Published Papers - Masuzaki Hiroaki

Extra virgin oliveおよび亜麻仁油は腸内細菌叢を調節しマウス粘膜および代謝の正常化を促す(Extra virgin olive and flaxseed oil modulate gut microbiota, enhancing mucosal & metabolic health in mice)

Frances Millman Jasmine, 岡本 士毅, 山崎 聡, 上間 次己, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 260 - 260   2019.10

Type of publication: Research paper (other science council materials etc.)

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma.

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer science ( Cancer Science )  110 ( 9 ) 2982 - 2991   2019.09 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK-STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P < .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression-free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.

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Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube KN, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant immunology ( Transplant Immunology )  55   101205 - 101205   2019.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5.1) splenocytes without conditioning irradiation or chemotherapy. AD-MSCs from C3H mice were injected intravenously via tail veins. GVHD was assessed using flowcytometry analysis of peripheral blood cells and histopathologic analysis of target organs. Histopathological analyses revealed that AD-MSCs markedly suppressed the infiltration of lymphocytes into liver as well as the aplasia in bone marrow. This study is the first to clarify the effectiveness of AD-MSCs against bone marrow aplasia in GVHD, supporting a rationale of AD-MSCs for ameliorating bone marrow suppression and infectivity after allo-HSCT in human clinics.

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A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly-sensitive assay

Hokama N, Shirakura T, Sunagawa S, Morishima S, Nakachi S, Nishi Y, Murayama Y, Matsui C, Hase N, Tamura M, Okamoto S, Shimabukuro M, Nakamura K, Masuzaki H

Hematological Oncology   37 ( 4 ) 527 - 530   2019.08 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women.

Murakami N, Kitajima M, Ohyama K, Aibara N, Taniguchi K, Wei M, Kitajima Y, Miura K, Masuzaki H

Clinica chimica acta; international journal of clinical chemistry   495   545 - 551   2019.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma: Possible role of STAT3 phosphorylation in clinical subtype, progression, and prognosis

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer Sci   110 ( 9 ) 2982 - 2991   2019.07 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Validation of a novel digital health monitoring system to measure the volume of voided urine.

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourology and urodynamics ( Neurourology and Urodynamics )  38 ( 4 ) 1106 - 1110   2019.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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AIM: To validate a novel digital health monitoring system to measure the volume of voided urine. METHODS: Micturition volume was calculated using our novel digital self-health monitoring system of urine excretion (s-HMSU) in 18 participants (16 women and 2 men; average age, 40.8 years), without a history of voiding symptoms. Participants completed a self-reported questionnaire regarding their medical history and water intake during the period of observation, as well as the Core Lower Urinary Tract Symptom Score (CLSS) questionnaire. To assess the reliability of the voided volumes measured using the s-HMSU, the intraclass correlation coefficient (ICC) was calculated between the volume and the change in body weight before and after micturition. RESULTS: The CLSS questionnaire confirmed the absence of urinary system diseases in all participants. The medical history was also negative with the exception of hypertension in one participant. The ICC (1,1) between the measured volume of urine excretion using the s-HMSU and the change in body weight was 0.972 (95% confidence interval, 0.957-0.982). CONCLUSIONS: The s-HMSU system provides a reliable measure of voiding volume and is appropriate for home use. It has the potential to facilitate large-scale clinical research to examine the relationship between medical diseases and voiding dysfunction.

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Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube K, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant Immunology   55   101205   2019.04 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Validation of a novel digital health monitoring system to measure the volume of voided urine

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourol Urodyn   38 ( 4 ) 1106 - 1110   2019.03 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Levels of Adiponectin Expression in Peri-Renal and Subcutaneous Adipose Tissue and Its Determinants in Human Biopsied Samples.

Maimaituxun G, Fukuda D, Izaki H, Hirata Y, Kanayama HO, Masuzaki H, Sata M, Shimabukuro M

Frontiers in endocrinology ( Frontiers in Endocrinology )  10   897 - 897   2019.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Background: The interactions of adipose tissue with the kidney are hypothesized to affect kidney function. Also, excessive peri-renal fat may increase the risk of cardiometabolic risk. However, the role(s) of peri-renal fat adipocytokine has never been evaluated. Objectives: To elucidate levels of adiponectin expression in peri-renal and subcutaneous adipose tissue and its determinants in human biopsied samples. Methods: A pair of subcutaneous and perirenal fat tissue samples were collected from 80 patients (men: 54; women: 26) who underwent urological operations. Subcutaneous adipose tissue (SAT) area, visceral adipose tissue (VAT) area and peri-renal adipose tissue (RAT) volume were quantified on abdominal computed tomography. Cytokine/adipocytokine expression was evaluated by real-time semi-quantitative polymerase chain reaction (qPCR). Probability was considered significant if P < 0.05. Results: Current study evaluated determinants of plasma adiponectin levels and expression levels of adiponectin in SAT and RAT in human samples. We found that: first, plasma adiponectin levels were correlated with VAT area but not with BMI, waist circumference, SAT area, and RAT volume; second, expression levels of adiponectin in SAT were correlated with BMI, waist circumference, and SAT area but not with VAT area and RAT volume; and third, expression levels of adiponectin in RAT were correlated with all adiposity indices including BMI, waist circumference, SAT area, VAT area, and RAT volume. Conclusion: This study evaluated levels of adiponectin expression in RAT and SAT and its determinants in patients who underwent urological operation. Levels of adiponectin mRNA in RAT were negatively correlated with remote fat mass in SAT and VAT and also with local fat mass in RAT, while level of adiponectin in SAT was not correlated with RAT volume. Further studies are warranted to evaluate roles of peri-renal fat mass accumulation and its pathophysiological machineries.

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Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Maemoto H, Ariga T, Kusada T, Heianna J, Manabe Y, Miyakawa A, Nakachi S, Morishima S, Iraha S, Ganaha F, Masuzaki H, Murayama S

Japanese journal of clinical oncology ( Japanese Journal of Clinical Oncology )  49 ( 2 ) 153 - 159   2019.02 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma.

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama S

Journal of radiation research ( Journal of Radiation Research )  60 ( 1 ) 98 - 108   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 94 - 103   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans.

Masuzaki H, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 18 - 25   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

J Diabetes Investig   10 ( 1 ) 94 - 103   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Brown rice-specific -oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans

Masuzaki H (senior, corresponding author, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

J Diabetes Investig   10 ( 1 ) 18 - 25   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lumphoma

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama M

Journal of Radiation Research   60 ( 1 ) 98 - 108   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (other science council materials etc.)

Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT.

Suzumori N, Sekizawa A, Takeda E, Samura O, Sasaki A, Akaishi R, Wada S, Hamanoue H, Hirahara F, Kuriki H, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Yamashita T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Endo M, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Nagamatsu T, Watanabe A, Nishikawa N, Hamajima N, Shirato N, Yotsumoto J, Nishiyama M, Koide K, Hirose T, Sago H

Prenatal diagnosis   39 ( 2 ) 100 - 106   2019.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation.

Maeda M, Oba K, Yamaguchi S, Arasaki O, Sata M, Masuzaki H, Shimabukuro M

The American journal of cardiology ( American Journal of Cardiology )  122 ( 10 ) 1694 - 1700   2018.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with post-ablation atrial fibrillation (AF), ranges of EATV predictive of post-ablation recurrence of AF remain unclear. In this study, we evaluated: (1) relationships between EATV and characteristics of AF, (2) impact of EATV on recurrent AF after radiofrequency ablation; , and (3) cut-off point for recurrent AF using a receiver operating characteristic curve. In 218 consecutive symptomatic patients undergoing who underwent ablation for AF (143 paroxysmal AF; 78 persistent AF), the EATV index (EATVI: EATV/body surface area, mL/m2) was measured using 320-row multidetector computed tomography. The high EATV group showed specific cardiometabolic derangements as well as left atrial dilatation and left ventricular dysfunction. Multivariate regression analysis showed that the EATVI was an independent predictor of recurrent AF after catheter ablation. High EATV (EATVI ≥ 85 mL/m2) or EATVI cutoff ≥116 mL/m2 can predict recurrent AF after catheter ablation, independent of other risk factors. In conclusion, EATVI was an independent predictor of recurrent AF after catheter ablation; a high EATV tertile or EATVI cutoff may be useful for prediction of recurrent AF after catheter ablation. Future studies should determine the utility of the EATVI in the clinical setting of AF ablation.

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Correction: Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.

Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K

Journal of human genetics   63 ( 11 ) 1195   2018.11 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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