論文 - 益崎　裕章

Transplant-related complications are impediments to the success of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia patients in non-complete remission.

Tomori S, Morishima S, Nishi Y, Nakachi S, Tamaki K, Morichika K, Tedokon I, Shimabukuro N, Hanashiro T, Kitamura S, Uchibori S, Miyagi R, Miyagi T, Karimata K, Ohama M, Yamanoha A, Tomoyose T, Karube K, Fukushima T, Masuzaki H

Bone marrow transplantation ( Bone Marrow Transplantation )  55 ( 1 ) 233 - 241   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for patients with adult T cell leukemia/lymphoma (ATL) are not satisfactory, particularly in patients in non-complete remission at transplantation (Pt-non-CR). We conducted a regional retrospective study in the ATL endemic area of Okinawa, Japan. Of 62 ATL patients, 21 received allo-HSCT in CR and 41 in non-CR. The 3-year overall survival (3yOS) rate and median survival time for the whole cohort was 25.6% and 7.7 months, respectively. The 3yOS of Pt-non-CR was significantly lower than that of patients in CR (Pt-CR) (16.8% vs. 43.6%, P = 0.005). Transplant-related mortality (TRM) was significantly higher in Pt-non-CR than in Pt-CR (46.3% vs. 15.7%, P = 0.025), while there was no significant difference in disease-associated mortality (DAM) between Pt-non-CR and Pt-CR. Multivariable analysis for Pt-non-CR revealed that poor performance status (poor-PS) and higher sIL-2R level (high sIL-2R) adversely affected OS. Poor-PS was associated with higher TRM, but not with higher DAM in Pt-non-CR. High sIL-2R did not affect TRM or DAM in Pt-non-CR. Overall, high TRM rates rather than DAM contribute to the poor outcomes of Pt-non-CR, suggesting that not only disease control but also management of transplant-related complications is required for allo-HSCT in ATL patients.

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Impaired early-phase suppression of glucagon secretion after glucose load is associated with insulin requirement during pregnancy in gestational diabetes.

Horie I, Haraguchi A, Ito A, Nozaki A, Natsuda S, Akazawa S, Mori Y, Ando T, Higashijima A, Hasegawa Y, Yoshida A, Miura K, Masuzaki H, Kawakami A, Abiru N

Journal of diabetes investigation   11 ( 1 ) 232 - 240   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Significance of p53-Binding Protein 1 Nuclear Foci in Cervical Squamous Intraepithelial Lesions: Association With High-Risk Human Papillomavirus Infection and P16(INK4a) Expression.

Kawashita S, Matsuda K, Kondo H, Kitajima Y, Hasegawa Y, Shimada T, Kitajima M, Miura K, Nakashima M, Masuzaki H

Cancer control : journal of the Moffitt Cancer Center   27 ( 1 ) 1073274819901170   2020年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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ペムブロリズマブ投与後に視床下部性のACTH単独欠損症を発症した一例

屋比久 賢光, 中山 良朗, 玉城 敦子, 久高 将太, 本間 健一郎, 吉村 蘭, 長谷川 千穂, 山城 清人, 池間 朋己, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  95 ( 3 ) 1251 - 1251   2020年01月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

人生100年時代の健康長寿の展望と課題:～沖縄クライシスからのレッスン～

益崎 裕章

理学療法学Supplement ( 公益社団法人 日本理学療法士協会 )  47 ( 0 ) G - 10-G-10   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>　世界に冠たる健康長寿を誇ってきた沖縄県は現在，2型糖尿病や肥満症が蔓延し，65歳までに死亡する割合（早逝率）や糖尿病患者の血液透析導入率は全国トップレベルにあります。2017年の47都道府県平均寿命ランキングでは沖縄県の男性が36位，女性が7位にまで後退しており，この驚くべき現実を私達，琉球大学第二内科で"沖縄クライシス"と命名し，この10年間，その実態解明と啓発に取り組んできました。日本で最後の国立大学医学部として琉球大学医学部が新設された1980年当時の80歳台，90歳台の沖縄県民患者の解剖所見によると，大動脈や冠状動脈の粥状動脈硬化や石灰化が殆ど認められず，血管年齢の若々しさに病理医たちが驚嘆した様子が記録されています。戦後の沖縄県民の脂肪エネルギー摂取比率は常に全国平均よりも5%以上上回っており，動脈硬化症の温床となる肥満症，糖尿病，脂質異常症の蔓延と平均寿命ランキングの降下が見事な好対照をなしています。</p><p>　健康に良くないと理屈ではわかっていても食べ過ぎや運動不足から脱却できないのはなぜでしょう？ 私達は2型糖尿病や肥満症の発症基盤にある"脳機能の異常"に注目し，脳科学と分子栄養学を用いて食事・運動療法の実効性を高める行動変容の分子基盤の解明に取り組んでいます。動物性脂肪の過剰摂取は脳をハッキングし，自らが必要とするエネルギー量や栄養成分を判断できない脳に変えてしまいます。このメカニズムには食欲中枢である視床下部における小胞体ストレスの上昇や幸せや歓びを受け取る報酬系におけるゲノム修飾というイヴェントが深く関わっています（Diabetologia 2017, Diabetes 2012）。また，肥満や動物性脂肪の過剰摂取に伴う脂肪細胞ホルモン，レプチンの作用不全（レプチン抵抗性）は脳内報酬系のドパミン神経に発現するレプチン受容体シグナルを介して運動欲求を低下させ，体重が増えていくほど，運動する意欲が減退してしまい，ますます太りやすくなります。運動嫌いな患者さんの脳の中ではこのようなことが生じていると考えられます。</p><p>　本講演では運動や食事と生活習慣病との関わりをめぐる最新の医学エビデンスを御紹介し，効果的な行動変容を実現するための理学療法の重要性に言及したいと思います。</p>

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Chest Computed Tomography Abnormalities and Their Relationship to the Clinical Manifestation of Respiratory Syncytial Virus Infection in a Genetically Confirmed Outbreak.

Nabeya D, Kinjo T, Parrott GL, Nakachi S, Yamashiro T, Ikemiyagi N, Arakaki W, Masuzaki H, Fujita J

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  59 ( 2 ) 247 - 252   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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<p>Studies reporting chest images of respiratory syncytial virus (RSV)-induced lower respiratory tract infection (LRTI) in an outbreak setting and their relationship to the clinical manifestation are limited. During a genetically confirmed RSV outbreak, eight patients underwent both chest X-ray and computed tomography (CT). Among these, 5 cases had newly appearing abnormalities on CT, although chest X-ray was able to detect abnormalities in only 2 cases (40%). Although bronchial wall thickening was common, other findings and their distribution were variable, even in an outbreak setting. All patients with both a history of anticancer chemotherapy against hematological cancer and lower respiratory symptoms, such as wheezing, sputum, and hypoxemia, had abnormalities on CT, suggesting that these two factors might be important for predicting the existence of LRTI in RSV-infected patients. </p>

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Safety and efficacy of nanoparticulated brown rice germ extract on reduction of body fat mass and improvement of fuel metabolism in both pre-obese and mild obese subjects without excess of visceral fat accumulation.

Masuzaki Hiroaki, Fukuda Kotaro, Ogata Mika, Kinjo Ayano, Matsuo Takeru, Nishihira Jun

Glycative Stress Research ( 一般社団法人 糖化ストレス研究会 )  7 ( 1 ) 1 - 12   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Beneficial effects on obesity and dysmetabolism of a variety of functional ingredients contained in brown rice have attracted academic as well as clinical attention. On the other hand, it is noteworthy that the absorption efficiency of some of the functional ingredients derived from brown rice from the digestive tract is significantly low. Based on these backgrounds, we developed the “nanoparticulated brown rice germ extract” by encapsulating brown rice germ extract containing γ-oryzanol, one of the functional ingredients abundantly and specifically in brown rice (rice bran), in nanoparticles, and conducted safety and efficacy tests in humans. The present study was performed appropriately after the approval from the ethics committee of Hokkaido Information University. Japanese men and women whose BMI is 23 kg/m² or more and less than 25 kg/m², or 25 kg/m² or more and less than 30 kg/m², and whose visceral fat area is less than 100 cm² when measured by bioelectric-impedance methods were recruited for the study. We conducted a placebo-controlled, randomized, double-blind, parallel-group comparative study targeting approximately 78 people who met the eligible criteria, and examined metabolic improvements when the “nanoparticulated brown rice germ extract” tablets were ingested once-a-day continuously for 12 weeks. Although a decreasing trend was observed in the abdominal visceral fat area, which is a primary endpoint, there were no significant differences among the ingestion groups of test food (low dose group: 5 mg, and medium-dose group: 10 mg). Among the secondary endpoints, plasma LDL-cholesterol (LDL-C) level showed a marginally significant decrease in the medium and low dose (5 mg) groups compared to the control group (placebo ingestion) after 8 weeks of ingestion (p = 0.078, p = 0.098). The plasma lipid ratio (LDL-C/HDL-C) showed a significant decrease in the low dose group compared to the control group after 4 and 8 weeks of ingestion (p = 0.016, p = 0.018). The plasma non-HDL-C level showed a marginally significant or significant decrease in the medium and low dose groups compared to the control group after 8 weeks of ingestion (p = 0.099, p = 0.031). Blood level of HbA1c also showed a significant decrease in the medium-dose group compared to the control group after 4, 8, and 12 weeks of ingestion (p = 0.029, p = 0.011, p = 0.011). Furthermore, plasma level of adiponectin, which has potent anti-atherosclerotic actions, showed a marked increase in the high, medium, and low dose groups (p = 0.012, p = 0.039, p = 0.017) after 4 weeks of ingestion compared to the control group, and also showed a marginally significant or significant increase after 8 and 12 weeks of ingestion. During the hospital visit, problematic changes were not observed in blood pressure, pulse rate, general blood tests, liver and kidney functions, and urinalysis, and adverse events suggesting a causal relationship with the test food were not observed. This clinical intervention study confirmed the safety of ingestion of the “nanoparticulated brown rice germ extract”, which was also proven to improve the atherogenic lipid profile, reduce HbA1c level, and increase plasma adiponectin concentration. Results obtained tempt us to expect that nanoparticulated brown rice germ extract is well eligible for practical use.

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「他疾患に合併する高血圧：肥満症・メタボリックシンドローム特集：高血圧診療Update:高血圧治療ガイドライン2019で何が変わるのか？」

岡本 士毅, 益崎 裕章

内科   125   227 - 230   2020年

掲載種別: 研究論文（学術雑誌）

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「特集/心血管疾患の残余リスクとしてのキサンチンオキシダーゼ(XO) XOR, XOの尿酸代謝・酸化ストレス生成における役割と病態意義―血中のXO活性と血清尿酸値との関連性をめぐる最近の知見―」

益崎 裕章, 岡本 士毅

循環器内科   87   4 - 10   2020年

掲載種別: 研究論文（学術雑誌）

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「特集/新しい時代の高血圧診療　合併症を伴う高血圧症の治療　脂質異常症・肥満症・高尿酸血症」

岡本 士毅, 益崎 裕章

臨床と研究   97   72 - 77   2020年

掲載種別: 研究論文（学術雑誌）

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「特集　食と腸内環境γ-オリザノールの多彩な作用と腸内環境へのインパクト」

益崎 裕章, 岡本 士毅

アグリバイオ   3   20 - 25   2020年

掲載種別: 研究論文（学術雑誌）

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肥満外科手術後早期の減量効果に寄与する要因の探索

岡本 士毅, 益崎 裕章

肥満研究   26   254 - 262   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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肥満症に伴う認知機能障害ー脳科学基礎研究の動向

益崎 裕章, 岡本 士毅

肥満研究   26   238 - 244   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Deleterious Effects of Epicardial Adipose Tissue Volume on Global Longitudinal Strain in Patients With Preserved Left Ventricular Ejection Fraction.

Maimaituxun G, Kusunose K, Yamada H, Fukuda D, Yagi S, Torii Y, Yamada N, Soeki T, Masuzaki H, Sata M, Shimabukuro M

Frontiers in cardiovascular medicine ( Frontiers in Cardiovascular Medicine )  7   607825 - 607825   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Background: It is known that epicardial adipose tissue (EAT) volume is linked to cardiac dysfunction. However, it is unclear whether EAT volume (EATV) is closely linked to abnormal LV strain. We examined the relationship between EATV and global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in patients with preserved LV function. Methods: Notably, 180 consecutive subjects (68 ± 12 years; 53% men) underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into coronary artery disease (CAD) (≥1 coronary artery branch stenosis ≥50%) and non-CAD groups. GLS, GCS, and GRS were evaluated by 2-dimensional speckle tracking in patients with preserved left ventricular (LV) ejection fraction (LVEF) ≥50%. Results: First, GLS, but not GRS and GCS, was lower in the high EATV group though the LVEF was comparable to the low EATV group. Frequency of GLS ≤18 was higher in the high EATV group. Second, multiple regression model showed that EATV, age, male sex, and CAD, were determinants of GLS. Third, the cutoff points of EATV were comparable (~116-117 mL) in both groups. The cutoff of EATV ≥116 showed a significant correlation with GLS ≤18 in overall subjects. Conclusions: Increasing EATV was independently associated with global longitudinal strain despite the preserved LVEF and lacking obstructive CAD. Our findings suggest an additional role of EAT on myocardial systolic function by impaired LV longitudinal strain.

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AMH Concentrations in Peritoneal Fluids of Women With and Without Endometriosis.

Kitajima M, Matsumoto K, Murakami N, Kajimura I, Harada A, Kitajima Y, Masuzaki H, Miura K

Frontiers in surgery   7   600202   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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フローサイトメトリーを用いたATL患者由来腫瘍細胞におけるProgram Death Ligand 1とHuman Leukocyte Antigenの発現解析系の構築

座覇 理子, 森島 聡子, 西 由希子, 玉城 啓太, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  39 ( 1-4 ) 86 - 86   2020年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

末梢血メタボロームデータを活用したうつと肥満症・2型糖尿病の病態連関に関する臨床研究 久米島デジタルヘルスプロジェクトのコホート解析から

町田 香菜子, 山城 清人, 上間 次己, 岡本 士毅, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  39 ( 1-4 ) 83 - 83   2020年

掲載種別: 研究論文（その他学術会議資料等）

Huge uterine fibroid arising from primary uterine cervical diverticulum: a case report and review of the literatures.

Noguchi M, Kitajima M, Abe S, Murakami N, Kitajima Y, Miura K, Masuzaki H

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology   39 ( 8 ) 1186 - 1187   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Somatic Mutations and Loss of Heterozygosity of HLA Genes Are Frequently Occurred and Tightly Associated with Poor Prognosis in Adult T Cell Leukemia-Lymphoma

Tamaki, K; Morishima, S; Suzuki, S; Shigenari, A; Nomura, I; Yokota, Y; Morichika, K; Nishi, Y; Nakachi, S; Okamoto, S; Karube, K; Fukushima, T; Shiina, T; Masuzaki, H

BLOOD ( AMER SOC HEMATOLOGY )  134   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 冠動脈疾患のリスク管理のフロントライン Ⅱ.冠動脈疾患リスクファクターをどう管理する? 肥満の是正はどうする?

島袋 充生, 益崎 裕章

循環器ジャーナル ( 株式会社　医学書院 )  67 ( 4 ) 619 - 623   2019年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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