Published Papers - Noguchi Hirofumi

Schumannione, a new butenolide derivative isolated from Schumannianthus dichotomus as a potential phytotoxic agent

Rob M.M.

Tetrahedron Letters ( Tetrahedron Letters )  61 ( 30 )   2020.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Mutations in the C1 element of the insulin promoter lead to diabetic phenotypes in homozygous mice.

Noguchi H, Miyagi-Shiohira C, Nakashima Y, Kinjo T, Saitoh I, Watanabe M

Communications biology ( Communications Biology )  3 ( 1 ) 309   2020.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Novel cell-permeable p38-MAPK inhibitor efficiently prevents porcine islet apoptosis and improves islet graft function.

Noguchi H, Miyagi-Shiohira C, Nakashima Y, Saitoh I, Watanabe M

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons ( American Journal of Transplantation )  20 ( 5 ) 1296 - 1308   2020.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Tree fern cyathea lepifera may survive by its phytotoxic property

Ida N.

Plants ( Plants )  9 ( 1 )   2020.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Reduced glycemic variability and flexible graft function after islet transplantation: A case report

Toshihiro Nakamura, Junji Fujikura, Takayuki Anazawa, Ryo Ito, Masahito Ogura, Hideaki Okajima, Hirofumi Noguchi, Shinji Uemoto, Nobuya Inagaki

Journal of Diabetes Investigation     2020 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd To date, studies of patients with islet transplantation addressing intermittently scanned continuous glucose monitoring profile and the flexibility of the graft islet function under different doses of insulin administration, both of which reflect the real daily life of patients, are quite limited. Here, we report a case of a 46-year-old woman who received islet transplantation after kidney transplantation. The patient was followed up over a period of 2 years after initial islet transplantation. Our results show that intermittently scanned continuous glucose monitoring can be useful for monitoring the reduction of glycemic variability, and suggest the appropriate regulation of insulin secretion from graft islets during mixed-meal test by using different doses of exogenous insulin administration. Additionally, during the 2-year observational period, glucagon elevation was detected only at hypoglycemia, whereas the level was within the normal range at normoglycemia or hyperglycemia.

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Potential use of Schumannianthus dichotomus waste: the phytotoxic activity of the waste and its identified compounds

Rob M.M.

Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes ( Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes )    2020 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Regulation of c-Jun NH₂-Terminal Kinase for Islet Transplantation.

Noguchi H

Journal of clinical medicine   8 ( 11 )   2019.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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piggyBac Transposon-Based Immortalization of Human Deciduous Tooth Dental Pulp Cells with Multipotency and Non-Tumorigenic Potential.

Inada E, Saitoh I, Kubota N, Iwase Y, Kiyokawa Y, Shibasaki S, Noguchi H, Yamasaki Y, Sato M

International journal of molecular sciences ( International Journal of Molecular Sciences )  20 ( 19 )   2019.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Excellent Islet Yields after 18-h Porcine Pancreas Preservation by Ductal Injection, Pancreas Preservation with MK Solution, Bottle Purification, and Islet Purification Using Iodixanol with UW Solution and Iodixanol with MK Solution.

Kuwae K, Miyagi-Shiohira C, Hamada E, Tamaki Y, Nishime K, Sakai M, Yonaha T, Makishi E, Saitoh I, Watanabe M, Noguchi H

Journal of clinical medicine   8 ( 10 )   2019.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube KN, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant immunology ( Transplant Immunology )  55   101205   2019.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Suppressor of Fused regulates the proliferation of postnatal neural stem and precursor cells via a Gli3-dependent mechanism.

Gomez HG, Noguchi H, Castillo JG, Aguilar D, Pleasure SJ, Yabut OR

Biology open   8 ( 6 )   2019.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells.

Kaitsuka T, Kojima R, Kawabe M, Noguchi H, Shiraki N, Kume S, Tomizawa K

Biomedical materials (Bristol, England) ( Biomedical Materials (Bristol) )  14 ( 4 ) 045019   2019.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors.

Noguchi H, Miyagi-Shiohira C, Nakashima Y, Kinjo T, Kobayashi N, Saitoh I, Watanabe M, Shapiro AMJ, Kin T

Molecular therapy. Methods & clinical development ( Molecular Therapy - Methods and Clinical Development )  13   243 - 252   2019.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Identification of Proteins Differentially Expressed by Adipose-derived Mesenchymal Stem Cells Isolated from Immunodeficient Mice.

Nakashima Y, Nahar S, Miyagi-Shiohira C, Kinjo T, Kobayashi N, Kitamura S, Saitoh I, Watanabe M, Fujita J, Noguchi H

International journal of molecular sciences ( International Journal of Molecular Sciences )  20 ( 11 )   2019.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells.

Noguchi H, Castillo JG, Nakashima K, Pleasure SJ

eLife   8   2019.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability.

Miki Soda, Issei Saitoh, Tomoya Murakami, Emi Inada, Yoko Iwase, Hirofumi Noguchi, Shinji Shibasaki, Mie Kurosawa, Tadashi Sawami, Miho Terunuma, Naoko Kubota, Yutaka Terao, Hayato Ohshima, Haruaki Hayasaki, Masahiro Sato

Scientific reports ( Scientific Reports )  9 ( 1 ) 1490 - 1490   2019.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Human tissue-specific stem cells (hTSCs), found throughout the body, can differentiate into several lineages under appropriate conditions in vitro and in vivo. By transfecting terminally differentiated cells with reprogramming factors, we previously produced induced TSCs from the pancreas and hepatocytes that exhibit additional properties than iPSCs, as exemplified by very low tumour formation after xenogenic transplantation. We hypothesised that hTSCs, being partially reprogrammed in a state just prior to iPSC transition, could be isolated from any terminally differentiated cell type through transient reprogramming factor overexpression. Cytochemical staining of human deciduous tooth-derived dental pulp cells (HDDPCs) and human skin-derived fibroblasts following transfection with Yamanaka's factors demonstrated increased ALP activity, a stem cell marker, three weeks after transfection albeit in a small percentage of clones. Repeated transfections (≤3) led to more efficient iPSC generation, with HDDPCs exhibiting greater multipotentiality at two weeks post-transfection than the parental intact HDDPCs. These results indicated the utility of iPSC technology to isolate TSCs from HDDPCs and fibroblasts. Generally, a step-wise loss of pluripotential phenotypes in ESCs/iPSCs occurs during their differentiation process. Our present findings suggest that the reverse phenomenon can also occur upon repeated introduction of reprogramming factors into differentiated cells such as HDDPCs and fibroblasts.

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A Novel Preservation Solution Containing a JNK Inhibitory Peptide Efficiently Improves Islet Yield for Porcine Islet Isolation.

Noguchi H, Miyagi-Shiohira C, Nakashima Y, Ebi N, Hamada E, Tamaki Y, Kuwae K, Kitamura S, Kobayashi N, Saitoh I, Watanabe M

Transplantation ( Transplantation )  103 ( 2 ) 344 - 352   2019.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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著明なQOLの改善が得られた，遺伝性膵炎に対する自家膵島移植の本邦第1例

富丸 慶人, 後藤 邦仁, 小林 省吾, 永野 浩昭, 森 正樹, 土岐 祐一郎, 江口 英利, 伊藤 壽記, 野口 洋文, 宮下 和幸, 川本 弘一, 岩上 佳史, 秋田 裕史, 野田 剛広

移植 ( 一般社団法人 日本移植学会 )  54 ( 4 ) 217 - 222   2019 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<p>Total pancreatectomy with islet autotransplantation is an ideal surgical procedure used to relieve chronic pain derived from the pancreatitis, while insulin-dependent diabetes is inevitably induced after the surgery. Islet autotransplantation combined with a total pancreatectomy can reduce the risk of severe diabetes by preserving available islet cells. We experienced a case with hereditary pancreatitis, which is a rare inherited condition characterized by recurrent acute pancreatitis and/or chronic pancreatitis. The case was that of a female in her thirties who was introduced to our hospital due to treatment-refractory abdominal pain derived from repeated pancreatitis even after surgical treatments. At the introduction, the pain was uncontrollable even by opioid use, and oral intake was impossible due to increase of the pain after the intake. She was genetically diagnosed with hereditary pancreatitis. For relieving the pancreatitis-derived pain, total remnant pancreatectomy with islet autotransplantation was planned. After the pancreatectomy, islet cells were extracted from the excised remnant pancreas, and injected into the portal vein for liver autotransplantation. The pain was completely relieved for her after the surgery, suggesting improvement of her quality-of-life. A glucose tolerance test and glucagon loading test performed one month after the surgery showed C-peptide secretion as the blood glucose rose. However, the serum c-peptide level and SUIT index had been gradually decreased after the surgery, and she is now treated with insulin. The case suggested that total pancreatectomy with islet autotransplantation is useful for improvement of the patient's quality of life by controlling the pain in cases with hereditary pancreatitis.</p>

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膵島移植・再生医療の現状と展望

野口 洋文

生体医工学 ( 公益社団法人 日本生体医工学会 )  57 ( 0 ) S195_2 - S195_2   2019 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<p>現在、糖尿病に対する移植療法として、膵臓移植と膵島移植がある。膵島移植は、局所麻酔下にて膵臓から分離した膵島を経門脈的に注入するため、膵臓移植に比べ低侵襲である。現在までに欧米で1000例以上の移植報告がなされており、日本でも2004年より臨床膵島移植が開始されている。発表者の野口はハーバード大学で膵島分離技術を習得したのち、日本初となる心停止ドナー膵島移植（2004年）、世界初成功例となる生体膵島移植（2005年）、日本初となる脳死ドナー膵島移植（2013年）を実施した。過去5年間に実施された膵島移植の約85%を発表者が実施している。しかしながら、本邦ではドナー数が圧倒的に少なく、脳死ドナー数をどのようにして増やすかが膵島移植の成功へのカギとなる。脳死ドナー不足の解消には時間がかかる現状を考慮し、別の治療法を模索する動きも活発化している。特に、再生医療研究が世界中で活発に行われているが、インスリン分泌細胞への分化誘導法が確立されておらず、いまだ研究段階であるのが現状である。本シンポジウムでは膵島移植の現状と問題点を示すとともに、最先端の糖尿病治療研究について紹介する。</p>

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A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Primary Cultured Cells and Subcultured Cells Using Mouse Adipose-Derived Mesenchymal Stem Cells.

Nakashima Y, Nahar S, Miyagi-Shiohira C, Kinjo T, Kobayashi N, Saitoh I, Watanabe M, Fujita J, Noguchi H

Stem cells international ( Stem Cells International )  2019   7274057   2019 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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