM for each 100 g/d increase (OR = 0.91, 95% CI: 0.87, 0.96). CONCLUSION: Total fruit consumption, flavonoid-rich fruits and 100% fruit juice consumption were inversely associated with risk of GDM.

  • Access this article

    DOI
  • Search related information
    PubMed

• Associations of household income and parental education with early childhood caries: the Japan Environment and Children's Study.

  Kaneko F, Yamada E, Miyazaki J, Ikehara S, Kawasaki R, Iso H, Japan Environment and Children’s Study (JECS) Group

  Environmental health and preventive medicine ( 一般社団法人日本衛生学会 )  31 ( 0 ) 23 - 23   2026 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  <p><b>Background:</b> Although the prevalence of early childhood caries (ECC) has declined over the past few decades, it remains a significant public health concern in Japan. Socioeconomic disparities in ECC risk have been reported; however, the extent to which these disparities exist across different indicators of socioeconomic status (SES) and the degree to which early oral health practices help explain them remain unclear. This study evaluated the association between parental SES and ECC and examined the extent to which early oral health behaviors contributed to these associations.</p><p><b>Methods:</b> We analyzed the data from 68,312 children and their parents participating in the Japan Environment and Children’s Study, a nationwide birth cohort recruited between 2011 and 2014. Parental SES, including household income equivalized using the OECD-modified equivalence scale and educational attainment, was assessed using self-reported questionnaires. Diagnoses of dental caries from birth to age 4 years were reported retrospectively by caregivers when the child was 4 years old. Multivariable logistic regression was used to examine associations between SES and ECC. Mediation analyses were conducted to evaluate whether oral health behaviors at age 2, including fluoride application, tooth brushing practices, continued bottle feeding, and frequency of between-meal snacks, mediated these associations. All models were adjusted for demographic and potential confounding factors.</p><p><b>Results:</b> Overall, 23.0% of children had been diagnosed with caries by age 4 years. The higher prevalence was consistently observed among children from lower SES backgrounds starting at around age 2 years. Both lower household income and lower parental educational attainment were associated with higher odds of ECC. The highest odds were observed among children whose parents had secondary-level education (adjusted odds ratio: 1.52; 95% confidence interval: 1.44–1.59). Although oral health behaviors mediated these associations, each behavior accounted for less than 5% of the total effect.</p><p><b>Conclusion:</b> Lower household income and parental educational attainment were consistently associated with a higher risk of ECC from early childhood. Mediation analyses using oral health behaviors assessed at age 2 indicated that these behaviors explained a small proportion of the observed socioeconomic disparities, suggesting a small contribution of individual behaviors to early-life socioeconomic inequalities in ECC.</p>

  • Access this article

    DOI
  • Search related information
    PubMed CiNii Research

• Associations between antenatal organophosphate pesticide exposure and pregnancy outcomes: The Japan Environment and Children's Study (JECS)

  Baba S, Tanigawa K, Nakayama SF, Nishihama Y, Hirata K, Ikehara S, Miyazaki J, Kawasaki R, Iso H.

  Science of The Total Environment     2025.08 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  • Access this article

    DOI

• Associations between parents' broader autism phenotype and children's developmental difficulty scores at 6 and 12 months: A prospective study

  Hirokawa, K; Baba, S; Ikehara, S; Cui, MS; Kitano, N; Nakayama, H; Ozono, K; Iso, H

  INTERNATIONAL JOURNAL OF BEHAVIORAL DEVELOPMENT ( International Journal of Behavioral Development )    2025.07 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

  　View Summary

  Previous studies have investigated the associations between parents’ broader autism phenotype (BAP) in the United States and various European and Asian countries, but few studies have examined large samples to consider sex differences in children. The current study investigated whether parents’ BAP was associated with children’s developmental difficulty using the Ages &amp; Stages Questionnaires, Third Edition (ASQ-3) at 6 and 12 months. The Japan Environment and Children’s Study (JECS) is a nationwide and government-funded birth cohort study, which began in January 2011. Among 46,438 dyads of mothers and fathers who provided complete data for the Japanese version of the Autism Spectrum Quotient (AQ-J-10) to measure BAP, the results of 31,079 dyads of mothers and fathers who also provided complete ASQ-3 data for their child were analyzed in the present study. Child sex differences were observed in ratings of developmental difficulties at 12 months, indicating that girls were rated as exhibiting less difficulty in the communication, problem solving, and personal-social domains than boys. Mothers’ BAP was strongly associated with children’s developmental difficulties at 6 and 12 months, while fathers’ BAP was associated with children’s developmental difficulty at 12 months. Fathers’ AQ-J-10 scores were associated with difficulties in girls at 12 months, and with low levels of partners’ participation in child rearing. Genetic, epigenetic, and environmental studies will be necessary to clarify the mechanisms underlying the effects of parental influences on children’s development.

  • Access this article

    DOI

display all >>

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2028.03 

  Direct: 3,600,000 (YEN)  Overheads: 4,680,000 (YEN)  Total: 1,080,000 (YEN)

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2020.04  -  2024.03 

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2018.04  -  2023.03 

  Direct: 0 (YEN)  Overheads: 0 (YEN)  Total: 0 (YEN)

• Grant-in-Aid for Scientific Research(B)

  Project Year: 2018.04  -  2020.03 

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2015.04  -  2018.03 

display all >>