論文 - 金城　武士

Tuberculous shadow in <i>Klebsiella oxytoca</i> pneumonia: An unexpected denouement.

Kinjo T, Hanaki Y, Nakamoto A, Fujita J

Clinical case reports ( Clinical Case Reports )  9 ( 11 ) e05053   2021年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Uncommon Presentation of Tuberculosis as an Incidentally Discovered Solitary Pleural Tuberculoma.

Kinjo T, Shimoji M, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  106 ( 2 ) 376 - 377   2021年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Rapid and simultaneous identification of three mutations by the Novaplex™ SARS-CoV-2 variants I assay kit.

Kami W, Kinjo T, Arakaki W, Oki H, Motooka D, Nakamura S, Fujita J

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology ( Journal of Clinical Virology )  141   104877   2021年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background:. The emergence of SARS-CoV-2 variants has caused an unexpected rebound globally. The World Health Organization has listed three variants (B.1.1.7, B.1.351, and P.1) as variants of concern. To understand the epidemiology and thereby plan appropriate safety measures, differential identification of the variants is indeed critical. Objectives:. Although whole-genome sequencing is the gold standard for variant identification, it is time-consuming and relatively expensive. Therefore, a rapid, easy, and cost-effective platform targeting multiple regions of the genome is required. Here, we assessed the usefulness of the Novaplex™ SARS-CoV-2 Variants I Assay kit in identifying mutations in the variants. Study design:. We retrospectively examined 30 stored nasal swabs from COVID-19-positive patients tested between November 2020 and March 2021. RNA extracted from these swabs was subjected to the commercial kit and real-time reverse transcription-PCR was performed. To determine the genome sequences of SARS-CoV-2 in the collected samples and deduce the consensus sequences among the identified variants, genome sequencing libraries were prepared and mapped to the reference genome. Results:. Four of the tested samples were determined as variants. Of them, two harbored both H69/V70 deletion and N501Y substitution, whereas two harbored E484K substitution alone. Conclusions:. The variant with E484K substitution alone (“R.1”) has been now categorized as a variant of interest in Japan. Additionally, the kit-based assay was found to be feasible, convenient, and user-friendly in identifying the abovementioned mutations with a turnaround time of only 2 h.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Emergence of a multidrug-resistant plasmid encoding <i>bla</i> _NDM-1, <i>bla</i> _OXA-420 and <i>armA</i> in a clinical isolate of <i>Acinetobacter variabilis</i> in Japan.

Uechi K, Tohya M, Tada T, Tome T, Takahashi A, Kinjo T, Maeda S, Kirikae T, Fujita J

Journal of medical microbiology ( Journal of Medical Microbiology )  70 ( 8 )   2021年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Acinetobacter variabilis (formerly genospecies 15 sensu Tjernberg and Ursing) has been isolated from humans and animals and was proposed to be a novel species in 2015. A multidrug-resistant A. variabilis isolate, RYU24, was obtained in 2012 from an inpatient in Okinawa, Japan, with no record of overseas travel. The isolate was resistant to carbapenems, aminoglycosides and ciprofloxacin, with minimum inhibitory concentrations (MICs) of 32 µg ml-1 for imipenem and meropenem; > 1024 µg ml-1 for amikacin, arbekacin, gentamicin and tobramycin; and 8 µg ml-1 for ciprofloxacin. The isolate was found to harbour a 68-kbp plasmid carrying bla NDM-1, which encodes New Delhi metallo-β-lactamase-1 (NDM-1); bla OXA-420, which encodes an OXA-58-like carbapenemase and; armA, which encodes ArmA 16S rRNA methylase conferring pan-aminoglycoside resistance. To our knowledge, this is the first report of a plasmid harbouring the three major drug-resistance genes, bla NDM-1, bla OXA-420 and armA.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

False-positive for SARS-CoV-2 antigen test in a man with acute HIV infection.

Yamaniha K, Kinjo T, Akamine M, Setoguchi M, Tateyama M, Fujita J

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  27 ( 7 ) 1112 - 1114   2021年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Critical respiratory failure in pregnancy complicated with COVID-19: A case report.

Chinen Y, Kinjyo Y, Mekaru K, Kinjo T, Higure Y, Kinjo T, Miyagi K, Yamada H, Masamoto H, Goya H, Yoshida T, Maeshiro S, Nakamatsu M, Fujita J, Aoki Y

Case reports in women's health ( Case Reports in Women's Health )  30   e00309   2021年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The case is presented of a 29-year-old primiparous woman who was COVID-19-positive at 34 weeks of gestation and who developed severe acute respiratory distress syndrome. After a four-day history of fever and mild dyspnea, she was referred to hospital. Ciclesonide, dexamethasone, heparin sodium, and sulbactam/ampicillin were initiated, followed by remdesivir and tocilizumab. On the fourth day after admission (at 34 weeks 5 days of gestation), respiratory failure required ventilator management. An emergency cesarean section was performed and a 2565-g male infant was delivered with an Apgar score of 8/8 and negative COVID-19 status. However, on the following day the patient's respiratory condition deteriorated and mechanical ventilation was initiated. Subsequently, her respiratory condition quickly improved and mechanical ventilation was terminated 4 days after intubation. She was discharged 12 days after cesarean delivery. Our case provides additional evidence that raises concerns regarding the unfavorable maternal consequences of COVID-19 infection during pregnancy.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Case Report: Ischemic Enterocolitis Associated with Coronavirus Disease 2019: Two Case Reports and a Review of the Literature.

Kinjo T, Hokama A, Nakamura H, Miyagi K, Higure Y, Otsuki M, Nishiyama N, Nakamatsu M, Kinjo T, Tateyama M, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  104 ( 5 ) 1655 - 1658   2021年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

The COVID-19 pandemic has caused serious health and social concerns worldwide. Although the primary target of SARS-CoV-2 is the respiratory tract, SARS-CoV-2 infection also causes extrapulmonary symptoms. Previous articles have reported ischemic colitis in COVID-19 patients; however, information regarding its clinical manifestations and pathophysiology is limited. In this case report, we present two cases of ischemic enterocolitis in COVID-19 patients and review past case reports. Our literature review has shown that computed tomography rather than endoscopy was used for the diagnosis, and any region of the intestine was affected. Because the elevation of the D-dimer, which suggested a hypercoagulable state, was reported in most cases, we assumed that thrombosis at any level in the artery and vein was involved in the pathophysiology of COVID-19-associated enterocolitis. SARS-CoV-2-induced endotheliitis can cause both coarctation of the vessels and thrombosis; therefore, both patterns of ischemic colitis, occlusive and nonocclusive, may be involved in COVID-19-associated enterocolitis.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Case Report: Iliopsoas Hematoma during the Clinical Course of Severe COVID-19 in Two Male Patients.

Nakamura H, Ouchi G, Miyagi K, Higure Y, Otsuki M, Nishiyama N, Kinjo T, Nakamatsu M, Tateyama M, Kukita I, Fujita J

The American journal of tropical medicine and hygiene ( American Journal of Tropical Medicine and Hygiene )  104 ( 3 ) 1018 - 1021   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Anticoagulation plays a major role in reducing the risk of systematic thrombosis in patients with severe COVID-19. Serious hemorrhagic complications, such as intracranial hemorrhage, have also been recognized. However, intra-abdominal hemorrhage is under-recognized because of its rare occurrence, despite high mortality. Here, we discuss two cases of spontaneous iliopsoas hematoma (IPH) likely caused by anticoagulants during the clinical course of COVID-19. We also explored published case reports to identify clinical characteristics of IPH in COVID-19 patients. The use of anticoagulants may increase the risk of lethal IPH among COVID-19 patients becsuse of scarce data on optimal dosage and adequate monitoring of anticoagulant effects. Rapid diagnosis and timely intervention are crucial to ensure good patient outcomes.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Serum KL-6 can distinguish between different phenotypes of severe COVID-19.

Nakamura H, Miyagi K, Otsuki M, Higure Y, Nishiyama N, Kinjo T, Nakamatsu M, Haranaga S, Tateyama M, Fujita J

Journal of medical virology ( Journal of Medical Virology )  93 ( 1 ) 158 - 160   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Role of zanamivir is likely to end in Okinawa, Japan.

Sunagawa S, Iha Y, Kinjo T, Nakamura K, Fujita J

Respiratory investigation ( Respiratory Investigation )  59 ( 1 ) 159 - 161   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Disappearance of summer influenza in the Okinawa prefecture during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.

Sunagawa S, Iha Y, Kinjo T, Nakamura K, Fujita J

Respiratory investigation ( Respiratory Investigation )  59 ( 1 ) 149 - 152   2021年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Emergence of clinical isolates of <i>Pseudomonas asiatica</i> and <i>Pseudomonas monteilii</i> from Japan harbouring an acquired gene encoding a carbapenemase VIM-2.

Tohya M, Uechi K, Tada T, Hishinuma T, Kinjo T, Ohshiro T, Maeda S, Kirikae T, Fujita J

Journal of medical microbiology ( Microbiology Society )  70 ( 1 )   2021年01月

掲載種別: 研究論文（学術雑誌）

　概要を見る

<jats:p> <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">Pseudomonas asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">Pseudomonas monteilii</jats:ext-link> </jats:named-content> </jats:italic>, belonging to the <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2674" xlink:type="simple">Pseudomonas putida</jats:ext-link> </jats:named-content> </jats:italic> phylogenetic group, are occasionally isolated from clinical samples, partly because they are often misidentified as <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2674" xlink:type="simple">P. putida</jats:ext-link> </jats:named-content> </jats:italic> in clinical laboratories. There are five reports describing carbapenem-resistant clinical isolates of these species. Carbapenem-resistant strains of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> were isolated from stool samples. These isolates were sequenced using Illumina MiSeq and reidentified using average nucleotide identity (ANI) based on comparisons of their whole-genome sequences using the OrthoANI algorithm. The clonal relatedness of the isolates was assessed by pulse-field gel electrophoresis (PFGE). The size of plasmids conveying <jats:italic>bla</jats:italic> <jats:sub>VIM-2</jats:sub> was examined by Southern blotting. A total of six carbapenem-resistant clinical isolates of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> (two isolates) and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> (four isolates) were obtained from stool samples from five patients in a Japanese hospital. All isolates harboured <jats:italic>bla<jats:sub>VIM-2</jats:sub> </jats:italic>. The two isolates of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> had a different pattern in the PFGE analysis, with both having a 23 kb plasmid. Of the four isolates of <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> with similar patterns in the PFGE analysis, three had 320 kb plasmids and one had a 240 kb plasmid. The genetic environments of the 320/240 kb and 23 kb plasmids differed. The results strongly indicated that carbapenem-resistant <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> producing metallo-β-lactamase are emerging in Japan. This is the first report of carbapenem-resistant <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.34407" xlink:type="simple">P. asiatica</jats:ext-link> </jats:named-content> </jats:italic> and <jats:italic> <jats:named-content content-type="species"> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://doi.org/10.1601/nm.2647" xlink:type="simple">P. monteilii</jats:ext-link> </jats:named-content> </jats:italic> in Japan.</jats:p>

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed CiNii Research

Hypertrophic pulmonary osteoarthropathy due to lung cancer: A case report and literature review.

Shinzato A, Kinjo T, Miyagi T, Yamazato S, Kaneku K, Nishiyama M, Miyagi K, Furugen M, Fujita J

Clinical case reports ( Clinical Case Reports )  8 ( 12 ) 3510 - 3514   2020年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Hypertrophic pulmonary osteoarthropathy (HPOA) is a rare paraneoplastic syndrome. Our literature review shows the location of arthralgia and existence of edema are referable information for the differential diagnosis in paraneoplastic arthralgia.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Acute Hypertriglyceridaemia Caused by Tocilizumab in a Patient with Severe COVID-19.

Nakamura H, Miyagi K, Otsuki M, Higure Y, Nishiyama N, Kinjo T, Nakamatsu M, Haranaga S, Tateyama M, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  59 ( 22 ) 2945 - 2949   2020年11月

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p>Treatment with tocilizumab (TCZ) to block interleukin-6 (IL-6) signalling is predicted to mitigate cytokine release syndrome (CRS) caused by coronavirus disease 2019 (COVID-19). However, the adverse effects of TCZ on patients with COVID-19 remain unclear. We herein report a patient with COVID-19 treated with TCZ who developed acute hypertriglyceridaemia. Despite favipiravir treatment, acute respiratory distress syndrome developed in a 45-year-old patient with COVID-19; thus, TCZ was initiated. The triglyceride levels greatly increased after TCZ administration. Physicians should consider the negative impact of TCZ on the lipid profile in patients with COVID-19, although COVID-19-induced CRS itself may be an aggravating factor. </p>

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed CiNii Research

Clinical characteristics of community-acquired pneumonia due to Moraxella catarrhalis in adults: a retrospective single-centre study.

Hirai J, Kinjo T, Koga T, Haranaga S, Motonaga E, Fujita J

BMC infectious diseases ( BMC Infectious Diseases )  20 ( 1 ) 821 - 821   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: Although Moraxella catarrhalis (M. catarrhalis) is a common cause of community-acquired pneumonia (CAP), studies investigating clinical manifestations of CAP due to M. catarrhalis (MC-CAP) in adults are limited. Since S. pneumoniae is the leading cause of CAP globally, it is important to distinguish between MC-CAP and CAP due to S. pneumoniae (SP-CAP) in clinical practice. However, no past study compared clinical characteristics of MC-CAP and SP-CAP by statistical analysis. We aimed to clarify the clinical characteristics of MC-CAP by comparing those of SP-CAP, as well as the utility of sputum Gram staining. METHODS: This retrospective study screened CAP patients aged over 20 years visiting or admitted to Okinawa Miyako Hospital between May 2013 and April 2018. Among these, we included patients whom either M. catarrhalis alone or S. pneumoniae alone was isolated from their sputum by bacterial cultures. RESULTS: We identified 134 MC-CAP and 130 SP-CAP patients. Although seasonality was not observed in SP-CAP, almost half of MC-CAP patients were admitted in the winter. Compared to those with SP-CAP, MC-CAP patients were older (p < 0.01) and more likely to have underlying pulmonary diseases such as asthma and bronchiectasis (p < 0.01). Approximately half of asthmatic MC-CAP and SP-CAP patients had asthma attacks. Although winter is an influenza season in Japan, co-infection with influenza virus was less common in MC-CAP compared to SP-CAP patients (3% vs. 15%, p < 0.01). Bronchopneumonia patterns on X-ray, as well as bronchial wall thickening, bilateral distribution, and segmental pattern on CT were more common in MC-CAP patients than in SP-CAP patients (p < 0.01). Sputum Gram stain was highly useful method for the diagnosis in both MC-CAP and SP-CAP (78.4% vs. 89.2%), and penicillins were most frequently chosen as an initial treatment for both pneumonias. CONCLUSIONS: This is the first study to show that MC-CAP occurred in older people compared to SP-CAP, influenza virus co-infection was less common in MC-CAP than SP-CAP, and that MC-CAP frequently caused asthma attacks. Gram stain contributed for the appropriate treatment, resulting in conserving broad-spectrum antibiotics such as cephalosporins and fluoroquinolones in both MC-CAP and SP-CAP patients.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Seizure followed by lung edema: An intriguing link between the brain and the lung.

Arakaki W, Kinjo T, Nakamura H, Fujita J

Clinical case reports ( Clinical Case Reports )  8 ( 11 ) 2291 - 2292   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

When observing diffuse ground-glass opacities in both lungs, physicians should consider several diseases, including heart failure, interstitial lung diseases, and pulmonary infections. However, brain diseases rarely cause lung infiltration. We present an instructive case of neurologic pulmonary edema showing a pathological link between the brain and the lung.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Use of the interleukin 6 inhibitor tocilizumab in Japanese patients with cytokine release syndrome caused by COVID-19-related acute respiratory distress syndrome: A case series.

Nakamura H, Miyagi K, Otsuki M, Higure Y, Nishiyama N, Kinjo T, Nakamatsu M, Haranaga S, Tateyama M, Fujita J

Respiratory investigation ( Respiratory Investigation )  58 ( 6 ) 510 - 512   2020年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Use of steroids to treat anti-tumor necrosis factor α induced tuberculosis-associated immune reconstitution inflammatory syndrome: Case report and literature review.

Nabeya D, Kinjo T, Yamaniha K, Yamazato S, Tome R, Miyagi K, Nakamura H, Kinjo T, Haranaga S, Higa F, Fujita J

Medicine ( Medicine )  99 ( 43 ) e22076   2020年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

INTRODUCTION: Individuals with tuberculosis (TB) who are being treated with anti-tumor necrosis factor α (anti-TNFα) for coexisting conditions may experience unexpected exacerbations of TB after the initiation of antituberculous therapy, so-called anti-TNFα-induced TB-immune reconstitution inflammatory syndrome (anti-TNFα-induced TB-IRIS). Anti-TNFα-induced TB-IRIS is often treated empirically with corticosteroids; however, the evidence of the effectiveness of corticosteroids is lacking and the management can be a challenge. PATIENT CONCERNS: A 32-year-old man on long-term infliximab therapy for Crohn disease visited a clinic complaining of persistent fever and cough that had started 1 week previously. His most recent infliximab injection had been administered 14 days before the visit. A chest X-ray revealed a left pleural effusion, and he was admitted to a local hospital. DIAGNOSIS: A chest computed tomography (CT) scan revealed miliary pulmonary nodules; acid-fast bacilli were found in a sputum smear and a urine sediment sample; and polymerase chain reaction confirmed the presence of Mycobacterium tuberculosis in both his sputum and the pleural effusion. He was diagnosed with miliary TB. INTERVENTIONS: Antituberculous therapy was started and he was transferred to our hospital for further management. His symptoms initially improved after the initiation of antituberculous therapy, but 2 weeks later, his symptoms recurred and shadows on chest X-ray worsened. A repeat chest CT scan revealed enlarged miliary pulmonary nodules, extensive ground-glass opacities, and an increased volume of his pleural effusion. This paradoxical exacerbation was diagnosed as TB-IRIS associated with infliximab. A moderate-dose of systemic corticosteroid was initiated [prednisolone 25 mg/day (0.5 mg/kg/day)]. OUTCOMES: After starting corticosteroid treatment, his radiological findings improved immediately, and his fever and cough disappeared within a few days. After discharge, prednisolone was tapered off over the course of 10 weeks, and he completed a 9-month course of antituberculous therapy uneventfully. He had not restarted infliximab at his most recent follow-up 14 months later. CONCLUSION: We successfully managed a patient with anti-TNFα-induced TB-IRIS using moderate-dose corticosteroids. Due to the limited evidence currently available, physicians should consider the necessity, dosage, and duration of corticosteroids for each case of anti-TNFα-induced TB-IRIS on an individual patient-by-patient basis.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Where is Chlamydophila pneumoniae pneumonia?

Fujita J, Kinjo T

Respiratory investigation ( Respiratory Investigation )  58 ( 5 ) 336 - 343   2020年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Serum levels of receptor-interacting protein kinase-3 in patients with COVID-19.

Nakamura H, Kinjo T, Arakaki W, Miyagi K, Tateyama M, Fujita J

Critical care (London, England) ( Critical Care )  24 ( 1 ) 484 - 484   2020年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed