論文 - 益崎　裕章

Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Maemoto H, Ariga T, Kusada T, Heianna J, Manabe Y, Miyakawa A, Nakachi S, Morishima S, Iraha S, Ganaha F, Masuzaki H, Murayama S

Japanese journal of clinical oncology ( Japanese Journal of Clinical Oncology )  49 ( 2 ) 153 - 159   2019年02月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

BACKGROUND: Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma. METHODS: We retrospectively reviewed 46 courses of radiotherapy administered to 15 consecutive patients with adult T-cell leukaemia/lymphoma (acute, n = 7; lymphoma, n = 7; smouldering, n = 1) who received mogamulizumab before or during radiotherapy at three institutions between 2012 and 2017. RESULTS: During 43 of the 46 radiotherapy courses, patients developed Grade ≤1 radiation-induced dermatitis. No patient developed Grade ≥3 radiation-induced dermatitis. No patient was prescribed ointments as prophylactic treatment for radiation-induced dermatitis. Development of radiation-induced dermatitis was not significantly associated with the number of days since the administration of mogamulizumab prior to radiotherapy (P = 0.85), frequency of administration of mogamulizumab before/during radiotherapy (P = 0.33), administration of mogamulizumab during radiotherapy (P = 0.41) or types of lesions in adult T-cell leukaemia/lymphoma cases (cutaneous vs. non-cutaneous, P = 0.74). Development of radiation-induced dermatitis was significantly related to the total cutaneous dose (mean, 31.9 Gy [95% confidence interval: 26.6-37.1 Gy] vs. 19.7 Gy [95% confidence interval: 16.2-23.2 Gy], P = 0.0004) and total prescribed dose (mean, 31.5 Gy [95% confidence interval: 26.2-36.8 Gy] vs. 18.5 Gy [95% confidence interval: 15.0-22.0 Gy], P = 0.0002). CONCLUSION: None of the 15 patients who received moderate-dose radiotherapy developed severe radiation-induced dermatitis during the 46 courses of radiotherapy after mogamulizumab administration.

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Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma.

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama S

Journal of radiation research ( Journal of Radiation Research )  60 ( 1 ) 98 - 108   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that occurs only in patients with human T-cell leukemia virus type 1. No large study or randomized trial investigating radiotherapy (RT) for ATL has been performed. We retrospectively reviewed 55 courses of RT for 41 consecutive patients with ATL who underwent RT between 2000 and 2016 at our institutions. The results showed that RT for local ATL lesions can achieve symptomatic improvement in 92% of cases. Local remission, either complete remission (CR) or partial response (PR), was achieved in 100% of the patients (CR: 89%, PR: 11%) with ≥40 Gy irradiation. CR or PR was achieved in 71% (CR: 29%, PR: 43%) with 30-39 Gy and in 73% (CR: 6.7%, PR: 67%) with ≤29 Gy irradiation. The mean total radiation dose in the CR and PR groups differed significantly (38 vs 25 Gy, P = 0.0002). The maximum acute toxicity was Grade 0-2 in all patients, except for one patient experienced Grade 3 radiation dermatitis. In-field relapses occurred in 36% of patients, and the frequency of in-field relapses was 11%, 30% and 71% among those who achieved CR, PR and SD, respectively. All 9 patients who received total skin irradiation experienced cutaneous relapses, with a median of 63 days (range, 7-210 days). Almost all (39 of 41) patients with ATL experienced out-of-field progression after RT. In conclusion, RT was confirmed to be effective and safe for palliative treatment of local ATL lesions.

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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study.

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 94 - 103   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans.

Masuzaki H, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

Journal of diabetes investigation ( Journal of Diabetes Investigation )  10 ( 1 ) 18 - 25   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study

Sunagawa S, Shirakura T, Hokama N, Kozuka C, Yonamine M, Namba T, Morishima S, Nakachi S, Nishi Y, Ikema T, Okamoto S, Matsui C, Hase N, Tamura M, Shimabukuro M, Masuzaki H

J Diabetes Investig   10 ( 1 ) 94 - 103   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Brown rice-specific -oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans

Masuzaki H (senior, corresponding author, Kozuka C, Okamoto S, Yonamine M, Tanaka H, Shimabukuro M

J Diabetes Investig   10 ( 1 ) 18 - 25   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lumphoma

Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama M

Journal of Radiation Research   60 ( 1 ) 98 - 108   2019年01月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT.

Suzumori N, Sekizawa A, Takeda E, Samura O, Sasaki A, Akaishi R, Wada S, Hamanoue H, Hirahara F, Kuriki H, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Yamashita T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Endo M, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Nagamatsu T, Watanabe A, Nishikawa N, Hamajima N, Shirato N, Yotsumoto J, Nishiyama M, Koide K, Hirose T, Sago H

Prenatal diagnosis   39 ( 2 ) 100 - 106   2019年01月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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メタボリックシンドロームと腸内細菌」

岡本 士毅, 益崎 裕章

カレントテラピー   37   65 - 70   2019年

掲載種別: 研究論文（学術雑誌）

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「健康長寿社会に求められる食と行動の科学」

益崎 裕章, 岡本 士毅

日本体質医学会雑誌   81   48 - 54   2019年

掲載種別: 研究論文（学術雑誌）

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「特集　代謝疾患と精神神経疾患の交点（サイコメタボリズム）「脳内炎症と過食・動物性脂肪依存」」

益崎 裕章, 岡本 士毅

Medical Science Digest   45   652 - 655   2019年

掲載種別: 研究論文（学術雑誌）

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「玄米機能成分を活用する脳機能改善～人生100年時代を生き抜く健康脳づくりのアプローチ～生物工学」

益崎 裕章, 岡本 士毅

日本生物工学会誌   97   14 - 17   2019年

掲載種別: 研究論文（学術雑誌）

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Adult T-cell leukemia/lymphoma(ATL)の悪性度と末梢血リンパ球におけるCell adhesion molecule 1(CADM1)発現との関連性

横田 雄太郎, 玉城 啓太, 野村 育美, 森島 聡子, 益崎 裕章

琉球医学会誌 ( 琉球医学会 )  37 ( 1-4 ) 132 - 132   2018年12月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

視床下部室傍核に存在するCRHニューロン内のAMPK活性化が、炭水化物嗜好性の誘導において必要十分である

岡本 士毅, 與那嶺 正人, 箕越 靖彦, 益崎 裕章

日本内分泌学会雑誌 ( (一社)日本内分泌学会 )  94 ( 4 ) 1558 - 1558   2018年12月

掲載種別: 研究論文（その他学術会議資料等）

Usefulness of Epicardial Adipose Tissue Volume to Predict Recurrent Atrial Fibrillation After Radiofrequency Catheter Ablation.

Maeda M, Oba K, Yamaguchi S, Arasaki O, Sata M, Masuzaki H, Shimabukuro M

The American journal of cardiology ( American Journal of Cardiology )  122 ( 10 ) 1694 - 1700   2018年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

　概要を見る

Although increasing evidence suggests that epicardial adipose tissue volume (EATV) is associated with post-ablation atrial fibrillation (AF), ranges of EATV predictive of post-ablation recurrence of AF remain unclear. In this study, we evaluated: (1) relationships between EATV and characteristics of AF, (2) impact of EATV on recurrent AF after radiofrequency ablation; , and (3) cut-off point for recurrent AF using a receiver operating characteristic curve. In 218 consecutive symptomatic patients undergoing who underwent ablation for AF (143 paroxysmal AF; 78 persistent AF), the EATV index (EATVI: EATV/body surface area, mL/m2) was measured using 320-row multidetector computed tomography. The high EATV group showed specific cardiometabolic derangements as well as left atrial dilatation and left ventricular dysfunction. Multivariate regression analysis showed that the EATVI was an independent predictor of recurrent AF after catheter ablation. High EATV (EATVI ≥ 85 mL/m2) or EATVI cutoff ≥116 mL/m2 can predict recurrent AF after catheter ablation, independent of other risk factors. In conclusion, EATVI was an independent predictor of recurrent AF after catheter ablation; a high EATV tertile or EATVI cutoff may be useful for prediction of recurrent AF after catheter ablation. Future studies should determine the utility of the EATVI in the clinical setting of AF ablation.

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Correction: Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan.

Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K

Journal of human genetics   63 ( 11 ) 1195   2018年11月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Minimal Shortening of Leukocyte Telomere Length Across Age Groups in a Cross-Sectional Study for Carriers of a Longevity-Associated FOXO3 Allele.

Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky RL, Morris BJ, Lim E, Allsopp RC, Willcox BJ

The journals of gerontology. Series A, Biological sciences and medical sciences ( Journals of Gerontology - Series A Biological Sciences and Medical Sciences )  73 ( 11 ) 1448 - 1452   2018年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

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Minimal shortening of leukocyte telomere length across age groups in a cross-sectional study for carriers of a longevity-associated FOXO3 allele

Davy PMC, Willcox DC, Shimabukuro M, Donlon TA, Torigoe T, Suzuki M, Higa M, Masuzaki H, Sata M, Chen R, Murkofsky R, Morris BJ, Lim E, Allsopp RC, Willcox BJ

J Gerontol A Biol Sci Med Sci   73 ( 11 ) 1448 - 1452   2018年10月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）

Usefulness of epicardial adipose tissue volume to predict recurrent atrial fibrillation after radiofrequency catheter ablation

Maeda M, Oba K, Yamaguchi S, Arasaki O, Sata M, Masuzaki H, Shimabukuro M

Am J Cardiol   122 ( 10 ) 1694 - 1700   2018年10月 [ 査読有り ]

掲載種別: 研究論文（その他学術会議資料等）

Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior

Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C

Neurosci Res   134   39 - 48   2018年09月 [ 査読有り ]

掲載種別: 研究論文（学術雑誌）