Current Affiliation Organization 【 display / non-display 】

Current Affiliation Organization 【 display / non-display 】

Graduate School 【 display / non-display 】

Graduate School 【 display / non-display 】

External Career 【 display / non-display 】

External Career 【 display / non-display 】

Research Interests 【 display / non-display 】

Research Interests 【 display / non-display 】

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Research Areas 【 display / non-display 】

Research Areas 【 display / non-display 】

Published Papers 【 display / non-display 】

Published Papers 【 display / non-display 】

• TRPV1 antagonist AMG9810 suppresses focal epileptiform discharges and seizures by decreasing extracellular glutamate concentrations in mice.

  Moriyama H, Imoto H, Nomura S, Mori N, Maruta Y, Fujii N, Fujitsuku S, Ishihara H

  Journal of pharmacological sciences ( Journal of Pharmacological Sciences )  159 ( 3 ) 163 - 171   2025.11 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels

  Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Kohei Haji, Michiyasu Suzuki, Hideyuki Ishihara

  Neuropsychopharmacology   in press   2025.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels.

  Moriyama H, Nomura S, Imoto H, Maruta Y, Mori N, Fujii N, Haji K, Suzuki M, Ishihara H

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology ( Neuropsychopharmacology )    2025.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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• Neuroprotective Effect of TRPA1 Activation in Focal Cerebral Ischemia: Insights from Wild-Type and Knockout Mice(タイトル和訳中)

  Okazaki Koki, Oka Fumiaki, Moriyama Hiroshi, Mori Naomasa, Nishimoto Takuma, Inoue Takao, Suzuki Michiyasu, Nomura Sadahiro, Ishihara Hideyuki

  Medical Science & Innovation ( 山口大学医学部 )  72 ( 1-2 ) 33 - 42   2025.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

• Anti-ischemic Effects of Focal Brain Cooling are Mediated by Modulation of Transient Receptor Potential Vanilloid 4 Channels in Mice(タイトル和訳中)

  Mori Naomasa, Moriyama Hiroshi, Okazaki Koki, Oka Fumiaki, Fujiyama Yuichi, Shinoyama Mizuya, Nomura Sadahiro, Inoue Takao, Suzuki Michiyasu, Ishihara Hideyuki

  Medical Science & Innovation ( 山口大学医学部 )  72 ( 1-2 ) 21 - 31   2025.06 [ Peer Review Accepted ]

  Type of publication: Research paper (scientific journal)

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Academic Awards 【 display / non-display 】

Academic Awards 【 display / non-display 】

• The 47th JUHN AND MARY WADA Encouragement Award

  2024.09   The 57th Annual Congress of Japan Epilepsy Society   Suppressive effects of a transient receptor potential melastatin 8 (TRPM8) agonist on hyperthermia-induced febrile seizures in infant mice

  Winner: Hiroshi Moriyama

• Oral Presentation Award

  2023.11   The 56th Annual Congress of Japan Epilepsy Society   Anti-epileptic like effects of TRPA1 agonist on focal epileptic seizures in mice via regulation of extracellular glutamate concentration

  Winner: Hiroshi Moriyama

• Poster award (Experimental research)

  2021.09   The 54th Annual Congress of the Japan Epilepsy Society  

  Winner: Hiroshi Moriyama

Grant-in-Aid for Scientific Research 【 display / non-display 】

Grant-in-Aid for Scientific Research 【 display / non-display 】

• Development of amyloid-β clearance therapy by promoting CSF turnover

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2022.04  -  2025.03 

  Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

• A study in the temperature-sensitive system of the brain by the analysis of pathophysiology of febrile seizure

  Grant-in-Aid for Scientific Research(C)

  Project Year: 2019.04  -  2022.03 

  Investigator(s): NOMURA Sadahiro 

  Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

  　View Summary

  We hypothesized that a transient receptor potential (TRP), the temperature sensor channel, inhibited febrile seizure. Changes in brain temperature and seizure threshold against warming in wild type and TRPM8 knockout (KO) mice were compared. Wild type mice maintained better than TRPM8KO mice in rectal and brain temperature and seizure threshold. A TRPM8 channel agonist effectively inhibited high frequency oscillation immediately before febrile seizure. In addition to the effect in the hypothermic zone, TRP channels was found to control brain function in hyperthermia. It may be one of the mechanism of febrile seizure, and could suggest treatment option.