論文 - 益崎　裕章

野菜摂取量が少ない20歳代、30歳代健康成人における腸内細菌叢解析と食事嗜好の関連性

上間 次己, 難波 豊隆, 池間 朋己, 知念 玲, 砂川 澄人, 中山 良朗, 仲村 英昭, 上原 盛幸, 與那嶺 正人, 仲村 武裕, 國場 司, 照屋 太輝, 本間 健一郎, 安澤 由香利, 岡本 士毅, 池松 智子, ミルマン・ジャスミン, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  61 ( Suppl.1 ) S - 314   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

中枢神経におけるインスリン抵抗性と糖代謝制御

益崎 裕章, 與那嶺 正人, 岡本 士毅, 田仲 秀明, 島袋 充生, 箕越 靖彦

糖尿病 ( (一社)日本糖尿病学会 )  61 ( Suppl.1 ) S - 117   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

視床下部室傍核に存在するCRHニューロン内のAMPK活性化が、炭水化物嗜好性の誘導において必要十分である

岡本 士毅, 益崎 裕章, 箕越 靖彦

日本臨床分子医学会学術総会プログラム・抄録集 ( 日本臨床分子医学会 )  55回   75 - 75   2018年04月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.

Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y

Cell reports ( Cell Reports )  22 ( 3 ) 706 - 721   2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Food selection is essential for metabolic homeostasis and is influenced by nutritional state, food palatability, and social factors such as stress. However, the mechanism responsible for selection between a high-carbohydrate diet (HCD) and a high-fat diet (HFD) remains unknown. Here, we show that activation of a subset of corticotropin-releasing hormone (CRH)-positive neurons in the rostral region of the paraventricular hypothalamus (PVH) induces selection of an HCD over an HFD in mice during refeeding after fasting, resulting in a rapid recovery from the change in ketone metabolism. These neurons manifest activation of AMP-activated protein kinase (AMPK) during food deprivation, and this activation is necessary and sufficient for selection of an HCD over an HFD. Furthermore, this effect is mediated by carnitine palmitoyltransferase 1c (CPT1c). Thus, our results identify the specific neurons and intracellular signaling pathway responsible for regulation of the complex behavior of selection between an HCD and an HFD. VIDEO ABSTRACT.

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Association between ovarian endometrioma and ovarian reserve.

Kitajima M, Khan KN, Harada A, Taniguchi K, Inoue T, Kaneuchi M, Miura K, Masuzaki H

Frontiers in bioscience (Elite edition)   10 ( 1 ) 92 - 102   2018年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Corrigendum: Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Fuchi N, Miura K, Doi H, Li TS, Masuzaki H

Scientific reports   7   46922   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Adrenal venous sampling in patients with primary aldosteronism: Which is the best evaluation method for laterality assessments?

Azama K, Okada M, Yogi A, Koga T, Iraha Y, Heianna J, Nakamura H, Masuzaki H, Murayama S

Open Journal of Radiology   7 ( 4 ) 219 - 227   2017年12月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

食欲・食嗜好の分子・神経基盤 視床下部AMPKは炭水化物嗜好性を制御する

岡本 士毅, 箕越 靖彦, 益崎 裕章

生命科学系学会合同年次大会 ( 生命科学系学会合同年次大会運営事務局 )  2017年度   [4AW08 - 5]   2017年12月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

Kozuka C, Shimizu-Okabe C, Takayama C, Nakano K, Morinaga H, Kinjo A, Fukuda K, Kamei A, Yasuoka A, Kondo T, Abe K, Egashira K, Masuzaki H

Drug delivery ( Drug Delivery )  24 ( 1 ) 558 - 568   2017年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Our previous works demonstrated that brown rice-specific bioactive substance, gamma-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)induced obese diabetic mice. However, extremely low absorption efficiency from intestine of gamma-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of gamma-oryzanol with super-high lipophilicity, we encapsulated gamma-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the bestknown severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude (similar to 1000-fold lower dose) compared with regular gamma-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward gamma-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

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特集 臓器炎症からみた糖尿病および糖尿病性合併症 脳における炎症と糖尿病

益崎 裕章, 岡本 士毅, 小塚 智沙代

糖尿病診療マスター ( 株式会社医学書院 )  15 ( 10 ) 825 - 830   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Clinical usefulness of FDG-PET/CT for the evaluation of various types of adult T-cell leukemia.

Nakachi S, Okada M, Morishima S, Agarie Y, Kitamura S, Uchibori S, Tomori S, Hanashiro T, Shimabukuro N, Tamaki K, Tedokon I, Morichika K, Nishi Y, Tomoyose T, Karube K, Fukushima T, Murayama S, Masuzaki H

Hematology (Amsterdam, Netherlands) ( TAYLOR & FRANCIS LTD )  22 ( 9 ) 536 - 543   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Purpose: The aim was to explore undefined useful indices for clinically grading adult T-cell leukemia (ATL) using [F-18] 2-fluoro-2-deoxyglucose (FDG) - positron emission tomography/computed tomography (PET/CT). Methods: A total of 28 patients with ATL (indolent, 9; aggressive, 19) were enrolled; all patients with aggressive ATL underwent FDG-PET/CT before chemotherapy. Patients with indolent ATL underwent FDG-PET/CT at the time of suspected disease progression and/or transformation; some received lymph node biopsy. The quantitative parameters maximum standardized uptake values (SUVmax), and mean and peak SUV, metabolic tumor volume (MTV), and volume-based total lesion glycolysis were calculated with the margin threshold as 25%, and 50% of the SUVmax for all lesions. Results: All parameters except for MTV-25% showed significant differences (P0.05) in differentiating the aggressive type from the indolent type of ATL. Areas under the curve for receiver-operating characteristic (ROC) analysis regarding the series of parameters investigated ranged from 0.75 to 0.92; this indicated relatively high accuracy in distinguishing the aggressive type from the indolent type. No malignant findings were detected in lymph node biopsies in indolent ATL patients with lymphadenopathy. Discussion: We performed evaluation of a line of parameters of FDG-PET, thereby demonstrating their significantly high accuracy for grading malignancy in ATL patients. In particular, low accumulation of FDG in indolent ATL patients with lymphadenopathy might predict that it is not a sign of disease transformation, but rather a reactive manifestation. Conclusion: FDG-PET/CT findings could be useful for clinically grading ATL.

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Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphom

Morichika K, Uchihara JN, Morishima S, Karube KN, Tanaka Y, Masuzaki H, Fukushima T

Leuk Res   61   18 - 24   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Increased expression of 11β-hydroxysteroid dehydrogenase type 1 in experimental periodontitis induced by lipopolysaccharide from Porphyromonas gingivalis

Fujita A, Nakata T, Umeda M, Masuzaki H, Sawai H

Open Journal of Stomatology   7 ( 10 ) 429 - 438   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma.

Sakihama S, Saito M, Kuba-Miyara M, Tomoyose T, Taira N, Miyagi T, Hayashi M, Kinjo S, Nakachi S, Tedokon I, Nishi Y, Tamaki K, Morichika K, Uchihara JN, Morishima S, Karube KN, Tanaka Y, Masuzaki H, Fukushima T

Leukemia research ( Leukemia Research )  61   18 - 24   2017年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Fetiform teratoma was a parthenogenetic tumor arising from a mature ovum.

Miura K, Kurabayashi T, Satoh C, Sasaki K, Ishiguro T, Yoshiura KI, Masuzaki H

Journal of human genetics   62 ( 9 ) 803 - 808   2017年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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食嗜好性を制御する脳内分子機構とその破綻 肥満症の病態解明を目指す新機軸 視床下部AMPKは炭水化物嗜好性を制御する

岡本 士毅, 箕越 靖彦, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  23 ( Suppl. ) 131 - 131   2017年09月

掲載種別: 研究論文（その他学術会議資料等）

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  J-GLOBAL

Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice.

Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H

Diabetologia ( Diabetologia )  60 ( 8 ) 1502 - 1511   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit.

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

Journal of medical virology ( Journal of Medical Virology )  89 ( 8 ) 1364 - 1372   2017年08月 [ 査読有り ]

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The clinical and phylogenetic investigation for a nosocomial outbreak of respiratory syncytial virus infection in an adult hemato-oncology unit

Nabeya D, Kinjo T, Parrott GL, Uehara A, Motooka D, Nakamura S, Nahar S, Nakachi S, Nakamatsu M, Maeshiro S, Haranaga S, Tateyama M, Tomoyose T, Masuzaki H, Horii T, Fujita J

J Med Virol   89 ( 8 ) 1364 - 1372   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Impact of Brown Rice-Specific -Oryzanol on Epigenetic Modulation of Dopamine D2 Receptor in Brain Striatum of High Fat Diet-Induced Obese Mice

Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H

Diabetologia   60 ( 8 ) 1502 - 1511   2017年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）