Published Papers - Masuzaki Hiroaki

Biological differences between functionalis and basalis endometria in women with and without adenomyosis.

Khan KN, Fujishita A, Kitajima M, Masuzaki H, Nakashima M, Kitawaki J

European journal of obstetrics, gynecology, and reproductive biology   203   49 - 55   2016.08 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients.

Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama HO, Masuzaki H, Sata M

BioFactors (Oxford, England) ( WILEY-BLACKWELL )  42 ( 4 ) 397 - 406   2016.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Gender difference in obesity-associated cardiovascular complication could be derived from divergent chronic inflammation. We evaluated depot- and gender-specific regulation of the innate immune system in human adipose tissues. Pair samples were obtained from subcutaneous (SAT) and visceral adipose tissue (VAT) during elective surgery (Male: 35; Female: 27). Expressions of pro- and anti-inflammatory adipocytokines were evaluated by semi-quantitative qPCR. Adipose cell-size distribution was obtained from tissue samples fixed in osmium tetroxide and analyzed by Beckman Coulter Multisizer. Levels of adiponectin were higher in SAT and VAT of female than those of male (P<0.001 and P=0.011, respectively). NLRP3, IL1-IL18, TLR2 were comparable in SAT and VAT between genders. However, TLR4 and TLR9 were increased in female SAT and VAT and HMGB1 in female VAT. Levels of adiponectin were not correlated with mean diameter of adipocyte (phi, m) in SAT and VAT of male, but negatively well correlated in those of female (r=-0.392 and r=-0.616). Such negative correlations were also observed between levels of TLR2, TLR4, and HMGB1 and phi in female. Levels of NLRP3 and IL1 were positively correlated with phi in male, but not in female. In conclusion, Innate signals were differentially expressed in male and female adipose tissues, suggesting that the depot- and gender-specific signals could be related to gender difference in chronic inflammation. (c) 2016 BioFactors, 42(4):397-406, 2016

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Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy.

Suzumori N, Ebara T, Yamada T, Samura O, Yotsumoto J, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Saldivar JS, Dharajiya N, Sago H, Sekizawa A, Japan NIPT Consortium

Journal of human genetics   61 ( 7 ) 647 - 52   2016.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Three-dimensional saline-infusion sonohysterography is useful for the identification of endometrial polyp.

Inoue T, Kitajima M, Taniguchi K, Masuzaki H

The journal of obstetrics and gynaecology research   42 ( 7 ) 855 - 9   2016.07 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice.

Ushiama S, Ishimaru Y, Narukawa M, Yoshioka M, Kozuka C, Watanabe N, Tsunoda M, Osakabe N, Asakura T, Masuzaki H, Abe K

EBioMedicine ( ELSEVIER SCIENCE BV )  8   60 - 71   2016.06 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis. This system is referred to as the gut-brain axis. Here we show that both brush cells and type II taste cells are eliminated in the gastrointestinal tract of transcription factor Skn-1 knockout (KO) mice. Despite unaltered food intake, Skn-1 KO mice have reduced body weight with lower body fat due to increased energy expenditure. In this model, 24-h urinary excretion of catecholamines was significantly elevated, accompanied by increased fatty acid beta-oxidation and fuel dissipation in skeletal muscle and impaired insulin secretion driven by glucose. These results suggest the existence of brain-mediated energy homeostatic pathways originating from brush cells and type II taste cells in the gastrointestinal tract and ending in peripheral tissues, including the adrenal glands. The discovery of food-derived factors that regulate these cells may open new avenues the treatment of obesity and diabetes. Research Context: Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis along the gut-brain axis. We propose the concept that taste-receiving cells in the oral cavity and/or food-borne chemicals-receiving brush cells in the gut are involved in regulation of the body weight and adiposity via the brain. The discovery of food-derived factors that regulate these cells may open new avenues for the treatment of obesity and diabetes. (C) 2016 The Authors. Published by Elsevier B.V.

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Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.

Shimabukuro M, Higa N, Masuzaki H, Sata M, Ueda S

Cardiovascular diabetology ( Cardiovascular Diabetology )  15 ( 1 ) 77   2016.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Impact of indivisual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men

M. Shimabukuro, N. Higa, H. Masuzaki, M. Sata, S. Ueda

Cardiovasc Diabetology   15   77   2016.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Recurrence of psoriasis vulgaris accompanied by the treatment with C-C chemokine receptor type 4 (CCR4) antibody (Mogamulizumab) therapies in a patient with adult T cell leukemia/ lymphoma: Insight into autoinflammatory syndrome

K. Morichika, T. Tomoyose, T. Hanashiro, N. Shimabukuro, K. Tamaki, I. Tedokon, Y. Nishi, T. S.Nakachi, K. Karube, T. Fukushima, H. Masuzaki

Intern Med   55 ( 10 ) 1345 - 1349   2016.05 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Influenza 2014-2015 among pregnant Japanese women: primiparous vs multiparous women.

Yamada T, Kawakami S, Yoshida Y, Kawamura H, Ohta S, Abe K, Hamada H, Dohi S, Ichizuka K, Takita H, Baba Y, Matsubara S, Mochizuki J, Unno N, Maegawa Y, Maeda M, Inubashiri E, Akutagawa N, Kubo T, Shirota T, Oda Y, Yamada T, Yamagishi E, Nakai A, Fuchi N, Masuzaki H, Urabe S, Kudo Y, Nomizo M, Sagawa N, Maeda T, Kamitomo M, Kawabata K, Kataoka S, Shiozaki A, Saito S, Sekizawa A, Minakami H

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology   35 ( 4 ) 665 - 71   2016.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Survey of prenatal testing for genetic disorders in Japan: Recent report.

Nobuzane T, Yamada T, Miura K, Sawai H, Masuzaki H, Kudo Y

The journal of obstetrics and gynaecology research   42 ( 4 ) 375 - 9   2016.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Molecular detection of intrauterine microbial colonization in women with endometriosis.

Khan KN, Fujishita A, Masumoto H, Muto H, Kitajima M, Masuzaki H, Kitawaki J

European journal of obstetrics, gynecology, and reproductive biology   199   69 - 75   2016.04 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier.

Fuchi N, Miura K, Imaizumi Y, Hasegawa H, Yanagihara K, Miyazaki Y, Masuzaki H

The journal of obstetrics and gynaecology research   42 ( 3 ) 336 - 40   2016.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Novel molecular mechanisms of brown rice-derived bioactive substance on anti-obesity and anti-diabetic properties

Kozuka, C; Masuzaki, H

JOURNAL OF PHARMACOLOGICAL SCIENCES   130 ( 3 ) S69 - S69   2016.03 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.

Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS

Scientific reports   6   18844   2016.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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The Increased Ratio of 11β-Hydroxysteroid Dehydrogenase Type 1 versus Type 2 in Chronic Periodontitis Irrespective of Obesity

T. Nakata, A. Fujita, M. Umeda, H. Yoshida, K. Inami, H. Masuzaki, H. Sawai

SpringerPlus   5   40   2016.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.

Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K

Early human development   92   33 - 6   2016.01 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.

Kitamoto A, Kitamoto T, Nakamura T, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Hotta K

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  23 ( 3 ) 309 - 19   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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<b><i>Aim</i></b><b>: </b>Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (<i>CDH13</i>) gene that are associated with adiponectin levels.<br><b><i>Methods</i></b><b>: </b>We investigated whether single nucleotide polymorphisms (SNPs) in <i>CDH13</i> was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals.<br><b><i>Results</i></b><b>:</b> We found that three <i>CDH13</i> SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (<i>P</i>＜1×10 ^－14), even after adjustment for VFA. However, these adiponectin-inducing alleles of <i>CDH13</i> SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment–insulin resistance (HOMA-IR) scores, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels.<br><b><i>Conclusion</i></b><b>: </b>These results suggested that <i>CDH13</i> SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

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CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass

Aya Kitamoto, Takuya Kitamoto, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ikuo Mineo, Jun Wada, Yuji Ogawa, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kikuko Hotta

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS ( JAPAN ATHEROSCLEROSIS SOC )  23 ( 3 ) 309 - 319   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Aim: Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (CDH13) gene that are associated with adiponectin levels. Methods: We investigated whether single nucleotide polymorphisms (SNPs) in CDH13 was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals. Results: We found that three CDH13 SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (P &lt; 1 x 10(-14)), even after adjustment for VFA. However, these adiponectin-inducing alleles of CDH13 SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment-insulin resistance (HOMA-IR) scores, and triglycerides and lower highdensity lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels. Conclusion: These results suggested that CDH13 SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma: Insight into Autoinflammatory Diseases.

Morichika K, Tomoyose T, Hanashiro T, Shimabukuro N, Tamaki K, Tedokon I, Nishi Y, Nakachi S, Karube KN, Fukushima T, Katoh T, Ohshima K, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 10 ) 1345 - 9   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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Adult T cell leukemia / lymphoma (ATL) is one of the most aggressive hematological malignancies caused by human T-lymphotropic virus type-I (HTLV-1). Mogamulizumab is a new defucosylated humanized monoclonal antibody agent which targets C-C chemokine receptor type 4 (CCR4) expressed occasionally on the surface of ATL cells. However, adverse events such as drug eruptions have also been highlighted, at least in part, via the dysfunction of regulatory T cells (Tregs). We herein report a pronounced recurrence of systemic psoriasis vulgaris accompanied by the treatment of mogamulizumab in a patient with ATL. Pathological examinations may suggest a mechanistic link between the recurrence of autoinflammatory diseases and anti-CCR4 antibody therapies.<br>

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Thromboembolism Supervened on Eosinophilia Induced by Mycoplasma Pneumonia.

Morichika K, Nakachi S, Tomoyose T, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 18 ) 2741 - 2   2016 [ Peer Review Accepted ]

Type of publication: Research paper (scientific journal)

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