論文 - 楠瀬　賢也

Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus

Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Hotimah Masdan Salim, Gulinu Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-ichi Aihara, Masashi Akaike, Michio Shimabukuro, Masataka Sata

DIABETOLOGY & METABOLIC SYNDROME ( BIOMED CENTRAL LTD )  9   78 - 78   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. Methods and results: We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography. Canagliflozin treatment for 6 months decreased hemoglobin A1c level from 7.1 +/- 0.5% to 6.7 +/- 0.6% (P < 0.05) and decreased EAT thickness from 9.3 +/- 2.5 to 7.3 +/- 2.0 mm (P < 0.001), along with a trend of decreasing VAT and SAT area. No association was found between any of these changes. Conclusion: Canagliflozin reduced EAT thickness in patients with type 2 diabetes mellitus independent of its effect on lowering blood glucose, suggesting that canagliflozin may have an effect in preventing cardiovascular events in these patients (UMIN000021327).

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RV Myocardial Strain During Pre-Load Augmentation Is Associated With Exercise Capacity in Patients With Chronic HF

Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Ayumi Ishii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata

JACC-CARDIOVASCULAR IMAGING ( ELSEVIER SCIENCE INC )  10 ( 10 ) 1240 - 1249   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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OBJECTIVES The aim of this study was to assess the relationship between right ventricular (RV) function during pre-load augmentation and exercise tolerance. BACKGROUND Peak oxygen uptake (VO2) is a strong predictor of mortality in chronic heart failure. Cardiac function during pre-load augmentation is an important part of the phenomenon in the evaluation of exercise capacity. METHODS We prospectively performed echocardiographic studies in 68 chronic heart failure patients with cardiopulmonary exercise testing (mean age 60 +/- 12 years; 69% male). After resting evaluations, echocardiographic parameters were repeated during leg positive pressure (LPP). Exercise capacity was assessed by peak VO2 in all patients (left ventricular ejection fraction: 43 +/- 15%). RESULTS Patients with severely reduced exercise capacity (peak VO2 < 14 ml/kg/min) had significantly lower stroke volume index, left ventricular global longitudinal strain and RV strain and higher filling pressure (E/e' and pulmonary arterial systolic pressure) than the remainder. Stroke volume index (beta = 0.49), global longitudinal strain (beta = -0.61), E/e' (beta = -0.32), pulmonary arterial systolic pressure (beta = -0.57), and RV strain (beta = -0.66) during LPP were independently correlated to peak VO2 (all p < 0.01). RV strain during LPP was the most powerful predictor in identifying patients with severely reduced exercise capacity (cut off value: -17%; sensitivity: 81%; specificity: 88%; areas under the curve: 0.88; p < 0.001) compared with other variables including resting parameters. CONCLUSIONS RV strain during pre-load augmentation correlated independently to peak V(O)2 and was a powerful predictor in identifying patients with severely reduced exercise capacity. (C) 2017 by the American College of Cardiology Foundation.

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Preload Stress Echocardiography Predicts Outcomes in Patients With Preserved Ejection Fraction and Low-Gradient Aortic Stenosis.

Kusunose K, Yamada H, Nishio S, Torii Y, Hirata Y, Seno H, Saijo Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M

Circulation. Cardiovascular imaging   10 ( 10 )   2017年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

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Low Serum Levels of Eicosapentaenoic Acid and Docosahexaenoic Acid are Risk Factors for Cardiogenic Syncope in Patients with Brugada Syndrome.

Yagi S, Soeki T, Aihara KI, Fukuda D, Ise T, Kadota M, Bando S, Matsuura T, Tobiume T, Yamaguchi K, Kusunose K, Yamada H, Wakatsuki T, Shimabukuro M, Akaike M, Sata M

International heart journal   58 ( 5 ) 720 - 723   2017年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

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Improved Exercise Capacity After Cardiac Rehabilitation Is Associated with Reduced Visceral Fat in Patients with Chronic Heart Failure.

Takagawa Y, Yagi S, Ise T, Ishii A, Nishikawa K, Fukuda D, Kusunose K, Matsuura T, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Katoh S, Aihara KI, Akaike M, Sata M

International heart journal   58 ( 5 ) 746 - 751   2017年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

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Echocardiographic Epicardial Adipose Tissue Thickness Is Associated with Symptomatic Coronary Vasospasm during Provocative Testing.

Nishio S, Kusunose K, Yamada H, Hirata Y, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Shimabukuro M, Sata M

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography   30 ( 10 ) 1021 - 1027.e1   2017年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

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Improved exercise capacity after cardiac rehabilitation is associated with reduced visceral fat in patients with chronic heart failure

Yuriko Takagawa, Shusuke Yagi, Takayuki Ise, Ayumi Ishii, Koji Nishikawa, Daiju Fukuda, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Michio Shimabukuro, Shinsuke Katoh, Ken-ichi Aihara, Masashi Akaike, Masataka Sata

International Heart Journal ( International Heart Journal Association )  58 ( 5 ) 746 - 751   2017年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Participation in a comprehensive cardiac rehabilitation (CR) program has been shown to reduce mortality and improve exercise capacity and symptoms in patients with chronic heart failure (CHF). Reduced exercise capacity leads to a concomitant reduction of skeletal muscle mass and accumulation of body fat. However, it is currently unknown whether CR reduces visceral adipose tissue (VAT) and/or subcutaneous abdominal adipose tissue (SAT) in patients with CHF. In addition, the body composition associated with improved exercise capacity after CR in patients with CHF has not been previously studied. Nineteen CHF patients who were categorized as NYHA functional class II or III and had received optimal medical treatment including a CR program for 5 months were enrolled in this study. The CR program significantly increased peak VO2 and reduced B-type natriuretic peptide. In addition, fat and body composition analysis showed reductions in the visceral fat tissue (VAT) area, subcutaneous abdominal adipose tissue (SAT) area, body weight, and total fat weight after CR. There were no changes in total water weight and total muscle weight. Single regression analysis revealed that the amelioration of reduced exercise capacity seen after CR is associated with reduced VAT area but not with SAT area or body weight. In conclusion, CR reduces VAT and improves exercise capacity in patients with CHF. This suggests that reducing VAT is important for CR to be most effective in the treatment of CHF.

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Low serum levels of eicosapentaenoic acid and docosahexaenoic acid are risk factors for cardiogenic syncope in patients with brugada syndrome

Shusuke Yagi, Takeshi Soeki, Ken-ichi Aihara, Daiju Fukuda, Takayuki Ise, Muneyuki Kadota, Sachiko Bando, Tomomi Matsuura, Takeshi Tobiume, Koji Yamaguchi, Kenya Kusunose, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Masashi Akaike, Masataka Sata

International Heart Journal ( International Heart Journal Association )  58 ( 5 ) 720 - 723   2017年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The n-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antiarrhythmic effects, possibly via modulation of the cardiac ion channels. Nevertheless, it is unknown whether low serum levels of n-3 PUFAs are risk factors for ventricular fibrillation in patients with Brugada syndrome (BrS). We retrospectively reviewed data from 62 men with BrS and evaluated their serum levels of EPA and DHA, and the risk factors for sudden cardiac death, including a history of cardiogenic syncope. Nineteen patients had a history of cardiogenic syncope, and their EPA and DHA levels were significantly lower than those of the patients without syncope. Multivariate logistic regression analysis revealed that low EPA and DHA levels were associated with the incidence of syncope. The receiver-operator characteristic curve showed the area under the curves of EPA and DHA for history of syncope were 0.84 and 0.72, respectively. In conclusion, low levels of EPA and DHA are risk factors for cardiogenic syncope in patients with BrS, which suggests that n-3 PUFAs play important roles in preventing ventricular fibrillation in BrS.

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Echocardiographic Predictors for Worsening of Six-Minute Walk Distances in Patients With Systemic Sclerosis (Scleroderma)

Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata

AMERICAN JOURNAL OF CARDIOLOGY ( EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC )  120 ( 2 ) 315 - 321   2017年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Change in 6-minute walk distance (6MWD) has been used as a clinical marker in pulmonary hypertension. Determinants and worsening of 6MWD remain a matter of debate because nonpulmonary factors have an impact on the 6MWD. We hypothesized that future reduction of 6MWD in patients with systemic sclerosis (SSc) was more closely associated with cardiac dysfunction. We prospectively performed standard clinical and echocardiographic evaluations in SSc patients with the 6-minute walk test at enrollment. Features associated with the 6MWD were sought in a multiple linear regression analysis and compared using standardized beta. Worsening of the 6MWD was defined as a 15% reduction and served as the primary outcome. Eighty-one patients were included. In the multivariate analysis, baseline 6MWD was related to SSc severity score (beta = -0.250, p = 0.024), left atrial volume index (beta = -0.222, p = 0.046), right ventricular fractional area change (beta = 0.252, p = 0.025), and the ratio of mean pulmonary artery pressure and cardiac output (beta = -0.31, p = 0.002). During follow-up, 20 patients reached the primary outcome. In sequential Cox models, a model based on right ventricular fractional area change at baseline (chi-square 4.8) was improved by left atrial volume index (chi-square 10.3, p = 0.007). In conclusion, determinants and worsening of 6MWD are explained by cardiac factors. When using the 6MWD as a clinical marker in pulmonary hypertension patients, their left ventricular diastolic function and right ventricular systolic function should be taken into consideration. (C) 2017 Elsevier Inc. All rights reserved.

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Plasma brain natriuretic peptide levels are elevated in patients with cancer

Sachiko Bando, Takeshi Soeki, Tomomi Matsuura, Takeshi Tobiume, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Michio Shimabukuro, Naoki Muguruma, Tetsuji Takayama, Ichiro Kishimoto, Kenji Kangawa, Masataka Sata

PLOS ONE ( PUBLIC LIBRARY SCIENCE )  12 ( 6 ) e0178607 - e0178607   2017年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background Natriuretic peptides have been proposed as biomarkers of cardiovascular disease, especially heart failure. Brain natriuretic peptide (BNP) has also been shown to be upregulated at the transcriptional and translational levels by pro-inflammatory cytokines in cardiac myocytes. Although we often measure plasma BNP levels in cancer patients, it remains unknown whether cancer-related inflammation affects the plasma BNP levels. We investigated the relationship between the BNP and human cancers. Methods We retrospectively studied 2,923 patients in whom the plasma BNP levels and serum Creactive protein (CRP) were measured and echocardiography was performed. Patients with clinically evident heart failure (NYHA II or higher), heart disease requiring medical treatment or surgery, renal dysfunction, and inflammatory disease were excluded. There were 234 patients in the final analysis. Blood sampling was performed before surgery and chemotherapy. In addition, we evaluated the relationship between the inflammation and plasma BNP levels in mouse models of colon cancer. Results Of the 234 patients, 80 were diagnosed with cancer. Both the plasma BNP and serum CRP levels were significantly higher in cancer patients than those without. There were no significant differences in the echocardiographic parameters. There was a significant positive correlation between the plasma BNP and serum CRP levels in cancer patients (r = 0.360, P < 0.01) but not in those without. In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index. In addition, in nude mice with subcutaneous colon cancer, the plasma BNP level was elevated compared with that in non-cancer mice, and there was a significant relationship between the plasma BNP and serum levels of the inflammatory markers. Conclusions In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammation. The effect of cancer on the BNP levels should be considered when using BNP as an indicator of heart failure in cancer patients.

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Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study

Hirotsugu Yamada, Atsushi Tanaka, Kenya Kusunose, Rie Amano, Munehide Matsuhisa, Hiroyuki Daida, Masaaki Ito, Hiroyuki Tsutsui, Mamoru Nanasato, Haruo Kamiya, Yasuko K. Bando, Masato Odawara, Hisako Yoshida, Toyoaki Murohara, Masataka Sata, Koichi Node

CARDIOVASCULAR DIABETOLOGY ( BIOMED CENTRAL LTD )  16 ( 1 ) 63 - 63   2017年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background: Diabetes is associated closely with an increased risk of cardiovascular events, including diastolic dysfunction and heart failure that leads to a shortening of life expectancy. It is therefore extremely valuable to evaluate the impact of antidiabetic agents on cardiac function. However, the influence of dipeptidyl peptidase 4 inhibitors on cardiac function is controversial and a major matter of clinical concern. We therefore evaluated the effect of sitagliptin on echocardiographic parameters of diastolic function in patients with type 2 diabetes as a sub-analysis of the PROLOGUE study. Methods: Patients in the PROLOGUE study were assigned randomly to either add-on sitagliptin treatment or conventional antidiabetic treatment. Of the 463 patients in the overall study, 115 patients ( 55 in the sitagliptin group and 60 in the conventional group) who had complete echocardiographic data of the ratio of peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annular velocity (e') at baseline and after 12 and 24 months were included in this study. The primary endpoint of this post hoc sub-analysis was a comparison of the changes in the ratio of E to e' (E/e') between the two groups from baseline to 24 months. Results: The baseline-adjusted change in E/e' during 24 months was significantly lower in the sitagliptin group than in the conventional group (-0.18 +/- 0.55 vs. 1.91 +/- 0.53, p = 0.008), irrespective of a higher E/e' value at baseline in the sitagliptin group. In analysis of covariance, sitagliptin treatment was significantly associated with change in E/e' over 24 months (beta = -9.959, p = 0.001), independent of other clinical variables at baseline such as blood pressure, HbA1c, and medications for diabetes. Changes in other clinical variables including blood pressure and glycemic parameters, and echocardiographic parameters, such as cardiac structure and systolic function, were comparable between the two groups. There was also no significant difference in the serum levels of N-terminal-pro brain natriuretic peptide and high-sensitive C-reactive protein between the two groups during the study period. Conclusions: Adding sitagliptin to conventional antidiabetic regimens in patients with T2DM for 24 months attenuated the annual exacerbation in the echocardiographic parameter of diastolic dysfunction (E/e') independent of other clinical variables such as blood pressure and glycemic control.

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剖検により診断されたAcromegalic cardiomyopathyの1例

西條 良仁, 山田 博胤, 楠瀬 賢也, 瀬野 弘光, 天野 里江, 山尾 雅美, 西尾 進, 黒部 裕嗣, 渡邉 俊介, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( Suppl. ) S476 - S476   2017年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Correlation between right ventricular T₁ mapping and right ventricular dysfunction in non-ischemic cardiomyopathy.

Jellis CL, Yingchoncharoen T, Gai N, Kusunose K, Popović ZB, Flamm S, Kwon D

The international journal of cardiovascular imaging     2017年03月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

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Clinical Utility of Longitudinal Strain to Predict Functional Recovery in Patients With Tachyarrhythmia and Reduced LVEF.

Kusunose K, Torii Y, Yamada H, Nishio S, Hirata Y, Seno H, Saijo Y, Ise T, Yamaguchi K, Tobiume T, Yagi S, Soeki T, Wakatsuki T, Sata M

JACC. Cardiovascular imaging ( ELSEVIER SCIENCE INC )  10 ( 2 ) 118 - 126   2017年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Objectives: The aim of this study was to assess the time course of presumptive TIC and the predictors of LV functional recovery in such patients.Background: Tachycardia-induced cardiomyopathy (TIC) is a potentially reversible cardiomyopathy with effective treatment of the tachyarrhythmia. However, cases without improvement of left ventricular (LV) systolic function were found occasionally. The diagnosis of TIC can be challenging, and the role of echocardiographic imaging in the prediction of LV functional recovery is limited.Methods: LV segmental longitudinal strains (LS) were evaluated by 2-dimensional speckle tracking in 71 consecutive patients (65±16 years; 61% men) with tachyarrhythmia and reduced LV ejection fraction (EF) without any other known cardiovascular disease, and 30 age and gender matched control subjects. Relative apical LS ratio (RALSR) was defined using the equation: average apical LS / (average basal LS + average mid LS) as a marker of strain distribution.Results: Compared to control subjects, patients with tachyarrhythmia had significantly lower global LS. Improvement in LVEF within 6 months after treatment of index arrhythmia was observed in 41 patients, and LVEF did not improve in 30 patients. In univariate analysis, lower LVEF at baseline (hazard ratio: HR: 0.59 per 1SD, p=0.04) and higher RALSR (HR: 11.2 per 1SD, p <0.001) were associated with no recovery in LVEF during follow-up. In a multivariate logistic regression model, the significant predictor of LV systolic functional recovery was RALSR (HR: 22.9 per 1SD, p=0.001). A RALSR of 0.61 was sensitive (71%) and specific (90%) in differentiating LV systolic functional recovery (area under the curve: 0.88).Conclusions: The RALSR was associated with LV systolic functional recovery. This information might be useful for clinical evaluation and follow-up in patients with reduced LVEF.

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酵素補充療法に対する反応性が異なる心ファブリー病の2例

衣川 尚知, 山田 博胤, 西尾 進, 山尾 雅美, 鳥居 裕太, 天野 里江, 西條 良仁, 林 修司, 楠瀬 賢也, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( 1 ) 74 - 74   2017年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

異なる体位変換により左室流出路狭窄が重症化したS字状中隔の2症例

鈴川 理乃, 山田 博胤, 平田 有紀奈, 西尾 進, 山尾 雅美, 天野 里江, 鳥居 裕太, 西條 良仁, 楠瀬 賢也, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( 1 ) 74 - 75   2017年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

僧帽弁口血流速波形の偽正常化パターンと心房機能低下パターンの鑑別

木村 優希, 山田 博胤, 松浦 一義, 楠瀬 賢也, 西條 良仁, 西尾 進, 山尾 雅美, 天野 里江, 平田 有紀奈, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( 1 ) 74 - 74   2017年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Acromegalic cardiomyopathyの一例

西條 良仁, 楠瀬 賢也, 山田 博胤, 瀬野 弘光, 天野 里江, 山尾 雅美, 西尾 進, 黒部 祐嗣, 渡邉 俊介, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( 1 ) 74 - 74   2017年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

肺動脈内に可動性に富む巨大血栓を認めた慢性血栓閉塞性肺動脈高血圧症の一例

瀬野 弘光, 山田 博胤, 楠瀬 賢也, 西條 良仁, 平田 有紀奈, 鳥居 裕太, 天野 里江, 山尾 雅美, 西尾 進, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( 1 ) 73 - 73   2017年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

運動負荷心エコー図検査で肺高血圧症を診断しえた一例

大櫛 祐一郎, 楠瀬 賢也, 西條 良仁, 山田 博胤, 西尾 進, 鳥居 裕太, 天野 里江, 山尾 雅美, 添木 武, 佐田 政隆

超音波医学 ( (公社)日本超音波医学会 )  44 ( 1 ) 73 - 73   2017年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）