論文 - 益崎　裕章

Safety and efficacy of nanoparticulated brown rice germ extract on reduction of body fat mass and improvement of fuel metabolism in both pre-obese and mild obese subjects without excess of visceral fat accumulation.

Masuzaki Hiroaki, Fukuda Kotaro, Ogata Mika, Kinjo Ayano, Matsuo Takeru, Nishihira Jun

Glycative Stress Research ( 一般社団法人 糖化ストレス研究会 )  7 ( 1 ) 1 - 12   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Beneficial effects on obesity and dysmetabolism of a variety of functional ingredients contained in brown rice have attracted academic as well as clinical attention. On the other hand, it is noteworthy that the absorption efficiency of some of the functional ingredients derived from brown rice from the digestive tract is significantly low. Based on these backgrounds, we developed the “nanoparticulated brown rice germ extract” by encapsulating brown rice germ extract containing γ-oryzanol, one of the functional ingredients abundantly and specifically in brown rice (rice bran), in nanoparticles, and conducted safety and efficacy tests in humans. The present study was performed appropriately after the approval from the ethics committee of Hokkaido Information University. Japanese men and women whose BMI is 23 kg/m² or more and less than 25 kg/m², or 25 kg/m² or more and less than 30 kg/m², and whose visceral fat area is less than 100 cm² when measured by bioelectric-impedance methods were recruited for the study. We conducted a placebo-controlled, randomized, double-blind, parallel-group comparative study targeting approximately 78 people who met the eligible criteria, and examined metabolic improvements when the “nanoparticulated brown rice germ extract” tablets were ingested once-a-day continuously for 12 weeks. Although a decreasing trend was observed in the abdominal visceral fat area, which is a primary endpoint, there were no significant differences among the ingestion groups of test food (low dose group: 5 mg, and medium-dose group: 10 mg). Among the secondary endpoints, plasma LDL-cholesterol (LDL-C) level showed a marginally significant decrease in the medium and low dose (5 mg) groups compared to the control group (placebo ingestion) after 8 weeks of ingestion (p = 0.078, p = 0.098). The plasma lipid ratio (LDL-C/HDL-C) showed a significant decrease in the low dose group compared to the control group after 4 and 8 weeks of ingestion (p = 0.016, p = 0.018). The plasma non-HDL-C level showed a marginally significant or significant decrease in the medium and low dose groups compared to the control group after 8 weeks of ingestion (p = 0.099, p = 0.031). Blood level of HbA1c also showed a significant decrease in the medium-dose group compared to the control group after 4, 8, and 12 weeks of ingestion (p = 0.029, p = 0.011, p = 0.011). Furthermore, plasma level of adiponectin, which has potent anti-atherosclerotic actions, showed a marked increase in the high, medium, and low dose groups (p = 0.012, p = 0.039, p = 0.017) after 4 weeks of ingestion compared to the control group, and also showed a marginally significant or significant increase after 8 and 12 weeks of ingestion. During the hospital visit, problematic changes were not observed in blood pressure, pulse rate, general blood tests, liver and kidney functions, and urinalysis, and adverse events suggesting a causal relationship with the test food were not observed. This clinical intervention study confirmed the safety of ingestion of the “nanoparticulated brown rice germ extract”, which was also proven to improve the atherogenic lipid profile, reduce HbA1c level, and increase plasma adiponectin concentration. Results obtained tempt us to expect that nanoparticulated brown rice germ extract is well eligible for practical use.

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肥満外科手術後早期の減量効果に寄与する要因の探索

岡本 士毅, 益崎 裕章

肥満研究   26   254 - 262   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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肥満症に伴う認知機能障害ー脳科学基礎研究の動向

益崎 裕章, 岡本 士毅

肥満研究   26   238 - 244   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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「特集　食と腸内環境γ-オリザノールの多彩な作用と腸内環境へのインパクト」

益崎 裕章, 岡本 士毅

アグリバイオ   3   20 - 25   2020年

掲載種別: 研究論文（学術雑誌）

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「他疾患に合併する高血圧：肥満症・メタボリックシンドローム特集：高血圧診療Update:高血圧治療ガイドライン2019で何が変わるのか？」

岡本 士毅, 益崎 裕章

内科   125   227 - 230   2020年

掲載種別: 研究論文（学術雑誌）

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「特集/心血管疾患の残余リスクとしてのキサンチンオキシダーゼ(XO) XOR, XOの尿酸代謝・酸化ストレス生成における役割と病態意義―血中のXO活性と血清尿酸値との関連性をめぐる最近の知見―」

益崎 裕章, 岡本 士毅

循環器内科   87   4 - 10   2020年

掲載種別: 研究論文（学術雑誌）

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「特集/新しい時代の高血圧診療　合併症を伴う高血圧症の治療　脂質異常症・肥満症・高尿酸血症」

岡本 士毅, 益崎 裕章

臨床と研究   97   72 - 77   2020年

掲載種別: 研究論文（学術雑誌）

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Deleterious Effects of Epicardial Adipose Tissue Volume on Global Longitudinal Strain in Patients With Preserved Left Ventricular Ejection Fraction.

Maimaituxun G, Kusunose K, Yamada H, Fukuda D, Yagi S, Torii Y, Yamada N, Soeki T, Masuzaki H, Sata M, Shimabukuro M

Frontiers in cardiovascular medicine ( Frontiers in Cardiovascular Medicine )  7   607825 - 607825   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Background: It is known that epicardial adipose tissue (EAT) volume is linked to cardiac dysfunction. However, it is unclear whether EAT volume (EATV) is closely linked to abnormal LV strain. We examined the relationship between EATV and global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) in patients with preserved LV function. Methods: Notably, 180 consecutive subjects (68 ± 12 years; 53% men) underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into coronary artery disease (CAD) (≥1 coronary artery branch stenosis ≥50%) and non-CAD groups. GLS, GCS, and GRS were evaluated by 2-dimensional speckle tracking in patients with preserved left ventricular (LV) ejection fraction (LVEF) ≥50%. Results: First, GLS, but not GRS and GCS, was lower in the high EATV group though the LVEF was comparable to the low EATV group. Frequency of GLS ≤18 was higher in the high EATV group. Second, multiple regression model showed that EATV, age, male sex, and CAD, were determinants of GLS. Third, the cutoff points of EATV were comparable (~116-117 mL) in both groups. The cutoff of EATV ≥116 showed a significant correlation with GLS ≤18 in overall subjects. Conclusions: Increasing EATV was independently associated with global longitudinal strain despite the preserved LVEF and lacking obstructive CAD. Our findings suggest an additional role of EAT on myocardial systolic function by impaired LV longitudinal strain.

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AMH Concentrations in Peritoneal Fluids of Women With and Without Endometriosis.

Kitajima M, Matsumoto K, Murakami N, Kajimura I, Harada A, Kitajima Y, Masuzaki H, Miura K

Frontiers in surgery   7   600202   2020年 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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フローサイトメトリーを用いたATL患者由来腫瘍細胞におけるProgram Death Ligand 1とHuman Leukocyte Antigenの発現解析系の構築

座覇 理子, 森島 聡子, 西 由希子, 玉城 啓太, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  39 ( 1-4 ) 86 - 86   2020年 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

末梢血メタボロームデータを活用したうつと肥満症・2型糖尿病の病態連関に関する臨床研究 久米島デジタルヘルスプロジェクトのコホート解析から

町田 香菜子, 山城 清人, 上間 次己, 岡本 士毅, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  39 ( 1-4 ) 83 - 83   2020年

掲載種別: 研究論文（その他学術会議資料等）

Huge uterine fibroid arising from primary uterine cervical diverticulum: a case report and review of the literatures.

Noguchi M, Kitajima M, Abe S, Murakami N, Kitajima Y, Miura K, Masuzaki H

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology   39 ( 8 ) 1186 - 1187   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Somatic Mutations and Loss of Heterozygosity of HLA Genes Are Frequently Occurred and Tightly Associated with Poor Prognosis in Adult T Cell Leukemia-Lymphoma

Tamaki, K; Morishima, S; Suzuki, S; Shigenari, A; Nomura, I; Yokota, Y; Morichika, K; Nishi, Y; Nakachi, S; Okamoto, S; Karube, K; Fukushima, T; Shiina, T; Masuzaki, H

BLOOD ( AMER SOC HEMATOLOGY )  134   2019年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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0

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特集 冠動脈疾患のリスク管理のフロントライン Ⅱ.冠動脈疾患リスクファクターをどう管理する? 肥満の是正はどうする?

島袋 充生, 益崎 裕章

循環器ジャーナル ( 株式会社　医学書院 )  67 ( 4 ) 619 - 623   2019年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay.

Hokama N, Shirakura T, Sunagawa S, Morishima S, Nakachi S, Nishi Y, Murayama Y, Matsui C, Hase N, Tamura M, Okamoto S, Shimabukuro M, Nakamura K, Masuzaki H

Hematological oncology ( Hematological Oncology )  37 ( 4 ) 527 - 530   2019年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Extra virgin oliveおよび亜麻仁油は腸内細菌叢を調節しマウス粘膜および代謝の正常化を促す(Extra virgin olive and flaxseed oil modulate gut microbiota, enhancing mucosal & metabolic health in mice)

Frances Millman Jasmine, 岡本 士毅, 山崎 聡, 上間 次己, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 260 - 260   2019年10月

掲載種別: 研究論文（その他学術会議資料等）

沖縄県在住の若年健康成人における腸内フローラのバランスと食嗜好性との関連性

上間 次己, Frances Millman Jasmine, 岡本 士毅, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 281 - 281   2019年10月

掲載種別: 研究論文（その他学術会議資料等）

術後3ヵ月における肥満外科治療の効果と減量に関連する要因

久場 美鈴, 岡本 士毅, 上間 次己, 安里 恵美子, 加島 ひとみ, 仲地 佐和子, 難波 豊隆, 稲嶺 進, 山崎 聡, 益崎 裕章

肥満研究 ( (一社)日本肥満学会 )  25 ( Suppl. ) 255 - 255   2019年10月

掲載種別: 研究論文（その他学術会議資料等）

Phosphorylated STAT3 expression predicts better prognosis in smoldering type of adult T-cell leukemia/lymphoma.

Morichika K, Karube K, Kayo H, Uchino S, Nishi Y, Nakachi S, Okamoto S, Morishima S, Ohshiro K, Nakazato I, Fukushima T, Masuzaki H

Cancer science ( Cancer Science )  110 ( 9 ) 2982 - 2991   2019年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm, and is divided into 2 indolent (smoldering and chronic) and 2 aggressive (acute and lymphoma) clinical subtypes. Based on previous integrated molecular analyses suggesting the importance of the JAK-STAT pathway in ATLL, we attempted to clarify the clinicopathological significance of this pathway. Clinical and morphological findings were reviewed in 116 cases with ATLL. The nuclear localizations of phosphorylated STAT3 (pSTAT3), pSTAT5, and pSTAT6 were analyzed by immunohistochemistry. Targeted sequencing was undertaken on the portion of STAT3 encoding the Src homology 2 domain. Expression of pSTAT3 was observed in 43% (50/116) of ATLL cases, whereas pSTAT5 and pSTAT6 were largely undetected. Cases with the lymphoma type showed significantly less frequent pSTAT3 expression (8/45, 18%) than those with the other subtypes (41/66, 62%; P < .001). STAT3 mutations were detected in 36% (10/28) and 19% (12/64) of cases with the smoldering and aggressive types of ATLL, respectively. The correlation between STAT3 mutation and pSTAT3 expression was not significant (P = .07). Both univariate and multivariate analysis revealed that pSTAT3 expression was significantly associated with better overall survival and progression-free survival in the smoldering type of ATLL, whereas STAT3 mutation was not related to a line of clinical outcome. Collectively, our data show that only the lymphoma type showed a low prevalence of tumor cells positive for pSTAT3 expression, and raises the possibility that pSTAT3 expression is a novel biomarker to predict better prognosis in the smoldering type of ATLL.

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高齢者糖尿病における糖尿病性網膜症の発症及び悪化要因に関する臨床疫学的後方視解析

新里 幸子, 中山 良朗, 比嘉 盛丈, 新垣 孝一郎, 島袋 充生, 古泉 英貴, 益崎 裕章

糖尿病 ( (一社)日本糖尿病学会 )  62 ( 9 ) 611 - 611   2019年09月

掲載種別: 研究論文（その他学術会議資料等）