論文 - 楠瀬　賢也

A case of renal artery stenosis in an elderly patient after nephrectomy diagnosed by ultrasound sonography, showing improvement of blood pressure and renal dysfunction after renal artery stenting

Kojiro Nagai, Kenya Kusunose, Susumu Nishio, Yoshio Taketani, Hirotsugu Yamada, Masataka Sata, Naoki Kondo, Fumi Kishi, Seiji Kishi, Toshikazu Araoka, Motokazu Matsuura, Akira Mima, Hideharu Abe, Taichi Murakami, Masayuki Nakamura, Toshio Doi

Japanese Journal of Nephrology   53 ( 1 ) 68 - 74   2011年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Arteriosclerotic renal artery stenosis is one of the increasingly common diseases that affects many aged patients. There are various non-invasive methods to diagnose renal artery stenosis, such as contrast enhanced CT or MRI. However, these methods are not appropriate for patients with renal dysfunction. Ultrasound sonography is becoming one of the promising methods to diagnose artery stenosis because of photographic improvements. In this case, a 72-year-old woman was hospitalized 7 months after nephrectomy because of severe hypertension, heart failure and kidney dysfunction. The heart failure was quite uncontrollable in spite of massive administration of diuretics, and finally, hemodialysis was started to control her volume status. In consideration of her past history and abdominal bruit, we evaluated the renal artery stenosis by ultrasound sonography and confirmed the diagnosis by renal angiography. To improve hypertension control, we performed renal artery stenting, which resulted in an impressive improvement of her blood pressure and renal function. We recognized the importance of careful causal evaluation of renal dysfunction, even though it is difficult to apply invasive therapy to patients after nephrectomy.

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Ventricular Tachycardia in Cardiac Sarcoidosis Controlled by Radiofrequency Catheter Ablation

Mika Bando, Takeshi Soeki, Toshiyuki Niki, Kenya Kusunose, Noriko Tomita, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE )  50 ( 11 ) 1201 - 1206   2011年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

We report a case of a 78-year-old woman with cardiac sarcoidosis with a history of syncope and palpitation. Further assessment with echocardiography, gadolinium-enhanced cardiovascular magnetic resonance (CMR) and histology led to a diagnosis of cardiac sarcoidosis. As the patient suffered from ventricular tachycardia (VT) despite active corticosteroid therapy, an implantable cardioverter-defibrillator (ICD) was positioned. She was also administered a beta blocker, but an electrical storm appeared every several days requiring ICD therapy. The drug-refractory VT was finally controlled with a catheter ablation session, during which we could detect the VT focus in the right ventricular outflow tract next to the aneurysm by using an electroanatomic mapping system (CARTO). Referring to echocardiographic and CMR images proved very useful in detecting the aneurysm using the CARTO system.

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Removal of a pinched off central venous catheter.

Kusunose K, Wakatsuki T, Sata M

Heart Asia   3 ( 1 ) 32 - 32   2011年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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PJ3-044 Congenital Long QT Syndrome with Compound Mutations in KCNH2 Gene

Sachiko Bando, Takeshi Soeki, Toshivuki Niki, Kenya kusunose, Koji Yamaguchi, Yoshio Taketani, Iwase Takashi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Wataru Simizu, Masataka Sata

Journal of Arrhythmia   27   2011年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

We report a case with long QT syndrome caused by compound mutations in KCNH2 gene.A 20-year-old man was referred to our hospital for evaluation of syncope. When he was a high school student, he experienced syncope. In electrocardiogram, the QT interval was prolonged to 498ms (QTc=479ms). His 22-year-old elder brother, who had syncopal episodes twice and the prolonged QT interval in electrocardiogram, suffered from ventricular fibrillation and became vegetative state on May 26, 2009. Genetic testing revealed the frameshift mutation by the insertion of 25 nucleotides causing both an altered amino acid sequence from codon 302 and a premature termination codon (i.e., TAG) at codon 339 and the missense mutation of c.1474 C&gt T (p.H492Y) in KCNH2 gene in both brothers. These mutations have not been reported previously. Family genetic screening found that their father had the same fameshift mutation and their mother and sister had the same missense mutation in KCNH2 gene. However the family members without two brothers experienced no symptoms and had no prolonged QT interval in electrocardiogram. These results suggest that the compound mutations in KCNH2 gene inherited independently from the parents made the phenotype of their sons more severe. Then we planted the implantable cardioverter defibrillator into him on March 17, 2010. © 2011, Japanese Heart Rhythm Society. All rights reserved.

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繰り返す心不全と維持透析導入から離脱しえた腎動脈狭窄症の一例

門田 宗之, 竹谷 善雄, 若槻 哲三, 山口 浩司, 楠瀬 賢也, 仁木 敏之, 坂東 左知子, 久岡 白陽花, 上田 由佳, 冨田 紀子, 竹内 秀和, 岩瀬 俊, 山田 博胤, 添木 武, 赤池 雅史, 佐田 政隆, 長井 幸二郎, 土井 俊夫

四国医学雑誌   Vol.66 ( No.5, 6 ) 175 - 180   2010年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Ghrelin Attenuates Myocardial Ischemia/Reperfusion Injury via the Extracellular Signal-Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase/Akt Pathway

Soeki Takeshi, Niki Toshiyuki, Bando Sachiko, Hisaoka Sahika, Takeuchi Hidekazu, Kusunose Kenya, Yamaguchi Koji, Hirata Yoichiro, Tomita Noriko, Taketani Yoshio, Iwase Takashi, Yamada Hirotsugu, Wakatsuki Tetsuzo, Akaike Masashi, Kangawa Kenji, Sata Masataka

CIRCULATION   122 ( 21 )   2010年11月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Time-Dependent Changes of Local Coagulative Response up to Five Years After Sirolimus-Eluting Stent Implantation

Yamaguchi Koji, Wakatsuki Tetsuzo, Niki Toshiyuki, Taketani Yoshio, Bando Sachiko, Hisaoka Sahika, Kusunose Kenya, Ueta Yuka, Takeuchi Hidekazu, Iwase Takashi, Tomita Noriko, Yamada Hirotsugu, Soeki Takeshi, Akaike Masashi, Sata Masataka

CIRCULATION   122 ( 21 )   2010年11月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Time Difference between Onset of Mitral Inflow and Onset of Early Diastolic Mitral Annulus Velocity predicts Left Ventricular End-diastolic Pressure: Assessment by Dual Doppler Echocardiography

Kusunose Kenya, Yamada Hirotsugu, Nishio Susumu, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Hisaoka Sahika, Niki Toshiyuki, Yamaguchi Koji, Taketani Yoshio, Iwase Takashi, Soeki Takeshi, Wakatsuki Tetsuzo, Akaike Masashi, Sata Masataka

CIRCULATION   122 ( 21 )   2010年11月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Left Ventricular Dyssynchrony during Lower Leg Positive Pressure Assessed by Real-time 3-dimensional Echocardiography

Kusunose Kenya, Yamada Hirotsugu, Nishio Susumu, Tomita Noriko, Hayashi Shuji, Bando Sachiko, Hisaoka Sahika, Niki Toshiyuki, Yamaguchi Koji, Taketani Yoshio, Iwase Takashi, Soeki Takeshi, Wakatsuki Tetsuzo, Akaike Masashi, Sata Masataka

CIRCULATION   122 ( 21 )   2010年11月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Ghrelin Protects Heart Against Ischemia-Induced Arrhythmias by Preserving Connexin43 Protein

Soeki Takeshi, Niki Toshiyuki, Bando Sachiko, Hisaoka Sahika, Takeuchi Hidekazu, Kusunose Kenya, Yamaguchi Koji, Hirata Yoichiro, Tomita Noriko, Taketani Yoshio, Iwase Takashi, Yamada Hirotsugu, Wakatsuki Tetsuzo, Akaike Masashi, Kangawa Kenji, Sata Masataka

CIRCULATION   122 ( 21 )   2010年11月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Bosentan ameliorated exercise-induced pulmonary arterial hypertension complicated with systemic sclerosis.

Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Sumiko Yoshida, Yuka Sumitomo-Ueda, Ken-ichi Aihara, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

Internal Medicine   Vol.49 ( No.21 ) 2309 - 2312   2010年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.

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Cardiac Magnetic Resonance Imaging and 2-Dimensional Speckle Tracking Echocardiography in Secondary Cardiac Amyloidosis

Kenya Kusunose, Hirotsugu Yamada, Takashi Iwase, Susumu Nishio, Noriko Tomita, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Takao Shoichiro, Masafumi Harada, Noriko Kagawa, Eiji Kudo, Masataka Sata

CIRCULATION JOURNAL ( JAPANESE CIRCULATION SOC )  74 ( 7 ) 1494 - 1496   2010年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Effects of Additional Administration of Low-Dose Indapamide on Patients With Hypertension Treated With Angiotensin II Receptor Blocker

Hirotsugu Yamada, Yuichiro Mishiro, Kenya Kusunose, Masataka Sata

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS ( SAGE PUBLICATIONS INC )  15 ( 2 ) 145 - 150   2010年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: Low-dose thiazide or thiazide-like diuretics have proven useful for the management of blood pressure in patients older than 65 years (elderly group). However, there are few reports about the antihypertensive effects of antihypertensive diuretic agents in patients younger than 65 years (middle-aged group). So, we evaluated the efficacy of low-dose indapamide on blood pressure. Methods: Indapamide(1 mg) was given daily for 3 months and was then given every other day for 3 months to patients whose hypertension was poorly controlled with angiotensin II receptor blocker (ARB)-based treatment. Results: After daily administration of indapamide, blood pressure was significantly decreased in both the middle-aged and elderly groups. Blood pressure was not significantly changed by every-other-day administration compared with that observed after daily administration in either group. The rate of attainment of the target blood pressure was 90.3% and 85.7% in the middle-aged and elderly groups, respectively. The serum uric acid levels were reduced after every-other-day administration compared to daily administration but tended to be higher than the levels at the baseline in both groups. Conclusions: The addition of low-dose indapamide is a useful strategy for the management of hypertension, as it reduced blood pressure without marked side effects.

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Congenital ventricular aneurysm as an unexpected complication of monomorphic premature ventricular contractions.

Shusuke Yagi, Masashi Akaike, Mitsunori Fujimura, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Ken-ichi Aihara, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

Internal Medicine   Vol.49 ( No.10 ) 907 - 912   2010年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Congenital ventricular diverticulum (CVD) in adults is a rare cardiac malformation, which includes fibrous type congenital ventricular aneurysm (CVA). CVA is often clinically asymptomatic and shows no abnormality in the electrocardiogram or chest X-ray. However, some cases of sudden death resulting from ventricular tachycardia, cardiac embolism or ventricular rupture have been reported. Therefore, physicians should perform further cardiac imaging studies to detect a CVA if ventricular arrhythmia originating from the left ventricle is observed. Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions.

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Ezetimibe ameliorates metabolic disorders and microalbuminuria in patients with hypercholesterolemia.

Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

Journal of Atherosclerosis and Thrombosis   Vol.17 ( No.2 ) 173 - 180   2010年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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AIM: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia. METHODS: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age- and sex-matched patients with hypercholesterolemia (n=38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment. RESULTS: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels. CONCLUSION: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.

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Bosentan Ameliorated Exercise-Induced Pulmonary Arterial Hypertension Complicated with Systemic Sclerosis

Shusuke Yagi, Masashi Akaike, Takashi Iwase, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Sumiko Yoshida, Yuka Sumitomo-Ueda, Ken-ichi Aihara, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE )  49 ( 21 ) 2309 - 2312   2010年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Pulmonary arterial hypertension (PAH) is a frequent complication in patients with systemic sclerosis. Bosentan is used in patients with symptomatic PAH; however, it has not been established whether or not bosentan ameliorates the progression of PAH in patients with no PAH-related symptoms. We present a case of systemic sclerosis with no PAH-related symptoms in which bosentan ameliorated exercise-induced PAH evaluated by 6-minute walk stress echocardiography, brachial flow-mediated dilation, and skin temperature of hands and feet. The results suggest that administration of bosentan in patients with early-stage PAH ameliorates pulmonary arterial vasodilatation through improvement of endothelial function.

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Ezetimibe Ameliorates Metabolic Disorders and Microalbuminuria in Patients with Hypercholesterolemia

Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Kazue Ishikawa, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS ( JAPAN ATHEROSCLEROSIS SOC )  17 ( 2 ) 173 - 180   2010年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Aim: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia. Methods: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age-and sex-matched patients with hypercholesterolemia (n = 38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment. Results: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels. Conclusion: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.

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Diagnostic utility of cardiac magnetic resonance for detection of cardiac involvement in female carriers of Duchenne muscular dystrophy.

Iwase T, Takao S, Akaike M, Adachi K, Sumitomo-Ueda Y, Yagi S, Niki T, Kusunose K, Tomita N, Hirata Y, Yamaguchi K, Koshiba K, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Aihara K, Harada M, Nishitani H, Sata M

Heart Asia   2 ( 1 ) 52 - 55   2010年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Congenital Ventricular Aneurysm as an Unexpected Complication of Monomorphic Premature Ventricular Contractions

Shusuke Yagi, Masashi Akaike, Mitsunori Fujimura, Takehiko Kimura, Takeshi Nishiuchi, Takashi Iwase, Ken-ichi Aihara, Sumiko Yoshida, Yuka Sumitomo-Ueda, Kenya Kusunose, Toshiyuki Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoichiro Hirata, Munkhbaatar Dagvasumberel, Yoshio Taketani, Noriko Tomita, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Toshio Matsumoto, Masataka Sata

INTERNAL MEDICINE ( JAPAN SOC INTERNAL MEDICINE )  49 ( 10 ) 907 - 912   2010年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Congenital ventricular diverticulum (CVD) in adults is a rare cardiac malformation, which includes fibrous type congenital ventricular aneurysm (CVA). CVA is often clinically asymptomatic and shows no abnormality in the electrocardiogram or chest X-ray. However, some cases of sudden death resulting from ventricular tachycardia, cardiac embolism or ventricular rupture have been reported. Therefore, physicians should perform further cardiac imaging studies to detect a CVA if ventricular arrhythmia originating from the left ventricle is observed. Here, we report two successfully followed cases of CVA which were diagnosed from premature ventricular contractions.

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冠動脈周囲脂肪組織におけるマクロファージ浸潤の動脈硬化病変形成に与える影響

平田 陽一郎, 仁木 敏之, 山口 浩司, 楠瀬 賢也, 小柴 邦彦, 八木 秀介, 竹谷 善雄, 岩瀬 俊, 山田 博胤, 添木 武, 若槻 哲三, 赤池 雅史, 佐田 政隆, 黒部 裕嗣, 神原 保, 筑後 文雄, 北川 哲也, 堀 貴樹

四国医学雑誌 ( 徳島医学会 )  65 ( 5-6 ) 199 - 199   2009年12月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）