論文 - 益崎　裕章

玄米由来機能成分γ-オリザノールによるドパミン受容体シグナルを介するグルコース応答性インスリン分泌増強の新規メカニズム

小塚 智沙代, 砂川 澄人, 植田 玲, 比嘉 盛丈, 池間 朋己, 田仲 秀明, 清水 千草, 高山 千利, 松下 正之, 中田 正範, 矢田 俊彦, 親泊 政一, 島袋 充生, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  59 ( Suppl.1 ) S - 457   2016年04月

掲載種別: 研究論文（その他学術会議資料等）

Adult T-cell leukemia-lymphoma in a pregnant woman diagnosed as a human T-cell lymphotropic virus type 1 carrier.

Fuchi N, Miura K, Imaizumi Y, Hasegawa H, Yanagihara K, Miyazaki Y, Masuzaki H

The journal of obstetrics and gynaecology research   42 ( 3 ) 336 - 40   2016年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Novel molecular mechanisms of brown rice-derived bioactive substance on anti-obesity and anti-diabetic properties

Kozuka, C; Masuzaki, H

JOURNAL OF PHARMACOLOGICAL SCIENCES   130 ( 3 ) S69 - S69   2016年03月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.

Doi H, Kitajima Y, Luo L, Yan C, Tateishi S, Ono Y, Urata Y, Goto S, Mori R, Masuzaki H, Shimokawa I, Hirano A, Li TS

Scientific reports   6   18844   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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目指せ!肥満症のトータルケア-減量に苦戦する患者について考える 肥満症の疫学 日本における肥満症の現状と対策

河本 絵里子, 益崎 裕章

内科 ( 南江堂 )  117 ( 1 ) 11 - 14   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The Increased Ratio of 11β-Hydroxysteroid Dehydrogenase Type 1 versus Type 2 in Chronic Periodontitis Irrespective of Obesity

T. Nakata, A. Fujita, M. Umeda, H. Yoshida, K. Inami, H. Masuzaki, H. Sawai

SpringerPlus   5   40   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.

Akahoshi E, Arima K, Miura K, Nishimura T, Abe Y, Yamamoto N, Oishi K, Masuzaki H, Aoyagi K

Early human development   92   33 - 6   2016年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.

Kitamoto A, Kitamoto T, Nakamura T, Matsuo T, Nakata Y, Hyogo H, Ochi H, Kamohara S, Miyatake N, Kotani K, Mineo I, Wada J, Ogawa Y, Yoneda M, Nakajima A, Funahashi T, Miyazaki S, Tokunaga K, Masuzaki H, Ueno T, Chayama K, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Sakata T, Tanaka K, Matsuzawa Y, Hotta K

Journal of atherosclerosis and thrombosis ( 一般社団法人 日本動脈硬化学会 )  23 ( 3 ) 309 - 19   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<b><i>Aim</i></b><b>: </b>Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (<i>CDH13</i>) gene that are associated with adiponectin levels.<br><b><i>Methods</i></b><b>: </b>We investigated whether single nucleotide polymorphisms (SNPs) in <i>CDH13</i> was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals.<br><b><i>Results</i></b><b>:</b> We found that three <i>CDH13</i> SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (<i>P</i>＜1×10 ^－14), even after adjustment for VFA. However, these adiponectin-inducing alleles of <i>CDH13</i> SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment–insulin resistance (HOMA-IR) scores, and triglycerides and lower high-density lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels.<br><b><i>Conclusion</i></b><b>: </b>These results suggested that <i>CDH13</i> SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

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CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass

Aya Kitamoto, Takuya Kitamoto, Takahiro Nakamura, Tomoaki Matsuo, Yoshio Nakata, Hideyuki Hyogo, Hidenori Ochi, Seika Kamohara, Nobuyuki Miyatake, Kazuaki Kotani, Ikuo Mineo, Jun Wada, Yuji Ogawa, Masato Yoneda, Atsushi Nakajima, Tohru Funahashi, Shigeru Miyazaki, Katsuto Tokunaga, Hiroaki Masuzaki, Takato Ueno, Kazuaki Chayama, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa, Toshiie Sakata, Kiyoji Tanaka, Yuji Matsuzawa, Kikuko Hotta

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS ( JAPAN ATHEROSCLEROSIS SOC )  23 ( 3 ) 309 - 319   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Aim: Visceral fat accumulation contributes to the development of metabolic syndrome. As visceral fat accumulation increases, adiponectin levels decrease; therefore, adiponectin provides a link between visceral fat accumulation and metabolic disorders. Genome-wide association studies (GWASs) have identified genetic variations in the cadherin 13 (CDH13) gene that are associated with adiponectin levels. Methods: We investigated whether single nucleotide polymorphisms (SNPs) in CDH13 was associated with adiponectin levels and metabolic syndrome traits independent of the visceral fat area (VFA), as measured using computed tomography (CT) in 945 Japanese individuals. Results: We found that three CDH13 SNPs reported by recent GWASs (i.e., rs3865188, rs4783244, and rs12051272) were significantly associated with higher adiponectin levels (P &lt; 1 x 10(-14)), even after adjustment for VFA. However, these adiponectin-inducing alleles of CDH13 SNPs were significantly associated with traits consistent with deteriorating metabolic symptoms, such as higher fasting insulin, homeostasis model assessment-insulin resistance (HOMA-IR) scores, and triglycerides and lower highdensity lipoprotein (HDL)-cholesterol levels, similar to increasing VFA and decreasing adiponectin levels. Conclusion: These results suggested that CDH13 SNPs cause an adiponectin-resistant status to compensate for increasing adiponectin levels and could result in the deterioration of metabolic syndrome traits.

Recurrence of Psoriasis Vulgaris Accompanied by Treatment with C-C Chemokine Receptor Type 4 (CCR4) Antibody (Mogamulizumab) Therapies in a Patient with Adult T cell Leukemia/ Lymphoma: Insight into Autoinflammatory Diseases.

Morichika K, Tomoyose T, Hanashiro T, Shimabukuro N, Tamaki K, Tedokon I, Nishi Y, Nakachi S, Karube KN, Fukushima T, Katoh T, Ohshima K, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 10 ) 1345 - 9   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T cell leukemia / lymphoma (ATL) is one of the most aggressive hematological malignancies caused by human T-lymphotropic virus type-I (HTLV-1). Mogamulizumab is a new defucosylated humanized monoclonal antibody agent which targets C-C chemokine receptor type 4 (CCR4) expressed occasionally on the surface of ATL cells. However, adverse events such as drug eruptions have also been highlighted, at least in part, via the dysfunction of regulatory T cells (Tregs). We herein report a pronounced recurrence of systemic psoriasis vulgaris accompanied by the treatment of mogamulizumab in a patient with ATL. Pathological examinations may suggest a mechanistic link between the recurrence of autoinflammatory diseases and anti-CCR4 antibody therapies.<br>

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Thromboembolism Supervened on Eosinophilia Induced by Mycoplasma Pneumonia.

Morichika K, Nakachi S, Tomoyose T, Masuzaki H

Internal medicine (Tokyo, Japan) ( 一般社団法人 日本内科学会 )  55 ( 18 ) 2741 - 2   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity.

Nakata T, Fujita A, Umeda M, Yoshida H, Inami K, Masuzaki H, Sawai H

SpringerPlus ( SpringerPlus )  5 ( 1 ) 40 - 7   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Screening of Coronary Artery Disease in Diabetic Patients: Who and How? - Reply.

Shimabukuro M, Saito T, Masuzaki H, Sata M

Circulation journal : official journal of the Japanese Circulation Society ( 一般社団法人 日本循環器学会 )  80 ( 2 ) 544 - 544   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

<b><i>Background:</i></b>Patients with type 2 diabetes mellitus (T2DM) show a greater risk for coronary artery disease (CAD), but the risk stratification in asymptomatic CAD patients has not been established. This study investigated the prevalence and severity for asymptomatic CAD and predictors in T2DM patients.<b><i>Methods and Results:</i></b>In a multiclinic group, diabetic patients (320 men, 186 women) without known symptoms suggestive of CAD were recruited for multidetector computed tomography (MDCT). Patients were categorized according to severity of coronary atherosclerosis: Grade 1 (normal findings), Grade 2 (mild atherosclerosis without significant stenosis), Grade 3 (moderate stenosis/atherosclerosis, 50–74% stenosis), Grade 4 (moderate stenosis/atherosclerosis, 75–89% stenosis), Grade 5 (severe stenosis/atherosclerosis, ≥90% stenosis). The trend for severity grade of CAD was slightly higher in men than women (P=0.054). For critical lesions (combined Grades 3–5), the prevalence was almost equal (men 44% vs. women 37%; P=0.113). Multivariate models showed that in men, HbA_1c≥7.4%, dyslipidemia, duration of diabetes, retinopathy, and other type of cardiovascular diseases were predictors of critical lesions and in women, duration of diabetes and retinopathy were predictors.<b><i>Conclusions:</i></b>The prevalence and severity of asymptomatic CAD are comparably high in men and women with T2DM. Risk stratification by using MDCT might be useful to predict asymptomatic coronary lesions requiring coronary revascularization. (<i>Circ J</i> 2015; <b>79:</b> 2422–2429)

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Relevant Obstetric Factors for Cerebral Palsy: From the Nationwide Obstetric Compensation System in Japan.

Hasegawa J, Toyokawa S, Ikenoue T, Asano Y, Satoh S, Ikeda T, Ichizuka K, Tamiya N, Nakai A, Fujimori K, Maeda T, Masuzaki H, Suzuki H, Ueda S, Prevention Recurrence Committee, Japan Obstetric Compensation System for Cerebral Palsy

PloS one   11 ( 1 ) e0148122   2016年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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いま知っておきたい!　内科最新トピックス (第10章)代謝・栄養 肥満を科学し,臨床に活かす

益崎 裕章, 小塚 智沙代, 島袋 充生

内科 ( 南江堂 )  116 ( 6 ) 1198 - 1202   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Authors' reply re: Transverse uterine fundal incision for placenta praevia with accreta, involving the entire anterior uterine wall: a case series.

Nishijima K, Orisaka M, Takahashi J, Yamamoto M, Nakago S, Yoshida A, Masuzaki H, Kotsuji F, Yoshida Y

BJOG : an international journal of obstetrics and gynaecology   122 ( 13 ) 1844 - 5   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation.

Hasegawa Y, Miura K, Higashijima A, Abe S, Miura S, Yoshiura K, Masuzaki H

Reproductive sciences (Thousand Oaks, Calif.)   22 ( 12 ) 1569 - 76   2015年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab.

Tamaki K, Kinjo T, Aoyama H, Tomoyose T, Nakachi S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Taira N, Fujita J, Yoshimi N, Fukushima T, Masuzaki H

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ( Journal of Infection and Chemotherapy )  21 ( 11 ) 820 - 3   2015年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab

K. Tamaki, T. T. Kinjo, H. Aoyama, Tomoyose, S. Nakachi, T. Hanashiro, N. Shimabukuro, I. Todokon, K. Morichika, Y. Nishi, N. Taira, J. Fujita, N. Yoshimi, T.Fukushima, H. Masuzaki

J Infect Chemother   21 ( 11 ) 820 - 823   2015年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Circulating chromosome 19 miRNA cluster microRNAs in pregnant women with severe pre-eclampsia.

Miura K, Higashijima A, Murakami Y, Tsukamoto O, Hasegawa Y, Abe S, Fuchi N, Miura S, Kaneuchi M, Masuzaki H

The journal of obstetrics and gynaecology research   41 ( 10 ) 1526 - 32   2015年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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