Yamada Naoki

写真a

Title

Special Professor
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Current Affiliation Organization 【 display / non-display 】

  • Duty   University of the Ryukyus   Hospital   Special Professor  

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External Career 【 display / non-display 】

  • 2025.02
    　
    　

    University of the Ryukyus  

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Affiliated academic organizations 【 display / non-display 】

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    THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE 

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    THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE 

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    World Federation for Neurorehabilitation 

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Research Interests 【 display / non-display 】

  • 脳卒中後遺症、痙縮、神経変性疾患、脳画像解析

  • functional MRI

  • stroke

  • Transcranial Magnetic Stimulation

  • regenerative medicine

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Research Areas 【 display / non-display 】

  • Life Science / Medical systems

  • Life Science / Rehabilitation science

  • Life Science / Radiological sciences

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Published Papers 【 display / non-display 】

  • Multiuser Exercise-Based Telerehabilitation Intervention for Older Adults with Frailty: A Pilot Study

    Yamada, N; Sato, I; Kinoshita, S; Muraji, A; Tokunaga, S; Naka, T; Okubo, R

    NEUROSCI   7 ( 1 )   2026.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    OBJECTIVES: This pilot study examined telerehabilitation, which has emerged as a crucial modality in light of recent global challenges such as the COVID-19 pandemic. We examined the effectiveness of a mobile health telerehabilitation intervention developed for older adults with frailty. METHODS: Six participants received a telerehabilitation intervention (Rehab Studio) that included exercise training videos. The participants were aged ≥65 years, had no history of dementia or psychiatric disorders, and had mild-to-moderate care needs. For 1 month, the participants received 1 h live online rehabilitation sessions with real-time communication with rehabilitation specialists (physical therapists and occupational therapists: PTs/OTs). The quality of life (QoL) (EuroQol 5 dimensions 5-level [EQ-5D-5L] questionnaire) and self-rated health scores were recorded before and after the intervention, and the data were analyzed using paired t-tests to determine whether the service was effective. RESULTS: Significant differences were found in the total EQ-5D-5L and self-rated health scores (p < 0.05). The mean EQ-5D-5L score increased from 0.63 ± 0.13 before the intervention to 0.77 ± 0.14 after the intervention (p = 0.010), while the mean self-rated health score increased from 66.0 ± 18.0 to 83.3 ± 10.3, respectively (p = 0.019). CONCLUSIONS: This study revealed that the mobile health telerehabilitation intervention is safe and can improve QoL for older adults with frailty. However, the effectiveness of the intervention needs to be further investigated in patients with poor performance in daily living activities. Telerehabilitation could help to reduce the burden of nursing care in aging societies with declining birthrates. However, given the extremely small sample size (N = 6), these p-values should be interpreted with considerable caution. Statistical significance in such a small sample does not provide strong evidence for population-level effects, and our findings should be regarded as hypothesis-generating rather than confirmatory.

  • Combinations of predictors of exercise-induced oxygen desaturation after lung resection: a retrospective observational study

    Goya, T; Naka, T; Takara, N; Furugen, T; Teruya, T; Furukawa, K; Yamada, N

    JOURNAL OF THORACIC DISEASE ( Journal of Thoracic Disease )  17 ( 10 ) 8399 - 8409   2025.10 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    BACKGROUND: Exercise-induced oxygen desaturation (EID) after lung resection can deteriorate the health-related quality of life. Therefore, it is important to identify predictors of EID in order to inform prompt interventions. We aimed to identify the combinations of predictive factors significantly associated with EID after lung resection. METHODS: This single-center, retrospective, observational study included patients who underwent lung resection for neoplastic lung disease. Patients were divided into the EID [Δ saturation of peripheral oxygen (SpO2) ≥4%] and non-EID (ΔSpO2 <4%) groups based on the ΔSpO2 assessed using the 6-minute walk test at the time of discharge. We performed decision-tree analysis using EID and non-EID as the outcome variables. The area under the curve (AUC) was calculated to evaluate the predictive accuracy of the decision-tree model. RESULTS: We included 100 patients in the analysis; among them, 43 [mean 66.1, standard deviation (SD) 9.8 years] and 57 (mean 63.4, SD 14.1 years) were in the EID and non-EID groups, respectively. Decision-tree analysis revealed that the combination of preoperative quadriceps force (QF) <64.7% of body weight, preoperative ΔSpO2 >1.7%, and intraoperative blood loss (IBL) ≥36 mL could predict postoperative EID with an 84% probability. The AUC of the model was 0.82 (95% confidence interval 0.73-0.89). CONCLUSIONS: Preoperative QF and ΔSpO2, as well as IBL, are crucial predictors of EID following lung resection. Further studies are warranted to verify the diagnostic validity of this predictive model.

  • Association of hospitalization-associated disability and all-cause mortality or hospitalizations for heart failure in elderly patients undergoing transcatheter aortic valve replacement(タイトル和訳中)

    Nagata Haruno, Yamada Naoki, Furukawa Kojiro, Kusunose Kenya

    Journal of Cardiology ( (一社)日本心臓病学会 )  86 ( 4 ) 417 - 419   2025.10 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

  • Association of hospitalization-associated disability and all-cause mortality or hospitalizations for heart failure in elderly patients undergoing transcatheter aortic valve replacement.

    Arasaki Y, Toma Y, Minei A, Hirata T, Ikemiya S, Wakugawa M, Koyama N, Tamaki Y, Nagata H, Yamada N, Furukawa K, Kusunose K

    Journal of cardiology ( Journal of Cardiology )  86 ( 4 ) 417 - 419   2025.10 [ Peer Review Accepted ]

    Type of publication: Research paper (other science council materials etc.)

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  • Association between Mortality and Time Spent Out of Bed in Older-Adult Nursing Home Residents.

    Shoji Kinoshita, Akio Shimizu, Naoki Yamada, Ryo Momosaki, Hidetaka Wakabayashi, Kotomi Sakai, Haruka Tohara, Ryosuke Yanagida, Tokiko Isowa, Kenta Ushida, Masahiro Abo

    Journal of the American Medical Directors Association   26 ( 3 ) 105458 - 105458   2025.01 [ Peer Review Accepted ]

    Type of publication: Research paper (scientific journal)

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    OBJECTIVES: For older adults, spending time out of bed is important for preventing functional decline, but its relationship to mortality is not clear. In this study, we aimed to investigate the association between mortality and time spent out of bed in Japanese older-adult nursing home residents. DESIGN: We conducted a cohort study using data from the Long-term Care Information System for Evidence database. SETTING AND PARTICIPANTS: We used data collected between April 2022 and March 2024 from older-adult nursing home residents who required assistance with the activities of daily living. METHODS: We compared outcome data between residents who spent 6 or more hours per day out of bed (group L) and those who spent less than 6 hours per day out of bed (group S). The outcome was all-cause mortality. Data were analyzed using Kaplan-Meier curves and Cox regression models. RESULTS: Data from 185 older-adult nursing home residents (median age: 89 years; 141 women) were analyzed. Group L included 144 residents (77.8% of all participants). Of the 185 participants, 40 died during the observation period. Mortality in group L was significantly lower than in group S (16.7% vs 39.0%, P = .002). Kaplan-Meier curve analysis after the log-rank test revealed a significantly higher mortality in group S than group L. Univariate and multivariate Cox regression analyses with robust (Huber-White) standard errors identified the factor of time spent out of bed (≥6 h) as a significant and independent risk factor for mortality. CONCLUSION AND IMPLICATIONS: More time spent out of bed is associated with lower mortality in older-adult nursing home residents who require assistance with the activities of daily living.

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Other Papers 【 display / non-display 】

  • The effect of sitting position on consciousness levels and pupillary light reflex

    Masachika Niimi, Koichi Katsurada, Kenji Higuchi, Chiko Kimura, Takatoshi Hara, Naoki Yamada, Masahiro Abo

    Journal of the Intensive Care Society     2020

     

    DOI Open Access

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2024.04  -  2027.03 

    Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2024.04  -  2027.03 

    Direct: 3,500,000 (YEN)  Overheads: 4,550,000 (YEN)  Total: 1,050,000 (YEN)

  • Development of transcranial magnetic stimulation therapy and image analysis method for Parkinson's disease

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2027.03 

    Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

  • Development of transcranial magnetic stimulation therapy and image analysis method for Parkinson's disease

    Grant-in-Aid for Scientific Research(C)

    Project Year: 2022.04  -  2027.03 

    Direct: 3,200,000 (YEN)  Overheads: 4,160,000 (YEN)  Total: 960,000 (YEN)

  • Intensive occupational therapy combined with rTMS using paraboliccoil for upper limb hemiparesis after stroke

    Grant-in-Aid for Early-Career Scientists

    Project Year: 2019.04  -  2022.03 

    Direct: 3,300,000 (YEN)  Overheads: 4,290,000 (YEN)  Total: 990,000 (YEN)

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