Published Papers - Masuzaki Hiroaki

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity.

Nakata T, Fujita A, Umeda M, Yoshida H, Inami K, Masuzaki H, Sawai H

SpringerPlus ( SpringerPlus )  5 ( 1 ) 40 - 7   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Screening of Coronary Artery Disease in Diabetic Patients: Who and How? - Reply.

Shimabukuro M, Saito T, Masuzaki H, Sata M

Circulation journal : official journal of the Japanese Circulation Society ( 一般社団法人 日本循環器学会 )  80 ( 2 ) 544 - 544   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<b><i>Background:</i></b>Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients.<b><i>Methods and Results:</i></b>In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50–74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75–89% stenosis), Grade 5 (severe stenosis/atherosclerosis, ≥90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3–5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA_1c≥7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.<b><i>Conclusions:</i></b>The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization. (<i>Circ J</i> 2015; <b>79:</b> 2422–2429)

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Relevant Obstetric Factors for Cerebral Palsy: From the Nationwide Obstetric Compensation System in Japan.

Hasegawa J, Toyokawa S, Ikenoue T, Asano Y, Satoh S, Ikeda T, Ichizuka K, Tamiya N, Nakai A, Fujimori K, Maeda T, Masuzaki H, Suzuki H, Ueda S, Prevention Recurrence Committee, Japan Obstetric Compensation System for Cerebral Palsy

PloS one   11 ( 1 ) e0148122   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Authors' reply re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series.

Nishijima K, Orisaka M, Takahashi J, Yamamoto M, Nakago S, Yoshida A, Masuzaki H, Kotsuji F, Yoshida Y

BJOG : an international journal of obstetrics and gynaecology   122 ( 13 ) 1844 - 5   2015.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation.

Hasegawa Y, Miura K, Higashijima A, Abe S, Miura S, Yoshiura K, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   22 ( 12 ) 1569 - 76   2015.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab.

Tamaki K, Kinjo T, Aoyama H, Tomoyose T, Nakachi S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Taira N, Fujita J, Yoshimi N, Fukushima T, Masuzaki H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  21 ( 11 ) 820 - 3   2015.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab

K. Tamaki, T. T. Kinjo, H. Aoyama, Tomoyose, S. Nakachi, T. Hanashiro, N. Shimabukuro, I. Todokon, K. Morichika, Y. Nishi, N. Taira, J. Fujita, N. Yoshimi, T.Fukushima, H. Masuzaki

J Infect Chemother   21 ( 11 ) 820 - 823   2015.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Circulating chromosome 19 miRNA cluster microRNAs in pregnant women with severe pre-eclampsia.

Miura K, Higashijima A, Murakami Y, Tsukamoto O, Hasegawa Y, Abe S, Fuchi N, Miura S, Kaneuchi M, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 10 ) 1526 - 32   2015.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D₂ receptor signalling in mouse islet.

Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H

British journal of pharmacology ( British Journal of Pharmacology )  172 ( 18 ) 4519 - 4534   2015.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background and Purpose gamma-Oryzanol, derived from unrefined rice, attenuated the preference for dietary fat in mice, by decreasing hypothalamic endoplasmic reticulum stress. However, no peripheral mechanisms, whereby -oryzanol could ameliorate glucose dyshomeostasis were explored. Dopamine D-2 receptor signalling locally attenuates insulin secretion in pancreatic islets, presumably via decreased levels of intracellular cAMP. We therefore hypothesized that -oryzanol would improve high-fat diet (HFD)-induced dysfunction of islets through the suppression of local D-2 receptor signalling. Experimental Approach Glucose metabolism and regulation of molecules involved in D-2 receptor signalling in pancreatic islets were investigated in male C57BL/6J mice, fed HFD and treated with gamma-oryzanol . In isolated murine islets and the beta cell line, MIN6 , the effects of gamma-oryzanol on glucose-stimulated insulin secretion (GSIS) was analysed using siRNA for D-2 receptors and a variety of compounds which alter D-2 receptor signalling. Key Results In islets, -oryzanol enhanced GSIS via the activation of the cAMP/PKA pathway. Expression of molecules involved in D-2 receptor signalling was increased in islets from HFD-fed mice, which were reciprocally decreased by -oryzanol. Experiments with siRNA for D-2 receptors and D-2 receptor ligands in vitro suggest that gamma-oryzanol suppressed D-2 receptor signalling and augmented GSIS. Conclusions and Implications gamma-Oryzanol exhibited unique anti-diabetic properties. The unexpected effects of gamma-oryzanol on D-2 receptor signalling in islets may provide a novel; natural food-based, approach to anti-diabetic therapy.

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Risk stratification of coronary artery disease in asymptomatic diabetic subjects using multi-detector computed tomography

M. Shimabukuro, T. Saito, T. Higa, K. Nakamura, H. Masuzaki, M. Sata

Circ J   79   2422 - 2429   2015.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Subclinical Carotid Atherosclerosis Burden in the Japanese: Comparison between Okinawa and Nagano Residents.

Shimabukuro M, Hasegawa Y, Higa M, Amano R, Yamada H, Mizushima S, Masuzaki H, Sata M

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  22 ( 8 ) 854 - 68   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<b><i>Aim</i></b><b>: </b>The prevalence of overweight and a change in atherosclerotic lipid profiles may be linked to region-specific differences in atherosclerotic diseases. We evaluated whether the lipid phenotype could be linked to region- and sex-specific differences in the degree of atherosclerosis.<br><b><i>Methods</i></b><b>: </b>Non-diabetic subjects included Okinawa (<i>n</i>=1674) and Nagano (<i>n</i>=1392) residents aged 30–75 years who underwent carotid ultrasonography for the measurement of maximum intima-media thickness (max IMT).<br><b><i>Results</i></b><b>: </b>Average max IMT was higher in Okinawa men and women, and the increase in max IMT with age was enhanced in men. Multiple regression analysis showed that in addition to age and systolic blood pressure, low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol were IMT determinants only in men for both Okinawa and Nagano. Meanwhile, HDL-cholesterol was a determinant for Okinawa men and women, but not for Nagano men and women.<br><b><i>Conclusions</i></b><b>: </b>This is the first report to show region- and sex-specific differences in the determinants for max IMT in a Japanese population. The evaluation of the relationship between lipid profile patterns and region- and sex-specific differences in carotid atherosclerosis burden may be required.

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Estrogen deficiency heterogeneously affects tissue specific stem cells in mice.

Kitajima Y, Doi H, Ono Y, Urata Y, Goto S, Kitajima M, Miura K, Li TS, Masuzaki H

Scientific reports   5   12861   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: Two case reports and review of the literature

Miyagi T.

Transplant Infectious Disease ( Transplant Infectious Disease )  17 ( 4 ) 593 - 598   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Successful treatment of toxoplasmic encephalitis quickly diagnosed by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two cases reports and review of the literature

T. Miyagi, H. Itonaga, F. Aosai, J. Taguchi, K. Norose, K. Mochiduki, H. Fujii, A. Furumoto, M. Ohama, K. Karimata, A. Yamanoha, H.Taniguchi, S. Sato, N. Taira, Y. Moriuchi, T. Fukushima, H. Masuzaki, Y. Miyazaki

Transpl Infect Dis   17 ( 4 ) 593 - 598   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Experience with recombinant activated factor VII for severe post-partum hemorrhage in Japan, investigated by Perinatology Committee, Japan Society of Obstetrics and Gynecology.

Murakami M, Kobayashi T, Kubo T, Hata T, Takeda S, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 8 ) 1161 - 8   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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National survey of fibrinogen concentrate usage for post-partum hemorrhage in Japan: investigated by the Perinatology Committee, Japan Society of Obstetrics and Gynecology.

Makino S, Takeda S, Kobayashi T, Murakami M, Kubo T, Hata T, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 8 ) 1155 - 60   2015.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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17β-estradiol and lipopolysaccharide additively promote pelvic inflammation and growth of endometriosis.

Khan KN, Kitajima M, Inoue T, Fujishita A, Nakashima M, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   22 ( 5 ) 585 - 94   2015.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Pregnancy-associated microRNAs in plasma as potential molecular markers of ectopic pregnancy.

Miura K, Higashijima A, Mishima H, Miura S, Kitajima M, Kaneuchi M, Yoshiura K, Masuzaki H

Fertility and sterility   103 ( 5 ) 1202 - 8.e1   2015.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Circulating levels of maternal plasma cell-free miR-21 are associated with maternal body mass index and neonatal birth weight.

Miura K, Higashijima A, Hasegawa Y, Abe S, Miura S, Kaneuchi M, Yoshiura K, Masuzaki H

Prenatal diagnosis   35 ( 5 ) 509 - 11   2015.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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[Discussion Meeting on Care and Treatment of Obesity Syndrome: Latest Approach through Nutrition, Diets, Exercise, Lifestyle Modification and Psychological Aspects].

Masuzaki H, Yabe D, Onishi Y, Matsuzawa Y, Matsuda Y

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine ( 一般社団法人 日本内科学会 )  104 ( 4 ) 748 - 62   2015.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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