論文 - 益崎　裕章

The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats

Nakata T, Umeda M, Masuzaki H, Sawai H

BMC Oral Health   16 ( 1 ) 108   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.

Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K

Journal of human genetics   61 ( 10 ) 879 - 884   2016年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Long-term effect of sitagliptin on endothelial function in type 2 diabetes: A sub-analysis of the PROLOGUE study

Maruhashi T.

Cardiovascular Diabetology ( Cardiovascular Diabetology )  15 ( 1 )   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction: a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe.

Shimabukuro M, Okawa C, Yamada H, Yanagi S, Uematsu E, Sugasawa N, Kurobe H, Hirata Y, Kim-Kaneyama JR, Lei XF, Takao S, Tanaka Y, Fukuda D, Yagi S, Soeki T, Kitagawa T, Masuzaki H, Sato M, Sata M

The Journal of nutritional biochemistry ( ELSEVIER SCIENCE INC )  35   66 - 73   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Oxidized cholesterols (oxycholesterols) in food have been recognized as strong atherogenic components, but their tissue distributions and roles in cardiovascular diseases remain unclear. To investigate whether accumulation of oxycholesterols is linked to cardiac morphology and function, and whether reduction of oxycholesterols can improve cardiac performance, domestic male swine were randomized to a control diet (C), high caloric diet (HCD) or HCD + Ezetimibe, an inhibitor of intestinal cholesterol absorption, group (HCD + E) and evaluated for: (1) distribution of oxycholesterol components in serum and tissues, (2) levels of oxycholesterol-related enzymes, (3) paracardial and epicardial coronary fat thickness, and (4) cardiac performance. Ezetimibe treatment for 8 weeks attenuated increases in oxycholesterols in the HCD group almost completely in liver, but reduced only levels of 4 beta-hydroxycholesterol in left ventricular (LV) myocardium. Ezetimibe treatment altered the expression of genes for cholesterol and fatty acid metabolism and decreased the expression of CYP3A46, which catabolizes cholesterol to 4 beta-hydroxycholesterol, strongly in liver. An increase in epicardial fat thickness and impaired cardiac performance in the HCD group were improved by ezetimibe treatment, and the improvement was closely related to the reduction in levels of 413-hydroxycholesterol in LV myocardium. In conclusion, an increase in oxycholesterols in the HCD group was closely related to cardiac hypertrophy and dysfunction, as well as an increase in epicardial fat thickness. Ezetimibe may directly reduce oxycholesterol in liver and LV myocardium, and improve cardiac morphology and function. (C) 2016 Elsevier Inc. All rights reserved.

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A significant association between rs8067378 at 17q12 and invasive cervical cancer originally identified by a genome-wide association study in Han Chinese is replicated in a Japanese population.

Miura K, Mishima H, Yasunami M, Kaneuchi M, Kitajima M, Abe S, Higashijima A, Fuchi N, Miura S, Yoshiura K, Masuzaki H

Journal of human genetics   61 ( 9 ) 793 - 6   2016年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Adipocyte size distribution and depot-specific modulation of pro- and anti-atherosclerotic adipocytokines and innate immune molecules in human adipose tissue

Shimabukuro, M; Sato, H; Izaki, H; Fukuda, D; Uematsu, E; Hirata, Y; Yagi, S; Soeki, T; Sakaue, H; Kanayama, H; Masuzaki, H; Sata, M

EUROPEAN HEART JOURNAL   37   183 - 183   2016年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats.

Shirakura T, Nomura J, Matsui C, Kobayashi T, Tamura M, Masuzaki H

Naunyn-Schmiedeberg's archives of pharmacology ( SPRINGER )  389 ( 8 ) 831 - 8   2016年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO produces considerable amount of oxidative stress throughout the body. To date, however, its pathophysiologic role in hypertension and endothelial dysfunction still remains controversial. To explore the possible involvement of XO-derived oxidative stress in the pathophysiology of vascular dysfunction, by use of a selective XO inhibitor, febuxostat, we investigated the impact of pharmacological inhibition of XO on hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats (SHRs). Sixteen-week-old SHR and normotensive Wistar-Kyoto (WKY) rats were treated with tap water (control) or water containing febuxostat (3 mg/kg/day) for 6 weeks. Systolic blood pressure (SBP) in febuxostat-treated SHR (220 +/- 3 mmHg) was significantly (P < 0.05) decreased compared with the control SHR (236 +/- 4 mmHg) while SBP in febuxostat-treated WKY was constant. Acetylcholine-induced endothelium-dependent relaxation in aortas from febuxostat-treated SHR was significantly (P < 0.05) improved compared with the control SHR, whereas relaxation in response to sodium nitroprusside was not changed. Vascular XO activity and tissue nitrotyrosine level, a representative indicator of local oxidative stress, were considerably elevated in the control SHR compared with the control WKY, and this increment was abolished by febuxostat. Our results suggest that exaggerated XO activity and resultant increase in oxidative stress in this experimental model contribute to the hypertension and endothelial dysfunction, thereby supporting a notion that pharmacological inhibition of XO is valuable not only for hyperuricemia but also for treating hypertension and related endothelial dysfunction in human clinics.

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Biological differences between functionalis and basalis endometria in women with and without adenomyosis.

Khan KN, Fujishita A, Kitajima M, Masuzaki H, Nakashima M, Kitawaki J

European journal of obstetrics, gynecology, and reproductive biology   203   49 - 55   2016年08月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Depot- and gender-specific expression of NLRP3 inflammasome and toll-like receptors in adipose tissue of cancer patients.

Shimabukuro M, Sato H, Izaki H, Fukuda D, Uematsu E, Hirata Y, Yagi S, Soeki T, Sakaue H, Kanayama HO, Masuzaki H, Sata M

BioFactors (Oxford, England) ( WILEY-BLACKWELL )  42 ( 4 ) 397 - 406   2016年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Gender difference in obesity-associated cardiovascular complication could be derived from divergent chronic inflammation. We evaluated depot- and gender-specific regulation of the innate immune system in human adipose tissues. Pair samples were obtained from subcutaneous (SAT) and visceral adipose tissue (VAT) during elective surgery (Male: 35; Female: 27). Expressions of pro- and anti-inflammatory adipocytokines were evaluated by semi-quantitative qPCR. Adipose cell-size distribution was obtained from tissue samples fixed in osmium tetroxide and analyzed by Beckman Coulter Multisizer. Levels of adiponectin were higher in SAT and VAT of female than those of male (P<0.001 and P=0.011, respectively). NLRP3, IL1-IL18, TLR2 were comparable in SAT and VAT between genders. However, TLR4 and TLR9 were increased in female SAT and VAT and HMGB1 in female VAT. Levels of adiponectin were not correlated with mean diameter of adipocyte (phi, m) in SAT and VAT of male, but negatively well correlated in those of female (r=-0.392 and r=-0.616). Such negative correlations were also observed between levels of TLR2, TLR4, and HMGB1 and phi in female. Levels of NLRP3 and IL1 were positively correlated with phi in male, but not in female. In conclusion, Innate signals were differentially expressed in male and female adipose tissues, suggesting that the depot- and gender-specific signals could be related to gender difference in chronic inflammation. (c) 2016 BioFactors, 42(4):397-406, 2016

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Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy.

Suzumori N, Ebara T, Yamada T, Samura O, Yotsumoto J, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Saldivar JS, Dharajiya N, Sago H, Sekizawa A, Japan NIPT Consortium

Journal of human genetics   61 ( 7 ) 647 - 52   2016年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Three-dimensional saline-infusion sonohysterography is useful for the identification of endometrial polyp.

Inoue T, Kitajima M, Taniguchi K, Masuzaki H

The journal of obstetrics and gynaecology research   42 ( 7 ) 855 - 9   2016年07月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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特集 食事療法Revisit 食べること-なぜ,適量で止まらないのか.なぜ,食べ物に対する依存が生じるのか

益崎 裕章

糖尿病診療マスター ( 株式会社医学書院 )  14 ( 6 ) 413 - 417   2016年06月 [ 査読有り ]

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Catecholamines Facilitate Fuel Expenditure and Protect Against Obesity via a Novel Network of the Gut-Brain Axis in Transcription Factor Skn-1-deficient Mice.

Ushiama S, Ishimaru Y, Narukawa M, Yoshioka M, Kozuka C, Watanabe N, Tsunoda M, Osakabe N, Asakura T, Masuzaki H, Abe K

EBioMedicine ( ELSEVIER SCIENCE BV )  8   60 - 71   2016年06月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis. This system is referred to as the gut-brain axis. Here we show that both brush cells and type II taste cells are eliminated in the gastrointestinal tract of transcription factor Skn-1 knockout (KO) mice. Despite unaltered food intake, Skn-1 KO mice have reduced body weight with lower body fat due to increased energy expenditure. In this model, 24-h urinary excretion of catecholamines was significantly elevated, accompanied by increased fatty acid beta-oxidation and fuel dissipation in skeletal muscle and impaired insulin secretion driven by glucose. These results suggest the existence of brain-mediated energy homeostatic pathways originating from brush cells and type II taste cells in the gastrointestinal tract and ending in peripheral tissues, including the adrenal glands. The discovery of food-derived factors that regulate these cells may open new avenues the treatment of obesity and diabetes. Research Context: Taste signals and nutrient stimuli sensed by the gastrointestinal tract are transmitted to the brain to regulate feeding behavior and energy homeostasis along the gut-brain axis. We propose the concept that taste-receiving cells in the oral cavity and/or food-borne chemicals-receiving brush cells in the gut are involved in regulation of the body weight and adiposity via the brain. The discovery of food-derived factors that regulate these cells may open new avenues for the treatment of obesity and diabetes. (C) 2016 The Authors. Published by Elsevier B.V.

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HLA抗体を有する急性骨髄性白血病患者の非血縁間同種造血幹細胞移植において計画的なHLA適合血小板輸血を行った1例

島袋 奈津紀, 花城 多恵子, 内堀 幸恵, 北村 紗希子, 友利 昌平, 玉城 啓太, 手登根 伊織, 森近 一穂, 西 由希子, 仲地 佐和子, 友寄 毅昭, 加留部 謙之輔, 福島 卓也, 益崎 裕章

日本輸血細胞治療学会誌 ( (一社)日本輸血・細胞治療学会 )  62 ( 3 ) 534 - 534   2016年06月

掲載種別: 研究論文（その他学術会議資料等）

Impact of individual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men.

Shimabukuro M, Higa N, Masuzaki H, Sata M, Ueda S

Cardiovascular diabetology ( Cardiovascular Diabetology )  15 ( 1 ) 77   2016年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Impact of indivisual metabolic risk components or its clustering on endothelial and smooth muscle cell function in men

M. Shimabukuro, N. Higa, H. Masuzaki, M. Sata, S. Ueda

Cardiovasc Diabetology   15   77   2016年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Recurrence of psoriasis vulgaris accompanied by the treatment with C-C chemokine receptor type 4 (CCR4) antibody (Mogamulizumab) therapies in a patient with adult T cell leukemia/ lymphoma: Insight into autoinflammatory syndrome

K. Morichika, T. Tomoyose, T. Hanashiro, N. Shimabukuro, K. Tamaki, I. Tedokon, Y. Nishi, T. S.Nakachi, K. Karube, T. Fukushima, H. Masuzaki

Intern Med   55 ( 10 ) 1345 - 1349   2016年05月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Influenza 2014-2015 among pregnant Japanese women: primiparous vs multiparous women.

Yamada T, Kawakami S, Yoshida Y, Kawamura H, Ohta S, Abe K, Hamada H, Dohi S, Ichizuka K, Takita H, Baba Y, Matsubara S, Mochizuki J, Unno N, Maegawa Y, Maeda M, Inubashiri E, Akutagawa N, Kubo T, Shirota T, Oda Y, Yamada T, Yamagishi E, Nakai A, Fuchi N, Masuzaki H, Urabe S, Kudo Y, Nomizo M, Sagawa N, Maeda T, Kamitomo M, Kawabata K, Kataoka S, Shiozaki A, Saito S, Sekizawa A, Minakami H

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology   35 ( 4 ) 665 - 71   2016年04月 [ 査読有り ]

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Survey of prenatal testing for genetic disorders in Japan: Recent report.

Nobuzane T, Yamada T, Miura K, Sawai H, Masuzaki H, Kudo Y

The journal of obstetrics and gynaecology research   42 ( 4 ) 375 - 9   2016年04月 [ 査読有り ]

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Molecular detection of intrauterine microbial colonization in women with endometriosis.

Khan KN, Fujishita A, Masumoto H, Muto H, Kitajima M, Masuzaki H, Kitawaki J

European journal of obstetrics, gynecology, and reproductive biology   199   69 - 75   2016年04月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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