論文 - 真栄田　裕行

Maxillary Cancer with Metastasis to the Rouviere Nodes -- Complete Response to Chemoradiotherapy Using a Selective Intra-Arterial Infusion Technique

Yamashiro K.

Gan to kagaku ryoho. Cancer & chemotherapy ( Gan to kagaku ryoho. Cancer & chemotherapy )  43 ( 2 ) 243 - 246   2016年02月

掲載種別: 研究論文（学術雑誌）

Maxillary Cancer with Metastasis to the Rouviere Nodes -- Complete Response to Chemoradiotherapy Using a Selective Intra-Arterial Infusion Technique

Yamashiro K

Gan to kagaku ryoho. Cancer & chemotherapy ( Gan to kagaku ryoho. Cancer & chemotherapy )  43 ( 2 ) 243 - 246   2016年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

[Maxillary Cancer with Metastasis to the Rouviere Nodes -- Complete Response to Chemoradiotherapy Using a Selective Intra-Arterial Infusion Technique].

Yamashiro K, Heianna J, Azama K, Iraha Y, Yamashiro T, Kinoshita R, Toita T, Toyama M, Agena S, Maeda H, Suzuki M, Murayama S

Gan to kagaku ryoho. Cancer & chemotherapy   43 ( 2 ) 243 - 6   2016年02月

掲載種別: 研究論文（学術雑誌）

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Surgical treatment of elongated styloid processes: A case report

Maeda H.

Otolaryngology - Head and Neck Surgery (Japan) ( Otolaryngology - Head and Neck Surgery (Japan) )  88 ( 1 ) 57 - 60   2016年01月

掲載種別: 研究論文（学術雑誌）

茎状突起過長症の手術治療

真栄田 裕行, 親川 仁貴, 鈴木 幹男

耳鼻咽喉科・頭頸部外科 ( (株)医学書院 )  88 ( 1 ) 57 - 60   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

症例は58歳女性で、2年前から咽頭痛、両頸部圧迫感を自覚し、最近は頸部後屈時の頸部痛が増悪し、紹介受診した。パノラマX線で両側の茎状突起の過伸長を認め、CTでの突起の長径は左38.8mm、右34.8mm、3D-CTでは両側の茎突起の内前方への偏位を認めた。茎状突起過伸長症の診断で経口的茎状突起切除術を行った。口蓋扁桃を摘出後に剥離子で扁桃窩筋層内を探索し、硬い索状物に沿って剥離を進め、扁桃窩上極に茎状突起を、その尾側に茎状突起と連続する茎突舌骨靱帯を確認して露出し、茎状突起を切断し、茎突舌骨靱帯を切離して摘出した。切除した茎状突起は左16mm、右9mmであった。術後2週間で全ての症状は消退し、CTで両側茎状突起の短縮を確認した。

頸部郭清術のメルクマール:―これから頸部郭清を始める頭頸部外科医のために―

真栄田 裕行

耳鼻咽喉科臨床 ( 耳鼻咽喉科臨床学会 )  109 ( 9 ) 672 - 673   2016年

掲載種別: 研究論文（学術雑誌）

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喉頭乳頭腫におけるヒト乳頭腫ウイルス感染と臨床経過

喜友名 朝則, 喜瀬 乗基, 真栄田 裕行, 又吉 宣, 比嘉 麻乃, 鈴木 幹男

喉頭 ( 日本喉頭科学会 )  28 ( 1 ) 24 - 30   2016年

掲載種別: 研究論文（学術雑誌）

　概要を見る

<p>A laryngeal papilloma is a benign tumor that occurs due to human papilloma virus infection. Although basically benign, the lesions often recur and grow in size. Furthermore, they sometimes show malignant transformation and often suffer from treatment. We performed a retrospective clinical analysis of 15 patients with laryngeal papilloma who were treated at our department over the past ten years. As with previous reports, most cases involved adult males and occupied the glottis. Canceration only occurred in one patient. Human papilloma virus infections were detected in 14 patients. All of the cases involved with type 6 or type 11（benign types）infections. Canceration occurred in one patient who did not show infection. The treatments performed at our center included, surgical resection and/or transpiration by a CO₂ laser. Recurrence was observed in some cases. This was treated with multiple surgeries. Remission was achieved by the combination of treatment under local anesthesia and adjuvant therapy. It is difficult to cure laryngeal papilloma radically because it is a viral disease. Thus, we treat the disease as follows; we first confirm the lesion with a laryngeal endoscope under general anesthesia and perform a biopsy; and then conduct resection and/or transpiration using CO₂ laser. When recurrence is observed, we immediately attempt extraction or laser transpiration under local anesthesia while the lesion is small. As the number of cases increases, it will be necessary to examine surgical method and postoperative adjuvant therapies.</p>

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副咽頭間隙に発生した海綿状血管腫の1手術例

真栄田 裕行, 當山 昌那, 安慶名 信也, 又吉 宣, 鈴木 幹男

頭頸部外科 ( 特定非営利活動法人 日本頭頸部外科学会 )  26 ( 1 ) 109 - 113   2016年

掲載種別: 研究論文（学術雑誌）

　概要を見る

今回われわれは副咽頭間隙に発生した海綿状血管腫の極めてまれな1例を経験した。患者は66歳の男性で主訴は嚥下時の違和感であった。MRI画像上，右副咽頭間隙に境界明瞭な楕円形の腫瘤を認めたため神経原性腫瘍と診断し，経耳下腺経頸部複合アプローチ法により腫瘍を摘出した。ところが術後の病理学的所見により最終的に海綿状血管腫と診断された。副咽頭間隙に初発した海綿状血管腫の報告はわれわれの渉猟しえた範囲では海外の報告と併せても3例のみであった。本症例においては術中の大量出血は認められなかった。血管原性腫瘍は術中出血のリスクが高いため術前に確定診断をつけておくことは重要であるが，本症例のように確定診断が得られない場合においても，当術式で十分に対応が可能であると考えられた。

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頭頸部骨軟部肉腫13例の検討

安慶名 信也, 上原 貴行, 山下 懐, 又吉 宣, 長谷川 昌宏, 真栄田 裕行, 鈴木 幹男

耳鼻咽喉科臨床 ( 耳鼻咽喉科臨床学会 )  108 ( 2 ) 145 - 152   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

Since bone and soft tissue sarcomas arising from the head and neck region are very rare, the standard treatment protocol has yet to be established. In the present study, 13 cases with bone and soft tissue sarcomas treated from 2007 to 2014 were analyzed. The mean period from initial visit to final pathological diagnosis was approximately 3 weeks, and 38.5% of the cases needed several biopsies for an accurate diagnosis. Death occurred early for those cases in which more than 40 days was needed to obtain the histological diagnosis. The 3-year overall survival in 13 cases was 35.2%. As the cause of death was uncontrolled local lesion, the locoregional control was more important than distant metastasis control for the prognosis. Tumor location, TNM stage, and histological grade affected the prognosis of the sarcomas. Radiation therapy including heavy ion and proton beam radiotherapy was not so effective as the primary treatment, as was the case with salvage treatment of sarcomas in the head and neck. Although the primary treatment of sarcomas was surgical treatment with an adequate margin, an efficient treatment protocol should be established to obtain a better prognosis.

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頭頸部癌に対する姑息的照射治療

上原 貴行, 真栄田 裕行, 山下 懐, 長谷川 昌宏, 安慶名 信也, 鈴木 幹男

耳鼻咽喉科臨床 ( 耳鼻咽喉科臨床学会 )  108 ( 6 ) 475 - 481   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

Patient profiles, compliance with palliative radiotherapy and the treatment outcomes were investigated in head and neck cancer patients who received palliative radiotherapy from 2006 to 2012. Clinicians selected patients who received palliative radiotherapy considering the clinical stage and the general body condition. There were no patients with severe acute or late toxicities during treatment and the completion rate of palliative radiotherapy was 79.3%. The palliative irradiation group showed significantly better overall survival rates as compared to the no-treatment group. Paliative irradiation of the primary tumor and lymph node metastases at the dose of over 50 Gy contributed to long-term disease-free survival and improvement of the quality of life (QOL), including reduction of tumorigenic pain and dysphasia. Thus, palliative radiotherapy may be a useful treatment option for patients with advanced head and neck cancer under the careful management.

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当科における下咽頭・頸部食道癌治療の妥当性に関する検討

真栄田 裕行, 杉田 早知子, 喜瀬 乗基, 喜友名 朝則, 鈴木 幹男

口腔・咽頭科 ( 日本口腔・咽頭科学会 )  28 ( 2 ) 165 - 170   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

下咽頭・頸部食道癌の治療成績は未だ満足できるものではないが, 手術手技の向上や放射線化学同時併用療法 (CCRT) による治療経験の積み重ねにより, 良好な予後が期待できるようになった. 今回我々は2009-2013年の過去5年間に経験した下咽頭・頸部食道癌128例におけるいくつかのパラメータごとの疾患特異的累積生存率をカプランマイヤー法を用いて解析した. その結果 N 分類での N2b 以上の群および M 分類での M1 群で, その予後に統計学的差異を認めた. 遠隔転移はT分類に関わらず N2b 以上の群で多く認められた. また疾患特異的生存率はIII期で81.5%, IV期で61.8%であった. これは CDDP を主薬に用いた他施設の報告と比べても遜色ない結果であり, CDGP をレジメンに含めた導入化学療法および CCRT による当科の下咽頭・頸部食道癌に対する治療方針には妥当性があると考えられた.

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Human papillomavirus infection and immunohistochemical expression of cell cycle proteins pRb, p53, and p16(INK4a) in sinonasal diseases.

Yamashita Y, Hasegawa M, Deng Z, Maeda H, Kondo S, Kyuna A, Matayoshi S, Agena S, Uehara T, Kouzaki H, Shimizu T, Ikegami T, Ganaha A, Suzuki M

Infectious agents and cancer ( Infectious Agents and Cancer )  10 ( 1 ) 23   2015年

掲載種別: 研究論文（学術雑誌）

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Clinical Outcome of Palliative Radiotherapy in Patients with Head and Neck Cancer

Uehara Takayuki, Maeda Hiroyuki, Yamashita Yukashi, Hasegawa Masahiro, Agena Shinya, Suzuki Mikio

耳鼻咽喉科臨床　補冊 ( 耳鼻咽喉科臨床学会 )  144 ( 0 ) 110 - 110   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

Patient profiles, compliance with palliative radiotherapy and the treatment outcomes were investigated in head and neck cancer patients who received palliative radiotherapy from 2006 to 2012. Clinicians selected patients who received palliative radiotherapy considering the clinical stage and the general body condition. There were no patients with severe acute or late toxicities during treatment and the completion rate of palliative radiotherapy was 79.3%. The palliative irradiation group showed significantly better overall survival rates as compared to the no-treatment group. Paliative irradiation of the primary tumor and lymph node metastases at the dose of over 50 Gy contributed to long-term disease-free survival and improvement of the quality of life (QOL), including reduction of tumorigenic pain and dysphasia. Thus, palliative radiotherapy may be a useful treatment option for patients with advanced head and neck cancer under the careful management.

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A Study on 13 Cases of Bone and Soft Tissue Sarcomas in the Head and Neck

Agena Shinya, Uehara Takayuki, Yamashita Yukashi, Matayoshi Sen, Hasegawa Masahiro, Maeda Hiroyuki, Suzuki Mikio

耳鼻咽喉科臨床　補冊 ( 耳鼻咽喉科臨床学会 )  144 ( 0 ) 86 - 88   2015年

掲載種別: 研究論文（学術雑誌）

　概要を見る

Since bone and soft tissue sarcomas arising from the head and neck region are very rare, the standard treatment protocol has yet to be established. In the present study, 13 cases with bone and soft tissue sarcomas treated from 2007 to 2014 were analyzed. The mean period from initial visit to final pathological diagnosis was approximately 3 weeks, and 38.5% of the cases needed several biopsies for an accurate diagnosis. Death occurred early for those cases in which more than 40 days was needed to obtain the histological diagnosis. The 3-year overall survival in 13 cases was 35.2%. As the cause of death was uncontrolled local lesion, the locoregional control was more important than distant metastasis control for the prognosis. Tumor location, TNM stage, and histological grade affected the prognosis of the sarcomas. Radiation therapy including heavy ion and proton beam radiotherapy was not so effective as the primary treatment, as was the case with salvage treatment of sarcomas in the head and neck. Although the primary treatment of sarcomas was surgical treatment with an adequate margin, an efficient treatment protocol should be established to obtain a better prognosis.

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  DOI