Published Papers - Noguchi Hirofumi

A Comparison of Proteins Expressed between Human and Mouse Adipose-Derived Mesenchymal Stem Cells by a Proteome Analysis through Liquid Chromatography with Tandem Mass Spectrometry.

Nahar S, Nakashima Y, Miyagi-Shiohira C, Kinjo T, Kobayashi N, Saitoh I, Watanabe M, Noguchi H, Fujita J

International journal of molecular sciences ( International Journal of Molecular Sciences )  19 ( 11 )   2018.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicating RNA.

Miyagi-Shiohira C, Nakashima Y, Kobayashi N, Kitamura S, Saitoh I, Watanabe M, Noguchi H

International journal of molecular sciences ( International Journal of Molecular Sciences )  19 ( 11 )   2018.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease.

Nahar S, Nakashima Y, Miyagi-Shiohira C, Kinjo T, Toyoda Z, Kobayashi N, Saitoh I, Watanabe M, Noguchi H, Fujita J

World journal of stem cells ( World Journal of Stem Cells )  10 ( 11 ) 146 - 159   2018.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of the Proteins Secreted by Human Adipose-Derived Mesenchymal Stem Cells.

Nakashima Y, Nahar S, Miyagi-Shiohira C, Kinjo T, Toyoda Z, Kobayashi N, Saitoh I, Watanabe M, Fujita J, Noguchi H

Cell transplantation ( Cell Transplantation )  27 ( 10 ) 1469 - 1494   2018.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson's Disease.

Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T

Brain sciences ( Brain Sciences )  8 ( 9 )   2018.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Comparison Between Modified Extracellular-Type Trehalose-Containing Kyoto Solution and University of Wisconsin Solution in 18-Hour Pancreas Preservation for Islet Transplantation.

Hamada E, Ebi N, Miyagi-Shiohira C, Tamaki Y, Nakashima Y, Kobayashi N, Saitoh I, Watanabe M, Kinjo T, Noguchi H

Pancreas ( Pancreas )  47 ( 7 ) e46 - e47   2018.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA.

Miyagi-Shiohira C, Nakashima Y, Kobayashi N, Saitoh I, Watanabe M, Noguchi H

Scientific reports ( Scientific Reports )  8 ( 1 ) 12341   2018.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells.

Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T

Molecular therapy : the journal of the American Society of Gene Therapy ( Molecular Therapy )  26 ( 7 ) 1715 - 1734   2018.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Cells Cultured in DMEM 10% FBS and Chemically Defined Medium Using Human Adipose-Derived Mesenchymal Stem Cells.

Nakashima Y, Nahar S, Miyagi-Shiohira C, Kinjo T, Kobayashi N, Saitoh I, Watanabe M, Fujita J, Noguchi H

International journal of molecular sciences ( International Journal of Molecular Sciences )  19 ( 7 )   2018.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Modified cell-permeable JNK inhibitors efficiently prevents islet apoptosis and improves the outcome of islet transplantation.

Noguchi H, Miyagi-Shiohira C, Nakashima Y, Ebi N, Hamada E, Tamaki Y, Kuwae K, Kobayashi N, Saitoh I, Watanabe M

Scientific reports ( Scientific Reports )  8 ( 1 ) 11082   2018.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Comparison of Tissue Loading Before and After the Creation of a Continuous Density Gradient in Porcine Islet Purification

Miyagi-Shiohira Chika, Nakashima Yoshiki, Ebi Nana, Hamada Eri, Tamaki Yoshihito, Kuwae Kazuho, Kobayashi Naoya, Saitoh Issei, Watanabe Masami, Kinjo Takao, Noguchi Hirofumi

CELL MEDICINE   10   2155179018781343   2018.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A Comparison of Pancreatic Islet Purification using Iodixanol with University of Wisconsin Solution and with Na-Lactobionate and Histidine Solution

Nakashima Yoshiki, Miyagi-Shiohira Chika, Ebi Nana, Hamada Eri, Tamaki Yoshihito, Kuwae Kazuho, Kobayashi Naoya, Saitoh Issei, Watanabe Masami, Kinjo Takao, Noguchi Hirofumi

CELL MEDICINE   10   2155179018775071   2018.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The Development of Cancer through the Transient Overexpression of Reprogramming Factors

Miyagi-Shiohira Chika, Nakashima Yoshiki, Kobayashi Naoya, Saitoh Issei, Watanabe Masami, Noguchi Yasufumi, Kinjo Takao, Noguchi Hirofumi

CELL MEDICINE   10   2155179017733172   2018.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Evaluation of Islet Purification Methods for Making a Continuous Density Gradient and Loading Tissue

Ebi Nana, Miyagi-Shiohira Chika, Hamada Eri, Tamaki Yoshihito, Masamoto Mariko, Makishi Erika, Nakashima Yoshiki, Kobayashi Naoya, Saitoh Issei, Watanabe Masami, Noguchi Yasufumi, Kinjo Takao, Noguchi Hirofumi

CELL MEDICINE   10   2155179017733090   2018.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adhesion characteristics of porcine pancreatic islets and exocrine tissue to coating materials

Yoshiki Nakashima, Chika Miyagi-Shiohira, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi

Islets ( Taylor and Francis Inc. )  10 ( 3 ) e1460294   2018.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Since the report of the Edmonton protocol in 2000, islet transplantation has been implemented worldwide, and xenotransplantation using porcine islets has also been reported. In addition, many basic experiments using pancreatic islets and exocrine tissue after isolation have been reported. Recently, exocrine cells have been found to be essential for inducing the differentiation of pancreatic islets. Therefore, the importance of the culture conditions for pancreatic tissue when conducting experiments using pancreatic tissue is also increasing. In this study, we focused on the coat material and examined the adhesive properties of porcine pancreatic islets and exocrine tissue after isolation. Porcine islet isolation was performed, and isolated islets (purity ≥95%) and exocrine tissue (purity ≥99%) were used to achieve adhesion to several extracellular matrixes, fibronectin, collagen type I, collagen type IV, laminin I, fibrinogen, and bovine serum albumin (BSA). DMEM with 0.5% FBS was used as the assay medium. For exocrine tissue, the adhesion was promoted in fibronectin, collagen type I, laminin I, and fibrinogen. The adhesive ability to fibronectin was more than twice that to BSA, while the adhesive ability to collagen type I, laminin I, and fibrinogen was less than twice that to BSA. For islets, the adhesive ability to fibronectin was weaker than that of exocrine tissue. Furthermore, the adhesion effect in fibronectin was obtained within 30 minutes and in medium containing little serum for both islets and exocrine tissues. These data suggest that fibronectin may be useful for the adhesion of pancreatic tissue.

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Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain.

Murao N, Matsubara S, Matsuda T, Noguchi H, Mutoh T, Mutoh M, Koseki H, Namihira M, Nakashima K

Neuroscience research   143   31 - 43   2018.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Induced tissue-specific stem cells and epigenetic memory in induced pluripotent stem cells

Hirofumi Noguchi, Chika Miyagi-Shiohira, Yoshiki Nakashima

International Journal of Molecular Sciences ( MDPI AG )  19 ( 4 )   2018.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem (ES) cells. The pattern of expressed genes, DNA methylation, and covalent histone modifications in iPS cells are very similar to those in ES cells. However, it has recently been shown that, following the reprogramming of mouse/human iPS cells, epigenetic memory is inherited from the parental cells. These findings suggest that the phenotype of iPS cells may be influenced by their cells of origin and that their skewed differentiation potential may prove useful in the generation of differentiated cell types that are currently difficult to produce from ES/iPS cells for the treatment of human diseases. Our recent study demonstrated the generation of induced tissue-specific stem (iTS) cells by transient overexpression of the reprogramming factors combined with tissue-specific selection. iTS cells are cells that inherit numerous components of epigenetic memory from donor tissue and acquire self-renewal potential. This review describes the “epigenetic memory” phenomenon in iPS and iTS cells and the possible clinical applications of these stem cells.

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Role of Egr1 on Pancreatic Endoderm Differentiation.

Tsugata T, Nikoh N, Kin T, Miyagi-Shiohira C, Nakashima Y, Saitoh I, Noguchi Y, Ueki H, Watanabe M, Kobayashi N, Shapiro AMJ, Noguchi H

Cell medicine   10   2155179017733177   2018 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Long-term Cryopreservation of Human and other Mammalian Cells at -80 °C for 8 Years.

Miyamoto Y, Ikeuchi M, Noguchi H, Hayashi S

Cell medicine   10   2155179017733148   2018 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A Comparison of the Preservation of Mouse Adipose Tissue-Derived Mesenchymal Stem Cells Using the University of Wisconsin Solution and Hank's Balanced Salt Solution.

Nahar S, Nakashima Y, Miyagi-Shiohira C, Kinjo T, Kobayashi N, Saitoh I, Watanabe M, Noguchi H, Fujita J

Stem cells international ( Stem Cells International )  2018   1625464   2018 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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