論文 - 金城　武士

Interleukin-17A in Legionella pneumonia: a retrospective study.

Higa F, Haroon A, Iha Y, Tasato D, Nakamura H, Kinjo T, Tamayose M, Furugen M, Miyagi K, Haranaga S, Tateyama M, Fujita J

Japanese journal of infectious diseases ( 国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会 )  68 ( 2 ) 148 - 50   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

Interleukin (IL)-17A affects the immune system of the lung. <i>Legionella</i> infection can potentially lead to severe pneumonia. The present study aimed to evaluate the role of IL-17A in <i>Legionella</i> pneumonia. Serum IL-17A levels were quantified in both patients with <i>Legionella</i> pneumonia and control subjects; IL-17 was detected in sera from 4 out of 31 patients with <i>Legionella</i> pneumonia but in any controls. There were no differences in peripheral white blood cell counts or other serum biomarkers (C-reactive protein, and lactate dehydrogenase) between IL-17A-positive and IL-17A-negative patients. All IL-17A-positive patients in this cohort survived, where 8 of 27 IL-17A-negative patients did not. IL-17A was detected in available bronchoalveolar (BA) fluid samples from 7 patients with <i>Legionella</i> pneumonia within our cohort. However, the IL-17A and IFN-γ concentrations in BA fluids did not correlate with each other. IL-17A might play a significant role in some cases of <i>Legionella</i> pneumonia.

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Falciparum Malaria Incidentally Pretreated with Azithromycin.

Shibahara D, Kinjo T, Nishiyama N, Kami W, Nabeya D, Haranaga S, Higa F, Tateyama M, Shinzato T, Toma H, Kishimoto H, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 19 ) 2513 - 6   2015年

掲載種別: 研究論文（学術雑誌）

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A 65-year-old man, who recently returned from Liberia, visited a clinic complaining of fever, and azithromycin was prescribed. The patient presented to a general hospital 5 days after the onset of symptoms, however, a blood smear examination failed to detect malaria. Contrary to the blood smear result, a rapid antigen test in our hospital was strongly-positive for falciparum malaria, indicating a high level of malarial antigen in the blood. Moreover, laboratory examinations on admission showed a tendency for improvement. We assumed that the administration of azithromycin partially treated malaria, thus complicating the blood smear diagnosis. We should be careful in prescribing azithromycin, which is widely used in clinics, to travelers returning from malaria-endemic countries.<br>

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Beau's Lines and Mees' Lines Formations after Chemotherapy.

Kinjo T, Shibahara D, Higa F, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 17 ) 2281 - 2281   2015年

掲載種別: 研究論文（学術雑誌）

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An Autopsy Case of Two Distinct, Acquired Drug Resistance Mechanisms in Epidermal Growth Factor Receptor-mutant Lung Adenocarcinoma: Small Cell Carcinoma Transformation and Epidermal Growth Factor Receptor T790M Mutation.

Furugen M, Uechi K, Hirai J, Aoyama H, Saio M, Yoshimi N, Kinjo T, Miyagi K, Haranaga S, Higa F, Tateyama M, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 19 ) 2491 - 6   2015年

掲載種別: 研究論文（学術雑誌）

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We herein describe the case of a 63-year-old man who died from relapsed <i>epidermal growth factor receptor</i> gene (<i>EGFR</i>) exon 19 deletion lung adenocarcinoma treated with erlotinib. According to the autopsy results, he was confirmed to have small cell carcinoma without the <i>EGFR</i> T790M mutation in his pancreas and left kidney metastatic specimens, while the adenocarcinoma metastatic lesion in his right kidney had the <i>EGFR</i> T790M mutation; both retained the somatic <i>EGFR</i> exon 19 deletion. We herein report an autopsy case of resistance to an EGFR tyrosine kinase inhibitor via small cell carcinoma transformation and the <i>EGFR</i>T790M mutation in separate metastatic organs.<br>

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Acute respiratory distress syndrome due to Strongyloides stercoralis infection in a patient with cervical cancer.

Kinjo T, Nabeya D, Nakamura H, Haranaga S, Hirata T, Nakamoto T, Atsumi E, Fuchigami T, Aoki Y, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  54 ( 1 ) 83 - 7   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

A 62-year-old woman complained of diarrhea and vomiting after receiving chemotherapy for cervical cancer in association with high doses of corticosteroids. Two months later, the patient developed acute respiratory distress syndrome, and numerous <i>Strongyloides stercoralis</i> parasites were found in the intrabronchial discharge. Ivermectin was administered daily until nematodes were no longer detected in the sputum, and the patient's condition was successfully rescued. Antibodies for human T-cell lymphotropic virus-1 (HTLV-1) were positive. HTLV-1 infection and the administration of corticosteroids are known risk factors for strongyloides hyperinfection syndrome. Therefore, physicians should consider this disease in the differential diagnosis of patients from endemic areas who present with gastrointestinal symptoms under these risk factors.<br>

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Clinical evaluation of high mobility group box 1 protein in Legionella pneumophila pneumonia

Higa F, Furugen M, Koide M, Karimata Y, Nabeya D, Iha Y, Kinjo T, Miyagi K, Haranaga S, Hokama A, Tateyama M, Fujita J

Journal of Infection and Chemotherapy   20 ( 5 ) 289 - 292   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Rhinovirus Pneumonia in a Patient Infected with HIV

Haranaga S, Kinjo T, Tateyama M, Fujita J

Internal Medicine   53 ( 17 ) 2027 - 2028   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Orange Sputum in a Patient with Legionella pneumophila Pneumonia

Kinjo T, Nabeya D, Higa F, Fujita J

Internal Medicine   53 ( 17 ) 2029 - 2030   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Suppressive oligodeoxynucleotides reduce lung cancer susceptibility in mice with silicosis

Bode C, Kinjo T, Alvord WG, Klinman DM

Carcinogenesis   35 ( 5 ) 1078 - 1083   2014年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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大学病院におけるCDIに対するmetronidazoleの使用状況

比嘉太, 狩俣洋介, 仲松正司, 仲村秀太, 田里大輔, 金城武士, 宮城一也, 原永修作, 健山正男, 藤田次郎

日本嫌気性菌感染症研究   42   73 - 76   2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

沖縄病院におけるGaffky 1号症例の検討　抗酸菌塗抹陽性例は入院適応か？

藤田香織, 上若生, 知花賢治, 仲本敦, 大湾勤子, 久場睦夫, 名嘉山裕子, 金城武士, 藤田次郎, 城間留奈, 宮城茂

沖縄医学会雑誌   52 ( 2 ) 16 - 20   2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy

Kinjo T, Tomaru K, Haines DC, Klinman DM

Respiratory research   13 ( 1 ) 47 - 47   2012年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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第3世代新規抗がん剤で効果が認められた胸腺上皮性腫瘍の2例

古堅誠, 上地華代子, 金城武士, 新里彰, 平井潤, 稲嶺盛史, 渡慶次賀博, 田里大輔, 狩俣洋介, 仲村秀太, 玉寄真紀, 仲松正司, 宮城一也, 熱海恵理子, 原永修作, 屋良さとみ, 比嘉太, 健山正男, 藤田次郎

沖縄医学会雑誌   51 ( 2 ) 36 - 39   2012年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas

Ikeuchi H, Kinjo T, Klinman DM

Cancer Prevention Research   4 ( 5 ) 752 - 757   2011年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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TLR-based immune adjuvants

Steinhagen F, Kinjo T, Bode C, Klinman DM

Vaccine   29 ( 17 ) 3341 - 3355   2011年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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CpG DNA as a vaccine adjuvant

Bode C, Zhao G, Steinhagen F, Kinjo T, Klinman DM

Expert Review of Vaccines   10 ( 4 ) 499 - 511   2011年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Addison's disease due to tuberculosis that required differentiation from SIADH

Kinjo T, Higuchi D, Oshiro Y, Nakamatsu Y, Fujita K, Nakamoto A, Owan I, Miyagi S, Kuba M, Fujita J

Journal of Infection and Chemotherapy   15 ( 4 ) 239 - 242   2009年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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当院で経験した好酸球性肺炎の4例

藤田香織, 仲松裕子, 金城武士, 城間留奈, 仲本敦, 大湾勤子, 宮城茂, 久場睦夫, 加藤誠也

国立   28   20 - 23   2008年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

多発嚢胞性陰影を呈した肺腺癌

藤田香織, 仲松裕子, 金城武士, 城間留奈, 仲本敦, 大湾勤子, 宮城茂, 久場睦夫

国立沖縄病院医学雑誌   28   6 - 8   2008年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Role of interferon-gamma in Valpha14+ natural killer T cell-mediated host defense against Streptococcus pneumoniae infection in murine lungs

Nakamatsu M, Yamamoto N, Hatta M, Nakasone C, Kinjo T, Miyagi K, Uezu K, Nakamura K, Nakayama T, Taniguchi M, Iwakura Y, Kaku M, Fujita J, Kawakami K

Microbes and Infection   9 ( 3 ) 364 - 374   2007年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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