研究者詳細 - 荒川　雅志

論文 - 荒川　雅志

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VDRGene Polymorphisms, Interaction with Smoking and Risk of Periodontal Disease in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study

K. Tanaka, Y. Miyake, T. Hanioka, M. Arakawa

SCANDINAVIAN JOURNAL OF IMMUNOLOGY ( WILEY-BLACKWELL ) 78 ( 4 ) 371 - 377 2013年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Abstract Epidemiological evidence on the relationship between vitamin D receptor (VDR) polymorphisms and periodontal disease is inconsistent. We investigated associations between four VDR single-nucleotide polymorphisms (SNPs) including rs731236 (TaqI), rs7975232 (ApaI), rs1544410 (BsmI) and rs2228570 (FokI), and the risk of periodontal disease among young Japanese women. Cases included 131 women who had at least one tooth with a probing depth of 3.5 mm or deeper. Controls included 1019 women without periodontal disease. Adjustment was made for age, region of residence, education, toothbrushing frequency and use of an interdental brush. Compared with the AA genotype of SNP rs731236, the GG genotype had a significantly increased risk of periodontal disease: the adjusted OR was 3.68 (95% confidence interval: 1.06-12.78). There were no significant relationships between SNPs rs7975232, rs1544410 or rs2228570 and periodontal disease. None of the haplotypes were significantly related to periodontal disease. Compared with subjects with the AA or AG genotype of SNP rs731236 who had never smoked, those with the GG genotype who had ever smoked had a significantly increased risk of periodontal disease; nevertheless, neither multiplicative nor additive interaction was significant. The additive interaction between SNP rs7975232 and smoking was significant, although the multiplicative interaction was not statistically significant. No multiplicative or additive interactions were observed between the other SNPs and smoking. Our results indicated that VDR SNP rs731236 might be associated with periodontal disease. In addition, we present new evidence for a biological interaction between VDR SNP rs7975232 and smoking that affects periodontal disease.

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Active and passive maternal smoking during pregnancy and birth outcomes: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC PREGNANCY AND CHILDBIRTH ( BIOMED CENTRAL LTD ) 13 2013年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: In Western countries, active maternal smoking during pregnancy is recognized as the most important preventable risk factor for adverse birth outcomes. However, the effect of passive maternal smoking is less clear and has not been extensively studied. In Japan, there has been only one epidemiological study which examined the effects of active smoking during early pregnancy on birth outcomes although the effects of passive smoking were not assessed. Methods: Study subjects were 1565 mothers with singleton pregnancies and the babies born from these pregnancies. Data on active maternal smoking status in the first, second, and third trimesters and maternal environmental tobacco smoke (ETS) exposure at home and work were collected with self-administered questionnaires. Results: Compared with children born to mothers who had never smoked during pregnancy, children born to mothers who had smoked throughout their pregnancy had a significantly increased risk of small-for-gestational-age (SGA) (adjusted odd ratio [OR] = 2.87; 95% confidence interval: 1.11-6.56). However, active maternal smoking only in the first trimester and active maternal smoking in the second and/or third trimesters but not throughout pregnancy were not significantly associated with SGA. With regard to the risk of preterm birth, the adjusted ORs for the above-mentioned three categories were not significant; however, the positive linear trend was significant (P for trend = 0.048). No significant association was found between active maternal smoking during pregnancy and the risk of low birth weight. There was a significant inverse relationship between active maternal smoking during pregnancy and birth weight; newborns of mothers who had smoked throughout pregnancy had an adjusted mean birth weight reduction of 169.6 g. When classifying babies by gender, a significant positive association between active maternal smoking throughout pregnancy and the risk of SGA was found only in male newborns, however, the interaction was not significant. Maternal ETS exposure at home or work was not significantly associated with any birth outcomes. Conclusions: This is the first study in Japan to show that active maternal smoking throughout pregnancy, but not during the first trimester, is significantly associated with an increased risk of SGA and a decrease in birth weight. Thus, women who smoke should quit smoking as soon as possible after conception.

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Case-Control Study of Eczema in Relation to IL4Rα Genetic Polymorphisms in Japanese Women: The Kyushu Okinawa Maternal and Child Health Study

Miyake Y, Tanaka K, Arakawa M

Scandinavian Journal of Immunology 77 ( 5 ) 413 - 418 2013年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fish and fat intake and prevalence of depressive symptoms during pregnancy in Japan: Baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

JOURNAL OF PSYCHIATRIC RESEARCH ( PERGAMON-ELSEVIER SCIENCE LTD ) 47 ( 5 ) 572 - 578 2013年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

The present study aimed to examine the relationship between consumption of meat, fish, and specific types of fatty acids and the prevalence of depressive symptoms during pregnancy in Japan. Study subjects were 1745 pregnant women. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Information on dietary factors was collected using a self-administered diet history questionnaire. The prevalence of depressive symptoms during pregnancy was 19.3%. Higher intake levels of fish, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) were independently associated with a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) between extreme quartiles (95% confidence intervals [CIs], P for trend) were 0.61 (0.42-0.87, 0.01), 0.66 (0.46-0.95, 0.02) and 0.64 (0.44-0.93, 0.007), respectively. Higher intake levels of total fat and saturated fatty acids were independently related to a higher prevalence of depressive symptoms during pregnancy: the adjusted ORs between extreme quartiles (95% CIs, P for trend) were 1.42 (1.00-2.03, 0.06) and 1.74 (1.22-2.49, 0.001), respectively. There were no significant associations between intake of monounsaturated fatty acids, n-3 polyunsaturated fatty acids (PUFAs), alpha-linolenic acid, n-6 PUFAs, linoleic acid, arachidonic acid, or cholesterol or the ratio of n-3 to n-6 PUFA intake and depressive symptoms during pregnancy. Intake levels of fish, EPA, and DHA may be inversely associated with depressive symptoms during pregnancy while intake levels of total fat and saturated fatty acids may be positively related to depressive symptoms during pregnancy. (C) 2013 Elsevier Ltd. All rights reserved.

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Relationship between polymorphisms in IL4 and asthma in Japanese women: The Kyushu Okinawa Maternal and child health study

Yoshihiro Miyake, K. Tanaka, M. Arakawa

Journal of Investigational Allergology and Clinical Immunology 23 ( 4 ) 242 - 247 2013年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: Interleukin (IL) 4 plays a critical role in immune responses by acting as a growth factor for type 2 helper T cells and inducing immunoglobulin (Ig) class switching to IgE. Epidemiological evidence of the relationship between single-nucleotide polymorphisms (SNPs) in IL4 and asthma is inconsistent. Objectives: We examined the association between the IL4 SNPs rs2243250, rs2070874, rs2227284, and rs2243290 and asthma in young adult Japanese women. Methods: The study population comprised 89 women who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma. The control group comprised 1281 nonasthmatic women (ECRHS criteria) who had not been diagnosed with asthma by a physician. Adjustment was made for age, region of residence, presence of older siblings, smoking, and education. Results: Compared with the AA genotype of rs2243290, the AC genotype, but not the CC genotype, was significantly associated with a reduced risk of asthma: the adjusted odds ratio for the AC genotype was 0.62 (95%CI, 0.39-0.996). No evident relationships were found between rs2243250, rs2070874, or rs2227284 and asthma. None of the haplotypes were significantly associated with asthma. No significant interactions were found between the 4 SNPs under study and smoking with respect to the risk of asthma. Conclusions: Ours is the first study in a non-Western population to show that the IL4 SNP rs2243290 was significantly associated with the risk of asthma. Smoking did not significantly modify the gene-disease associations under study. © 2013 Esmon Publicidad.

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PubMed

Polymorphisms in the IL4 gene, smoking, and rhinoconjunctivitis in Japanese women: The Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

HUMAN IMMUNOLOGY ( ELSEVIER SCIENCE INC ) 73 ( 10 ) 1046 - 1049 2012年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Epidemiological evidence on the relationship between IL4 single nucleotide polymorphisms (SNPs) and allergic rhinitis is limited. We conducted a case-control study to investigate this issue in young adult Japanese women. Included were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 703 women without rhinoconjunctivitis based on the ISAAC criteria who had not been diagnosed with allergic rhinitis and/or asthma by a doctor. Compared with the TT genotype of IL4 SNP rs2227284, the GG genotype, occurring in 10.2% of control subjects, was significantly inversely associated with the risk of rhinoconjunctivitis: the adjusted OR was 0.60 (95% CI: 0.37-0.98). There were no significant relationships between SNP rs2243250, rs2070874, or rs2243290 and rhinoconjunctivitis. None of the haplotypes were significantly related to rhinoconjunctivitis. A significant inverse relationship between the combination of the TG and GG geno-types of SNP rs2227284 and rhinoconjunctivitis was observed in women who had never smoked, but not in those who had ever smoked (P for interaction = 0.11). This is the first study to demonstrate a significant relationship between IL4 SNP rs2227284 and rhinoconjunctivitis. Smoking may modify the relationship between SNP rs2227284 and rhinoconjunctivitis. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

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Employment, income, and education and prevalence of depressive symptoms during pregnancy: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC PSYCHIATRY ( BIOMED CENTRAL LTD ) 12 ( 117 ) 2012年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: Epidemiological evidence for the association of socioeconomic status with prenatal depression has been inconsistent. The current cross-sectional study examined the association between employment, job type, household income, and educational level and the prevalence of depressive symptoms during pregnancy. Methods: Subjects were 1741 Japanese women. Depressive symptoms were defined as present when subjects had a Center for Epidemiologic Studies Depression Scale score of 16 or higher. Adjustment was made for age, gestation, region of residence, family structure, personal and family history of depression, smoking, secondhand smoke exposure at home and at work, employment, household income, and education. Results: The prevalence of depressive symptoms during pregnancy was 19.3%. Compared with unemployment, employment, part-time employment, and full-time employment were significantly associated with a lower prevalence of depressive symptoms during pregnancy: the adjusted odds ratios (ORs) were 0.65 (95% confidence interval [CI]: 0.50 - 0.86), 0.66 (95% CI: 0.46 - 0.95), and 0.66 (95% CI: 0.48 - 0.90), respectively. Regarding the job type held, women with a professional or technical job and those with a clerical or related occupation had a significantly lower prevalence of depressive symptoms during pregnancy: the adjusted ORs were 0.67 (95% CI: 0.47 - 0.96) and 0.62 (95% CI: 0.43 - 0.90), respectively. Sales, service, production, and other occupations were not significantly related to the prevalence of depressive symptoms during pregnancy. There were no relationships between household income or education and the prevalence of depressive symptoms during pregnancy. Conclusions: Employment, whether full-time or part-time, and holding a professional or technical job or a clerical or related occupation may be inversely associated with the prevalence of depressive symptoms during pregnancy.

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日本の子供における食事の自己申告速度と肥満の危険性琉球小児健康調査(Self-Reported Rate of Eating and Risk of Overweight in Japanese Children: Ryukyus Child Health Study)

Murakami Kentaro, Miyake Yoshihiro, Sasaki Satoshi, Tanaka Keiko, Arakawa Masashi

Journal of Nutritional Science and Vitaminology ( (公社)日本栄養・食糧学会 ) 58 ( 4 ) 247 - 252 2012年08月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

食事速度と肥満の状況の関連性について検討した。15974名の子供(6-11歳、男子7956名、女子8018名)を対象とした。BMIは子供が申告した体重と身長から計算した。肥満の判定はInternational Obesity Task Forceの年齢と性別に特異的な切り捨て値に基づいて行った。全体の肥満の割合は13.2%であった。タンパク質、脂質、および食物繊維の摂取量とは独立に食事速度は体重超過の危険性と正に相関していた。食事速度ごとの肥満の多変量オッズ比(95%信頼区間)は男児で極めて低速が0.31、やや低速が0.49、中程度が1(基準値)、やや高速が2.81、極めて高速が4.49であり、女児で順に0.42、0.49、1(基準値)、2.74、5.69であった。成人男性については順に0.13、0.43、1(基準値)、2.31、そして3.84であった。成人女性で順に0.55、0.46、1(基準値)、1.30、1.49であった。すべて集団で食事の速度と肥満は有意に相関していた。日本の小児と成人において食事速度の速さが肥満の危険性の増加と独立かつ正に相関していた。

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ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Y. Miyake, K. Tanaka, M. Arakawa

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ( INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) ) 16 ( 7 ) 974 - 979 2012年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

SETTING: Multiple A disintegrin and metalloprotease 33 (ADAM33) single nucleotide polymorphisms (SNPs) have been shown to be associated with asthma, but results have been inconsistent. OBJECTIVES: To examine the association between ADAM33 SNPs rs2787094, rs628977, rs2280089, rs2280090, rs2280091, rs2853209, rs528557 and rs612709 and asthma in young adult Japanese women, and to perform haplotype analyses and assess interactions between SNPs and smoking. DESIGN: A total of 89 cases who met the criteria of the European Community Respiratory Health Survey (ECRHS) for asthma were included in the study. Control subjects were 1281 women without asthma, as per ECRHS criteria, who had not been diagnosed with asthma by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking and education. RESULTS: Under a co-dominant model, the AA genotype of the rs612709 SNP was significantly positively associated with asthma compared with the GG genotype: the adjusted OR was 4.27 (95%CI 1.49-12.25). A significant positive relationship was found between the CCGGAAGA haplotype and asthma. Interactions between SNPs rs628977 and rs528557 and smoking were marginally significant (P = 0.09 and 0.095, respectively). CONCLUSIONS: ADAM33 SNP rs612709 and the CCGGAAGA haplotype may be associated with asthma. Smoking may modify the associations between SNPs rs628977 and rs528557 and asthma.

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An energy-dense diet is cross-sectionally associated with an increased risk of overweight in male children, but not in female children, male adolescents, or female adolescents in Japan: the Ryukyus Child Health Study

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Masashi Arakawa

NUTRITION RESEARCH ( PERGAMON-ELSEVIER SCIENCE LTD ) 32 ( 7 ) 486 - 494 2012年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Epidemiologic evidence concerning the role of dietary energy density in increased body weight status during childhood and adolescence is limited, particularly in non-Western populations. We investigated the hypothesis that higher dietary energy density is associated with increasing risk of overweight in Japanese children and adolescents. This Japanese cross-sectional study included 15974 children (6-11 years old; 7956 boys and 8018 girls) and 8202 adolescents (12-15 years old; 3944 boys and 4258 girls). Dietary intake was assessed using a self-administered diet history questionnaire for children and adolescents. Dietary energy density was calculated based on foods only (excluding beverages). Body mass index (BMI) was calculated from self-reported body weight and height. Overweight (including obesity) was defined according to the International Obesity Task Force age- and sex-specific BMI cutoffs, which correspond to an adult BMI of at least 25 kg/m(2). The overall prevalence of overweight was 13.2%. Mean dietary energy density was 5.02 (standard deviation, 0.59) kJ/g. After adjustment for potential confounding factors, dietary energy density was positively associated with the risk of overweight in male children (P for trend = .048). No such associations were observed among female children, male adolescents, or female adolescents. In conclusion, this large cross-sectional study in Japan suggests that an energy-dense diet is associated with an increased risk of overweight in male children, but not in female children, male adolescents, or female adolescents. (C) 2012 Elsevier Inc. All rights reserved.

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Characteristics of under- and over-reporters of energy intake among Japanese children and adolescents: The Ryukyus Child Health Study

Kentaro Murakami, Yoshihiro Miyake, Satoshi Sasaki, Keiko Tanaka, Masashi Arakawa

NUTRITION ( ELSEVIER SCIENCE INC ) 28 ( 5 ) 532 - 538 2012年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Objective: Evidence on factors associated with misreporting of energy intake in children and adolescents is sparse, particularly in non-Western countries. We examined the characteristics of under- and over-reporters of energy intake in Japanese children and adolescents. Methods: This study included 25 761 Japanese boys and girls 6 to 15 y old. Energy intake was assessed using a self-administered diet history questionnaire developed for Japanese children and adolescents. Estimated energy requirement was calculated from self-reported body weight with the use of equations from the Food and Agriculture Organization (FAO)/World Health Organization (WHO)/United Nations University (UNU) Expert Consultation Report on Human Energy Requirements. Under-reporters, acceptable reporters, and over-reporters of energy intake were identified based on the ratio of energy intake to estimated energy requirement (<0.76, 0.76 to 1.24, and >1.24, respectively). The risk of being an under- or over-reporter of energy intake compared with being an acceptable reporter was analyzed using logistic regression. Results: The percentages of under-, acceptable, and over-reporters of energy intake were 31.6%, 53.2%, and 15.2%, respectively. Under-reporting was associated with female sex, older age, overweight and obesity, low parental education, and completion of the dietary questionnaire without the cooperation of parent(s)/caregiver(s). Over-reporting was associated with younger age, normal weight, low parental education, and completion of the dietary questionnaire by the child/adolescent alone (compared with completion by the child/adolescent and parent[s]/caregiverls]). Conclusions: Although under- and over-reporting of energy intake were common and differential in this study of Japanese children and adolescents, the cooperation of parent(s)/caregiver(s) in answering the dietary questionnaire seemed to improve the quality of dietary intake data. (C) 2012 Elsevier Inc. All rights reserved.

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ADAM33 genetic polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

HUMAN IMMUNOLOGY ( ELSEVIER SCIENCE INC ) 73 ( 4 ) 411 - 415 2012年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Two previous studies have demonstrated a significant relationship between ADAM33 single nucleotide polymorphisms (SNPs) and allergic rhinitis. Here, we investigated this issue in young adult Japanese women. The study included 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls included 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor. The GC genotype of rs2787094, the CT genotype of rs628977, and the haplotype containing the rs2787094 C allele, the rs628977 T allele, the rs2853209 T allele, and the rs612709 G allele were significantly inversely associated with rhinoconjunctivitis. The AA genotype of rs2853209, the GA genotype of rs612709, and the haplotype carrying the rs2787094 G allele, the rs628977 C allele, the rs2853209 A allele, and the rs612709 G allele were significantly positively associated with rhinoconjunctivitis. A significant inverse relationship between rs628977 and rhinoconjunctivitis was demonstrated only in women who had never smoked, indicating a significant interaction between rs628977 and smoking. Our results suggest that SNPs and haplotypes in the ADAM33 gene are associated with rhinoconjunctivitis. This study is the first to demonstrate an interaction between rs628977 and smoking that affects rhinoconjunctivitis. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

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Dietary meat and fat intake and prevalence of rhinoconjunctivitis in pregnant Japanese women: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

NUTRITION JOURNAL ( BIOMED CENTRAL LTD ) 11 2012年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: Dietary fat exerts numerous complex effects on proinflammatory and immunologic pathways. Several epidemiological studies have examined the relationships between intake of fatty acids and/or foods high in fat and allergic rhinitis, but have provided conflicting findings. The current cross-sectional study investigated such relationships in Japan. Methods: Study subjects were 1745 pregnant women. The definition of rhinoconjunctivitis was based on criteria from the International Study of Asthma and Allergies in Childhood. Information on dietary factors was collected using a validated self-administered diet history questionnaire. Adjustment was made for age; gestation; region of residence; number of older siblings; number of children; smoking; secondhand smoke exposure at home and at work; family history of asthma, atopic eczema, and allergic rhinitis; household income; education; and body mass index. Results: The prevalence of rhinoconjunctivitis in the past 12 months was 25.9%. Higher meat intake was significantly associated with an increased prevalence of rhinoconjunctivitis: the adjusted odds ratio between extreme quartiles was 1.71 (95% confidence interval: 1.25-2.35, P for trend = 0.002). No measurable association was found between fish intake and rhinoconjunctivitis. Intake of total fat, saturated fatty acids, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, a-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, linoleic acid, arachidonic acid, and cholesterol and the ratio of n-3 to n-6 polyunsaturated fatty acid intake were not evidently related to the prevalence of rhinoconjunctivitis. Conclusions: The current results suggest that meat intake may be positively associated with the prevalence of rhinoconjunctivitis in young adult Japanese women.

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Smoking and prevalence of allergic disorders in Japanese pregnant women: baseline data from the Kyushu Okinawa Maternal and Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa

ENVIRONMENTAL HEALTH ( BIOMED CENTRAL LTD ) 11 11 - 15 2012年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: Studies on the associations between smoking and allergic diseases have mostly focused on asthma. Epidemiological studies in adults on the effects of smoking on allergic diseases other than asthma, such as eczema and rhinoconjunctivitis, have been limited, and the information that is available has been inconsistent. The aim of this study was to investigate the association between smoking status and environmental tobacco smoke (ETS) exposure and the prevalence of allergic diseases. Methods: Study subjects were 1743 pregnant Japanese women. The definitions of wheeze and asthma were based on criteria from the European Community Respiratory Health Survey whereas those of eczema and rhinoconjunctivitis were based on criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age; region of residence; family history of asthma, atopic eczema, and allergic rhinitis; household income; and education. Results: Compared with never smoking, current smoking and >= 4 pack-years of smoking were independently positively associated with the prevalence of wheeze. There were no associations between smoking status and the prevalence of asthma, eczema, or rhinoconjunctivitis. When subjects who had never smoked were classified into four categories based on the source of ETS exposure (never, only at home, only at work, and both), exposure occurring both at home and at work was independently associated with an increased prevalence of two outcomes: wheeze and rhinoconjunctivitis. No relationships were observed between exposure to ETS and the prevalence of asthma or eczema. Conclusions: Our results provide evidence that current smoking and ETS exposure may increase the likelihood of wheeze. The possibility of a positive association between ETS exposure and rhinoconjunctivitis was also suggested.

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Dairy food, calcium and vitamin D intake and prevalence of allergic disorders in pregnant Japanese women

Y. Miyake, K. Tanaka, H. Okubo, S. Sasaki, M. Arakawa

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ( INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) ) 16 ( 2 ) 255 - 261 2012年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

SETTING : Epidemiological evidence for the associations between intake of dairy products, calcium and vitamin D and allergic disorders has been inconsistent. OBJECTIVES: To examine such associations in Japan. DESIGN: This cross-sectional study enrolled 1745 pregnant women. The definitions of wheeze and asthma were based on European Community Respiratory Health Survey criteria, whereas those of eczema and rhinoconjunctivitis were based on International Study of Asthma and Allergies in Childhood criteria. Information on dietary factors was collected using a validated self-administered diet history questionnaire. RESULTS: Intake of total dairy products, milk, yoghurt, cheese and calcium was not related to the prevalence of wheeze, asthma, eczema or rhinoconjunctivitis. After adjustment for potential confounders, vitamin D intake was found to be independently positively associated with the prevalence of asthma: the adjusted ORs for asthma in the first, second, third and fourth quartiles were respectively 1.00 (reference), 1.26 (95%CI 0.65-2.50), 2.08 (95%CI 1.13-3.94), and 1.82 (95%CI 0.97-3.51, P for trend = 0.03). There were no relationships between vitamin D consumption and the prevalence of wheeze, eczema or rhinoconjunctivitis. CONCLUSIONS: These findings suggest that vitamin D intake may be positively related to the prevalence of asthma in young adult Japanese women.

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Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC MEDICAL GENETICS ( BIOMED CENTRAL LTD ) 12 ( 143 ) 142 2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: Six previous studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the IL13 gene and allergic rhinitis, but the results have been inconsistent. However, a recent meta-analysis using data from these 6 studies has shown that the A allele of IL13 SNP rs20541 was associated with an increased risk of allergic rhinitis, whereas no such relationship existed between IL13 SNP rs1800925 and allergic rhinitis. We investigated the associations between IL13 SNPs rs1800925 and rs20541 and the risk of rhinoconjunctivitis in Japanese women. Methods: Included were 393 cases who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Control subjects were 767 women without rhinoconjunctivitis according to the ISAAC criteria, who had also not been diagnosed with allergic rhinitis by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking, family history of allergic rhinitis, and education. Results: Compared with the GG genotype of IL13 SNP rs20541, the AA genotype, occurring in 7.1% of control subjects, was significantly positively related to the risk of rhinoconjunctivitis: the adjusted odds ratio was 1.65 (95% confidence interval: 1.05 - 2.60). SNP rs1800925 was not associated with rhinoconjunctivitis. The haplotype comprising the rs1800925 C allele and the rs20541 A allele was significantly positively related to rhinoconjunctivitis. The multiplicative interactions between the two SNPs under study and smoking on the risk of rhinoconjunctivitis were not statistically significant. Based on the recessive model, however, the additive interaction between SNP rs1800925, but not rs20541, and smoking was significant. Conclusions: This study suggests that the minor genotype of IL13 SNP rs20541 and the CA haplotype are significantly positively associated with the risk of rhinoconjunctivitis. In addition, a new pattern of biological interaction that affects the risk of rhinoconjunctivitis is described between SNP rs1800925 and smoking.

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Organochlorine concentrations in breast milk and prevalence of allergic disorders in Japanese women

Yoshihiro Miyake, Keiko Tanaka, Yuko Masuzaki, Nobuyuki Sato, Yoshirou Ikeda, Youichi Chisaki, Masashi Arakawa

CHEMOSPHERE ( PERGAMON-ELSEVIER SCIENCE LTD ) 85 ( 3 ) 374 - 378 2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Persistent organic pollutants have been shown to have immunomodulating effects in humans. However, epidemiological evidence regarding the relationships between organochlorine compound exposure and allergic disorders coming from studies of children has been limited and inconsistent. The current cross-sectional study examined the associations between the concentrations of beta-hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), p,p'-dichlorodiphenyldichloroethylene (DDE), and trans-nonachlordane in breast milk and the prevalence of allergic disorders in 124 adult Japanese women. The definition of wheeze and asthma was based on criteria from the European Community Respiratory Health Survey whereas that of eczema and rhinoconjunctivitis was based on criteria from the International Study of Asthma and Allergies in Childhood. Adjustment was made for age, smoking, family history of allergic disorders, and education. The prevalence values of wheeze, asthma, eczema, and rhinoconjunctivitis in the past 12 months were 9.7%, 4.8%, 13.7%, and 29.8%, respectively. The median concentrations of beta-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk were 28.3, 7.0, 71.6, and 23.9 ng g(-1) lipid, respectively (range, 4.5-253, 2.1-14.5, 7.5-362, and 1.8-130 ng g(-1) lipid, respectively). When the exposures were treated as continuous variables, no significant associations were found between concentrations of HCB, beta-HCH, p,p'-DDE, or trans-nonachlordane and the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis. Our results suggest that concentrations of beta-HCH, HCB, p,p'-DDE, and trans-nonachlordane in breast milk are not evidently associated with the prevalence of wheeze, asthma, eczema, or rhinoconjunctivitis in young female Japanese adults. (C) 2011 Elsevier Ltd. All rights reserved.

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IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan

Yoshihiro Miyake, Keiko Tanaka, Masashi Arakawa

BMC MEDICAL GENETICS ( BIOMED CENTRAL LTD ) 12 ( 142 ) 142 2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background: Several genetic association studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the IL13 gene and eczema, and have provided contradictory results. We investigated the relationship between the IL13 SNPs rs1800925 and rs20541 and the risk of eczema in Japanese young adult women. Methods: Included were 188 cases who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for eczema. Control subjects were 1,082 women without eczema according to the ISAAC criteria, who had not been diagnosed with atopic eczema by a doctor and who had no current asthma as defined by the European Community Respiratory Health Survey criteria. Adjustment was made for age, region of residence, number of children, smoking, and education. Results: The minor TT genotype of SNP rs1800925 was significantly associated with an increased risk of eczema in the co-dominant model: the adjusted odds ratio was 2.19 (95% confidence interval: 1.03-4.67). SNP rs20541 was not related to eczema. None of the haplotypes were significantly associated with eczema. Compared with women with the CC or CT genotype of SNP rs1800925 who had never smoked, those with the TT genotype who had ever smoked had a 2.85-fold increased risk of eczema, though the adjusted odds ratio was not statistically significant, and neither multiplicative nor additive interaction was statistically significant. Conclusions: Our findings suggest that the IL13 SNP rs1800925 is significantly associated with eczema in Japanese young adult women. We could not find evidence for an interaction between SNP rs1800925 and smoking with regard to eczema.

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U-Shaped Association between Body Mass Index and the Prevalence of Wheeze and Asthma, but not Eczema or Rhinoconjunctivitis: The Ryukyus Child Health Study

Keiko Tanaka, Yoshihiro Miyake, Masashi Arakawa, Satoshi Sasaki, Yukihiro Ohya

JOURNAL OF ASTHMA ( INFORMA HEALTHCARE ) 48 ( 8 ) 804 - 810 2011年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Background. Studies reporting on the association between obesity and allergies have mostly focused on asthma. Little is known about the relationship of obesity to other allergic diseases, and the information that is available has been inconsistent. We examined the association between body mass index (BMI) and the prevalence of wheeze, asthma, eczema, and rhinoconjunctivitis in Japanese schoolchildren. Methods. Study subjects were 24,399 children aged 6-15 years in Okinawa, Japan. Outcomes were based on diagnostic criteria from the International Study of Asthma and Allergies in Childhood. BMI was categorized into five groups; <5th, 5th to 35th, >35th to 65th, >65th to 95th, and >95th percentile groups. Adjustment was made for sex, age, region of residence, number of siblings, smoking in the household, physical activity, paternal and maternal history of allergic disorders, and paternal and maternal educational levels. Results. The prevalence values of wheeze, asthma, eczema, and rhinoconjunctivitis in the previous 12 months were 10.8%, 7.6%, 6.9%, and 7.6%, respectively. Compared with the referent category (>35th to 65th percentile group), higher percentile categories were positively associated with the prevalence of wheeze. A U-shaped relationship between BMI and asthma was observed. No material associations between BMI percentile categories and the prevalence of eczema or rhinoconjunctivitis were found. Conclusion. These findings suggested that being either underweight or overweight might increase the likelihood of asthma among Japanese schoolchildren.

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Dietary glycemic index and glycemic load in relation to risk of overweight in Japanese children and adolescents: the Ryukyus Child Health Study

K. Murakami, Y. Miyake, S. Sasaki, K. Tanaka, M. Arakawa

INTERNATIONAL JOURNAL OF OBESITY ( NATURE PUBLISHING GROUP ) 35 ( 7 ) 925 - 936 2011年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Objective: Epidemiologic evidence concerning the role of dietary glycemic index (GI) and glycemic load (GL) in obesity during childhood and adolescence is limited, particularly in non-Western populations. We examined the association between dietary GI and GL as well as dietary fiber intake and overweight status in Japanese children and adolescents. Subjects: This Japanese cross-sectional study included 15 974 children (6-11 years; 7956 boys and 8018 girls) and 8202 adolescents (12-15 years; 3944 boys and 4258 girls). Methods: Dietary intake was assessed using a self-administered diet history questionnaire for children and adolescents. Body mass index (BMI) was calculated from self-reported body weight and height. Overweight was defined according to the International Obesity Task Force age-and sex-specific BMI cutoffs, which correspond to an adult BMI of >= 25 kgm(-2). Results: The overall prevalence of overweight was 13.2%. Mean (s.d.) dietary GI was 63.0 (3.1), mean dietary GL was 85.0 (12.4) per 4184 kJ (1000 kcal) and mean dietary fiber intake was 5.9 (1.2) g/4184 kJ. After adjustment for potential confounding factors, dietary GL was positively associated with the risk of overweight in male children, female children and male adolescents (P for trend <0.0001, <0.0001 and 0.006, respectively), but not in female adolescents. No such independent associations were observed for dietary GI or fiber intake. Conclusion: This large cross-sectional study in Japan suggests that higher dietary GL is associated with increasing risk of overweight in male and female children and male adolescents, but not female adolescents. International Journal of Obesity (2011) 35, 925-936; doi: 10.1038/ijo.2011.59; published online 29 March 2011

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