Published Papers - Masuzaki Hiroaki

Association between ovarian endometrioma and ovarian reserve.

Kitajima M, Khan KN, Harada A, Taniguchi K, Inoue T, Kaneuchi M, Miura K, Masuzaki H

Frontiers in bioscience (Elite edition)   10 ( 1 ) 92 - 102   2018.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Corrigendum: Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Fuchi N, Miura K, Doi H, Li TS, Masuzaki H

Scientific reports   7   46922   2017.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adrenal venous sampling in patients with primary aldosteronism: Which is the best evaluation method for laterality assessments?

Azama K, Okada M, Yogi A, Koga T, Iraha Y, Heianna J, Nakamura H, Masuzaki H, Murayama S

Open Journal of Radiology   7 ( 4 ) 219 - 227   2017.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K, Masuzaki H

Drug delivery ( Drug Delivery )  24 ( 1 ) 558 - 568   2017.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Our previous works demonstrated that brown rice-specific bioactive substance, gamma-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)induced obese diabetic mice. However, extremely low absorption efficiency from intestine of gamma-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of gamma-oryzanol with super-high lipophilicity, we encapsulated gamma-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the bestknown severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude (similar to 1000-fold lower dose) compared with regular gamma-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward gamma-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

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Clinical usefulness of FDG-PET/CT for the evaluation of various types of adult T-cell leukemia.

Nakachi S, Okada M, Morishima S, Agarie Y, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tamaki K, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Murayama S, Masuzaki H

Hematology (Amsterdam, Netherlands) ( TAYLOR & FRANCIS LTD )  22 ( 9 ) 536 - 543   2017.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Purpose: The aim was to explore undefined useful indices for clinically grading adult T-cell leukemia (ATL) using [F-18] 2-fluoro-2-deoxyglucose (FDG) - positron emission tomography/computed tomography (PET/CT). Methods: A total of 28 patients with ATL (indolent, 9; aggressive, 19) were enrolled; all patients with aggressive ATL underwent FDG-PET/CT before chemotherapy. Patients with indolent ATL underwent FDG-PET/CT at the time of suspected disease progression and/or transformation; some received lymph node biopsy. The quantitative parameters maximum standardized uptake values (SUVmax), and mean and peak SUV, metabolic tumor volume (MTV), and volume-based total lesion glycolysis were calculated with the margin threshold as 25%, and 50% of the SUVmax for all lesions. Results: All parameters except for MTV-25% showed significant differences (P0.05) in differentiating the aggressive type from the indolent type of ATL. Areas under the curve for receiver-operating characteristic (ROC) analysis regarding the series of parameters investigated ranged from 0.75 to 0.92; this indicated relatively high accuracy in distinguishing the aggressive type from the indolent type. No malignant findings were detected in lymph node biopsies in indolent ATL patients with lymphadenopathy. Discussion: We performed evaluation of a line of parameters of FDG-PET, thereby demonstrating their significantly high accuracy for grading malignancy in ATL patients. In particular, low accumulation of FDG in indolent ATL patients with lymphadenopathy might predict that it is not a sign of disease transformation, but rather a reactive manifestation. Conclusion: FDG-PET/CT findings could be useful for clinically grading ATL.

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Increased expression of 11β-hydroxysteroid dehydrogenase type 1 in experimental periodontitis induced by lipopolysaccharide from Porphyromonas gingivalis

Fujita A, Nakata T, Umeda M, Masuzaki H, Sawai H

Open Journal of Stomatology   7 ( 10 ) 429 - 438   2017.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

Sakihama S, Saito M, Kuba-Miyara M, Tomoyose T, Taira N, Miyagi T, Hayashi M, Kinjo S, Nakachi S, Tedokon I, Nishi Y, Tamaki K, Morichika K, Uchihara JN, Morishima S, Karube KN, Tanaka Y, Masuzaki H, Fukushima T

Leukemia research ( Leukemia Research )  61   18 - 24   2017.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphom

Morichika K, Uchihara JN, Morishima S, Karube KN, Tanaka Y, Masuzaki H, Fukushima T

Leuk Res   61   18 - 24   2017.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Fetiform teratoma was a parthenogenetic tumor arising from a mature ovum.

Miura K, Kurabayashi T, Satoh C, Sasaki K, Ishiguro T, Yoshiura KI, Masuzaki H

Journal of human genetics   62 ( 9 ) 803 - 808   2017.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit.

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

Journal of medical virology ( Journal of Medical Virology )  89 ( 8 ) 1364 - 1372   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

J Med Virol   89 ( 8 ) 1364 - 1372   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Impact of Brown Rice-Specific -Oryzanol on Epigenetic Modulation of Dopamine D2 Receptor in Brain Striatum of High Fat Diet-Induced Obese Mice

Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H

Diabetologia   60 ( 8 ) 1502 - 1511   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice.

Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H

Diabetologia ( Diabetologia )  60 ( 8 ) 1502 - 1511   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Current status of non-invasive prenatal testing in Japan.

Samura O, Sekizawa A, Suzumori N, Sasaki A, Wada S, Hamanoue H, Hirahara F, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Nakayama S, Okai T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Kido Y, Fukao T, Miharu N, Nagamatsu T, Watanabe A, Hamajima N, Hirose M, Sanui A, Shirato N, Yotsumoto J, Nishiyama M, Hirose T, Sago H

The journal of obstetrics and gynaecology research   43 ( 8 ) 1245 - 1255   2017.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice.

Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M

Diabetologia ( SPRINGER )  60 ( 6 ) 1138 - 1151   2017.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Nitric oxide (NO) is synthesised not only from l-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, but whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency would induce the metabolic syndrome in mice. To this end, we prepared a low-nitrite/nitrate diet (LND) consisting of an amino acid-based low-nitrite/nitrate chow, in which the contents of l-arginine, fat, carbohydrates, protein and energy were identical with a regular chow, and potable ultrapure water. Nitrite and nitrate were undetectable in both the chow and the water. Three months of the LND did not affect food or water intake in wild-type C57BL/6J mice compared with a regular diet (RD). However, in comparison with the RD, 3 months of the LND significantly elicited visceral adiposity, dyslipidaemia and glucose intolerance. Eighteen months of the LND significantly provoked increased body weight, hypertension, insulin resistance and impaired endothelium-dependent relaxations to acetylcholine, while 22 months of the LND significantly led to death mainly due to cardiovascular disease, including acute myocardial infarction. These abnormalities were reversed by simultaneous treatment with sodium nitrate, and were significantly associated with endothelial NOS downregulation, adiponectin insufficiency and dysbiosis of the gut microbiota. These results provide the first evidence that long-term dietary nitrite/nitrate deficiency gives rise to the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice, indicating a novel pathogenetic role of the exogenous NO production system in the metabolic syndrome and its vascular complications.

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Carbon dioxide angiography and arterial embolization could successfully control postpartum uterine hemorrhage for the patient with hypersensitivity to iodine compound.

Kawashita S, Kaneuchi M, Nakayama D, Fuchi N, Murakami Y, Miura K, Masuzaki H

Radiology case reports   12 ( 2 ) 261 - 264   2017.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<i>FOXO3</i> GENOTYPE PROTECTS AGAINST TELOMERE SHORTENING WITH AGE

Davy, PMC; Morris, BJ; Willcox, DC; Shimabukaro, M; Donlon, TA; Suzuki, M; Higa, M; Masuzaki, H; Sata, M; Chen, R; He, Q; Murkofsky, R; Lim, E; Allsopp, RC; Willcox, BJ

HYPERTENSION   69 ( 6 ) E30 - E31   2017.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Fuchi N, Miura K, Doi H, Li TS, Masuzaki H

Scientific reports   7   46220   2017.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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An Atypical Case of Late-Onset Systemic Lupus Erythematosus with Systemic Lymphadenopathy and Severe Autoimmune Thrombocytopenia/Neutropenia Mimicking Malignant Lymphoma

Tamaki K, Morishima S, Nakachi S, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Masuzaki H

Int J Hematol   105 ( 4 ) 526 - 531   2017.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

An atypical case of late-onset systemic lupus erythematosus with systemic lymphadenopathy and severe autoimmune thrombocytopenia/neutropenia mimicking malignant lymphoma.

Tamaki K, Morishima S, Nakachi S, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Masuzaki H

International journal of hematology ( International Journal of Hematology )  105 ( 4 ) 526 - 531   2017.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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