Published Papers - Masuzaki Hiroaki

[Programs for Continuing Medical Education 2016: A Session: 4. Obesity Disease and Metabolic Syndrome: Clinical Progress and Future Outlook].

Masuzaki H, Shimabukuro M

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   106 ( 3 ) 477 - 83   2017.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Brown Rice-Specific -Oryzanol-Based Novel Approach toward Lifestyle-Related Brain Dysfunction and Impaired Glucose Metabolism

Masuzaki H (senior, corresponding author, Kozuka C, Yonamine M, Shimabukuro M

Glycative Stress Research   4 ( 1 ) 58 - 66   2017.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Purification of Two Novel Sugar Acid-binding Lectins from Haplomitrium Mnioides (bryophyte, Plantae) and their Preliminary Characterization.

Masuzaki H, Hosono M, Nitta K

Applied biochemistry and biotechnology   181 ( 1 ) 65 - 82   2017.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Circulating Levels of Pregnancy-Associated, Placenta-Specific microRNAs in Pregnant Women With Placental Abruption.

Miura K, Higashijima A, Murakami Y, Fuchi N, Tsukamoto O, Abe S, Hasegawa Y, Miura S, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   24 ( 1 ) 148 - 155   2017.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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孤立性脊髄硬膜外顆粒球肉腫で発症した急性骨髄性白血病の1例

北村 紗希子, 益崎 裕章, 森島 聡子, 玉城 啓太, 仲地 佐和子, 手登根 伊織, 島袋 奈津紀, 花城 多恵子, 玉城 智子, 福島 卓也

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  106 ( 10 ) 2214 - 2221   2017 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<p>28歳，男性．7カ月持続する臀部痛と左下腿運動麻痺があり，MRI（magnetic resonance imaging）で脊柱管内に腫瘤性病変を認め，精査で孤立性顆粒球肉腫の診断に至ったが，治療開始直前に急性骨髄性白血病に移行した．寛解導入療法後に分子遺伝学的寛解に到達し，地固め療法後に既往の統合失調症が増悪し治療中断となったが，22カ月経過した現在も完全寛解を維持している．顆粒球肉腫は急性骨髄性白血病に準じた治療が必要とされ，正確な診断と早期の治療介入が重要である．</p>

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4．肥満症とメタボリックシンドローム：最近の知見と展望

益崎 裕章, 島袋 充生

日本内科学会雑誌 ( 一般社団法人 日本内科学会 )  106 ( 3 ) 477 - 483   2017 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior

Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C

Neurosci Res   17   30313 - 30319   2017 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Round ligament varicosities diagnosed as inguinal hernia during pregnancy: A case report and series from two regional hospitals in Japan.

Mine Y, Eguchi S, Enjouji A, Fukuda M, Yamaguchi J, Inoue Y, Fujita F, Tsukamoto O, Masuzaki H

International journal of surgery case reports   36   122 - 125   2017 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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A survey on awareness of genetic counseling for non-invasive prenatal testing: the first year experience in Japan.

Yotsumoto J, Sekizawa A, Suzumori N, Yamada T, Samura O, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Endo T, Fukushima A, Namba A, Osada H, Kasai Y, Watanabe A, Katagiri Y, Takeshita N, Ogawa M, Okai T, Izumi S, Hamanoue H, Inuzuka M, Haino K, Hamajima N, Nishizawa H, Okamoto Y, Nakamura H, Kanegawa T, Yoshimatsu J, Tairaku S, Naruse K, Masuyama H, Hyodo M, Kaji T, Maeda K, Matsubara K, Ogawa M, Yoshizato T, Ohba T, Kawano Y, Sago H, Japan NIPT Consortium

Journal of human genetics   61 ( 12 ) 995 - 1001   2016.12 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Catecholamines facilitate fuel expenditure and protect against obesity via a novel network of the gut-brain axis in transcription factor Skn-1 -deficient mice

Yoshiro Ishimaru, Shota Ushiama, Masataka Narukawa, Misako Yoshioka, Chisayo Kozuka, Naoki Watanabe, Makoto Tsunoda, Naomi Osakabe, Tomiko Asakura, Hiroaki Masuzaki, Keiko Abe

CHEMICAL SENSES ( OXFORD UNIV PRESS )  41 ( 9 ) E218 - E218   2016.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats.

Nakata T, Umeda M, Masuzaki H, Sawai H

BMC oral health ( BMC Oral Health )  16 ( 1 ) 108   2016.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Characterization of patients with aggressive adult T-cell leukemia-lymphoma in Okinawa, Japan: a retrospective analysis of a large cohort

Nishi Y, Fukushima T, Nomura S, Tomoyose T, Nakachi S, Morichika K, Tedokon I, Tamaki K, Shimabukuro N, Taira N, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tamaki K, Hayashi M, Arakaki H, Uchihara JN, Ohshiro K, Asakura Y, Kuba-Miyara M, Karube K, Masuzaki H

Int J Hematol   104 ( 4 ) 468 - 475   2016.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats

Nakata T, Umeda M, Masuzaki H, Sawai H

BMC Oral Health   16 ( 1 ) 108   2016.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Characterization of patients with aggressive adult T-cell leukemia-lymphoma in Okinawa, Japan: a retrospective analysis of a large cohort.

Nishi Y, Fukushima T, Nomura S, Tomoyose T, Nakachi S, Morichika K, Tedokon I, Tamaki K, Shimabukuro N, Taira N, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tamaki K, Hayashi M, Arakaki H, Uchihara JN, Ohshiro K, Asakura Y, Kuba-Miyara M, Karube K, Masuzaki H

International journal of hematology ( International Journal of Hematology )  104 ( 4 ) 468 - 75   2016.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.

Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K

Journal of human genetics   61 ( 10 ) 879 - 884   2016.10 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Long-term effect of sitagliptin on endothelial function in type 2 diabetes: A sub-analysis of the PROLOGUE study

Maruhashi T.

Cardiovascular Diabetology ( Cardiovascular Diabetology )  15 ( 1 )   2016.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.

Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M

The Journal of nutritional biochemistry ( ELSEVIER SCIENCE INC )  35   66 - 73   2016.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD + Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD + E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8 weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4 beta-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4 beta-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 413-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function. (C) 2016 Elsevier Inc. All rights reserved.

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A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population.

Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe S, Higashijima A, Fuchi N, Miura S, Yoshiura K, Masuzaki H

Journal of human genetics   61 ( 9 ) 793 - 6   2016.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adipocyte size distribution and depot-specific modulation of pro- and anti-atherosclerotic adipocytokines and innate immune molecules in human adipose tissue

Shimabukuro, M; Sato, H; Izaki, H; Fukuda, D; Uematsu, E; Hirata, Y; Yagi, S; Soeki, T; Sakaue, H; Kanayama, H; Masuzaki, H; Sata, M

EUROPEAN HEART JOURNAL   37   183 - 183   2016.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.

Shirakura T, Nomura J, Matsui C, Kobayashi T, Tamura M, Masuzaki H

Naunyn-Schmiedeberg's archives of pharmacology ( SPRINGER )  389 ( 8 ) 831 - 8   2016.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO produces considerable amount of oxidative stress throughout the body. To date, however, its pathophysiologic role in hypertension and endothelial dysfunction still remains controversial. To explore the possible involvement of XO-derived oxidative stress in the pathophysiology of vascular dysfunction, by use of a selective XO inhibitor, febuxostat, we investigated the impact of pharmacological inhibition of XO on hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats (SHRs). Sixteen-week-old SHR and normotensive Wistar-Kyoto (WKY) rats were treated with tap water (control) or water containing febuxostat (3 mg/kg/day) for 6 weeks. Systolic blood pressure (SBP) in febuxostat-treated SHR (220 +/- 3 mmHg) was significantly (P &lt; 0.05) decreased compared with the control SHR (236 +/- 4 mmHg) while SBP in febuxostat-treated WKY was constant. Acetylcholine-induced endothelium-dependent relaxation in aortas from febuxostat-treated SHR was significantly (P &lt; 0.05) improved compared with the control SHR, whereas relaxation in response to sodium nitroprusside was not changed. Vascular XO activity and tissue nitrotyrosine level, a representative indicator of local oxidative stress, were considerably elevated in the control SHR compared with the control WKY, and this increment was abolished by febuxostat. Our results suggest that exaggerated XO activity and resultant increase in oxidative stress in this experimental model contribute to the hypertension and endothelial dysfunction, thereby supporting a notion that pharmacological inhibition of XO is valuable not only for hyperuricemia but also for treating hypertension and related endothelial dysfunction in human clinics.

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