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• Low-Intensity Extracorporeal Shock Wave Therapy Restores Passive Urethral Closure Mechanism in Vaginal Distension Rat Model

  Akimoto, T; Ashikari, A; Kurobe, M; Takamatsu, G; Akiyama, Y; Kume, H; Miyazato, M

  INTERNATIONAL UROGYNECOLOGY JOURNAL ( International Urogynecology Journal )    2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  INTRODUCTION AND HYPOTHESIS: Low-intensity extracorporeal shock wave therapy (LiESWT) is a promising noninvasive therapy for stress urinary incontinence (SUI). We assessed whether LiESWT restores urethral function in a vaginal distension (VD)-induced rat model of SUI, focusing on pelvic floor tissue remodeling and endoplasmic reticulum stress pathway as potential mechanisms. METHODS: Eighty-one female Sprague-Dawley rats underwent functional and tissue analyses. Sneezing was induced to assess urethral pressure responses. Leak point pressure (LPP) was measured with or without hypogastric and pudendal nerve transections. Tissue remodeling and molecular pathways were assessed using histological and molecular expression analyses. RESULTS: In VD rats, baseline urethral pressure (9.9 ± 4.3 vs 17.6 ± 3.1 cmH2O) and LPP (27.4 ± 4.7 vs 37.0 ± 7.0 cmH2O) were lower than in normal rats (both p < 0.05). LiESWT restored the baseline urethral pressure (16.3 ± 4.7 cmH2O) and LPP (37.5 ± 4.9 cmH2O) in VD rats (p < 0.05). Notably, LPP enhancement persisted after bilateral hypogastric and pudendal nerve transections. Additionally, LiESWT tended to reduce VD-induced vaginal smooth muscle fibrosis histologically, whereas collagen type I alpha and elastin mRNA expression remained elevated in both groups. Western blotting revealed no sustained activation of protein kinase R-like endoplasmic reticulum kinase (PERK) at 96 h after the final LiESWT. CONCLUSIONS: LiESWT enhanced urethral function in the VD-induced SUI model by potentially facilitating pelvic floor tissue remodeling, thereby restoring passive urethral closure. The absence of sustained PERK activation in the late phase indicates the safety of LiESWT for SUI.

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• Differential association between perceived social support and andropause symptoms by psychological distress level in employed men

  Tanji, F; Nanbu, H; Kawajiri, M; Nishimoto, D; Akimoto, T; Kurobe, M

  COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY ( Comprehensive Psychoneuroendocrinology )  26   100343 - 100343   2026.05 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  This study examined the association between andropause symptoms and multiple sources of perceived social support-supervisors, coworkers, and family or friends-among employed Japanese men and investigated whether these associations differed according to the level of psychological distress. Data were obtained from a 2024 cross-sectional internet-based survey of 1104 employed men aged 20-69 years. Andropause symptoms were assessed using the Aging Males' Symptoms Scale and classified into severe (≥50 points) and moderate or less (17-49 points) categories. Perceived social support was evaluated using validated scales for support from supervisors, coworkers, family members, or friends. Multivariate logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) after adjusting for sociodemographic and health-related covariates. Stratified analyses were conducted based on psychological distress levels. The prevalence of severe andropause symptoms was 8.3%. In addition, 7.8% met the criteria for a composite outcome defined as severe symptoms with suspected testosterone deficiency. Higher levels of supervisor support were associated with lower odds of severe andropause symptoms (OR = 0.50, 95% CI = 0.35-0.72), as was support from family or friends (OR = 0.72, 95% CI = 0.56-0.93), whereas coworker support was not significantly associated with symptoms. In stratified analyses, higher supervisor support was associated with lower odds of symptoms particularly evident among men experiencing high levels of psychological distress. These findings suggest that supervisor support may play an important role in protecting against andropause symptoms, particularly among employees experiencing high levels of psychological distress.

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• Low-intensity energy shock wave therapy modulates bladder function and anxiety-like behavior in maternal separation rats

  Kamijo, TC; Kurobe, M; Akimoto, T; Miyazato, M

  INTERNATIONAL UROLOGY AND NEPHROLOGY ( International Urology and Nephrology )  58 ( 4 ) 1307 - 1320   2026.04 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  AIMS: To investigate whether low-intensity energy shock wave therapy (LiESWT) applied to the bladder can alleviate maternal separation (MS)-induced lower urinary tract dysfunction and anxiety-like behavior in a rat model. METHODS: Sprague-Dawley rat pups were divided into normal, MS, and MS + LiESWT groups. MS was performed on postnatal days 2-14. At 6 weeks of age, the MS + LiESWT group received shock wave therapy (0.12 mJ/mm2, 2 Hz, 200 shocks per session, nine sessions) in the bladder region. At 9 weeks of age, all groups underwent anxiety-like behavior assessment using the elevated plus maze test, followed by metabolic cage evaluation, cystometry, and histology to assess bladder function and morphology. RESULTS: Compared to normal rats, MS rats exhibited increased bladder weight, shortened intercontraction intervals, and increased anxiety-like behavior. LiESWT treatment normalized bladder weight and improved urinary frequency compared to MS rats, and reduced anxiety-like behavior, as evidenced by recovery of time spent in the open arms of the elevated plus maze. Sex-related differences were observed, with effects being more pronounced in females. This was particularly evident in the voiding frequency during the dark phase and the adrenal gland weight. CONCLUSIONS: LiESWT applied to the bladder improved bladder dysfunction and reduced anxiety-like behavior in MS rats, suggesting potential interactions between bladder function and emotional state that may involve shared neural circuits. The findings indicated the potential therapeutic applications of LiESWT for improving the stress-induced dysfunction affecting the integrated neurobiological pathways that govern both bladder control and behavioral regulation.

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• Back Muscle Strength Is Associated with Self-Reported Morning-Erection Frequency in Apparently Healthy Japanese Male University Students: A Cross-Sectional Study

  Endo, Y; Tanaka, T; Kojo, K; Matsumoto, C; Kurobe, M; Nishiyama, H; Takayama, T; Miyazaki, J

  HEALTHCARE ( Healthcare Switzerland )  14 ( 6 )   2026.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Near infrared ray-guided partial cystectomy using da Vinci Firefly® technology and intraoperative cystoscopy for urachal cyst, suspected of urachal tumor

  Kurobe, M; Ogawa, T; Satoh, Y; Yamamoto, M; Ushijima, K; Okamoto, K; Numahata, D; Ohta, T; Takayama, T

  INVESTIGATIVE AND CLINICAL UROLOGY ( Investigative and Clinical Urology )  67 ( 2 ) 178 - 185   2026.03 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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  PURPOSE: Urachal cyst is a type of congenital anomaly that may undergo malignant transformation. Partial cystectomy with en-bloc resection of the urachus is appropriate treatment for urachal remnants. We performed near infrared ray-guided surgery (NIRGS) for the accurate localization of tumor margins using the Firefly® technology of the da Vinci surgical system and intraoperative cystoscopy. In the normal visible light mode, we could not recognize the cystoscopic light. However, after changing to the Firefly® mode, the near infrared rays transmitted through the bladder wall were visible as green images. MATERIALS AND METHODS: The patient is a 76-year-old woman. She was referred to urology for a tumor at the dome of the bladder. Cystoscopy revealed a round submucosal mass at the dome of the bladder. The possibility of a urachal tumor could not be excluded. Since she was already diagnosed with rectal cancer and scheduled to undergo robot-assisted laparoscopic proctosigmoidectomy, we performed robot-assisted partial cystectomy during the same operative session. RESULTS: The rectum was removed by a surgeon with robot-assistance. Then we detached the median umbilical ligament from just below the umbilicus toward the bladder. Both medial umbilical ligaments were dissected from abdominal wall to the dome of the bladder. A simultaneous cystoscopic light depicted the bladder boundaries of the mass with the Firefly® mode. There was no residual tumor at the resected margin, and pathological findings revealed that the urachal cyst was benign. CONCLUSIONS: Robot-assisted partial cystectomy for urachal tumors is technically feasible. NIRGS should be considered in selected cases.

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Other Papers 【 display / non-display 】

• 膀胱出口部閉塞による慢性期前立腺肥大症モデルラットを用いた,膀胱リモデリングの検討

  黒部 匡広, 高岡 栄一郎, 秋元 隆宏, 泉 惠一朗, 長嶺 覚子, 上條 中庸, 芦刈 明日香, 木村 隆, 大城 琢磨, 細川 浩, 宮里 実, 吉村 直樹

  日本生理学雑誌 ( (一社)日本生理学会 )  88 ( 1 ) 6 - 6   2026.02  [Refereed]

   

• Attempt to classify the pathology of azoospermia by ultrasonography and MRI examination

  太田智行, 黒部匡広, 高山達也, 古城公佑, 岩本晃明, 山崎一恭, 岡田真也

  超音波医学 Supplement   50   2023  [Refereed]

   

  J-GLOBAL

• DIFFERENTIAL EFFECTS ON URETHRAL FUNCTION, EPITHELIAL MORPHOLOGY, AND MOLECULAR PROFILE IN TWO DIFFERENT RAT MODELS OF STRESS URINARY INCONTINENCE BY SIMULATED BIRTH TRAUMA OR ESTROGEN DEFICIENCY

  Kurobe, M; Takaoka, E; Suzuki, T; Mizoguchi, S; Saito, T; Alexandre, CE; Gotoh, D; Igarashi, T; Inamura, S; Ando, T; Inai, H; Uchida, K; Miyazaki, J; Yoshimura, N

  JOURNAL OF SEXUAL MEDICINE   19 ( 5 ) S135 - S135   2022.05  [Refereed]

   

• Progressive changes of bladder function, histology, and molecular expression in early and late-phases of partial bladder outlet obstruction in a male rat model(和訳中)

  黒部 匡広, 高岡 栄一郎, 齊藤 徹一, 後藤 大輔, 五十嵐 太郎, 宮崎 淳, 西山 博之, 吉村 直樹

  日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  109回   ISP03 - 04   2021.12  [Refereed]

   

• 雄ラット膀胱出口部部分閉塞の初期および後期における膀胱機能、組織像および分子発現の経時的変化(Progressive changes of bladder function, histology, and molecular expression in early and late-phases of partial bladder outlet obstruction in a male rat model)

  黒部 匡広, 高岡 栄一郎, 齊藤 徹一, 後藤 大輔, 五十嵐 太郎, 宮崎 淳, 西山 博之, 吉村 直樹

  日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  109回   ISP03 - 04   2021.12  [Refereed]

   

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Presentations 【 display / non-display 】

Presentations 【 display / non-display 】

• 慢性陰嚢痛に対する顕微鏡下精索除神経術の治療成績についての検討(Therapeutic results of microsurgical denervation of spermatic cord for chronic testicular pain)

  Numahata Daisuke, Kojo Kosuke, Kurobe Masahiro, Ushijima Kei, Okamoto Keita, Inai Hiromu, Uchida Katsunori, Ohta Tomoyuki, Takayama Tatsuya

  日本泌尿器科学会総会  1900.01  -  1900.01 

• 尿膜管腫瘍が疑われた尿膜管嚢胞に対し、ロボット支援膀胱部分切除術を施行した1例(Robot-Assisted Partial Cystectomy for Urachal remnants, suspected of urachal tumor)

  Kurobe Masahiro, Ushijima Kei, Numahata Daisuke, Inai Hiromu, Uchida Katsunori, Kamada Teppei, Ohta Tomoyuki, Nakazato Yoshimasa, Takayama Tatsuya

  日本泌尿器科学会総会  1900.01  -  1900.01 

• 国際医療福祉大学病院におけるロボット支援下根治的前立腺全摘除術後のQOLと機能的転帰(Postoperative QOL and functional outcomes after Robot-Assisted Radical Prostatectomy in IUHW hospital)

  Okamoto Keita, Kurobe Masahiro, Takaoka Eiichiro, Inai Hiromu, Takayama Tatsuya, Uchida Katsunori, Miyazaki Jun

  日本泌尿器科学会総会  1900.01  -  1900.01 

• 雄ラット膀胱出口部部分閉塞の初期および後期における膀胱機能、組織像および分子発現の経時的変化(Progressive changes of bladder function, histology, and molecular expression in early and late-phases of partial bladder outlet obstruction in a male rat model)

  黒部 匡広, 高岡 栄一郎, 齊藤 徹一, 後藤 大輔, 五十嵐 太郎, 宮崎 淳, 西山 博之, 吉村 直樹

  日本泌尿器科学会総会  1900.01  -  1900.01 

• 精索静脈瘤手術の予後因子としての血中亜鉛濃度の検討(Analysis of serum zinc concentration as a prognostic factor in varicocelectomy)

  Kojo Kosuke, Tanaka Takazo, Kurobe Masahiro, Numahata Daisuke, Kimura Tomokazu, Nishiyama Hiroyuki, Ohta Tomoyuki, Takayama Tatsuya

  日本泌尿器科学会総会  1900.01  -  1900.01 

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Grant-in-Aid for Scientific Research 【 display / non-display 】

• Grant-in-Aid for Scientific Research(C)

  Project Year: 2024.04  -  2028.03 

  Direct: 3,400,000 (YEN)  Overheads: 4,420,000 (YEN)  Total: 1,020,000 (YEN)

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