論文 - 益崎　裕章

Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models.

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube KN, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant immunology ( Transplant Immunology )  55   101205 - 101205   2019年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potential of adipose tissue-derived mesenchymal stem cells (AD-MSCs) in controlling GVHD in murine models with a special focus on bone marrow aplasia related with acute GVHD. The CB6F1 mice were induced GVHD by the injection intravenously of C57BL/6 (B6-Ly-5.1) splenocytes without conditioning irradiation or chemotherapy. AD-MSCs from C3H mice were injected intravenously via tail veins. GVHD was assessed using flowcytometry analysis of peripheral blood cells and histopathologic analysis of target organs. Histopathological analyses revealed that AD-MSCs markedly suppressed the infiltration of lymphocytes into liver as well as the aplasia in bone marrow. This study is the first to clarify the effectiveness of AD-MSCs against bone marrow aplasia in GVHD, supporting a rationale of AD-MSCs for ameliorating bone marrow suppression and infectivity after allo-HSCT in human clinics.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly-sensitive assay

Hokama N, Shirakura T, Sunagawa S, Morishima S, Nakachi S, Nishi Y, Murayama Y, Matsui C, Hase N, Tamura M, Okamoto S, Shimabukuro M, Nakamura K, Masuzaki H

Hematological Oncology   37 ( 4 ) 527 - 530   2019年08月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women.

Murakami N, Kitajima M, Ohyama K, Aibara N, Taniguchi K, Wei M, Kitajima Y, Miura K, Masuzaki H

Clinica chimica acta; international journal of clinical chemistry   495   545 - 551   2019年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma: Possible role of STAT3 phosphorylation in clinical subtype, progression, and prognosis

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer Sci   110 ( 9 ) 2982 - 2991   2019年07月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Validation of a novel digital health monitoring system to measure the volume of voided urine.

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourology and urodynamics ( Neurourology and Urodynamics )  38 ( 4 ) 1106 - 1110   2019年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

AIM: To validate a novel digital health monitoring system to measure the volume of voided urine. METHODS: Micturition volume was calculated using our novel digital self-health monitoring system of urine excretion (s-HMSU) in 18 participants (16 women and 2 men; average age, 40.8 years), without a history of voiding symptoms. Participants completed a self-reported questionnaire regarding their medical history and water intake during the period of observation, as well as the Core Lower Urinary Tract Symptom Score (CLSS) questionnaire. To assess the reliability of the voided volumes measured using the s-HMSU, the intraclass correlation coefficient (ICC) was calculated between the volume and the change in body weight before and after micturition. RESULTS: The CLSS questionnaire confirmed the absence of urinary system diseases in all participants. The medical history was also negative with the exception of hypertension in one participant. The ICC (1,1) between the measured volume of urine excretion using the s-HMSU and the change in body weight was 0.972 (95% confidence interval, 0.957-0.982). CONCLUSIONS: The s-HMSU system provides a reliable measure of voiding volume and is appropriate for home use. It has the potential to facilitate large-scale clinical research to examine the relationship between medical diseases and voiding dysfunction.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models

Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube K, Fukushima T, Morishima S, Kishimoto H, Masuzaki H

Transplant Immunology   55   101205   2019年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

久米島デジタルヘルスプロジェクトにおけるトイレ後付け型自動排尿モニタリングシステムの検証

宮里 実, 米本 孝二, 芦刈 明日香, 山城 清人, 上原 盛幸, 益崎 裕章, 石田 肇, 松下 正之, 斎藤 誠一

日本泌尿器科学会総会 ( (一社)日本泌尿器科学会総会事務局 )  107回   PP2 - 351   2019年04月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

日本国内における耐糖能の地域性 沖縄県,長野県,徳島県,福島県での比較

下地 桐子, 齋藤 悠, 五十嵐 彩華, 田辺 隼人, 鴻野 央征, 金成 文平, 岩崎 麻里子, 待井 典剛, 工藤 明宏, 比嘉 盛丈, 長谷川 吉正, 佐田 政隆, 益崎 裕章, 島袋 充生

糖尿病 ( (一社)日本糖尿病学会 )  62 ( Suppl.1 ) S - 317   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

玄米由来生理活性物質を活用した高脂肪食肥満・糖尿病予防

小塚 智沙代, 井上 梓, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 1 ) 317 - 317   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

肥満症患者に対する減量入院治療後の腸内フローラ・発酵代謝産物の解析

難波 豊隆, 上間 次己, 岡本 士毅, 照屋 理子, 本間 健一郎, 屋比久 賢光, 照屋 太輝, 國場 司, 仲村 武裕, 中山 良朗, 砂川 澄人, 池間 朋己, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  62 ( Suppl.1 ) S - 260   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

ストレス・情動応答を介する生体の恒常性維持 ストレス後の食嗜好性変化を制御する恒常性維持機構 ストレス後に甘いものが欲しくなる脳内メカニズムに迫る

岡本 士毅, 與那嶺 正人, 箕越 靖彦, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 1 ) 224 - 224   2019年04月

掲載種別: 研究論文（その他学術会議資料等）

特集 肥満と消化器 4 .肥満の治療(1) 食事・運動療法-メタボリック症候群の治療を目的とした肥満解消の食事療法・運動療法

山崎 聡, 尾形 絵美, 益崎 裕章

臨床消化器内科 ( 日本メディカルセンター )  34 ( 4 ) 431 - 436   2019年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  CiNii Research

Validation of a novel digital health monitoring system to measure the volume of voided urine

Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M

Neurourol Urodyn   38 ( 4 ) 1106 - 1110   2019年03月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Levels of Adiponectin Expression in Peri-Renal and Subcutaneous Adipose Tissue and Its Determinants in Human Biopsied Samples.

Maimaituxun G, Fukuda D, Izaki H, Hirata Y, Kanayama HO, Masuzaki H, Sata M, Shimabukuro M

Frontiers in endocrinology ( Frontiers in Endocrinology )  10   897 - 897   2019年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: The interactions of adipose tissue with the kidney are hypothesized to affect kidney function. Also, excessive peri-renal fat may increase the risk of cardiometabolic risk. However, the role(s) of peri-renal fat adipocytokine has never been evaluated. Objectives: To elucidate levels of adiponectin expression in peri-renal and subcutaneous adipose tissue and its determinants in human biopsied samples. Methods: A pair of subcutaneous and perirenal fat tissue samples were collected from 80 patients (men: 54; women: 26) who underwent urological operations. Subcutaneous adipose tissue (SAT) area, visceral adipose tissue (VAT) area and peri-renal adipose tissue (RAT) volume were quantified on abdominal computed tomography. Cytokine/adipocytokine expression was evaluated by real-time semi-quantitative polymerase chain reaction (qPCR). Probability was considered significant if P < 0.05. Results: Current study evaluated determinants of plasma adiponectin levels and expression levels of adiponectin in SAT and RAT in human samples. We found that: first, plasma adiponectin levels were correlated with VAT area but not with BMI, waist circumference, SAT area, and RAT volume; second, expression levels of adiponectin in SAT were correlated with BMI, waist circumference, and SAT area but not with VAT area and RAT volume; and third, expression levels of adiponectin in RAT were correlated with all adiposity indices including BMI, waist circumference, SAT area, VAT area, and RAT volume. Conclusion: This study evaluated levels of adiponectin expression in RAT and SAT and its determinants in patients who underwent urological operation. Levels of adiponectin mRNA in RAT were negatively correlated with remote fat mass in SAT and VAT and also with local fat mass in RAT, while level of adiponectin in SAT was not correlated with RAT volume. Further studies are warranted to evaluate roles of peri-renal fat mass accumulation and its pathophysiological machineries.

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed

Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Maemoto H, Ariga T, Kusada T, Heianna J, Manabe Y, Miyakawa A, Nakachi S, Morishima S, Iraha S, Ganaha F, Masuzaki H, Murayama S

Japanese journal of clinical oncology ( Japanese Journal of Clinical Oncology )  49 ( 2 ) 153 - 159   2019年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed CiNii Research

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma.

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama S

Journal of radiation research ( Journal of Radiation Research )  60 ( 1 ) 98 - 108   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed CiNii Research

Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 94 - 103   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed CiNii Research

Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans.

Masuzaki H, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 18 - 25   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

• この論文にアクセスする

  DOI
• 関連情報を調べる
  PubMed CiNii Research

Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

J Diabetes Investig   10 ( 1 ) 94 - 103   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Brown rice-specific -oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans

Masuzaki H (senior, corresponding author, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

J Diabetes Investig   10 ( 1 ) 18 - 25   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）